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Items: 1 to 50 of 142

1.

Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.

Schoenherr C, Frame MC, Byron A.

Annu Rev Cell Dev Biol. 2018 Oct 6;34:29-58. doi: 10.1146/annurev-cellbio-100617-062559. Epub 2018 Aug 15. Review.

PMID:
30110558
2.

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

Yen-Pon E, Li B, Acebrón-Garcia-de-Eulate M, Tomkiewicz-Raulet C, Dawson J, Lietha D, Frame MC, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H.

ACS Chem Biol. 2018 Aug 17;13(8):2067-2073. doi: 10.1021/acschembio.8b00250. Epub 2018 Jun 22.

PMID:
29897729
3.

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Serrels B, McGivern N, Canel M, Byron A, Johnson SC, McSorley HJ, Quinn N, Taggart D, Von Kreigsheim A, Anderton SM, Serrels A, Frame MC.

Sci Signal. 2017 Dec 5;10(508). pii: eaan8355. doi: 10.1126/scisignal.aan8355.

4.

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Canel M, Byron A, Sims AH, Cartier J, Patel H, Frame MC, Brunton VG, Serrels B, Serrels A.

Cancer Res. 2017 Oct 1;77(19):5301-5312. doi: 10.1158/0008-5472.CAN-17-0418. Epub 2017 Aug 14.

5.

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Schoenherr C, Byron A, Sandilands E, Paliashvili K, Baillie GS, Garcia-Munoz A, Valacca C, Cecconi F, Serrels B, Frame MC.

Elife. 2017 Mar 31;6. pii: e23172. doi: 10.7554/eLife.23172.

6.

Cellular functions of the ADF/cofilin family at a glance.

Kanellos G, Frame MC.

J Cell Sci. 2016 Sep 1;129(17):3211-8. doi: 10.1242/jcs.187849. Epub 2016 Aug 9. Review.

7.

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy.

Serrels A, Frame MC.

Oncoimmunology. 2016 Jan 13;5(4):e1119356. eCollection 2016 Apr.

8.

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A.

J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4.

9.

Kindlin1 regulates microtubule function to ensure normal mitosis.

Patel H, Stavrou I, Shrestha RL, Draviam V, Frame MC, Brunton VG.

J Mol Cell Biol. 2016 Aug;8(4):338-48. doi: 10.1093/jmcb/mjw009. Epub 2016 Mar 18.

10.

The ROCKs on which tumour cells thrive.

Wilkinson S, Frame MC.

Elife. 2016 Mar 7;5:e14511. doi: 10.7554/eLife.14511.

11.

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts.

Byron A, Frame MC.

Curr Opin Cell Biol. 2016 Apr;39:93-100. doi: 10.1016/j.ceb.2016.02.013. Epub 2016 Feb 27. Review.

12.

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Kanellos G, Zhou J, Patel H, Ridgway RA, Huels D, Gurniak CB, Sandilands E, Carragher NO, Sansom OJ, Witke W, Brunton VG, Frame MC.

Cell Rep. 2015 Dec 1;13(9):1949-64. doi: 10.1016/j.celrep.2015.10.056. Epub 2015 Nov 19.

13.

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.

Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC.

Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001.

14.

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy.

Sandilands E, Schoenherr C, Frame MC.

Cell Signal. 2015 Sep;27(9):1816-23. doi: 10.1016/j.cellsig.2015.05.017. Epub 2015 Jun 9.

15.

FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.

Frame MC, Serrels A.

Cancer Cell. 2015 Apr 13;27(4):429-31. doi: 10.1016/j.ccell.2015.03.013.

16.

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

Schoenherr C, Serrels B, Proby C, Cunningham DL, Findlay JE, Baillie GS, Heath JK, Frame MC.

J Cell Sci. 2014 Dec 15;127(Pt 24):5303-16. doi: 10.1242/jcs.157560. Epub 2014 Oct 29.

17.

The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.

Sauter KA, Pridans C, Sehgal A, Bain CC, Scott C, Moffat L, Rojo R, Stutchfield BM, Davies CL, Donaldson DS, Renault K, McColl BW, Mowat AM, Serrels A, Frame MC, Mabbott NA, Hume DA.

PLoS One. 2014 Aug 19;9(8):e105429. doi: 10.1371/journal.pone.0105429. eCollection 2014.

18.

c-Src drives intestinal regeneration and transformation.

Cordero JB, Ridgway RA, Valeri N, Nixon C, Frame MC, Muller WJ, Vidal M, Sansom OJ.

EMBO J. 2014 Jul 1;33(13):1474-91. doi: 10.1002/embj.201387454. Epub 2014 Apr 30.

19.

V-SRC informs integrin signalling.

Frame MC.

Nat Rev Mol Cell Biol. 2013 Sep;14(9):548. doi: 10.1038/nrm3647. Epub 2013 Aug 14. No abstract available.

PMID:
23942448
20.

Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

Patel H, Zich J, Serrels B, Rickman C, Hardwick KG, Frame MC, Brunton VG.

Nat Commun. 2013;4:2056. doi: 10.1038/ncomms3056.

PMID:
23804033
21.

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Nobis M, McGhee EJ, Morton JP, Schwarz JP, Karim SA, Quinn J, Edward M, Campbell AD, McGarry LC, Evans TR, Brunton VG, Frame MC, Carragher NO, Wang Y, Sansom OJ, Timpson P, Anderson KI.

Cancer Res. 2013 Aug 1;73(15):4674-86. doi: 10.1158/0008-5472.CAN-12-4545. Epub 2013 Jun 7.

22.

E-cadherin-integrin crosstalk in cancer invasion and metastasis.

Canel M, Serrels A, Frame MC, Brunton VG.

J Cell Sci. 2013 Jan 15;126(Pt 2):393-401. doi: 10.1242/jcs.100115. Epub 2013 Mar 22. Review.

23.

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM.

Curr Biol. 2013 Jan 21;23(2):107-17. doi: 10.1016/j.cub.2012.11.059. Epub 2012 Dec 27.

24.

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.

Sandilands E, Serrels B, Wilkinson S, Frame MC.

EMBO Rep. 2012 Aug;13(8):733-40. doi: 10.1038/embor.2012.92. Epub 2012 Jun 26. Erratum in: EMBO Rep. 2012 Sep;13(9):867.

25.

Diversity of matriptase expression level and function in breast cancer.

Welman A, Sproul D, Mullen P, Muir M, Kinnaird AR, Harrison DJ, Faratian D, Brunton VG, Frame MC.

PLoS One. 2012;7(4):e34182. doi: 10.1371/journal.pone.0034182. Epub 2012 Apr 13.

26.

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Carragher NO, Brunton VG, Frame MC.

Drug Discov Today. 2012 Mar;17(5-6):203-14. Review.

PMID:
22493783
27.
28.

FAK and talin: who is taking whom to the integrin engagement party?

Serrels B, Frame MC.

J Cell Biol. 2012 Jan 23;196(2):185-7. doi: 10.1083/jcb.201112128.

29.

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.

Graham K, Moran-Jones K, Sansom OJ, Brunton VG, Frame MC.

PLoS One. 2011;6(12):e27806. doi: 10.1371/journal.pone.0027806. Epub 2011 Dec 14.

30.

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

Sandilands E, Serrels B, McEwan DG, Morton JP, Macagno JP, McLeod K, Stevens C, Brunton VG, Langdon WY, Vidal M, Sansom OJ, Dikic I, Wilkinson S, Frame MC.

Nat Cell Biol. 2011 Dec 4;14(1):51-60. doi: 10.1038/ncb2386.

PMID:
22138575
31.

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging.

Serrels A, Canel M, Brunton VG, Frame MC.

Cell Adh Migr. 2011 Jul-Aug;5(4):360-5. Epub 2011 Jul 1. Review.

32.

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells.

Serrels A, McLeod K, Canel M, Kinnaird A, Graham K, Frame MC, Brunton VG.

Int J Cancer. 2012 Jul 15;131(2):287-97. doi: 10.1002/ijc.26351. Epub 2011 Aug 30.

33.

Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1.

Serrels B, Sandilands E, Frame MC.

Small GTPases. 2011 Jan;2(1):54-61.

34.

The calpain system and cancer.

Storr SJ, Carragher NO, Frame MC, Parr T, Martin SG.

Nat Rev Cancer. 2011 May;11(5):364-74. doi: 10.1038/nrc3050. Review.

PMID:
21508973
35.
36.

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.

Timpson P, McGhee EJ, Morton JP, von Kriegsheim A, Schwarz JP, Karim SA, Doyle B, Quinn JA, Carragher NO, Edward M, Olson MF, Frame MC, Brunton VG, Sansom OJ, Anderson KI.

Cancer Res. 2011 Feb 1;71(3):747-57. doi: 10.1158/0008-5472.CAN-10-2267. Epub 2011 Jan 25.

37.

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Canel M, Serrels A, Miller D, Timpson P, Serrels B, Frame MC, Brunton VG.

Cancer Res. 2010 Nov 15;70(22):9413-22. doi: 10.1158/0008-5472.CAN-10-1454. Epub 2010 Nov 2.

38.

The FERM domain: organizing the structure and function of FAK.

Frame MC, Patel H, Serrels B, Lietha D, Eck MJ.

Nat Rev Mol Cell Biol. 2010 Nov;11(11):802-14. doi: 10.1038/nrm2996. Review.

PMID:
20966971
39.

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ.

Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015.

40.

mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion.

Tanji M, Ishizaki T, Ebrahimi S, Tsuboguchi Y, Sukezane T, Akagi T, Frame MC, Hashimoto N, Miyamoto S, Narumiya S.

Mol Cell Biol. 2010 Oct;30(19):4604-15. doi: 10.1128/MCB.00197-10. Epub 2010 Aug 2.

41.

Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane.

Canel M, Serrels A, Anderson KI, Frame MC, Brunton VG.

Cell Adh Migr. 2010 Oct-Dec;4(4):491-501.

42.

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Hannigan A, Smith P, Kalna G, Lo Nigro C, Orange C, O'Brien DI, Shah R, Syed N, Spender LC, Herrera B, Thurlow JK, Lattanzio L, Monteverde M, Maurer ME, Buffa FM, Mann J, Chu DC, West CM, Patridge M, Oien KA, Cooper JA, Frame MC, Harris AL, Hiller L, Nicholson LJ, Gasco M, Crook T, Inman GJ.

J Clin Invest. 2010 Aug;120(8):2842-57. doi: 10.1172/JCI36125. Epub 2010 Jul 1.

43.

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, Machesky LM, Anderson KI, Frame MC.

Curr Biol. 2010 Jun 22;20(12):1086-92. doi: 10.1016/j.cub.2010.04.042. Epub 2010 May 20.

44.

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.

Morton JP, Jamieson NB, Karim SA, Athineos D, Ridgway RA, Nixon C, McKay CJ, Carter R, Brunton VG, Frame MC, Ashworth A, Oien KA, Evans TR, Sansom OJ.

Gastroenterology. 2010 Aug;139(2):586-97, 597.e1-6. doi: 10.1053/j.gastro.2010.04.055. Epub 2010 May 6.

45.

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma.

Morton JP, Karim SA, Graham K, Timpson P, Jamieson N, Athineos D, Doyle B, McKay C, Heung MY, Oien KA, Frame MC, Evans TR, Sansom OJ, Brunton VG.

Gastroenterology. 2010 Jul;139(1):292-303. doi: 10.1053/j.gastro.2010.03.034. Epub 2010 Mar 17.

PMID:
20303350
46.

Two-color photoactivatable probe for selective tracking of proteins and cells.

Welman A, Serrels A, Brunton VG, Ditzel M, Frame MC.

J Biol Chem. 2010 Apr 9;285(15):11607-16. doi: 10.1074/jbc.M110.102392. Epub 2010 Feb 5.

47.

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.

Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TR, Sansom OJ.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):246-51. doi: 10.1073/pnas.0908428107. Epub 2009 Dec 14.

48.

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.

Timpson P, Serrels A, Canel M, Frame MC, Brunton VG, Anderson KI.

Cell Adh Migr. 2009 Oct-Dec;3(4):351-4. Epub 2009 Oct 7. Review.

49.

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Serrels A, Timpson P, Canel M, Schwarz JP, Carragher NO, Frame MC, Brunton VG, Anderson KI.

Cancer Res. 2009 Apr 1;69(7):2714-9. doi: 10.1158/0008-5472.CAN-08-4308. Epub 2009 Mar 24.

50.

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.

Seong J, Lu S, Ouyang M, Huang H, Zhang J, Frame MC, Wang Y.

Chem Biol. 2009 Jan 30;16(1):48-57. doi: 10.1016/j.chembiol.2008.11.007.

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