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Items: 1 to 50 of 56

1.

Sex differences in the peripubertal response to a short-term, high-fat diet intake.

Freire-Regatillo A, Fernández-Gómez MJ, Díaz F, Barrios V, Sánchez-Jabonero I, Frago LM, Argente J, García-Segura LM, Chowen JA.

J Neuroendocrinol. 2020 Jan;32(1):e12756. doi: 10.1111/jne.12756. Epub 2019 Jul 1.

PMID:
31179596
2.

Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system.

Aguado-Llera D, Canelles S, Fernández-Mendívil C, Frago LM, Argente J, Arilla-Ferreiro E, López MG, Barrios V.

Neuropharmacology. 2019 Jun;151:112-126. doi: 10.1016/j.neuropharm.2019.04.008. Epub 2019 Apr 11.

PMID:
30981749
3.

Physiological and pathophysiological roles of hypothalamic astrocytes in metabolism.

Chowen JA, Frago LM, Fernández-Alfonso MS.

J Neuroendocrinol. 2019 May;31(5):e12671. doi: 10.1111/jne.12671. Epub 2019 Jan 21. Review.

PMID:
30561077
4.

The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A.

Aguado-Llera D, Canelles S, Frago LM, Chowen JA, Argente J, Arilla E, Barrios V.

Neuroscience. 2018 Mar 15;374:104-118. doi: 10.1016/j.neuroscience.2018.01.041. Epub 2018 Feb 3.

PMID:
29406271
5.

Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid.

Frago LM, Canelles S, Freire-Regatillo A, Argente-Arizón P, Barrios V, Argente J, Garcia-Segura LM, Chowen JA.

Front Mol Neurosci. 2017 Oct 24;10:330. doi: 10.3389/fnmol.2017.00330. eCollection 2017.

6.

The increase in fiber size in male rat gastrocnemius after chronic central leptin infusion is related to activation of insulin signaling.

Burgos-Ramos E, Canelles S, Rodríguez A, Frago LM, Gómez-Ambrosi J, Chowen JA, Frühbeck G, Argente J, Barrios V.

Mol Cell Endocrinol. 2018 Jul 15;470:48-59. doi: 10.1016/j.mce.2017.09.029. Epub 2017 Sep 27.

PMID:
28962893
7.

Involvement of Astrocytes in Mediating the Central Effects of Ghrelin.

Frago LM, Chowen JA.

Int J Mol Sci. 2017 Mar 2;18(3). pii: E536. doi: 10.3390/ijms18030536. Review.

8.

Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes.

Fuente-Martín E, García-Cáceres C, Argente-Arizón P, Díaz F, Granado M, Freire-Regatillo A, Castro-González D, Ceballos ML, Frago LM, Dickson SL, Argente J, Chowen JA.

Sci Rep. 2016 Mar 30;6:23673. doi: 10.1038/srep23673.

9.

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.

Baquedano E, Burgos-Ramos E, Canelles S, González-Rodríguez A, Chowen JA, Argente J, Barrios V, Valverde AM, Frago LM.

Dis Model Mech. 2016 May 1;9(5):573-83. doi: 10.1242/dmm.023515. Epub 2016 Mar 24.

10.

The role of astrocytes in the hypothalamic response and adaptation to metabolic signals.

Chowen JA, Argente-Arizón P, Freire-Regatillo A, Frago LM, Horvath TL, Argente J.

Prog Neurobiol. 2016 Sep;144:68-87. doi: 10.1016/j.pneurobio.2016.03.001. Epub 2016 Mar 18. Review.

PMID:
27000556
11.

Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism.

Burgos-Ramos E, Canelles S, Frago LM, Chowen JA, Arilla-Ferreiro E, Argente J, Barrios V.

Nutr Metab (Lond). 2016 Mar 1;13:19. doi: 10.1186/s12986-016-0079-9. eCollection 2016.

12.

Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone.

Perianes-Cachero A, Canelles S, Aguado-Llera D, Frago LM, Toledo-Lobo MV, Carrera I, Cacabelos R, Chowen JA, Argente J, Arilla-Ferreiro E, Barrios V.

J Neurochem. 2015 Dec;135(6):1257-71. doi: 10.1111/jnc.13381. Epub 2015 Nov 6.

13.

Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism.

Burgos-Ramos E, Canelles S, Rodríguez A, Gómez-Ambrosi J, Frago LM, Chowen JA, Frühbeck G, Argente J, Barrios V.

Mol Cell Endocrinol. 2015 Nov 5;415:157-72. doi: 10.1016/j.mce.2015.08.014. Epub 2015 Aug 18.

PMID:
26296906
14.

Hypothalamic Leptin and Ghrelin Signaling as Targets for Improvement in Metabolic Control.

Frago LM, Chowen JA.

Curr Pharm Des. 2015;21(25):3596-605. Review.

PMID:
26166609
15.

The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice.

Baquedano E, Ruiz-Lopez AM, Sustarsic EG, Herpy J, List EO, Chowen JA, Frago LM, Kopchick JJ, Argente J.

Endocrinology. 2014 Dec;155(12):4856-67. doi: 10.1210/en.2014-1367. Epub 2014 Sep 19.

PMID:
25237935
16.

The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats.

García-Cáceres C, Fuente-Martín E, Díaz F, Granado M, Argente-Arizón P, Frago LM, Freire-Regatillo A, Barrios V, Argente J, Chowen JA.

Endocrinology. 2014 Aug;155(8):2868-80. doi: 10.1210/en.2014-1074. Epub 2014 May 21.

PMID:
24848869
17.

Acute up-regulation of the rat brain somatostatin receptor-effector system by leptin is related to activation of insulin signaling and may counteract central leptin actions.

Perianes-Cachero A, Burgos-Ramos E, Puebla-Jiménez L, Canelles S, Frago LM, Hervás-Aguilar A, de Frutos S, Toledo-Lobo MV, Mela V, Viveros MP, Argente J, Chowen JA, Arilla-Ferreiro E, Barrios V.

Neuroscience. 2013 Nov 12;252:289-301. doi: 10.1016/j.neuroscience.2013.08.019. Epub 2013 Aug 23.

PMID:
23973620
18.

Differential effects of GH and GH-releasing peptide-6 on astrocytes.

Baquedano E, Chowen JA, Argente J, Frago LM.

J Endocrinol. 2013 Jul 29;218(3):263-74. doi: 10.1530/JOE-13-0053. Print 2013 Sep.

PMID:
23792323
19.

Maternal stress alters the developmental program of embryonic hippocampal neurons growing in vitro.

Diz-Chaves Y, Baquedano E, Frago LM, Chowen JA, Garcia-Segura LM, Arevalo MA.

Psychoneuroendocrinology. 2013 Mar;38(3):455-9. doi: 10.1016/j.psyneuen.2012.07.001. Epub 2012 Jul 24.

PMID:
22832184
20.

Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet.

Fuente-Martín E, García-Cáceres C, Granado M, Sánchez-Garrido MA, Tena-Sempere M, Frago LM, Argente J, Chowen JA.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1586-98. doi: 10.1152/ajpendo.00618.2011. Epub 2012 Apr 17.

21.

Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.

Burgos-Ramos E, González-Rodríguez A, Canelles S, Baquedano E, Frago LM, Revuelta-Cervantes J, Gómez-Ambrosi J, Frühbeck G, Chowen JA, Argente J, Valverde AM, Barrios V.

Endocrinology. 2012 Mar;153(3):1129-40. doi: 10.1210/en.2011-1278. Epub 2011 Dec 30.

22.

Early nutritional changes induce sexually dimorphic long-term effects on body weight gain and the response to sucrose intake in adult rats.

Fuente-Martín E, Granado M, García-Cáceres C, Sanchez-Garrido MA, Frago LM, Tena-Sempere M, Argente J, Chowen JA.

Metabolism. 2012 Jun;61(6):812-22. doi: 10.1016/j.metabol.2011.11.003. Epub 2011 Dec 29.

PMID:
22209665
23.

Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats.

Baquedano E, García-Cáceres C, Diz-Chaves Y, Lagunas N, Calmarza-Font I, Azcoitia I, Garcia-Segura LM, Argente J, Chowen JA, Frago LM.

PLoS One. 2011;6(11):e27549. doi: 10.1371/journal.pone.0027549. Epub 2011 Nov 9.

24.

Neuroprotective actions of ghrelin and growth hormone secretagogues.

Frago LM, Baquedano E, Argente J, Chowen JA.

Front Mol Neurosci. 2011 Sep 28;4:23. doi: 10.3389/fnmol.2011.00023. eCollection 2011.

25.

Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats.

Granado M, García-Cáceres C, Tuda M, Frago LM, Chowen JA, Argente J.

Mol Cell Endocrinol. 2011 Apr 30;337(1-2):101-13. doi: 10.1016/j.mce.2011.02.002. Epub 2011 Feb 23.

PMID:
21352888
26.

Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels.

García-Cáceres C, Fuente-Martín E, Burgos-Ramos E, Granado M, Frago LM, Barrios V, Horvath T, Argente J, Chowen JA.

Endocrinology. 2011 May;152(5):1809-18. doi: 10.1210/en.2010-1252. Epub 2011 Feb 22.

27.

Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition.

Tapia-González S, García-Segura LM, Tena-Sempere M, Frago LM, Castellano JM, Fuente-Martín E, García-Cáceres C, Argente J, Chowen JA.

J Neuroendocrinol. 2011 Apr;23(4):365-70. doi: 10.1111/j.1365-2826.2011.02113.x.

PMID:
21314736
28.

Gender differences in the long-term effects of chronic prenatal stress on the HPA axis and hypothalamic structure in rats.

García-Cáceres C, Lagunas N, Calmarza-Font I, Azcoitia I, Diz-Chaves Y, García-Segura LM, Baquedano E, Frago LM, Argente J, Chowen JA.

Psychoneuroendocrinology. 2010 Nov;35(10):1525-35. doi: 10.1016/j.psyneuen.2010.05.006. Epub 2010 Jun 16.

PMID:
20558007
29.

The positive effects of growth hormone-releasing peptide-6 on weight gain and fat mass accrual depend on the insulin/glucose status.

Granado M, García-Cáceres C, Frago LM, Argente J, Chowen JA.

Endocrinology. 2010 May;151(5):2008-18. doi: 10.1210/en.2009-1394. Epub 2010 Mar 10.

PMID:
20219977
30.

The weight gain response to stress during adulthood is conditioned by both sex and prenatal stress exposure.

García-Cáceres C, Diz-Chaves Y, Lagunas N, Calmarza-Font I, Azcoitia I, Garcia-Segura LM, Frago LM, Argente J, Chowen JA.

Psychoneuroendocrinology. 2010 Apr;35(3):403-13. doi: 10.1016/j.psyneuen.2009.08.001. Epub 2009 Sep 1.

PMID:
19726133
31.

Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats.

Granado M, Chowen JA, García-Cáceres C, Delgado-Rubín A, Barrios V, Castillero E, Argente J, Frago LM.

Mol Cell Endocrinol. 2009 Oct 15;309(1-2):67-75. doi: 10.1016/j.mce.2009.06.006. Epub 2009 Jun 18.

PMID:
19540304
32.

Growth hormone-releasing peptide 6 protection of hypothalamic neurons from glutamate excitotoxicity is caspase independent and not mediated by insulin-like growth factor I.

Delgado-Rubín A, Chowen JA, Argente J, Frago LM.

Eur J Neurosci. 2009 Jun;29(11):2115-24. doi: 10.1111/j.1460-9568.2009.06770.x. Epub 2009 May 21.

PMID:
19490089
33.

Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice.

Pañeda C, Huitron-Resendiz S, Frago LM, Chowen JA, Picetti R, de Lecea L, Roberts AJ.

J Neurosci. 2009 Apr 1;29(13):4155-61. doi: 10.1523/JNEUROSCI.5256-08.2009.

34.

Death of hypothalamic astrocytes in poorly controlled diabetic rats is associated with nuclear translocation of apoptosis inducing factor.

García-Cáceres C, Lechuga-Sancho A, Argente J, Frago LM, Chowen JA.

J Neuroendocrinol. 2008 Dec;20(12):1348-60. doi: 10.1111/j.1365-2826.2008.01795.x.

PMID:
19094082
35.

Cell-specific expression of X-linked inhibitor of apoptosis in the anterior pituitary of streptozotocin-induced diabetic rats.

Arroba AI, Lechuga-Sancho AM, Frago LM, Argente J, Chowen JA.

J Endocrinol. 2007 Jan;192(1):215-27.

PMID:
17210759
36.

Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity.

Delgado-Rubín de Célix A, Chowen JA, Argente J, Frago LM.

J Neurochem. 2006 Nov;99(3):839-49.

37.

Increased apoptosis of lactotrophs in streptozotocin-induced diabetic rats is followed by increased proliferation.

Arroba AI, Lechuga-Sancho AM, Frago LM, Argente J, Chowen JA.

J Endocrinol. 2006 Oct;191(1):55-63.

PMID:
17065389
38.

Reduction in the number of astrocytes and their projections is associated with increased synaptic protein density in the hypothalamus of poorly controlled diabetic rats.

Lechuga-Sancho AM, Arroba AI, Frago LM, García-Cáceres C, de Célix AD, Argente J, Chowen JA.

Endocrinology. 2006 Nov;147(11):5314-24. Epub 2006 Jul 27.

PMID:
16873533
39.

17Beta-estradiol protects depletion of rat temporal cortex somatostatinergic system by beta-amyloid.

Aguado-Llera D, Arilla-Ferreiro E, Chowen JA, Argente J, Puebla-Jiménez L, Frago LM, Barrios V.

Neurobiol Aging. 2007 Sep;28(9):1396-409. Epub 2006 Jul 14.

PMID:
16843571
40.

Activation of the intrinsic cell death pathway, increased apoptosis and modulation of astrocytes in the cerebellum of diabetic rats.

Lechuga-Sancho AM, Arroba AI, Frago LM, Pañeda C, García-Cáceres C, Delgado Rubín de Célix A, Argente J, Chowen JA.

Neurobiol Dis. 2006 Aug;23(2):290-9. Epub 2006 Jun 6.

PMID:
16753303
41.

Basic physiology of the growth hormone/insulin-like growth factor axis.

Frago LM, Chowen JA.

Adv Exp Med Biol. 2005;567:1-25. Review. No abstract available.

PMID:
16370134
42.
43.

Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs.

Arroba AI, Frago LM, Argente J, Chowen JA.

Endocrinology. 2005 Oct;146(10):4417-24. Epub 2005 Jun 23.

PMID:
15976052
44.
45.

The regulation of GH secretion by sex steroids.

Chowen JA, Frago LM, Argente J.

Eur J Endocrinol. 2004 Nov;151 Suppl 3:U95-100. Review.

PMID:
15554893
46.

Growth hormone-releasing peptide-6 inhibits cerebellar cell death in aged rats.

Pañeda C, Arroba AI, Frago LM, Holm AM, Rømer J, Argente J, Chowen JA.

Neuroreport. 2003 Aug 26;14(12):1633-5.

PMID:
14502090
47.

The number of lactotrophs is reduced in the anterior pituitary of streptozotocin-induced diabetic rats.

Arroba AI, Frago LM, Pañeda C, Argente J, Chowen JA.

Diabetologia. 2003 May;46(5):634-8. Epub 2003 May 13.

PMID:
12743699
48.

Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I.

Frago LM, Cañón S, de la Rosa EJ, León Y, Varela-Nieto I.

J Cell Sci. 2003 Feb 1;116(Pt 3):475-86.

49.
50.

Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.

Colombaioni L, Frago LM, Varela-Nieto I, Pesi R, Garcia-Gil M.

Neurochem Int. 2002 Apr;40(4):327-36.

PMID:
11792463

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