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STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype.

Della Corte CM, Sen T, Gay CM, Ramkumar K, Diao L, Cardnell RJ, Rodriguez BL, Stewart CA, Papadimitrakopoulou VA, Gibson L, Fradette JJ, Wang Q, Fan Y, Peng DH, Negrao MV, Wistuba II, Fujimoto J, Solis Soto LM, Behrens C, Skoulidis F, Heymach JV, Wang J, Gibbons DL, Byers LA.

J Thorac Oncol. 2020 Feb 15. pii: S1556-0864(20)30030-7. doi: 10.1016/j.jtho.2020.01.009. [Epub ahead of print]


The Good, the Bad and the Unknown of CD38 in the Metabolic Microenvironment and Immune Cell Functionality of Solid Tumors.

Konen JM, Fradette JJ, Gibbons DL.

Cells. 2019 Dec 24;9(1). pii: E52. doi: 10.3390/cells9010052. Review.


Combining transcutaneous electrical nerve stimulation with therapeutic exercise to reduce pain in an elderly population: a pilot study.

Vaillancourt S, Coulombe-Lévêque A, Fradette J, Martel S, Naour W, da Silva RA, Léonard G.

Disabil Rehabil. 2019 Dec 15:1-8. doi: 10.1080/09638288.2019.1693639. [Epub ahead of print]


ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.

Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, Heffernan T, Creighton CJ, Raught B, Gibbons DL.

Nat Commun. 2019 Nov 12;10(1):5125. doi: 10.1038/s41467-019-12832-z.


Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue.

Ouellette MÈ, Bérubé JC, Bourget JM, Vallée M, Bossé Y, Fradette J.

PLoS One. 2019 Oct 22;14(10):e0224228. doi: 10.1371/journal.pone.0224228. eCollection 2019.


Modulation of the Lipid Profile of Reconstructed Skin Substitutes after Essential Fatty Acid Supplementation Affects Testosterone Permeability.

Simard M, Julien P, Fradette J, Pouliot R.

Cells. 2019 Sep 25;8(10). pii: E1142. doi: 10.3390/cells8101142.


Isolation and Culture of Human Dermal Microvascular Endothelial Cells.

Bourland J, Mayrand D, Tremblay N, Moulin VJ, Fradette J, Auger FA.

Methods Mol Biol. 2019;1993:79-90. doi: 10.1007/978-1-4939-9473-1_7.


Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.

Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA.

Cancers (Basel). 2019 May 24;11(5). pii: E714. doi: 10.3390/cancers11050714. Review.


Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer.

Konen JM, Rodriguez BL, Fradette JJ, Gibson L, Davis D, Minelli R, Peoples MD, Kovacs J, Carugo A, Bristow C, Heffernan T, Gibbons DL.

Cancers (Basel). 2019 Apr 2;11(4). pii: E462. doi: 10.3390/cancers11040462.


A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-small cell lung cancer.

Padhye A, Ungewiss C, Fradette JJ, Rodriguez BL, Albritton JL, Miller JS, Gibbons DL.

Sci Rep. 2019 Mar 20;9(1):4819. doi: 10.1038/s41598-019-41301-2.


ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.

Peng DH, Kundu ST, Fradette JJ, Diao L, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Mino B, Yang Y, Minelli R, Peoples MD, Bristow CA, Heffernan TP, Carugo A, Wistuba II, Gibbons DL.

Sci Transl Med. 2019 Mar 13;11(483). pii: eaaq1238. doi: 10.1126/scitranslmed.aaq1238.


Corrigendum to "Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes" EBioMedicine 30C (2018) 237-247.

Rakotoarivelo V, Lacraz G, Mayhue M, Brown C, Rottembourg D, Fradette J, Ilangumaran S, Menendez A, Langlois MF, Ramanathan S.

EBioMedicine. 2018 Nov;37:564-568. doi: 10.1016/j.ebiom.2018.10.025. Epub 2018 Oct 16. No abstract available.


Short-term post-implantation dynamics of in vitro engineered human microvascularized adipose tissues.

Proulx M, Mayrand D, Vincent C, Boisvert A, Aubin K, Trottier V, Fradette J.

Biomed Mater. 2018 Oct 2;13(6):065013. doi: 10.1088/1748-605X/aadff7.


Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development.

Bourland J, Fradette J, Auger FA.

Sci Rep. 2018 Sep 4;8(1):13191. doi: 10.1038/s41598-018-31502-6.


TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.

Kundu ST, Grzeskowiak CL, Fradette JJ, Gibson LA, Rodriguez LB, Creighton CJ, Scott KL, Gibbons DL.

Nat Commun. 2018 Jul 16;9(1):2731. doi: 10.1038/s41467-018-05013-x.


In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.

Grzeskowiak CL, Kundu ST, Mo X, Ivanov AA, Zagorodna O, Lu H, Chapple RH, Tsang YH, Moreno D, Mosqueda M, Eterovic K, Fradette JJ, Ahmad S, Chen F, Chong Z, Chen K, Creighton CJ, Fu H, Mills GB, Gibbons DL, Scott KL.

Nat Commun. 2018 Jul 16;9(1):2732. doi: 10.1038/s41467-018-04572-3.


CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade.

Chen L, Diao L, Yang Y, Yi X, Rodriguez BL, Li Y, Villalobos PA, Cascone T, Liu X, Tan L, Lorenzi PL, Huang A, Zhao Q, Peng D, Fradette JJ, Peng DH, Ungewiss C, Roybal J, Tong P, Oba J, Skoulidis F, Peng W, Carter BW, Gay CM, Fan Y, Class CA, Zhu J, Rodriguez-Canales J, Kawakami M, Byers LA, Woodman SE, Papadimitrakopoulou VA, Dmitrovsky E, Wang J, Ullrich SE, Wistuba II, Heymach JV, Qin FX, Gibbons DL.

Cancer Discov. 2018 Sep;8(9):1156-1175. doi: 10.1158/2159-8290.CD-17-1033. Epub 2018 Jul 16.


High Definition Confocal Imaging Modalities for the Characterization of Tissue-Engineered Substitutes.

Mayrand D, Fradette J.

Methods Mol Biol. 2018;1773:93-105. doi: 10.1007/978-1-4939-7799-4_8.


Self-assembled human osseous cell sheets as living biopapers for the laser-assisted bioprinting of human endothelial cells.

Kawecki F, Clafshenkel WP, Auger FA, Bourget JM, Fradette J, Devillard R.

Biofabrication. 2018 Apr 30;10(3):035006. doi: 10.1088/1758-5090/aabd5b.


Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes.

Rakotoarivelo V, Lacraz G, Mayhue M, Brown C, Rottembourg D, Fradette J, Ilangumaran S, Menendez A, Langlois MF, Ramanathan S.

EBioMedicine. 2018 Apr;30:237-247. doi: 10.1016/j.ebiom.2018.03.004. Epub 2018 Mar 8. Erratum in: EBioMedicine. 2018 Nov;37:564-568.


Biomimetic Tissue-Engineered Bone Substitutes for Maxillofacial and Craniofacial Repair: The Potential of Cell Sheet Technologies.

Kawecki F, Clafshenkel WP, Fortin M, Auger FA, Fradette J.

Adv Healthc Mater. 2018 Mar;7(6):e1700919. doi: 10.1002/adhm.201700919. Epub 2017 Dec 27. Review.


Workshop to address gaps in regulation of minimally manipulated autologous cell therapies for homologous use in Canada.

Chisholm J, von Tigerstrom B, Bedford P, Fradette J, Viswanathan S.

Cytotherapy. 2017 Dec;19(12):1400-1411. doi: 10.1016/j.jcyt.2017.08.015. Epub 2017 Sep 28.


Role of the TGF-β pathway in dedifferentiation of human mature adipocytes.

Côté JA, Lessard J, Pelletier M, Marceau S, Lescelleur O, Fradette J, Tchernof A.

FEBS Open Bio. 2017 Jul 10;7(8):1092-1101. doi: 10.1002/2211-5463.12250. eCollection 2017 Aug.


A Cell-Based Self-Assembly Approach for the Production of Human Osseous Tissues from Adipose-Derived Stromal/Stem Cells.

Galbraith T, Clafshenkel WP, Kawecki F, Blanckaert C, Labbé B, Fortin M, Auger FA, Fradette J.

Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201600889. Epub 2016 Dec 22.


Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.

Chen L, Yi X, Goswami S, Ahn YH, Roybal JD, Yang Y, Diao L, Peng D, Peng D, Fradette JJ, Wang J, Byers LA, Kurie JM, Ullrich SE, Qin FX, Gibbons DL.

Oncoimmunology. 2016 Sep 26;5(11):e1234570. doi: 10.1080/2162402X.2016.1234570. eCollection 2016.


Correction: Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Nov 8;11(11):e0166537. doi: 10.1371/journal.pone.0166537. eCollection 2016.


Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Sep 29;11(9):e0162995. doi: 10.1371/journal.pone.0162995. eCollection 2016. Erratum in: PLoS One. 2016 Nov 8;11(11):e0166537.


Characterization of In Vitro Engineered Human Adipose Tissues: Relevant Adipokine Secretion and Impact of TNF-α.

Aubin K, Safoine M, Proulx M, Audet-Casgrain MA, Côté JF, Têtu FA, Roy A, Fradette J.

PLoS One. 2015 Sep 14;10(9):e0137612. doi: 10.1371/journal.pone.0137612. eCollection 2015.


Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2.

Fouad Mansour M, Pelletier M, Boulet MM, Mayrand D, Brochu G, Lebel S, Poirier D, Fradette J, Cianflone K, Luu-The V, Tchernof A.

Mol Cell Endocrinol. 2015 Oct 15;414:168-76. doi: 10.1016/j.mce.2015.06.016. Epub 2015 Jun 26.


Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes.

Vallières K, Laterreur V, Tondreau MY, Ruel J, Germain L, Fradette J, Auger FA.

Acta Biomater. 2015 Sep;24:209-19. doi: 10.1016/j.actbio.2015.06.011. Epub 2015 Jun 15.


Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells.

Talele NP, Fradette J, Davies JE, Kapus A, Hinz B.

Stem Cell Reports. 2015 Jun 9;4(6):1016-30. doi: 10.1016/j.stemcr.2015.05.004. Epub 2015 May 28.


Enhancing repair of full-thickness excisional wounds in a murine model: Impact of tissue-engineered biological dressings featuring human differentiated adipocytes.

Morissette Martin P, Maux A, Laterreur V, Mayrand D, L Gagné V, Moulin VJ, Fradette J.

Acta Biomater. 2015 Aug;22:39-49. doi: 10.1016/j.actbio.2015.04.036. Epub 2015 Apr 29.


Melatonin pretreatment of human adipose tissue-derived mesenchymal stromal cells enhances their prosurvival and protective effects on human kidney cells.

Zhao J, Young YK, Fradette J, Eliopoulos N.

Am J Physiol Renal Physiol. 2015 Jun 15;308(12):F1474-83. doi: 10.1152/ajprenal.00512.2014. Epub 2015 Apr 22.


Magnetic Resonance Imaging of Human Tissue-Engineered Adipose Substitutes.

Proulx M, Aubin K, Lagueux J, Audet P, Auger M, Fortin MA, Fradette J.

Tissue Eng Part C Methods. 2015 Jul;21(7):693-704. doi: 10.1089/ten.TEC.2014.0409. Epub 2015 Feb 25.


Creating capillary networks within human engineered tissues: impact of adipocytes and their secretory products.

Aubin K, Vincent C, Proulx M, Mayrand D, Fradette J.

Acta Biomater. 2015 Jan;11:333-45. doi: 10.1016/j.actbio.2014.09.044. Epub 2014 Sep 30.


Using human umbilical cord cells for tissue engineering: a comparison with skin cells.

Hayward CJ, Fradette J, Morissette Martin P, Guignard R, Germain L, Auger FA.

Differentiation. 2014 Mar-Apr;87(3-4):172-81. doi: 10.1016/j.diff.2014.05.001. Epub 2014 Jun 11.


Adipose-derived stromal cells for the reconstruction of a human vesical equivalent.

Rousseau A, Fradette J, Bernard G, Gauvin R, Laterreur V, Bolduc S.

J Tissue Eng Regen Med. 2015 Nov;9(11):E135-43. doi: 10.1002/term.1717. Epub 2013 Apr 11.


Human epithelial stem cells persist within tissue-engineered skin produced by the self-assembly approach.

Lavoie A, Fugère C, Beauparlant A, Goyer B, Larouche D, Paquet C, Desgagné M, Sauvé S, Robitaille H, Dunnwald M, Kim DH, Pouliot R, Fradette J, Germain L.

Tissue Eng Part A. 2013 Apr;19(7-8):1023-38. doi: 10.1089/ten.TEA.2012.0117. Epub 2013 Feb 15.


Harvesting the potential of the human umbilical cord: isolation and characterisation of four cell types for tissue engineering applications.

Hayward CJ, Fradette J, Galbraith T, Rémy M, Guignard R, Gauvin R, Germain L, Auger FA.

Cells Tissues Organs. 2013;197(1):37-54. doi: 10.1159/000341254. Epub 2012 Sep 5.


Dynamic culture induces a cell type-dependent response impacting on the thickness of engineered connective tissues.

Fortier GM, Gauvin R, Proulx M, Vallée M, Fradette J.

J Tissue Eng Regen Med. 2013 Apr;7(4):292-301. doi: 10.1002/term.522. Epub 2011 Dec 12.


Clinical decision making regarding intervention needs of infants with torticollis.

Fradette J, Gagnon I, Kennedy E, Snider L, Majnemer A.

Pediatr Phys Ther. 2011 Fall;23(3):249-56. doi: 10.1097/PEP.0b013e318227cb2a.


Stem cells of the skin and cornea: their clinical applications in regenerative medicine.

Proulx S, Fradette J, Gauvin R, Larouche D, Germain L.

Curr Opin Organ Transplant. 2011 Feb;16(1):83-9. doi: 10.1097/MOT.0b013e32834254f1. Review.


Considerations in the choice of a skin donor site for harvesting keratinocytes containing a high proportion of stem cells for culture in vitro.

Lavoie A, Fugère C, Fradette J, Larouche D, Paquet C, Beauparlant A, Gauvin R, Têtu FA, Roy A, Bouchard M, Genest H, Auger FA, Germain L.

Burns. 2011 May;37(3):440-7. doi: 10.1016/j.burns.2010.09.004. Epub 2010 Dec 3.


Cell sheet technology for tissue engineering: the self-assembly approach using adipose-derived stromal cells.

Labbé B, Marceau-Fortier G, Fradette J.

Methods Mol Biol. 2011;702:429-41. doi: 10.1007/978-1-61737-960-4_31.


Tissue engineering of skin and cornea: Development of new models for in vitro studies.

Paquet C, Larouche D, Bisson F, Proulx S, Simard-Bisson C, Gaudreault M, Robitaille H, Carrier P, Martel I, Duranceau L, Auger FA, Fradette J, Guérin SL, Germain L.

Ann N Y Acad Sci. 2010 Jun;1197:166-77. doi: 10.1111/j.1749-6632.2009.05373.x. Review.


Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform.

Benabdallah BF, Allard E, Yao S, Friedman G, Gregory PD, Eliopoulos N, Fradette J, Spees JL, Haddad E, Holmes MC, Beauséjour CM.

Cytotherapy. 2010 May;12(3):394-9. doi: 10.3109/14653240903583803.


Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries.

Rochon MH, Fradette J, Fortin V, Tomasetig F, Roberge CJ, Baker K, Berthod F, Auger FA, Germain L.

Tissue Eng Part A. 2010 May;16(5):1457-68. doi: 10.1089/ten.TEA.2009.0090.


The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation.

Couture JP, Daviau A, Fradette J, Blouin R.

PLoS One. 2009;4(3):e4743. doi: 10.1371/journal.pone.0004743. Epub 2009 Mar 9.


Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering.

Auxenfans C, Fradette J, Lequeux C, Germain L, Kinikoglu B, Bechetoille N, Braye F, Auger FA, Damour O.

Eur J Dermatol. 2009 Mar-Apr;19(2):107-13. doi: 10.1684/ejd.2008.0573. Epub 2008 Dec 23. Review.


Regeneration of skin and cornea by tissue engineering.

Larouche D, Paquet C, Fradette J, Carrier P, Auger FA, Germain L.

Methods Mol Biol. 2009;482:233-56. doi: 10.1007/978-1-59745-060-7_15.


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