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Items: 31


Virus DNA Replication and the Host DNA Damage Response.

Weitzman MD, Fradet-Turcotte A.

Annu Rev Virol. 2018 Sep 29;5(1):141-164. doi: 10.1146/annurev-virology-092917-043534. Epub 2018 Jul 11. Review.


A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein.

Ho TH, Sitz J, Shen Q, Leblanc-Lacroix A, Campos EI, Borozan I, Marcon E, Greenblatt J, Fradet-Turcotte A, Jin DY, Frappier L.

J Virol. 2018 Jun 29;92(14). pii: e00262-18. doi: 10.1128/JVI.00262-18. Print 2018 Jul 15.


Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D.

Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.


ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins.

Krassowski M, Paczkowska M, Cullion K, Huang T, Dzneladze I, Ouellette BFF, Yamada JT, Fradet-Turcotte A, Reimand J.

Nucleic Acids Res. 2018 Jan 4;46(D1):D901-D910. doi: 10.1093/nar/gkx973.


The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE.

Elife. 2017 Apr 13;6. pii: e23872. doi: 10.7554/eLife.23872.


BRCA2 functions: from DNA repair to replication fork stabilization.

Fradet-Turcotte A, Sitz J, Grapton D, Orthwein A.

Endocr Relat Cancer. 2016 Oct;23(10):T1-T17. doi: 10.1530/ERC-16-0297. Epub 2016 Aug 16. Review.


The structural basis of modified nucleosome recognition by 53BP1.

Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D.

Nature. 2016 Aug 4;536(7614):100-3. Epub 2016 Jul 27.


The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.

Mol Cell. 2016 May 5;62(3):409-421. doi: 10.1016/j.molcel.2016.03.031.


High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.

Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25.


A quantitative and high-throughput assay of human papillomavirus DNA replication.

Gagnon D, Fradet-Turcotte A, Archambault J.

Methods Mol Biol. 2015;1249:305-16. doi: 10.1007/978-1-4939-2013-6_23.


Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response.

Lehoux M, Fradet-Turcotte A, Archambault J.

Methods Mol Biol. 2015;1249:67-80. doi: 10.1007/978-1-4939-2013-6_5.


Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.

Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D.

Science. 2014 Apr 11;344(6180):189-93. doi: 10.1126/science.1248024. Epub 2014 Mar 20.


RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.


53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D.

Nature. 2013 Jul 4;499(7456):50-4. doi: 10.1038/nature12318. Epub 2013 Jun 12.


A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkáč J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D.

Mol Cell. 2013 Mar 7;49(5):872-83. doi: 10.1016/j.molcel.2013.01.001. Epub 2013 Jan 17.


Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D.

Mol Cell. 2012 Aug 10;47(3):383-95. doi: 10.1016/j.molcel.2012.05.045. Epub 2012 Jun 27.


Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide.

Lehoux M, Fradet-Turcotte A, Lussier-Price M, Omichinski JG, Archambault J.

J Virol. 2012 Apr;86(7):3486-500. doi: 10.1128/JVI.07003-11. Epub 2012 Jan 25.


Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.

Fradet-Turcotte A, Bergeron-Labrecque F, Moody CA, Lehoux M, Laimins LA, Archambault J.

J Virol. 2011 Sep;85(17):8996-9012. doi: 10.1128/JVI.00542-11. Epub 2011 Jul 6.


Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain.

Meinke G, Phelan P, Fradet-Turcotte A, Archambault J, Bullock PA.

Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):560-7. doi: 10.1107/S0907444911014302. Epub 2011 May 17.


A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication.

Morin G, Fradet-Turcotte A, Di Lello P, Bergeron-Labrecque F, Omichinski JG, Archambault J.

J Virol. 2011 Jun;85(11):5287-300. doi: 10.1128/JVI.01829-10. Epub 2011 Mar 30.


Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA.

Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA.

J Virol. 2011 Jan;85(2):818-27. doi: 10.1128/JVI.01738-10. Epub 2010 Oct 27.


Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance.

Fradet-Turcotte A, Moody C, Laimins LA, Archambault J.

J Virol. 2010 Nov;84(22):11747-60. doi: 10.1128/JVI.01445-10. Epub 2010 Sep 15.


Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication.

Fradet-Turcotte A, Morin G, Lehoux M, Bullock PA, Archambault J.

Virology. 2010 Mar 30;399(1):65-76. doi: 10.1016/j.virol.2009.12.026. Epub 2010 Jan 15.


Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9.

Fradet-Turcotte A, Brault K, Titolo S, Howley PM, Archambault J.

Virology. 2009 Dec 20;395(2):190-201. doi: 10.1016/j.virol.2009.09.020.


Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.

Gagnon D, Joubert S, Sénéchal H, Fradet-Turcotte A, Torre S, Archambault J.

J Virol. 2009 May;83(9):4127-39. doi: 10.1128/JVI.02468-08. Epub 2009 Feb 11.


p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH.

Di Lello P, Miller Jenkins LM, Mas C, Langlois C, Malitskaya E, Fradet-Turcotte A, Archambault J, Legault P, Omichinski JG.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):106-11. Epub 2007 Dec 26.


Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification.

Moody CA, Fradet-Turcotte A, Archambault J, Laimins LA.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19541-6. Epub 2007 Nov 28.


Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes.

Côté-Martin A, Moody C, Fradet-Turcotte A, D'Abramo CM, Lehoux M, Joubert S, Poirier GG, Coulombe B, Laimins LA, Archambault J.

J Virol. 2008 Feb;82(3):1271-83. Epub 2007 Nov 21.


Recent advances in the search for antiviral agents against human papillomaviruses.

Fradet-Turcotte A, Archambault J.

Antivir Ther. 2007;12(4):431-51. Review.


Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.

Fradet-Turcotte A, Vincent C, Joubert S, Bullock PA, Archambault J.

J Virol. 2007 Sep;81(17):9162-74. Epub 2007 Jun 27.


Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.

Kumar A, Meinke G, Reese DK, Moine S, Phelan PJ, Fradet-Turcotte A, Archambault J, Bohm A, Bullock PA.

J Virol. 2007 May;81(9):4808-18. Epub 2007 Feb 7.

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