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Items: 1 to 50 of 87

1.

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.

Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F.

Eur J Med Chem. 2018 Apr 10;149:69-78. doi: 10.1016/j.ejmech.2018.02.048. Epub 2018 Feb 19.

PMID:
29499488
2.

Corrigendum: Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids.

Cal PM, Frade RF, Cordeiro C, Gois PM.

Chemistry. 2016 Nov 14;22(47):16711. doi: 10.1002/chem.201503646. Epub 2015 Sep 29. No abstract available.

PMID:
27870284
3.

Synthesis of Symmetric Bis(N-alkylaniline)triarylmethanes via Friedel-Crafts-Catalyzed Reaction between Secondary Anilines and Aldehydes.

Gomes RF, Coelho JA, Frade RF, Trindade AF, Afonso CA.

J Org Chem. 2015 Oct 16;80(20):10404-11. doi: 10.1021/acs.joc.5b01875. Epub 2015 Oct 5.

PMID:
26402221
4.

Reversible lysine modification on proteins by using functionalized boronic acids.

Cal PM, Frade RF, Cordeiro C, Gois PM.

Chemistry. 2015 May 26;21(22):8182-7. doi: 10.1002/chem.201500127. Epub 2015 Apr 20. Erratum in: Chemistry. 2016 Nov 14;22(47):16711.

PMID:
25900406
5.

Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.

Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R.

ChemMedChem. 2015 May;10(5):883-90. doi: 10.1002/cmdc.201500011. Epub 2015 Mar 17.

PMID:
25784585
6.

Development of novel sophorolipids with improved cytotoxic activity toward MDA-MB-231 breast cancer cells.

Ribeiro IA, Faustino CM, Guerreiro PS, Frade RF, Bronze MR, Castro MF, Ribeiro MH.

J Mol Recognit. 2015 Mar;28(3):155-65. doi: 10.1002/jmr.2403. Epub 2015 Feb 3.

PMID:
25647712
7.

"Click and go": simple and fast folic acid conjugation.

Trindade AF, Frade RF, Maçôas EM, Graça C, Rodrigues CA, Martinho JM, Afonso CA.

Org Biomol Chem. 2014 May 28;12(20):3181-90. doi: 10.1039/c4ob00150h. Epub 2014 Apr 10.

PMID:
24723199
8.

Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.

Cal PM, Frade RF, Chudasama V, Cordeiro C, Caddick S, Gois PM.

Chem Commun (Camb). 2014 May 25;50(40):5261-3. doi: 10.1039/c3cc47534d. Epub 2013 Nov 21.

PMID:
24257446
9.

Toxicological evaluation of magnetic ionic liquids in human cell lines.

Frade RF, Simeonov S, Rosatella AA, Siopa F, Afonso CA.

Chemosphere. 2013 Jun;92(1):100-5. doi: 10.1016/j.chemosphere.2013.02.047. Epub 2013 Apr 3.

PMID:
23561571
10.

Isolation, chemical, and biotransformation routes of labdane-type diterpenes.

Frija LM, Frade RF, Afonso CA.

Chem Rev. 2011 Aug 10;111(8):4418-52. doi: 10.1021/cr100258k. Epub 2011 May 27. Review. No abstract available.

PMID:
21618966
11.

Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.

Barbarin A, Frade R.

Biochem J. 2011 Jul 1;437(1):97-107. doi: 10.1042/BJ20110361.

12.

Impact of ionic liquids in environment and humans: an overview.

Frade RF, Afonso CA.

Hum Exp Toxicol. 2010 Dec;29(12):1038-54. doi: 10.1177/0960327110371259. Epub 2010 May 28. Review. Erratum in: Hum Exp Toxicol. 2010 Dec;29(12):1055-7.

PMID:
20511289
13.

New dirhodium complex with activity towards colorectal cancer.

Frade RF, Candeias NR, Duarte CM, André V, Duarte MT, Gois PM, Afonso CA.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3413-5. doi: 10.1016/j.bmcl.2010.04.002. Epub 2010 Apr 9.

PMID:
20434912
14.

Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation.

Makiyi EF, Frade RF, Lebl T, Jaffray EG, Cobb SE, Harvey AL, Slawin AM, Hay RT, Westwood NJ.

European J Org Chem. 2009 Nov;2009(33):5711-5715. Epub 2009 Oct 7.

15.

Down-regulation of the expression of RB18A/MED1, a cofactor of transcription, triggers strong tumorigenic phenotype of human melanoma cells.

Ndong Jde L, Jean D, Rousselet N, Frade R.

Int J Cancer. 2009 Jun 1;124(11):2597-606. doi: 10.1002/ijc.24253.

16.

Intratumoral gene delivery of anti-cathepsin L single-chain variable fragment by lentiviral vector inhibits tumor progression induced by human melanoma cells.

Frade R, Rousselet N, Jean D.

Cancer Gene Ther. 2008 Sep;15(9):591-604. doi: 10.1038/cgt.2008.51. Epub 2008 Jul 11.

PMID:
18617916
17.

Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region.

Jean D, Rousselet N, Frade R.

Biochem J. 2008 Jul 1;413(1):125-34. doi: 10.1042/BJ20071255.

PMID:
18366346
19.

Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.

Jean D, Rousselet N, Frade R.

Oncogene. 2006 Mar 9;25(10):1474-84.

PMID:
16261157
21.

RB18A enhances expression of mutant p53 protein in human cells.

Lottin-Divoux S, Barel M, Frade R.

FEBS Lett. 2005 Apr 25;579(11):2323-6.

22.

Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment.

Rousselet N, Mills L, Jean D, Tellez C, Bar-Eli M, Frade R.

Cancer Res. 2004 Jan 1;64(1):146-51.

25.

RB18A regulates p53-dependent apoptosis.

Frade R, Balbo M, Barel M.

Oncogene. 2002 Jan 31;21(6):861-6.

28.
29.

p56lck activity and expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus.

Matache C, Stefanescu M, Onu A, Tanaseanu S, Matei I, Frade R, Szegli G.

Autoimmunity. 1999;29(2):111-20.

PMID:
10433072
31.
34.
35.
36.
37.

Co-expression and secretion of C3, the third component of complement and a C3-cleaving cysteine proteinase in a highly metastatic human melanoma cell line.

Jean D, Rodrigues-Lima F, Cassinat B, Hermann J, Cabane J, Frade R.

Immunol Lett. 1997 Jul;58(2):107-12.

PMID:
9271321
38.

A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma.

Jean D, Bar-Eli M, Huang S, Xie K, Rodrigues-Lima F, Hermann J, Frade R.

Cancer Res. 1996 Jan 15;56(2):254-8.

39.

Tyrosine phosphorylation in peripheral lymphocytes from patients with systemic lupus erythematosus.

Matache C, Stefanescu M, Onu A, Szegli G, Barel M, Tanaseanu S, Matei I, Bouillie S, Frade R.

Autoimmunity. 1996;24(4):217-28.

PMID:
9147580
40.
42.

Wild-type p53 regulates its own transcription in a cell-type specific manner.

Hudson JM, Frade R, Bar-Eli M.

DNA Cell Biol. 1995 Sep;14(9):759-66.

PMID:
7669253
43.

Epstein-Barr virus/C3d receptor (CR2, CD21) activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways.

Bouillie S, Barel M, Drane P, Cassinat B, Balbo M, Holers VM, Frade R.

Eur J Immunol. 1995 Sep;25(9):2661-7.

PMID:
7589142
45.
46.

Expression of complement receptors (CR1 and CR3) and Fc gamma RIII on polymorphonuclears from patients with spondylarthropathies.

Kahan A, Collantes-Estevez E, Barel M, Frade R, Amor B.

Clin Exp Rheumatol. 1993 Jan-Feb;11(1):27-34.

PMID:
8453794
49.

Nuclear localization of the Epstein-Barr virus/C3d receptor (CR2) in the human Burkitt B lymphoma cell, Raji.

Gauffre A, Viron A, Barel M, Hermann J, Puvion E, Frade R.

Mol Immunol. 1992 Sep;29(9):1113-20.

PMID:
1323059
50.

Intracellular interaction of EBV/C3d receptor (CR2) with p68, a calcium-binding protein present in normal but not in transformed B lymphocytes.

Barel M, Gauffre A, Lyamani F, Fiandino A, Hermann J, Frade R.

J Immunol. 1991 Aug 15;147(4):1286-91.

PMID:
1831222

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