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Items: 1 to 50 of 69

1.

Plasma and brain concentrations of doxycycline after single and repeated doses in wild-type and APP23 mice.

Lucchetti J, Fracasso C, Balducci C, Passoni A, Forloni G, Salmona M, Gobbi M.

J Pharmacol Exp Ther. 2018 Nov 5. pii: jpet.118.252064. doi: 10.1124/jpet.118.252064. [Epub ahead of print]

2.

Reproductive phenology of Melastomataceae species with contrasting reproductive systems: contemporary and historical drivers.

Brito VLG, Maia FR, Silveira FAO, Fracasso CM, Lemos-Filho JP, Fernandes GW, Goldenberg R, Morellato LPC, Sazima M, Staggemeier VG.

Plant Biol (Stuttg). 2017 Sep;19(5):806-817. doi: 10.1111/plb.12591. Epub 2017 Jul 16.

PMID:
28627760
3.

Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice.

Fracasso C, Bagnati R, Passoni A, Guiso G, Cantoni L, Riva A, Morazzoni P, Gobbi M.

J Nat Prod. 2015 Aug 28;78(8):2029-35. doi: 10.1021/acs.jnatprod.5b00302. Epub 2015 Aug 19.

PMID:
26287496
4.

Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest.

Ristagno G, Latini R, Vaahersalo J, Masson S, Kurola J, Varpula T, Lucchetti J, Fracasso C, Guiso G, Montanelli A, Barlera S, Gobbi M, Tiainen M, Pettilä V, Skrifvars MB; FINNRESUSCI Investigators.

J Am Heart Assoc. 2014 Aug 4;3(4). pii: e001094. doi: 10.1161/JAHA.114.001094.

5.

Reproductive biology and species geographical distribution in the Melastomataceae: a survey based on New World taxa.

dos Santos AP, Fracasso CM, Luciene dos Santos M, Romero R, Sazima M, Oliveira PE.

Ann Bot. 2012 Aug;110(3):667-79. doi: 10.1093/aob/mcs125. Epub 2012 Jun 28.

6.

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.

Gemma S, Colombo L, Forloni G, Savini L, Fracasso C, Caccia S, Salmona M, Brindisi M, Joshi BP, Tripaldi P, Giorgi G, Taglialatela-Scafati O, Novellino E, Fiorini I, Campiani G, Butini S.

Org Biomol Chem. 2011 Jul 21;9(14):5137-48. doi: 10.1039/c1ob05288h. Epub 2011 Jun 1.

PMID:
21629961
7.

Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptors.

Lacivita E, De Giorgio P, Lee IT, Rodeheaver SI, Weiss BA, Fracasso C, Caccia S, Berardi F, Perrone R, Zhang MR, Maeda J, Higuchi M, Suhara T, Schetz JA, Leopoldo M.

J Med Chem. 2010 Oct 28;53(20):7344-55. doi: 10.1021/jm100925m.

8.

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.

Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R.

Neurosci Lett. 2010 Aug 30;481(1):12-6. doi: 10.1016/j.neulet.2010.06.036. Epub 2010 Jun 23.

9.

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

Butini S, Budriesi R, Hamon M, Morelli E, Gemma S, Brindisi M, Borrelli G, Novellino E, Fiorini I, Ioan P, Chiarini A, Cagnotto A, Mennini T, Fracasso C, Caccia S, Campiani G.

J Med Chem. 2009 Nov 12;52(21):6946-50. doi: 10.1021/jm901126m.

PMID:
19831400
10.

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.

Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G, Colombo L, Manzoni C, Salmona M, Caccia S, Negro A, Forloni G.

J Neurochem. 2009 Sep;110(5):1445-56. doi: 10.1111/j.1471-4159.2009.06228.x. Epub 2009 Jun 22.

11.

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

Morelli E, Gemma S, Budriesi R, Campiani G, Novellino E, Fattorusso C, Catalanotti B, Coccone SS, Ros S, Borrelli G, Persico M, Fiorini I, Nacci V, Ioan P, Chiarini A, Hamon M, Cagnotto A, Mennini T, Fracasso C, Colovic M, Caccia S, Butini S.

J Med Chem. 2009 Jun 11;52(11):3548-62. doi: 10.1021/jm900018b.

PMID:
19425598
12.

Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse.

Colovic M, Fracasso C, Caccia S.

Drug Metab Lett. 2008 Apr;2(2):90-4.

PMID:
19356077
13.

Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice.

Calcagno E, Guzzetti S, Canetta A, Fracasso C, Caccia S, Cervo L, Invernizzi RW.

Int J Neuropsychopharmacol. 2009 Jul;12(6):793-803. doi: 10.1017/S1461145708009760. Epub 2009 Jan 5.

PMID:
19123962
14.

Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

Leopoldo M, Lacivita E, De Giorgio P, Fracasso C, Guzzetti S, Caccia S, Contino M, Colabufo NA, Berardi F, Perrone R.

J Med Chem. 2008 Sep 25;51(18):5813-22. doi: 10.1021/jm800615e.

PMID:
18800769
15.

Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin.

Guzzetti S, Calcagno E, Canetta A, Sacchetti G, Fracasso C, Caccia S, Cervo L, Invernizzi RW.

Eur J Pharmacol. 2008 Oct 10;594(1-3):117-24. doi: 10.1016/j.ejphar.2008.07.031. Epub 2008 Jul 24.

PMID:
18691569
16.

Optimized synthesis of AMPA receptor antagonist ZK 187638 and neurobehavioral activity in a mouse model of neuronal ceroid lipofuscinosis.

Elger B, Schneider M, Winter E, Carvelli L, Bonomi M, Fracasso C, Guiso G, Colovic M, Caccia S, Mennini T.

ChemMedChem. 2006 Oct;1(10):1142-8.

PMID:
16972289
17.

Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease.

Tortarolo M, Grignaschi G, Calvaresi N, Zennaro E, Spaltro G, Colovic M, Fracasso C, Guiso G, Elger B, Schneider H, Seilheimer B, Caccia S, Bendotti C.

J Neurosci Res. 2006 Jan;83(1):134-46.

PMID:
16323214
18.

Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

Cervo L, Canetta A, Calcagno E, Burbassi S, Sacchetti G, Caccia S, Fracasso C, Albani D, Forloni G, Invernizzi RW.

J Neurosci. 2005 Sep 7;25(36):8165-72.

19.

High-performance liquid chromatography measurement of hyperforin and its reduced derivatives in rodent plasma.

Rozio M, Fracasso C, Riva A, Morazzoni P, Caccia S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):21-7.

PMID:
15664329
20.

Effects of chronic treatment with escitalopram or citalopram on extracellular 5-HT in the prefrontal cortex of rats: role of 5-HT1A receptors.

Ceglia I, Acconcia S, Fracasso C, Colovic M, Caccia S, Invernizzi RW.

Br J Pharmacol. 2004 Jun;142(3):469-78. Epub 2004 May 17.

21.

5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum.

Porras G, Di Matteo V, Fracasso C, Lucas G, De Deurwaerdère P, Caccia S, Esposito E, Spampinato U.

Neuropsychopharmacology. 2002 Mar;26(3):311-24.

22.

Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P).

Cafaro A, Titti F, Fracasso C, Maggiorella MT, Baroncelli S, Caputo A, Goletti D, Borsetti A, Pace M, Fanales-Belasio E, Ridolfi B, Negri DR, Sernicola L, Belli R, Corrias F, Macchia I, Leone P, Michelini Z, ten Haaft P, Buttò S, Verani P, Ensoli B.

Vaccine. 2001 Apr 6;19(20-22):2862-77.

PMID:
11282197
23.
24.

SHIV89.6P pathogenicity in cynomolgus monkeys and control of viral replication and disease onset by human immunodeficiency virus type 1 Tat vaccine.

Cafaro A, Caputo A, Maggiorella MT, Baroncelli S, Fracasso C, Pace M, Borsetti A, Sernicola L, Negri DR, Ten Haaft P, Betti M, Michelini Z, Macchia I, Fanales-Belasio E, Belli R, Corrias F, Buttò S, Verani P, Titti F, Ensoli B.

J Med Primatol. 2000 Aug;29(3-4):193-208.

PMID:
11085582
25.

Immune activation in africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project.

Clerici M, Butto S, Lukwiya M, Saresella M, Declich S, Trabattoni D, Pastori C, Piconi S, Fracasso C, Fabiani M, Ferrante P, Rizzardini G, Lopalco L.

AIDS. 2000 Sep 29;14(14):2083-92.

PMID:
11061648
26.

Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.

Campiani G, Fabbrini M, Morelli E, Nacci V, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Fracasso C, Caccia S.

Antivir Chem Chemother. 2000 Mar;11(2):141-55.

PMID:
10819438
27.

Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.

Campiani G, Morelli E, Gemma S, Nacci V, Butini S, Hamon M, Novellino E, Greco G, Cagnotto A, Goegan M, Cervo L, Dalla Valle F, Fracasso C, Caccia S, Mennini T.

J Med Chem. 1999 Oct 21;42(21):4362-79.

PMID:
10543880
28.

Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine.

Cafaro A, Caputo A, Fracasso C, Maggiorella MT, Goletti D, Baroncelli S, Pace M, Sernicola L, Koanga-Mogtomo ML, Betti M, Borsetti A, Belli R, Akerblom L, Corrias F, Buttò S, Heeney J, Verani P, Titti F, Ensoli B.

Nat Med. 1999 Jun;5(6):643-50.

PMID:
10371502
29.

Orally administered ranitidine plasma concentrations before and after biliopancreatic diversion in morbidly obese patients.

Cossu ML, Caccia S, Coppola M, Fais E, Ruggiu M, Fracasso C, Nacca A, Noya G.

Obes Surg. 1999 Feb;9(1):36-9.

PMID:
10065579
31.

Citalopram-induced hypophagia is enhanced by blockade of 5-HT(1A) receptors: role of 5-HT(2C) receptors.

Grignaschi G, Invernizzi RW, Fanelli E, Fracasso C, Caccia S, Samanin R.

Br J Pharmacol. 1998 Aug;124(8):1781-7.

32.

Acid-catalysed hydrolysis and benzodiazepine-like properties of 5-(dialkylamino)- and 5-(alkylthio)-substituted 8-chloro-6-phenyl-6H-[1,2,4]triazolol[4,3-a][1,5]benzodiazepines in mice.

Caccia S, Grossi G, Fracasso C, Nacca A, Cagnotto A, Mennini T, Ghia M, Roma G.

J Pharm Pharmacol. 1998 Jul;50(7):723-8.

PMID:
9720620
33.

Evolution of the dystrophin muscular promoter and 5' flanking region in primates.

Fracasso C, Patarnello T.

J Mol Evol. 1998 Feb;46(2):168-79.

PMID:
9452519
34.
35.

Augmented serum neutralizing activity against primary human immunodeficiency virus type 1 (HIV-1) isolates in two groups of HIV-1-infected long-term nonprogressors.

Zhang YJ, Fracasso C, Fiore JR, Björndal A, Angarano G, Gringeri A, Fenyö EM.

J Infect Dis. 1997 Nov;176(5):1180-7.

PMID:
9359717
36.

Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.

Campiani G, Cappelli A, Nacci V, Anzini M, Vomero S, Hamon M, Cagnotto A, Fracasso C, Uboldi C, Caccia S, Consolo S, Mennini T.

J Med Chem. 1997 Oct 24;40(22):3670-8.

PMID:
9357534
37.
38.

Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine.

Caccia S, Confalonieri S, Bergami A, Fracasso C, Anelli M, Garattini S.

Pharmacol Biochem Behav. 1997 Aug;57(4):851-6.

PMID:
9259015
39.

Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats.

Gobbi M, Crespi D, Foddi MC, Fracasso C, Mancini L, Parotti L, Mennini T.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Jul;356(1):22-8.

PMID:
9228186
40.

The role of HIV type 1 phenotype and genotype in long-term responders to zidovudine therapy.

Angarano G, Monno L, Vivirito MC, Appice A, Romanelli C, Giannelli A, La Grasta L, Fracasso C, Fiore JR, Milazzo F.

AIDS Res Hum Retroviruses. 1996 Jul 20;12(11):969-75.

PMID:
8827212
41.

Prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users in south-eastern Italy.

Angarano G, Monno L, Fiore JR, Fracasso C, La Grasta L, Romanelli C.

AIDS. 1996 Jun;10(7):805-6. No abstract available.

PMID:
8805882
42.

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat.

Mennini T, Fracasso C, Cagnotto A, Bergami A, Frittoli E, Gobbi M, Caccia S, Garattini S.

Naunyn Schmiedebergs Arch Pharmacol. 1996 May;353(6):641-7.

PMID:
8738297
43.

Novel missense mutation of the connexin32 (GJB1) gene in X-linked dominant Charcot-Marie-Tooth neuropathy.

Schiavon F, Fracasso C, Mostacciuolo ML.

Hum Mutat. 1996;8(1):83-4. No abstract available.

PMID:
8807343
44.

Depletion and time-course of recovery of brain serotonin after repeated subcutaneous dexfenfluramine in the mouse. A comparison with the rat.

Fracasso C, Guiso G, Confalonieri S, Bergami A, Garattini S, Caccia S.

Neuropharmacology. 1995 Dec;34(12):1653-9.

PMID:
8788963
45.

Oral kinetics of dexfenfluramine and dexnorfenfluramine in non-human primates.

Caccia S, Bergami A, Fracasso C, Garattini S, Campbell B.

Xenobiotica. 1995 Nov;25(10):1143-50.

PMID:
8578770
46.

Effect of d-fenfluramine on the indole contents of the rat brain after treatment with different inducers of cytochrome P450 isoenzymes.

Anelli M, Fracasso C, Bergami A, Ferrarese A, Garattini S, Caccia S.

Psychopharmacology (Berl). 1995 Mar;118(2):188-94.

PMID:
7617807
47.

The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain.

Caccia S, Anelli M, Codegoni AM, Fracasso C, Garattini S.

Br J Pharmacol. 1993 Sep;110(1):355-9.

48.

Reciprocal interaction of 5-hydroxytryptamine and cholecystokinin in the control of feeding patterns in rats.

Grignaschi G, Mantelli B, Fracasso C, Anelli M, Caccia S, Samanin R.

Br J Pharmacol. 1993 Jun;109(2):491-4.

49.

The role of d-norfenfluramine in the indole-depleting effect of d-fenfluramine in the rat.

Caccia S, Anelli M, Ferrarese A, Fracasso C, Garattini S.

Eur J Pharmacol. 1993 Mar 16;233(1):71-7.

PMID:
7682511
50.

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms.

Caccia S, Anelli M, Fracasso C, Frittoli E, Giorcelli P, Gobbi M, Taddei C, Garattini S, Mennini T.

Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):306-12.

PMID:
8479546

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