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Items: 1 to 50 of 164

1.

Stabilization of cyclohexanone monooxygenase by computational and experimental library design.

Fürst MJLJ, Boonstra M, Bandstra S, Fraaije MW.

Biotechnol Bioeng. 2019 Sep;116(9):2167-2177. doi: 10.1002/bit.27022. Epub 2019 Jun 24.

PMID:
31124128
2.

Editorial: Actinobacteria, a Source of Biocatalytic Tools.

Tischler D, van Berkel WJH, Fraaije MW.

Front Microbiol. 2019 Apr 16;10:800. doi: 10.3389/fmicb.2019.00800. eCollection 2019. No abstract available.

3.

Characterization of a New DyP-Peroxidase from the Alkaliphilic Cellulomonad, Cellulomonas bogoriensis.

Habib MH, Rozeboom HJ, Fraaije MW.

Molecules. 2019 Mar 27;24(7). pii: E1208. doi: 10.3390/molecules24071208.

4.

Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases.

Fürst MJ, Fiorentini F, Fraaije MW.

Curr Opin Struct Biol. 2019 Mar 1;59:29-37. doi: 10.1016/j.sbi.2019.01.019. [Epub ahead of print] Review.

5.

Convergent Cascade Catalyzed by Monooxygenase-Alcohol Dehydrogenase Fusion Applied in Organic Media.

Huang L, Aalbers FS, Tang W, Röllig R, Fraaije MW, Kara S.

Chembiochem. 2019 Jul 1;20(13):1653-1658. doi: 10.1002/cbic.201800814. Epub 2019 May 24.

PMID:
30811825
6.

Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme.

Fürst MJLJ, Romero E, Gómez Castellanos JR, Fraaije MW, Mattevi A.

ACS Catal. 2018 Dec 7;8(12):11648-11656. doi: 10.1021/acscatal.8b03793. Epub 2018 Oct 30.

7.

Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO).

Lončar N, Fiorentini F, Bailleul G, Savino S, Romero E, Mattevi A, Fraaije MW.

Appl Microbiol Biotechnol. 2019 Feb;103(4):1755-1764. doi: 10.1007/s00253-018-09579-w. Epub 2019 Jan 4.

PMID:
30607493
8.

Reconstructing the evolutionary history of F420-dependent dehydrogenases.

Mascotti ML, Kumar H, Nguyen QT, Ayub MJ, Fraaije MW.

Sci Rep. 2018 Dec 4;8(1):17571. doi: 10.1038/s41598-018-35590-2.

9.

Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol.

Nguyen QT, Romero E, Dijkman WP, de Vasconcellos SP, Binda C, Mattevi A, Fraaije MW.

Biochemistry. 2018 Oct 30;57(43):6209-6218. doi: 10.1021/acs.biochem.8b00918. Epub 2018 Oct 16.

10.

Enantio- and regioselective ene-reductions using F420H2-dependent enzymes.

Mathew S, Trajkovic M, Kumar H, Nguyen QT, Fraaije MW.

Chem Commun (Camb). 2018 Oct 2;54(79):11208-11211. doi: 10.1039/c8cc04449j.

PMID:
30230493
11.

Design of Artificial Alcohol Oxidases: Alcohol Dehydrogenase-NADPH Oxidase Fusions for Continuous Oxidations.

Aalbers FS, Fraaije MW.

Chembiochem. 2019 Jan 2;20(1):51-56. doi: 10.1002/cbic.201800421. Epub 2018 Oct 4.

PMID:
30184296
12.

Enzyme Fusions in Biocatalysis: Coupling Reactions by Pairing Enzymes.

Aalbers FS, Fraaije MW.

Chembiochem. 2019 Jan 2;20(1):20-28. doi: 10.1002/cbic.201800394. Epub 2018 Oct 2. Review.

13.

Experimental Protocols for Generating Focused Mutant Libraries and Screening for Thermostable Proteins.

Fürst MJLJ, Martin C, Lončar N, Fraaije MW.

Methods Enzymol. 2018;608:151-187. doi: 10.1016/bs.mie.2018.04.007. Epub 2018 Jun 9.

PMID:
30173762
14.

Mining the Genome of Streptomyces leeuwenhoekii: Two New Type I Baeyer-Villiger Monooxygenases From Atacama Desert.

Gran-Scheuch A, Trajkovic M, Parra L, Fraaije MW.

Front Microbiol. 2018 Jul 18;9:1609. doi: 10.3389/fmicb.2018.01609. eCollection 2018.

15.

Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution.

Li G, Garcia-Borràs M, Fürst MJLJ, Ilie A, Fraaije MW, Houk KN, Reetz MT.

J Am Chem Soc. 2018 Aug 22;140(33):10464-10472. doi: 10.1021/jacs.8b04742. Epub 2018 Aug 13.

16.

The Biocatalytic Synthesis of Syringaresinol from 2,6-Dimethoxy-4-allylphenol in One-Pot Using a Tailored Oxidase/Peroxidase System.

Habib M, Trajkovic M, Fraaije MW.

ACS Catal. 2018 Jun 1;8(6):5549-5552. doi: 10.1021/acscatal.8b01235. Epub 2018 May 14.

17.

Creating a more robust 5-hydroxymethylfurfural oxidase by combining computational predictions with a novel effective library design.

Martin C, Ovalle Maqueo A, Wijma HJ, Fraaije MW.

Biotechnol Biofuels. 2018 Mar 1;11:56. doi: 10.1186/s13068-018-1051-x. eCollection 2018.

18.

Kinetic Resolution of sec-Thiols by Enantioselective Oxidation with Rationally Engineered 5-(Hydroxymethyl)furfural Oxidase.

Pickl M, Swoboda A, Romero E, Winkler CK, Binda C, Mattevi A, Faber K, Fraaije MW.

Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2864-2868. doi: 10.1002/anie.201713189. Epub 2018 Feb 15.

PMID:
29384246
19.

Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes.

Romero E, Gómez Castellanos JR, Gadda G, Fraaije MW, Mattevi A.

Chem Rev. 2018 Feb 28;118(4):1742-1769. doi: 10.1021/acs.chemrev.7b00650. Epub 2018 Jan 11.

PMID:
29323892
20.

Characterization of Two VAO-Type Flavoprotein Oxidases from Myceliophthora thermophila.

Ferrari AR, Rozeboom HJ, Vugts ASC, Koetsier MJ, Floor R, Fraaije MW.

Molecules. 2018 Jan 5;23(1). pii: E111. doi: 10.3390/molecules23010111.

21.

Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase.

Burgener S, Schwander T, Romero E, Fraaije MW, Erb TJ.

Molecules. 2017 Dec 28;23(1). pii: E68. doi: 10.3390/molecules23010068.

22.

Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids.

Pickl M, Winkler CK, Glueck SM, Fraaije MW, Faber K.

Molecules. 2017 Dec 12;22(12). pii: E2205. doi: 10.3390/molecules22122205.

23.

Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites.

Beyer N, Kulig JK, Fraaije MW, Hayes MA, Janssen DB.

Chembiochem. 2018 Feb 16;19(4):326-337. doi: 10.1002/cbic.201700470. Epub 2018 Jan 17.

PMID:
29181885
24.

Manipulating the stereoselectivity of the thermostable Baeyer-Villiger monooxygenase TmCHMO by directed evolution.

Li G, Fürst MJLJ, Mansouri HR, Ressmann AK, Ilie A, Rudroff F, Mihovilovic MD, Fraaije MW, Reetz MT.

Org Biomol Chem. 2017 Nov 29;15(46):9824-9829. doi: 10.1039/c7ob02692g.

PMID:
29130465
25.

Exploring the Substrate Scope of Baeyer-Villiger Monooxygenases with Branched Lactones as Entry towards Polyesters.

Delgove MAF, Fürst MJLJ, Fraaije MW, Bernaerts KV, De Wildeman SMA.

Chembiochem. 2018 Feb 16;19(4):354-360. doi: 10.1002/cbic.201700427. Epub 2017 Nov 29.

PMID:
29078017
26.

Coupled reactions by coupled enzymes: alcohol to lactone cascade with alcohol dehydrogenase-cyclohexanone monooxygenase fusions.

Aalbers FS, Fraaije MW.

Appl Microbiol Biotechnol. 2017 Oct;101(20):7557-7565. doi: 10.1007/s00253-017-8501-4. Epub 2017 Sep 15.

27.

Creating Oxidase-Peroxidase Fusion Enzymes as a Toolbox for Cascade Reactions.

Colpa DI, Lončar N, Schmidt M, Fraaije MW.

Chembiochem. 2017 Nov 16;18(22):2226-2230. doi: 10.1002/cbic.201700478. Epub 2017 Oct 11.

28.

Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism.

Fiorentini F, Romero E, Fraaije MW, Faber K, Hall M, Mattevi A.

ACS Chem Biol. 2017 Sep 15;12(9):2379-2387. doi: 10.1021/acschembio.7b00470. Epub 2017 Aug 21.

PMID:
28783300
29.

Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase.

Ewing TA, Nguyen QT, Allan RC, Gygli G, Romero E, Binda C, Fraaije MW, Mattevi A, van Berkel WJH.

J Biol Chem. 2017 Sep 1;292(35):14668-14679. doi: 10.1074/jbc.M117.778449. Epub 2017 Jul 17.

30.

The VAO/PCMH flavoprotein family.

Ewing TA, Fraaije MW, Mattevi A, van Berkel WJH.

Arch Biochem Biophys. 2017 Oct 15;632:104-117. doi: 10.1016/j.abb.2017.06.022. Epub 2017 Jun 30. Review.

PMID:
28669855
31.

Crystal structures and atomic model of NADPH oxidase.

Magnani F, Nenci S, Millana Fananas E, Ceccon M, Romero E, Fraaije MW, Mattevi A.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6764-6769. doi: 10.1073/pnas.1702293114. Epub 2017 Jun 12.

32.

Isolation and characterization of a thermostable F420:NADPH oxidoreductase from Thermobifida fusca.

Kumar H, Nguyen QT, Binda C, Mattevi A, Fraaije MW.

J Biol Chem. 2017 Jun 16;292(24):10123-10130. doi: 10.1074/jbc.M117.787754. Epub 2017 Apr 14.

33.

Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.

Fürst MJ, Savino S, Dudek HM, Gómez Castellanos JR, Gutiérrez de Souza C, Rovida S, Fraaije MW, Mattevi A.

J Am Chem Soc. 2017 Jan 18;139(2):627-630. doi: 10.1021/jacs.6b12246. Epub 2017 Jan 3.

PMID:
28010060
34.

Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.

Nguyen QT, Trinco G, Binda C, Mattevi A, Fraaije MW.

Appl Microbiol Biotechnol. 2017 Apr;101(7):2831-2842. doi: 10.1007/s00253-016-8038-y. Epub 2016 Dec 13.

35.

Engineering Cyclohexanone Monooxygenase for the Production of Methyl Propanoate.

van Beek HL, Romero E, Fraaije MW.

ACS Chem Biol. 2017 Jan 20;12(1):291-299. doi: 10.1021/acschembio.6b00965. Epub 2016 Dec 20.

PMID:
27935281
36.

P450BM3 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations.

Beyer N, Kulig JK, Bartsch A, Hayes MA, Janssen DB, Fraaije MW.

Appl Microbiol Biotechnol. 2017 Mar;101(6):2319-2331. doi: 10.1007/s00253-016-7993-7. Epub 2016 Nov 29.

37.

Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase.

Romero E, Castellanos JR, Mattevi A, Fraaije MW.

Angew Chem Int Ed Engl. 2016 Dec 19;55(51):15852-15855. doi: 10.1002/anie.201608951. Epub 2016 Nov 22.

38.

Discovery of a Xylooligosaccharide Oxidase from Myceliophthora thermophila C1.

Ferrari AR, Rozeboom HJ, Dobruchowska JM, van Leeuwen SS, Vugts AS, Koetsier MJ, Visser J, Fraaije MW.

J Biol Chem. 2016 Nov 4;291(45):23709-23718. Epub 2016 Sep 14.

39.

Bacterial enzymes involved in lignin degradation.

de Gonzalo G, Colpa DI, Habib MH, Fraaije MW.

J Biotechnol. 2016 Oct 20;236:110-9. doi: 10.1016/j.jbiotec.2016.08.011. Epub 2016 Aug 17. Review.

40.

Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst.

Nguyen QT, de Gonzalo G, Binda C, Rioz-Martínez A, Mattevi A, Fraaije MW.

Chembiochem. 2016 Jul 15;17(14):1359-66. doi: 10.1002/cbic.201600148. Epub 2016 Jun 7.

41.

Characterization of a chitinase from the cellulolytic actinomycete Thermobifida fusca.

Gaber Y, Mekasha S, Vaaje-Kolstad G, Eijsink VGH, Fraaije MW.

Biochim Biophys Acta. 2016 Sep;1864(9):1253-1259. doi: 10.1016/j.bbapap.2016.04.010. Epub 2016 Apr 22.

PMID:
27108953
42.

Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites.

Gul T, Krzek M, Permentier HP, Fraaije MW, Bischoff R.

Drug Metab Dispos. 2016 Aug;44(8):1270-6. doi: 10.1124/dmd.115.069104. Epub 2016 Mar 16.

PMID:
26984198
43.

Covalent immobilization of a flavoprotein monooxygenase via its flavin cofactor.

Krzek M, van Beek HL, Permentier HP, Bischoff R, Fraaije MW.

Enzyme Microb Technol. 2016 Jan;82:138-143. doi: 10.1016/j.enzmictec.2015.09.006. Epub 2015 Sep 30.

PMID:
26672460
44.

Erratum: Cloning, overexpression and biocatalytic exploration of a novel Baeyer-Villiger monooxygenase from Aspergillus fumigatus Af293.

Mascotti ML, Ayub MJ, Dudek H, Sanz MK, Fraaije MW.

AMB Express. 2014 Dec;4(1):62. doi: 10.1186/s13568-014-0062-7. Epub 2014 Sep 20. No abstract available.

45.

Lyophilization conditions for the storage of monooxygenases.

van Beek HL, Beyer N, Janssen DB, Fraaije MW.

J Biotechnol. 2015 Jun 10;203:41-4. doi: 10.1016/j.jbiotec.2015.03.010. Epub 2015 Mar 26.

PMID:
25817248
46.

Catalases as biocatalysts in technical applications: current state and perspectives.

Lončar N, Fraaije MW.

Appl Microbiol Biotechnol. 2015 Apr;99(8):3351-7. doi: 10.1007/s00253-015-6512-6. Epub 2015 Mar 12. Review.

PMID:
25761626
47.

Expanding the substrate scope of chitooligosaccharide oxidase from Fusarium graminearum by structure-inspired mutagenesis.

Ferrari AR, Lee M, Fraaije MW.

Biotechnol Bioeng. 2015 Jun;112(6):1074-80. doi: 10.1002/bit.25532. Epub 2015 Mar 2.

PMID:
25565162
48.

Finding the switch: turning a baeyer-villiger monooxygenase into a NADPH oxidase.

Brondani PB, Dudek HM, Martinoli C, Mattevi A, Fraaije MW.

J Am Chem Soc. 2014 Dec 10;136(49):16966-9. doi: 10.1021/ja508265b. Epub 2014 Dec 1.

PMID:
25423359
49.

The oxidation of thiols by flavoprotein oxidases: a biocatalytic route to reactive thiocarbonyls.

Ewing TA, Dijkman WP, Vervoort JM, Fraaije MW, van Berkel WJ.

Angew Chem Int Ed Engl. 2014 Nov 24;53(48):13206-9. doi: 10.1002/anie.201407520. Epub 2014 Oct 5.

PMID:
25284255
50.

Insights in the kinetic mechanism of the eukaryotic Baeyer-Villiger monooxygenase BVMOAf1 from Aspergillus fumigatus Af293.

Mascotti ML, Kurina-Sanz M, Juri Ayub M, Fraaije MW.

Biochimie. 2014 Dec;107 Pt B:270-6. doi: 10.1016/j.biochi.2014.09.005. Epub 2014 Sep 16.

PMID:
25230086

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