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Items: 1 to 50 of 137

1.

A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge.

Hansen SG, Marshall EE, Malouli D, Ventura AB, Hughes CM, Ainslie E, Ford JC, Morrow D, Gilbride RM, Bae JY, Legasse AW, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Womack J, Shao J, Edlefsen PT, Reed JS, Burwitz BJ, Sacha JB, Axthelm MK, Früh K, Lifson JD, Picker LJ.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaaw2607. doi: 10.1126/scitranslmed.aaw2607.

PMID:
31316007
2.

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity.

Marshall EE, Malouli D, Hansen SG, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Selseth AN, Ford JC, Burke D, Kreklywich CN, Womack J, Legasse AW, Axthelm MK, Kahl C, Streblow D, Edlefsen PT, Picker LJ, Früh K.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaaw2603. doi: 10.1126/scitranslmed.aaw2603.

PMID:
31316006
3.

Vaccine-mediated Inhibition of the Transporter Associated with Antigen Processing is Insufficient to Induce MHC-E Restricted CD8+ T cells in Nonhuman Primates.

Abdulhaqq SA, Wu H, Schell JB, Hammond KB, Reed JS, Legasse AW, Axthelm MK, Park BS, Asokan A, Früh K, Hansen SG, Picker LJ, Sacha JB.

J Virol. 2019 Jul 17. pii: JVI.00592-19. doi: 10.1128/JVI.00592-19. [Epub ahead of print]

PMID:
31315990
4.

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

D'Souza MP, Adams E, Altman JD, Birnbaum ME, Boggiano C, Casorati G, Chien YH, Conley A, Eckle SBG, Früh K, Gondré-Lewis T, Hassan N, Huang H, Jayashankar L, Kasmar AG, Kunwar N, Lavelle J, Lewinsohn DM, Moody B, Picker L, Ramachandra L, Shastri N, Parham P, McMichael AJ, Yewdell JW.

PLoS Pathog. 2019 Feb 21;15(2):e1007567. doi: 10.1371/journal.ppat.1007567. eCollection 2019 Feb. Review.

5.

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.

Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR.

MBio. 2019 Feb 12;10(1). pii: e02510-18. doi: 10.1128/mBio.02510-18.

6.

Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection.

Beyranvand Nejad E, Ratts RB, Panagioti E, Meyer C, Oduro JD, Cicin-Sain L, Früh K, van der Burg SH, Arens R.

J Immunother Cancer. 2019 Jan 31;7(1):25. doi: 10.1186/s40425-019-0500-9.

7.

Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge.

Hansen SG, Womack J, Scholz I, Renner A, Edgel KA, Xu G, Ford JC, Grey M, St Laurent B, Turner JM, Planer S, Legasse AW, Richie TL, Aguiar JC, Axthelm MK, Villasante ED, Weiss W, Edlefsen PT, Picker LJ, Früh K.

PLoS One. 2019 Jan 23;14(1):e0210252. doi: 10.1371/journal.pone.0210252. eCollection 2019.

8.

Identification and Functional Characterization of a Novel Fc Gamma-Binding Glycoprotein in Rhesus Cytomegalovirus.

Kolb P, Sijmons S, McArdle MR, Taher H, Womack J, Hughes C, Ventura A, Jarvis MA, Stahl-Hennig C, Hansen S, Picker LJ, Malouli D, Hengel H, Früh K.

J Virol. 2019 Feb 5;93(4). pii: e02077-18. doi: 10.1128/JVI.02077-18. Print 2019 Feb 15.

9.

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Nov 13;9(1):4833. doi: 10.1038/s41467-018-07304-9.

10.

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Aug 7;9(1):3137. doi: 10.1038/s41467-018-05459-z. Erratum in: Nat Commun. 2018 Nov 13;9(1):4833.

11.

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.

Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Valvo J, Braun JM, Shankar S, Lu L, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Axthelm MK, Früh K, Edlefsen PT, Picker LJ.

Nat Med. 2018 Feb;24(2):130-143. doi: 10.1038/nm.4473. Epub 2018 Jan 15.

12.

Antagonism of the Protein Kinase R Pathway in Human Cells by Rhesus Cytomegalovirus.

Child SJ, Hickson SE, Bayer A, Malouli D, Früh K, Geballe AP.

J Virol. 2018 Feb 26;92(6). pii: e01793-17. doi: 10.1128/JVI.01793-17. Print 2018 Mar 15.

13.

Quantitative membrane proteomics reveals a role for tetraspanin enriched microdomains during entry of human cytomegalovirus.

Viswanathan K, Verweij MC, John N, Malouli D, Früh K.

PLoS One. 2017 Nov 9;12(11):e0187899. doi: 10.1371/journal.pone.0187899. eCollection 2017.

14.

Cloning, Assembly, and Modification of the Primary Human Cytomegalovirus Isolate Toledo by Yeast-Based Transformation-Associated Recombination.

Vashee S, Stockwell TB, Alperovich N, Denisova EA, Gibson DG, Cady KC, Miller K, Kannan K, Malouli D, Crawford LB, Voorhies AA, Bruening E, Caposio P, Früh K.

mSphere. 2017 Oct 4;2(5). pii: e00331-17. doi: 10.1128/mSphereDirect.00331-17. eCollection 2017 Sep-Oct.

15.

CD8+ T cell programming by cytomegalovirus vectors: applications in prophylactic and therapeutic vaccination.

Früh K, Picker L.

Curr Opin Immunol. 2017 Aug;47:52-56. doi: 10.1016/j.coi.2017.06.010. Epub 2017 Jul 19. Review.

16.

Addendum: Immune clearance of highly pathogenic SIV infection.

Hansen SG, Piatak M, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K, Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ.

Nature. 2017 Jul 6;547(7661):123-124. doi: 10.1038/nature22984. Epub 2017 Jun 21.

PMID:
28636599
17.

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors.

Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M, Meyer C, Lemmermann NA, Holtappels R, Arens R, Klenerman P, Früh K, Reddehase MJ, Riemer AB, Cicin-Sain L.

PLoS Pathog. 2016 Dec 15;12(12):e1006072. doi: 10.1371/journal.ppat.1006072. eCollection 2016 Dec.

18.

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques.

Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB, Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A, Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ, Früh K, Sacha JB.

PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi: 10.1371/journal.ppat.1006014. eCollection 2016 Nov.

19.

p120-catenin regulates VE-cadherin endocytosis and degradation induced by the Kaposi sarcoma-associated ubiquitin ligase K5.

Nanes BA, Grimsley-Myers CM, Cadwell CM, Robinson BS, Lowery AM, Vincent PA, Mosunjac M, Früh K, Kowalczyk AP.

Mol Biol Cell. 2017 Jan 1;28(1):30-40. doi: 10.1091/mbc.E16-06-0459. Epub 2016 Oct 26.

20.

Epigraph: A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filovirus Vaccine.

Theiler J, Yoon H, Yusim K, Picker LJ, Fruh K, Korber B.

Sci Rep. 2016 Oct 5;6:33987. doi: 10.1038/srep33987.

21.

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus.

Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K.

PLoS Pathog. 2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868. eCollection 2016 Aug.

22.

Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.

Hansen SG, Wu HL, Burwitz BJ, Hughes CM, Hammond KB, Ventura AB, Reed JS, Gilbride RM, Ainslie E, Morrow DW, Ford JC, Selseth AN, Pathak R, Malouli D, Legasse AW, Axthelm MK, Nelson JA, Gillespie GM, Walters LC, Brackenridge S, Sharpe HR, López CA, Früh K, Korber BT, McMichael AJ, Gnanakaran S, Sacha JB, Picker LJ.

Science. 2016 Feb 12;351(6274):714-20. doi: 10.1126/science.aac9475. Epub 2016 Jan 21.

23.

The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.

Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Früh K, Verweij MC.

J Virol. 2015 Sep;89(17):8687-700. doi: 10.1128/JVI.01149-15. Epub 2015 Jun 17.

24.

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.

Verweij MC, Wellish M, Whitmer T, Malouli D, Lapel M, Jonjić S, Haas JG, DeFilippis VR, Mahalingam R, Früh K.

PLoS Pathog. 2015 May 14;11(5):e1004901. doi: 10.1371/journal.ppat.1004901. eCollection 2015 May.

25.

Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species.

Malouli D, Howell GL, Legasse AW, Kahl C, Axthelm MK, Hansen SG, Früh K.

Virol Rep. 2014 Sep;3-4:18-29.

26.

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

Luteijn RD, Hoelen H, Kruse E, van Leeuwen WF, Grootens J, Horst D, Koorengevel M, Drijfhout JW, Kremmer E, Früh K, Neefjes JJ, Killian A, Lebbink RJ, Ressing ME, Wiertz EJ.

J Immunol. 2014 Aug 15;193(4):1578-89. doi: 10.4049/jimmunol.1400964. Epub 2014 Jul 14.

27.

T cell inactivation by poxviral B22 family proteins increases viral virulence.

Alzhanova D, Hammarlund E, Reed J, Meermeier E, Rawlings S, Ray CA, Edwards DM, Bimber B, Legasse A, Planer S, Sprague J, Axthelm MK, Pickup DJ, Lewinsohn DM, Gold MC, Wong SW, Sacha JB, Slifka MK, Früh K.

PLoS Pathog. 2014 May 15;10(5):e1004123. doi: 10.1371/journal.ppat.1004123. eCollection 2014 May.

28.

Cytomegalovirus pp65 limits dissemination but is dispensable for persistence.

Malouli D, Hansen SG, Nakayasu ES, Marshall EE, Hughes CM, Ventura AB, Gilbride RM, Lewis MS, Xu G, Kreklywich C, Whizin N, Fischer M, Legasse AW, Viswanathan K, Siess D, Camp DG 2nd, Axthelm MK, Kahl C, DeFilippis VR, Smith RD, Streblow DN, Picker LJ, Früh K.

J Clin Invest. 2014 May;124(5):1928-44. Epub 2014 Apr 1.

29.

Inhibition of dengue virus replication by a class of small-molecule compounds that antagonize dopamine receptor d4 and downstream mitogen-activated protein kinase signaling.

Smith JL, Stein DA, Shum D, Fischer MA, Radu C, Bhinder B, Djaballah H, Nelson JA, Früh K, Hirsch AJ.

J Virol. 2014 May;88(10):5533-42. doi: 10.1128/JVI.00365-14. Epub 2014 Mar 5.

30.

Immune clearance of highly pathogenic SIV infection.

Hansen SG, Piatak M Jr, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K, Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ.

Nature. 2013 Oct 3;502(7469):100-4. doi: 10.1038/nature12519. Epub 2013 Sep 11. Erratum in: Nature. 2014 Oct 30;514(7524):654. Nature. 2017 Jul 6;547(7661):123-124.

31.

Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.

Fischer MA, Smith JL, Shum D, Stein DA, Parkins C, Bhinder B, Radu C, Hirsch AJ, Djaballah H, Nelson JA, Früh K.

J Virol. 2013 Sep;87(17):9411-9. doi: 10.1128/JVI.00101-13. Epub 2013 Jul 3.

32.

Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.

Feng P, Moses A, Früh K.

Curr Opin Virol. 2013 Jun;3(3):285-95. doi: 10.1016/j.coviro.2013.05.011. Epub 2013 Jun 2. Review.

33.

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms.

Hansen SG, Sacha JB, Hughes CM, Ford JC, Burwitz BJ, Scholz I, Gilbride RM, Lewis MS, Gilliam AN, Ventura AB, Malouli D, Xu G, Richards R, Whizin N, Reed JS, Hammond KB, Fischer M, Turner JM, Legasse AW, Axthelm MK, Edlefsen PT, Nelson JA, Lifson JD, Früh K, Picker LJ.

Science. 2013 May 24;340(6135):1237874. doi: 10.1126/science.1237874.

34.

Comprehensive analysis of varicella-zoster virus proteins using a new monoclonal antibody collection.

Lenac Roviš T, Bailer SM, Pothineni VR, Ouwendijk WJ, Šimić H, Babić M, Miklić K, Malić S, Verweij MC, Baiker A, Gonzalez O, von Brunn A, Zimmer R, Früh K, Verjans GM, Jonjić S, Haas J.

J Virol. 2013 Jun;87(12):6943-54. doi: 10.1128/JVI.00407-13. Epub 2013 Apr 17.

35.

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.

Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray L, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, Gale M Jr, Früh K, Diamond MS.

PLoS Pathog. 2013 Jan;9(1):e1003118. doi: 10.1371/journal.ppat.1003118. Epub 2013 Jan 3. Erratum in: PLoS Pathog. 2013 May;9(5). :10.1371/annotation/4de7ddfd-52df-4f87-8ca4-d48afe646ca8.

36.

Tollip-induced down-regulation of MARCH1.

Bourgeois-Daigneault MC, Pezeshki AM, Galbas T, Houde M, Baril M, Früh K, Amrani A, Ishido S, Lamarre D, Thibodeau J.

Results Immunol. 2013 Feb 20;3:17-25. doi: 10.1016/j.rinim.2013.02.002. eCollection 2013.

37.

CD31 immunohistochemical staining in Kaposi Sarcoma.

Pantanowitz L, Moses AV, Früh K.

Arch Pathol Lab Med. 2012 Nov;136(11):1329; author reply 1330. doi: 10.5858/arpa.2012-0153-LE. No abstract available.

PMID:
23106575
38.

Reevaluation of the coding potential and proteomic analysis of the BAC-derived rhesus cytomegalovirus strain 68-1.

Malouli D, Nakayasu ES, Viswanathan K, Camp DG 2nd, Chang WL, Barry PA, Smith RD, Früh K.

J Virol. 2012 Sep;86(17):8959-73. doi: 10.1128/JVI.01132-12. Epub 2012 Jun 20.

39.

BST2/Tetherin enhances entry of human cytomegalovirus.

Viswanathan K, Smith MS, Malouli D, Mansouri M, Nelson JA, Früh K.

PLoS Pathog. 2011 Nov;7(11):e1002332. doi: 10.1371/journal.ppat.1002332. Epub 2011 Nov 3.

40.

Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

Wahl-Jensen V, Kurz S, Feldmann F, Buehler LK, Kindrachuk J, DeFilippis V, da Silva Correia J, Früh K, Kuhn JH, Burton DR, Feldmann H.

PLoS Negl Trop Dis. 2011 Oct;5(10):e1359. doi: 10.1371/journal.pntd.0001359. Epub 2011 Oct 18.

41.

Viral takeover of the host ubiquitin system.

Gustin JK, Moses AV, Früh K, Douglas JL.

Front Microbiol. 2011 Jul 28;2:161. doi: 10.3389/fmicb.2011.00161. eCollection 2011.

42.

Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence.

Stein DA, Perry ST, Buck MD, Oehmen CS, Fischer MA, Poore E, Smith JL, Lancaster AM, Hirsch AJ, Slifka MK, Nelson JA, Shresta S, Früh K.

J Virol. 2011 Oct;85(19):10154-66. doi: 10.1128/JVI.05298-11. Epub 2011 Jul 27.

43.

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.

Eyster CA, Cole NB, Petersen S, Viswanathan K, Früh K, Donaldson JG.

Mol Biol Cell. 2011 Sep;22(17):3218-30. doi: 10.1091/mbc.E10-11-0874. Epub 2011 Jul 14.

44.

The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation.

Richards R, Scholz I, Powers C, Skach WR, Früh K.

J Virol. 2011 Sep;85(17):8766-76. doi: 10.1128/JVI.05021-11. Epub 2011 Jun 29.

45.

Kaposi's sarcoma and human dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus express CCL21.

Sugaya M, Reed S, Rose PP, de la Motte S, Raggo CM, Kurtz SE, Moses AV, Früh K, Blauvelt A.

J Dermatol Sci. 2011 Feb;61(2):139-42. doi: 10.1016/j.jdermsci.2010.11.017. Epub 2010 Dec 5. No abstract available.

46.

Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.

Bartee E, Eyster CA, Viswanathan K, Mansouri M, Donaldson JG, Früh K.

PLoS One. 2010 Dec 2;5(12):e15132. doi: 10.1371/journal.pone.0015132.

47.

Reversible occlusion (on-off) valves in shunted tumor patients.

Hertle DN, Tilgner J, Fruh K, Keinert T, Hagenston AM, Unterberg AW, Aschoff A.

Neurosurg Rev. 2010 Apr;34(2):235-42. doi: 10.1007/s10143-010-0297-y. Epub 2010 Nov 25.

PMID:
21107629
48.

High-content assay to identify inhibitors of dengue virus infection.

Shum D, Smith JL, Hirsch AJ, Bhinder B, Radu C, Stein DA, Nelson JA, Früh K, Djaballah H.

Assay Drug Dev Technol. 2010 Oct;8(5):553-70. doi: 10.1089/adt.2010.0321.

49.

Viral hijacking of the host ubiquitin system to evade interferon responses.

Viswanathan K, Früh K, DeFilippis V.

Curr Opin Microbiol. 2010 Aug;13(4):517-23. doi: 10.1016/j.mib.2010.05.012. Epub 2010 Jun 17. Review.

50.

Modulation of the host immune response by cowpox virus.

Alzhanova D, Früh K.

Microbes Infect. 2010 Nov;12(12-13):900-9. doi: 10.1016/j.micinf.2010.07.007. Epub 2010 Jul 29. Review.

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