Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 178

1.

Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.

Sheets MF, Fozzard HA, Hanck DA.

Biophys J. 2015 Dec 1;109(11):2277-86. doi: 10.1016/j.bpj.2015.10.012.

2.

The sodium channel as a target for local anesthetic drugs.

Fozzard HA, Sheets MF, Hanck DA.

Front Pharmacol. 2011 Nov 1;2:68. doi: 10.3389/fphar.2011.00068. eCollection 2011.

3.

A molecular model of the inner pore of the Ca channel in its open state.

Lipkind GM, Fozzard HA, Hanck DA.

Channels (Austin). 2011 Nov-Dec;5(6):482-8. doi: 10.4161/chan.5.6.18354. Epub 2011 Nov 1.

4.

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.

J Biol Chem. 2010 Dec 10;285(50):39458-70. doi: 10.1074/jbc.M110.132886. Epub 2010 Oct 6.

5.

Sodium channel molecular conformations and antiarrhythmic drug affinity.

Sheets MF, Fozzard HA, Lipkind GM, Hanck DA.

Trends Cardiovasc Med. 2010 Jan;20(1):16-21. doi: 10.1016/j.tcm.2010.03.002. Review.

6.

Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.

Lipkind GM, Fozzard HA.

Mol Pharmacol. 2010 Oct;78(4):631-8. doi: 10.1124/mol.110.064683. Epub 2010 Jul 19.

7.

The tetrodotoxin binding site is within the outer vestibule of the sodium channel.

Fozzard HA, Lipkind GM.

Mar Drugs. 2010 Feb 1;8(2):219-34. doi: 10.3390/md8020219. Review.

8.

Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.

Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF.

Circ Res. 2009 Aug 28;105(5):492-9. doi: 10.1161/CIRCRESAHA.109.198572. Epub 2009 Aug 6.

9.

Increased sensitivity to local anesthetic drugs: bedside to bench.

Fozzard HA.

Circ Res. 2008 Aug 15;103(4):325-7. doi: 10.1161/CIRCRESAHA.108.182055. No abstract available.

10.

Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue.

Lipkind GM, Fozzard HA.

J Gen Physiol. 2008 Jun;131(6):523-9. doi: 10.1085/jgp.200809991. Review. No abstract available.

11.

Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.

Jost MC, Hillis DM, Lu Y, Kyle JW, Fozzard HA, Zakon HH.

Mol Biol Evol. 2008 Jun;25(6):1016-24. doi: 10.1093/molbev/msn025. Epub 2008 Feb 6.

12.

Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

Szendroedi J, Sandtner W, Zarrabi T, Zebedin E, Hilber K, Dudley SC Jr, Fozzard HA, Todt H.

Biophys J. 2007 Dec 15;93(12):4209-24. Epub 2007 Aug 24.

13.

Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.

McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM.

J Physiol. 2007 Jun 1;581(Pt 2):741-55. Epub 2007 Mar 15.

14.

Isoform-dependent interaction of voltage-gated sodium channels with protons.

Khan A, Kyle JW, Hanck DA, Lipkind GM, Fozzard HA.

J Physiol. 2006 Oct 15;576(Pt 2):493-501. Epub 2006 Jul 27.

15.

Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels.

Hilber K, Sandtner W, Zarrabi T, Zebedin E, Kudlacek O, Fozzard HA, Todt H.

Biochemistry. 2005 Oct 25;44(42):13874-82.

PMID:
16229476
16.

Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels.

Lipkind GM, Fozzard HA.

Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20.

17.

Mechanism of local anesthetic drug action on voltage-gated sodium channels.

Fozzard HA, Lee PJ, Lipkind GM.

Curr Pharm Des. 2005;11(21):2671-86. Review.

PMID:
16101448
18.

Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.

Sunami A, Tracey A, Glaaser IW, Lipkind GM, Hanck DA, Fozzard HA.

J Physiol. 2004 Dec 1;561(Pt 2):403-13. Epub 2004 Oct 7.

19.

Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.

Sandtner W, Szendroedi J, Zarrabi T, Zebedin E, Hilber K, Glaaser I, Fozzard HA, Dudley SC, Todt H.

Mol Pharmacol. 2004 Sep;66(3):648-57.

21.

Fifty years of cardiovascular science together.

Fozzard HA.

Circ Res. 2003 Jan 10;92(1):4-5. No abstract available.

22.

Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.

Khan A, Romantseva L, Lam A, Lipkind G, Fozzard HA.

J Physiol. 2002 Aug 15;543(Pt 1):71-84.

23.

Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

Hilber K, Sandtner W, Kudlacek O, Schreiner B, Glaaser I, Sch├╝tz W, Fozzard HA, Dudley SC, Todt H.

J Biol Chem. 2002 Oct 4;277(40):37105-15. Epub 2002 Jul 23.

24.

Cardiac sodium and calcium channels: a history of excitatory currents.

Fozzard HA.

Cardiovasc Res. 2002 Jul;55(1):1-8. Review.

PMID:
12062702
25.

Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias?

Fozzard HA, Kyle JW.

Sci STKE. 2002 Apr 30;2002(130):pe19. Review.

PMID:
11983936
26.

Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.

Hui K, Lipkind G, Fozzard HA, French RJ.

J Gen Physiol. 2002 Jan;119(1):45-54.

28.

Gap junctions and liminal length in hypertrophy: something old and something new.

Fozzard HA.

J Cardiovasc Electrophysiol. 2001 Jul;12(7):836-7. Review. No abstract available.

PMID:
11469439
29.

Modeling of the outer vestibule and selectivity filter of the L-type Ca2+ channel.

Lipkind GM, Fozzard HA.

Biochemistry. 2001 Jun 12;40(23):6786-94.

PMID:
11389592
30.

The selectivity filter of the voltage-gated sodium channel is involved in channel activation.

Hilber K, Sandtner W, Kudlacek O, Glaaser IW, Weisz E, Kyle JW, French RJ, Fozzard HA, Dudley SC, Todt H.

J Biol Chem. 2001 Jul 27;276(30):27831-9. Epub 2001 May 29.

32.

Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.

Penzotti JL, Lipkind G, Fozzard HA, Dudley SC Jr.

Biophys J. 2001 Feb;80(2):698-706.

33.

mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.

Dudley SC Jr, Chang N, Hall J, Lipkind G, Fozzard HA, French RJ.

J Gen Physiol. 2000 Nov;116(5):679-90.

34.

KcsA crystal structure as framework for a molecular model of the Na(+) channel pore.

Lipkind GM, Fozzard HA.

Biochemistry. 2000 Jul 18;39(28):8161-70.

PMID:
10889022
35.

Channel-specific therapy of cardiac arrhythmias in our time?

Fozzard HA.

J Cardiovasc Electrophysiol. 2000 Mar;11(3):369-70. Review. No abstract available.

PMID:
10749361
37.

Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule.

Todt H, Dudley SC Jr, Kyle JW, French RJ, Fozzard HA.

Biophys J. 1999 Mar;76(3):1335-45.

38.

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.

Penzotti JL, Fozzard HA, Lipkind GM, Dudley SC Jr.

Biophys J. 1998 Dec;75(6):2647-57.

39.

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis.

Chang NS, French RJ, Lipkind GM, Fozzard HA, Dudley S Jr.

Biochemistry. 1998 Mar 31;37(13):4407-19.

PMID:
9521760
40.

Sodium channel selectivity filter regulates antiarrhythmic drug binding.

Sunami A, Dudley SC Jr, Fozzard HA.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14126-31.

41.

A model of scorpion toxin binding to voltage-gated K+ channels.

Lipkind GM, Fozzard HA.

J Membr Biol. 1997 Aug 1;158(3):187-96.

PMID:
9263881
42.

The guanidinium toxin binding site on the sodium channel.

Fozzard HA, Lipkind G.

Jpn Heart J. 1996 Sep;37(5):683-92. Review.

PMID:
8973381
43.
44.
45.

Unitary conductance of Na+ channel isoforms in cardiac and NB2a neuroblastoma cells.

Baumgarten CM, Dudley SC Jr, Rogart RB, Fozzard HA.

Am J Physiol. 1995 Dec;269(6 Pt 1):C1356-63.

PMID:
8572163
46.
47.

University of Wisconsin solution preserves myocardial calcium current response to isoproterenol in isolated canine ventricular myocytes.

Ono K, Gondo N, Arita M, Fozzard HA, Hadama T, Uchida Y.

Circulation. 1995 Nov 1;92(9 Suppl):II452-7.

PMID:
7586454
48.

A structural motif for the voltage-gated potassium channel pore.

Lipkind GM, Hanck DA, Fozzard HA.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9215-9.

49.

A direct effect of forskolin on sodium channel bursting.

Ono K, Fozzard HA, Hanck DA.

Pflugers Arch. 1995 Feb;429(4):561-9.

PMID:
7617447
50.

Ion channels and pumps in cardiac function.

Fozzard HA, Lipkind G.

Adv Exp Med Biol. 1995;382:3-10.

PMID:
8540407

Supplemental Content

Loading ...
Support Center