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Items: 1 to 50 of 168

1.

An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.

Beattie D, Beer D, Bradley ME, Bruce I, Charlton SJ, Cuenoud BM, Fairhurst RA, Farr D, Fozard JR, Janus D, Rosethorne EM, Sandham DA, Sykes DA, Trifilieff A, Turner KL, Wissler E.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6280-5. doi: 10.1016/j.bmcl.2012.07.096. Epub 2012 Aug 4.

PMID:
22932315
2.

Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.

Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Tyler JW, Wagner T, Fozard JR, Trifilieff A.

J Med Chem. 2012 Sep 13;55(17):7472-9. doi: 10.1021/jm300459a. Epub 2012 Aug 30.

PMID:
22889281
3.

Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.

Trifilieff A, Fozard JR.

J Pharmacol Exp Ther. 2012 Aug;342(2):399-406. doi: 10.1124/jpet.112.191585. Epub 2012 May 8.

4.

A role for sensory nerves in the late asthmatic response.

Raemdonck K, de Alba J, Birrell MA, Grace M, Maher SA, Irvin CG, Fozard JR, O'Byrne PM, Belvisi MG.

Thorax. 2012 Jan;67(1):19-25. doi: 10.1136/thoraxjnl-2011-200365. Epub 2011 Aug 13.

PMID:
21841185
5.

Progress towards novel adenosine receptor therapeutics gleaned from the recent patent literature.

Press NJ, Fozard JR.

Expert Opin Ther Pat. 2010 Aug;20(8):987-1005. doi: 10.1517/13543776.2010.495388. Review.

PMID:
20649373
6.

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

Baur F, Beattie D, Beer D, Bentley D, Bradley M, Bruce I, Charlton SJ, Cuenoud B, Ernst R, Fairhurst RA, Faller B, Farr D, Keller T, Fozard JR, Fullerton J, Garman S, Hatto J, Hayden C, He H, Howes C, Janus D, Jiang Z, Lewis C, Loeuillet-Ritzler F, Moser H, Reilly J, Steward A, Sykes D, Tedaldi L, Trifilieff A, Tweed M, Watson S, Wissler E, Wyss D.

J Med Chem. 2010 May 13;53(9):3675-84. doi: 10.1021/jm100068m.

PMID:
20402514
7.

Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.

Beattie D, Brearley A, Brown Z, Charlton SJ, Cox B, Fairhurst RA, Fozard JR, Gedeck P, Kirkham P, Meja K, Nanson L, Neef J, Oakman H, Spooner G, Taylor RJ, Turner RJ, West R, Woodward H.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1219-24. doi: 10.1016/j.bmcl.2009.11.131. Epub 2009 Dec 1.

PMID:
20031406
8.

Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips.

Trifilieff A, Baur F, Fozard JR.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Oct;380(4):303-9. doi: 10.1007/s00210-009-0438-4. Epub 2009 Jul 28.

PMID:
19636535
9.

In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.

Karmouty-Quintana H, Blé FX, Cannet C, Zurbruegg S, Fozard JR, Page CP, Beckmann N.

Br J Pharmacol. 2008 Jul;154(5):1063-72. doi: 10.1038/bjp.2008.174. Epub 2008 May 12.

10.

Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI.

Karmouty-Quintana H, Cannet C, Zurbruegg S, Blé FX, Fozard JR, Page CP, Beckmann N.

J Magn Reson Imaging. 2007 Oct;26(4):941-9.

PMID:
17896392
11.

Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging.

Karmouty-Quintana H, Cannet C, Sugar R, Fozard JR, Page CP, Beckmann N.

Br J Pharmacol. 2007 Apr;150(8):1022-30. Epub 2007 Mar 12.

12.

Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI.

Tigani B, Cannet C, Karmouty-Quintana H, Blé FX, Zurbruegg S, Schaeublin E, Fozard JR, Beckmann N.

Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L644-53. Epub 2006 Nov 3.

13.

Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats.

Quintana HK, Cannet C, Zurbruegg S, Blé FX, Fozard JR, Page CP, Beckmann N.

Magn Reson Med. 2006 Dec;56(6):1242-50.

14.

Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat.

Quintana HK, Cannet C, Schaeublin E, Zurbruegg S, Sugar R, Mazzoni L, Page CP, Fozard JR, Beckmann N.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L651-7. Epub 2006 May 25.

15.

In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action.

Battram C, Charlton SJ, Cuenoud B, Dowling MR, Fairhurst RA, Farr D, Fozard JR, Leighton-Davies JR, Lewis CA, McEvoy L, Turner RJ, Trifilieff A.

J Pharmacol Exp Ther. 2006 May;317(2):762-70. Epub 2006 Jan 24.

16.

Effects of endotoxin and allergen alone and in combination on the sensitivity of the rat airways to adenosine.

Karmouty Quintana H, Mazzoni L, Fozard JR.

Auton Autacoid Pharmacol. 2005 Oct;25(4):167-70.

PMID:
16176448
17.

BP-294 (Ste Civile Bioprojet).

Fozard JR.

IDrugs. 2000 Aug;3(8):935-9.

PMID:
16059810
18.

A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.

Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Brown L, Cheung R, Christie J, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Press NE, Sahri H, Tuffnell AR, Tweed M, Fozard JR.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3081-5.

PMID:
15876531
19.
20.

A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.

Hersperger R, Buchheit KH, Cammisuli S, Enz A, Lohse O, Ponelle M, Schuler W, Schweitzer A, Walker C, Zehender H, Zenke G, Zimmerlin AG, Zollinger M, Mazzoni L, Fozard JR.

J Med Chem. 2004 Sep 23;47(20):4950-7.

PMID:
15369399
21.
22.

Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.

Sandham DA, Barker L, Beattie D, Beer D, Bidlake L, Bentley D, Butler KD, Craig S, Farr D, Ffoulkes-Jones C, Fozard JR, Haberthuer S, Howes C, Hynx D, Jeffers S, Keller TH, Kirkham PA, Maas JC, Mazzoni L, Nicholls A, Pilgrim GE, Schaebulin E, Spooner GM, Stringer R, Tranter P, Turner KL, Tweed MF, Walker C, Watson SJ, Cuenoud BM.

Bioorg Med Chem. 2004 Oct 1;12(19):5213-24.

PMID:
15351404
23.

Suppression of histamine-induced tachypnoea in the rhesus monkey by sibenadet: no role for dopamine D2 receptors.

Fozard JR, Buescher H, Farr DC, Mazzoni L.

Auton Autacoid Pharmacol. 2004 Jan;24(1):9-16.

PMID:
15307823
24.

New highly potent and selective adenosine A(3) receptor antagonists.

Press NJ, Keller TH, Tranter P, Beer D, Jones K, Faessler A, Heng R, Lewis C, Howe T, Gedeck P, Mazzoni L, Fozard JR.

Curr Top Med Chem. 2004;4(8):863-70.

PMID:
15078217
25.

Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats.

Ellis KM, Cannet C, Mazzoni L, Fozard JR.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):166-78. Epub 2004 Jan 15.

PMID:
14727005
26.

Effects of a mitogen-activated protein kinase inhibitor on allergic airways inflammation in the rat studied by magnetic resonance imaging.

Tigani B, Di Padova F, Zurbrügg S, Schaeublin E, Revesz L, Fozard JR, Beckmann N.

Eur J Pharmacol. 2003 Dec 15;482(1-3):319-24.

PMID:
14660038
27.

Techniques: magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs.

Beckmann N, Tigani B, Mazzoni L, Fozard JR.

Trends Pharmacol Sci. 2003 Oct;24(10):550-4. Review. No abstract available.

PMID:
14559408
28.

Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging.

Tigani B, Cannet C, Zurbrugg S, Schaeublin E, Mazzoni L, Fozard JR, Beckmann N.

Br J Pharmacol. 2003 Sep;140(2):239-46. Epub 2003 Aug 18.

29.

Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog.

Fozard JR, Baur F, Wolber C.

Eur J Pharmacol. 2003 Aug 15;475(1-3):79-84.

PMID:
12954362
31.
32.

Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen.

Tigani B, Hannon JP, Schaeublin E, Mazzoni L, Fozard JR.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):17-25. Epub 2003 Jun 24.

PMID:
12827216
33.

The case for a role for adenosine in asthma: almost convincing?

Fozard JR.

Curr Opin Pharmacol. 2003 Jun;3(3):264-9. Review.

PMID:
12810190
34.

Controversies in respiratory diseases and their management.

Fozard JR, Walker C.

Curr Opin Pharmacol. 2003 Jun;3(3):209-11. No abstract available.

PMID:
12810181
35.

Species differences in bradykinin receptor-mediated responses of the airways.

Ellis KM, Fozard JR.

Auton Autacoid Pharmacol. 2002 Feb;22(1):3-16. Review.

PMID:
12423422
36.

Suppression of adenosine A(3) receptor-mediated hypotension and mast cell degranulation in the rat by dexamethasone.

Hannon JP, Tigani B, Schuurman HJ, Fozard JR.

J Pharmacol Exp Ther. 2002 Aug;302(2):725-30.

37.

Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI.

Beckmann N, Tigani B, Sugar R, Jackson AD, Jones G, Mazzoni L, Fozard JR.

Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L22-30.

38.

Adenosine receptor ligands as potential therapeutics in asthma.

Fozard JR, McCarthy C.

Curr Opin Investig Drugs. 2002 Jan;3(1):69-77. Review.

PMID:
12054076
39.

Airway hyperresponsiveness to adenosine induced by lipopolysaccharide in Brown Norway rats.

Tigani B, Hannon JP, Rondeau C, Mazzoni L, Fozard JR.

Br J Pharmacol. 2002 May;136(1):111-9.

40.

Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.

Fozard JR, Ellis KM, Villela Dantas MF, Tigani B, Mazzoni L.

Eur J Pharmacol. 2002 Mar 8;438(3):183-8.

PMID:
11909610
41.

Pulmonary inflammation monitored noninvasively by MRI in freely breathing rats.

Tigani B, Schaeublin E, Sugar R, Jackson AD, Fozard JR, Beckmann N.

Biochem Biophys Res Commun. 2002 Mar 22;292(1):216-21.

PMID:
11890695
42.

KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects.

Buchheit KH, Manley PW, Quast U, Russ U, Mazzoni L, Fozard JR.

Naunyn Schmiedebergs Arch Pharmacol. 2002 Mar;365(3):220-30. Epub 2002 Jan 23.

PMID:
11882918
43.
44.

Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by beta 2-adrenoceptors.

Fozard JR, Baur F, Wolber C, Collingwood SP.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):570-2.

PMID:
11770013
45.

Effects of wortmannin on airways inflammation induced by allergen in actively sensitised Brown Norway rats.

Tigani B, Hannon JP, Mazzoni L, Fozard JR.

Eur J Pharmacol. 2001 Dec 21;433(2-3):217-23.

PMID:
11755155
46.

MRI of lung parenchyma in rats and mice using a gradient-echo sequence.

Beckmann N, Tigani B, Mazzoni L, Fozard JR.

NMR Biomed. 2001 Aug;14(5):297-306.

PMID:
11477650
47.

Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice.

Zhong H, Chunn JL, Volmer JB, Fozard JR, Blackburn MR.

J Pharmacol Exp Ther. 2001 Aug;298(2):433-40.

49.

Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats.

Hannon JP, Tigani B, Williams I, Mazzoni L, Fozard JR.

Br J Pharmacol. 2001 Apr;132(7):1509-23.

50.

BP-294 Ste Civile Bioprojet.

Fozard JR.

Curr Opin Investig Drugs. 2000 Sep;1(1):86-9. Review.

PMID:
11249601

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