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Items: 1 to 50 of 54

1.

Assessment of Digital PCR as a Primary Reference Measurement Procedure to Support Advances in Precision Medicine.

Whale AS, Jones GM, Pavšič J, Dreo T, Redshaw N, Akyürek S, Akgöz M, Divieto C, Sassi MP, He HJ, Cole KD, Bae YK, Park SR, Deprez L, Corbisier P, Garrigou S, Taly V, Larios R, Cowen S, O'Sullivan DM, Bushell CA, Goenaga-Infante H, Foy CA, Woolford AJ, Parkes H, Huggett JF, Devonshire AS.

Clin Chem. 2018 Sep;64(9):1296-1307. doi: 10.1373/clinchem.2017.285478. Epub 2018 Jun 14.

PMID:
29903874
2.

Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA.

Gale D, Lawson ARJ, Howarth K, Madi M, Durham B, Smalley S, Calaway J, Blais S, Jones G, Clark J, Dimitrov P, Pugh M, Woodhouse S, Epstein M, Fernandez-Gonzalez A, Whale AS, Huggett JF, Foy CA, Jones GM, Raveh-Amit H, Schmitt K, Devonshire A, Green E, Forshew T, Plagnol V, Rosenfeld N.

PLoS One. 2018 Mar 16;13(3):e0194630. doi: 10.1371/journal.pone.0194630. eCollection 2018.

3.

Instability of 8E5 calibration standard revealed by digital PCR risks inaccurate quantification of HIV DNA in clinical samples by qPCR.

Busby E, Whale AS, Ferns RB, Grant PR, Morley G, Campbell J, Foy CA, Nastouli E, Huggett JF, Garson JA.

Sci Rep. 2017 Apr 26;7(1):1209. doi: 10.1038/s41598-017-01221-5.

4.

Inter-laboratory assessment of different digital PCR platforms for quantification of human cytomegalovirus DNA.

Pavšič J, Devonshire A, Blejec A, Foy CA, Van Heuverswyn F, Jones GM, Schimmel H, Žel J, Huggett JF, Redshaw N, Karczmarczyk M, Mozioğlu E, Akyürek S, Akgöz M, Milavec M.

Anal Bioanal Chem. 2017 Apr;409(10):2601-2614. doi: 10.1007/s00216-017-0206-0. Epub 2017 Jan 26.

5.

International Interlaboratory Digital PCR Study Demonstrating High Reproducibility for the Measurement of a Rare Sequence Variant.

Whale AS, Devonshire AS, Karlin-Neumann G, Regan J, Javier L, Cowen S, Fernandez-Gonzalez A, Jones GM, Redshaw N, Beck J, Berger AW, Combaret V, Dahl Kjersgaard N, Davis L, Fina F, Forshew T, Fredslund Andersen R, Galbiati S, González Hernández Á, Haynes CA, Janku F, Lacave R, Lee J, Mistry V, Pender A, Pradines A, Proudhon C, Saal LH, Stieglitz E, Ulrich B, Foy CA, Parkes H, Tzonev S, Huggett JF.

Anal Chem. 2017 Feb 7;89(3):1724-1733. doi: 10.1021/acs.analchem.6b03980. Epub 2017 Jan 18.

PMID:
27935690
6.

The use of digital PCR to improve the application of quantitative molecular diagnostic methods for tuberculosis.

Devonshire AS, O'Sullivan DM, Honeyborne I, Jones G, Karczmarczyk M, Pavšič J, Gutteridge A, Milavec M, Mendoza P, Schimmel H, Van Heuverswyn F, Gorton R, Cirillo DM, Borroni E, Harris K, Barnard M, Heydenrych A, Ndusilo N, Wallis CL, Pillay K, Barry T, Reddington K, Richter E, Mozioğlu E, Akyürek S, Yalçınkaya B, Akgoz M, Žel J, Foy CA, McHugh TD, Huggett JF.

BMC Infect Dis. 2016 Aug 3;16:366. doi: 10.1186/s12879-016-1696-7.

7.

An international comparability study on quantification of mRNA gene expression ratios: CCQM-P103.1.

Devonshire AS, Sanders R, Whale AS, Nixon GJ, Cowen S, Ellison SL, Parkes H, Pine PS, Salit M, McDaniel J, Munro S, Lund S, Matsukura S, Sekiguchi Y, Kawaharasaki M, Granjeiro JM, Falagan-Lotsch P, Saraiva AM, Couto P, Yang I, Kwon H, Park SR, Demšar T, Žel J, Blejec A, Milavec M, Dong L, Zhang L, Sui Z, Wang J, Viroonudomphol D, Prawettongsopon C, Partis L, Baoutina A, Emslie K, Takatsu A, Akyurek S, Akgoz M, Vonsky M, Konopelko LA, Cundapi EM, Urquiza MP, Huggett JF, Foy CA.

Biomol Detect Quantif. 2016 Jun 6;8:15-28. doi: 10.1016/j.bdq.2016.05.003. eCollection 2016 Jun.

8.

Detection of Rare Drug Resistance Mutations by Digital PCR in a Human Influenza A Virus Model System and Clinical Samples.

Whale AS, Bushell CA, Grant PR, Cowen S, Gutierrez-Aguirre I, O'Sullivan DM, Žel J, Milavec M, Foy CA, Nastouli E, Garson JA, Huggett JF.

J Clin Microbiol. 2016 Feb;54(2):392-400. doi: 10.1128/JCM.02611-15. Epub 2015 Dec 9.

9.

Highly reproducible absolute quantification of Mycobacterium tuberculosis complex by digital PCR.

Devonshire AS, Honeyborne I, Gutteridge A, Whale AS, Nixon G, Wilson P, Jones G, McHugh TD, Foy CA, Huggett JF.

Anal Chem. 2015 Apr 7;87(7):3706-13. doi: 10.1021/ac5041617. Epub 2015 Mar 10.

PMID:
25646934
10.

Quantification of epigenetic biomarkers: an evaluation of established and emerging methods for DNA methylation analysis.

Redshaw N, Huggett JF, Taylor MS, Foy CA, Devonshire AS.

BMC Genomics. 2014 Dec 23;15:1174. doi: 10.1186/1471-2164-15-1174.

11.

Assessing the accuracy of quantitative molecular microbial profiling.

O'Sullivan DM, Laver T, Temisak S, Redshaw N, Harris KA, Foy CA, Studholme DJ, Huggett JF.

Int J Mol Sci. 2014 Nov 21;15(11):21476-91. doi: 10.3390/ijms151121476.

12.

A novel approach for evaluating the performance of real time quantitative loop-mediated isothermal amplification-based methods.

Nixon GJ, Svenstrup HF, Donald CE, Carder C, Stephenson JM, Morris-Jones S, Huggett JF, Foy CA.

Biomol Detect Quantif. 2014 Nov 22;2:4-10. eCollection 2014 Dec.

13.

Standardization of Nucleic Acid Tests for Clinical Measurements of Bacteria and Viruses.

Pavšič J, Devonshire AS, Parkes H, Schimmel H, Foy CA, Karczmarczyk M, Gutiérrez-Aguirre I, Honeyborne I, Huggett JF, McHugh TD, Milavec M, Zeichhardt H, Žel J.

J Clin Microbiol. 2015 Jul;53(7):2008-14. doi: 10.1128/JCM.02136-14. Epub 2014 Nov 12. Review.

14.

Considerations for digital PCR as an accurate molecular diagnostic tool.

Huggett JF, Cowen S, Foy CA.

Clin Chem. 2015 Jan;61(1):79-88. doi: 10.1373/clinchem.2014.221366. Epub 2014 Oct 22. Review.

15.

Carpal Wedge Osteotomy in the Arthrogrypotic Patient.

Oishi SN, Foy CA, Wheeler L, Ezaki M.

JBJS Essent Surg Tech. 2014 Oct 22;4(4):e20. doi: 10.2106/JBJS.ST.M.00054. eCollection 2014 Dec.

16.

Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples.

Sanders R, Mason DJ, Foy CA, Huggett JF.

Anal Bioanal Chem. 2014 Oct;406(26):6471-83. doi: 10.1007/s00216-014-7857-x. Epub 2014 May 25. Review.

17.

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification.

Devonshire AS, Whale AS, Gutteridge A, Jones G, Cowen S, Foy CA, Huggett JF.

Anal Bioanal Chem. 2014 Oct;406(26):6499-512. doi: 10.1007/s00216-014-7835-3. Epub 2014 May 24.

18.
19.

Validation of high-throughput single cell analysis methodology.

Devonshire AS, Baradez MO, Morley G, Marshall D, Foy CA.

Anal Biochem. 2014 May 1;452:103-13. doi: 10.1016/j.ab.2014.03.001. Epub 2014 Mar 11.

PMID:
24631519
20.

Long-term outcome following carpal wedge osteotomy in the arthrogrypotic patient.

Foy CA, Mills J, Wheeler L, Ezaki M, Oishi SN.

J Bone Joint Surg Am. 2013 Oct 16;95(20):e150. doi: 10.2106/JBJS.L.01122.

PMID:
24132365
21.

Evaluation of digital PCR for absolute RNA quantification.

Sanders R, Mason DJ, Foy CA, Huggett JF.

PLoS One. 2013 Sep 20;8(9):e75296. doi: 10.1371/journal.pone.0075296. eCollection 2013.

22.

The digital MIQE guidelines: Minimum Information for Publication of Quantitative Digital PCR Experiments.

Huggett JF, Foy CA, Benes V, Emslie K, Garson JA, Haynes R, Hellemans J, Kubista M, Mueller RD, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT, Bustin SA.

Clin Chem. 2013 Jun;59(6):892-902. doi: 10.1373/clinchem.2013.206375. Epub 2013 Apr 9.

23.

A comparison of miRNA isolation and RT-qPCR technologies and their effects on quantification accuracy and repeatability.

Redshaw N, Wilkes T, Whale A, Cowen S, Huggett J, Foy CA.

Biotechniques. 2013 Mar;54(3):155-64. doi: 10.2144/000114002.

24.

Methods for applying accurate digital PCR analysis on low copy DNA samples.

Whale AS, Cowen S, Foy CA, Huggett JF.

PLoS One. 2013;8(3):e58177. doi: 10.1371/journal.pone.0058177. Epub 2013 Mar 5.

25.

Progress in metagenomics requires a balanced appraisal of the available technologies.

Huggett JF, Studholme DJ, Laver T, Foy CA.

Eur J Clin Microbiol Infect Dis. 2013 Aug;32(8):1097-8. doi: 10.1007/s10096-013-1842-8. Epub 2013 Feb 23. No abstract available.

PMID:
23435754
26.

Application of next generation qPCR and sequencing platforms to mRNA biomarker analysis.

Devonshire AS, Sanders R, Wilkes TM, Taylor MS, Foy CA, Huggett JF.

Methods. 2013 Jan;59(1):89-100. doi: 10.1016/j.ymeth.2012.07.021. Epub 2012 Jul 24. Review.

PMID:
22841564
27.

Quality assessment of biobanked nucleic acid extracts for downstream molecular analysis.

Wahlberg K, Huggett J, Sanders R, Whale AS, Bushell C, Elaswarapu R, Scott DJ, Foy CA.

Biopreserv Biobank. 2012 Jun;10(3):266-75. doi: 10.1089/bio.2012.0004.

PMID:
24835065
28.

Comparison of reverse transcription-quantitative polymerase chain reaction methods and platforms for single cell gene expression analysis.

Fox BC, Devonshire AS, Baradez MO, Marshall D, Foy CA.

Anal Biochem. 2012 Aug 15;427(2):178-86. doi: 10.1016/j.ab.2012.05.010. Epub 2012 May 19.

PMID:
22617801
29.

Comparison of microfluidic digital PCR and conventional quantitative PCR for measuring copy number variation.

Whale AS, Huggett JF, Cowen S, Speirs V, Shaw J, Ellison S, Foy CA, Scott DJ.

Nucleic Acids Res. 2012 Jun;40(11):e82. doi: 10.1093/nar/gks203. Epub 2012 Feb 28.

30.

Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets.

Scott DJ, Devonshire AS, Adeleye YA, Schutte ME, Rodrigues MR, Wilkes TM, Sacco MG, Gribaldo L, Fabbri M, Coecke S, Whelan M, Skinner N, Bennett A, White A, Foy CA.

Toxicology. 2011 Nov 28;290(1):50-8. doi: 10.1016/j.tox.2011.08.015. Epub 2011 Aug 19.

PMID:
21871943
31.

A pilot study to evaluate the application of a generic protein standard panel for quality control of biomarker detection technologies.

Pang S, Ahsan ES, Valdivia HJ, Minguez J, Foy CA.

BMC Res Notes. 2011 Aug 11;4:281. doi: 10.1186/1756-0500-4-281.

32.

Evaluation of digital PCR for absolute DNA quantification.

Sanders R, Huggett JF, Bushell CA, Cowen S, Scott DJ, Foy CA.

Anal Chem. 2011 Sep 1;83(17):6474-84. doi: 10.1021/ac103230c. Epub 2011 Aug 1.

PMID:
21446772
33.

Applicability of RNA standards for evaluating RT-qPCR assays and platforms.

Devonshire AS, Elaswarapu R, Foy CA.

BMC Genomics. 2011 Feb 18;12:118. doi: 10.1186/1471-2164-12-118.

34.

Evaluation of external RNA controls for the standardisation of gene expression biomarker measurements.

Devonshire AS, Elaswarapu R, Foy CA.

BMC Genomics. 2010 Nov 24;11:662. doi: 10.1186/1471-2164-11-662.

35.

Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers.

Fox BC, Devonshire AS, Schutte ME, Foy CA, Minguez J, Przyborski S, Maltman D, Bokhari M, Marshall D.

Toxicol In Vitro. 2010 Oct;24(7):1962-70. doi: 10.1016/j.tiv.2010.08.007. Epub 2010 Aug 21.

PMID:
20732408
36.

Improved detection of cell surface proteins using an electrochemiluminescent cell-binding assay.

Pang S, Ahsan ES, Foy CA.

J Immunol Methods. 2010 Oct 31;362(1-2):176-9. doi: 10.1016/j.jim.2010.07.010. Epub 2010 Aug 3.

PMID:
20688072
37.

Evaluation of a novel approach for the measurement of RNA quality.

Wilkes TM, Devonshire AS, Ellison SL, Foy CA.

BMC Res Notes. 2010 Apr 1;3:89. doi: 10.1186/1756-0500-3-89.

38.

An international comparability study on quantification of total methyl cytosine content.

Yang I, Kim SK, Burke DG, Griffiths K, Kassir Z, Emslie KR, Gao Y, Wang J, Foy CA, Pardos-Pardos AC, Ellison S, Domann PJ, Fujii S, Park SR.

Anal Biochem. 2009 Jan 15;384(2):288-95. doi: 10.1016/j.ab.2008.09.036. Epub 2008 Sep 30.

PMID:
18929528
39.

Knee pain and leg-length discrepancy after retrograde femoral nailing.

Reina R, Vilella FE, Ramírez N, Valenzuela R, Nieves G, Foy CA.

Am J Orthop (Belle Mead NJ). 2007 Jun;36(6):325-8.

PMID:
17643147
40.

Microarray data quality - review of current developments.

Wilkes T, Laux H, Foy CA.

OMICS. 2007 Spring;11(1):1-13. Review.

PMID:
17411392
41.
42.

The development of microarray standards.

Andersen MT, Foy CA.

Anal Bioanal Chem. 2005 Jan;381(1):87-9. No abstract available.

PMID:
15614502
43.

Development of a facile fluorescent assay for the detection of 80 mutations within the p53 gene.

Hodgson DR, Foy CA, Partridge M, Pateromichelakis S, Gibson NJ.

Mol Med. 2002 May;8(5):227-37.

44.

Emerging homogeneous DNA-based technologies in the clinical laboratory.

Foy CA, Parkes HC.

Clin Chem. 2001 Jun;47(6):990-1000. Review.

45.

ARMS allele-specific amplification-based detection of mutant p53 DNA and mRNA in tumors of the breast.

Hodgson DR, Clayton SJ, Girdler F, Brotherick I, Shenton B, Browell D, Stuart M, Fox JC, Ceuppens P, Foy CA, Whitcombe D, Gibson NJ.

Clin Chem. 2001 Apr;47(4):774-8. No abstract available.

46.
48.

Angiotensin-converting enzyme (ACE) gene polymorphisms in patients characterised by coronary angiography.

Foy CA, Rice GI, Ossei-Gerning N, Mansfield MW, Grant PJ.

Hum Genet. 1997 Sep;100(3-4):420-5.

PMID:
9272166
49.

Genes and the development of vascular disease.

Foy CA, Grant PJ.

Postgrad Med J. 1997 May;73(859):271-8. Review.

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