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RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.

Gasparini C, Foxwell BM, Feldmann M.

Cytokine. 2013 Mar;61(3):736-40. doi: 10.1016/j.cyto.2012.12.029. Epub 2013 Feb 6.


Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20518-22. doi: 10.1073/pnas.1014557107. Epub 2010 Nov 1.


Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.

Turner JJ, Foxwell KM, Kanji R, Brenner C, Wood S, Foxwell BM, Feldmann M.

Clin Exp Immunol. 2010 Dec;162(3):487-93. doi: 10.1111/j.1365-2249.2010.04260.x. Epub 2010 Sep 15.


Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

Page TH, Turner JJ, Brown AC, Timms EM, Inglis JJ, Brennan FM, Foxwell BM, Ray KP, Feldmann M.

J Immunol. 2010 Sep 15;185(6):3694-701. doi: 10.4049/jimmunol.1000906. Epub 2010 Aug 16.


SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

Drexler SK, Kong P, Inglis J, Williams RO, Garlanda C, Mantovani A, Yazdi AS, Brennan F, Feldmann M, Foxwell BM.

Arthritis Rheum. 2010 Aug;62(8):2249-61. doi: 10.1002/art.27517.


Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

Drexler SK, Wales J, Andreakos E, Kong P, Davis A, Garlanda C, Mantovani A, Hussell T, Feldmann M, Foxwell BM.

Scand J Immunol. 2010 Jun;71(6):393-402. doi: 10.1111/j.1365-3083.2010.02392.x.


Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.

de Souza JB, Okomo U, Alexander ND, Aziz N, Owens BM, Kaur H, Jasseh M, Muangnoicharoen S, Sumariwalla PF, Warhurst DC, Ward SA, Conway DJ, Ulloa L, Tracey KJ, Foxwell BM, Kaye PM, Walther M.

PLoS One. 2010 Apr 15;5(4):e9867. doi: 10.1371/journal.pone.0009867.


Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.

Monaco C, Gregan SM, Navin TJ, Foxwell BM, Davies AH, Feldmann M.

Circulation. 2009 Dec 15;120(24):2462-9. doi: 10.1161/CIRCULATIONAHA.109.851881.


The role of toll-like receptors in chronic inflammation.

Drexler SK, Foxwell BM.

Int J Biochem Cell Biol. 2010 Apr;42(4):506-18. doi: 10.1016/j.biocel.2009.10.009. Epub 2009 Oct 29. Review.


TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

Kuai J, Gregory B, Hill A, Pittman DD, Feldman JL, Brown T, Carito B, O'Toole M, Ramsey R, Adolfsson O, Shields KM, Dower K, Hall JP, Kurdi Y, Beech JT, Nanchahal J, Feldmann M, Foxwell BM, Brennan FM, Winkler DG, Lin LL.

Rheumatology (Oxford). 2009 Nov;48(11):1352-8. doi: 10.1093/rheumatology/kep235. Epub 2009 Aug 27.


RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

Gasparini C, Foxwell BM, Feldmann M.

Eur J Immunol. 2009 Aug;39(8):2215-23. doi: 10.1002/eji.200939209.


Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease.

Smith AM, Rahman FZ, Hayee B, Graham SJ, Marks DJ, Sewell GW, Palmer CD, Wilde J, Foxwell BM, Gloger IS, Sweeting T, Marsh M, Walker AP, Bloom SL, Segal AW.

J Exp Med. 2009 Aug 31;206(9):1883-97. doi: 10.1084/jem.20091233. Epub 2009 Aug 3. Erratum in: J Exp Med. 2009 Sep 28;206(10):2301.


The role of transposable elements in the regulation of IFN-lambda1 gene expression.

Thomson SJ, Goh FG, Banks H, Krausgruber T, Kotenko SV, Foxwell BM, Udalova IA.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11564-9. doi: 10.1073/pnas.0904477106. Epub 2009 Jul 1.


Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

Midwood K, Sacre S, Piccinini AM, Inglis J, Trebaul A, Chan E, Drexler S, Sofat N, Kashiwagi M, Orend G, Brennan F, Foxwell B.

Nat Med. 2009 Jul;15(7):774-80. doi: 10.1038/nm.1987. Epub 2009 Jun 28.


Induction of TLR tolerance in human macrophages by adiponectin: does LPS play a role?

Turner JJ, Smolinska MJ, Sacre SM, Foxwell BM.

Scand J Immunol. 2009 Apr;69(4):329-36. doi: 10.1111/j.1365-3083.2008.02224.x.


Mycolactone inhibits monocyte cytokine production by a posttranscriptional mechanism.

Simmonds RE, Lali FV, Smallie T, Small PL, Foxwell BM.

J Immunol. 2009 Feb 15;182(4):2194-202. doi: 10.4049/jimmunol.0802294.


Tyrosine kinases and inflammatory signalling.

Page TH, Smolinska M, Gillespie J, Urbaniak AM, Foxwell BM.

Curr Mol Med. 2009 Feb;9(1):69-85. Review.


Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1.

Albrecht V, Hofer TP, Foxwell B, Frankenberger M, Ziegler-Heitbrock L.

BMC Immunol. 2008 Nov 24;9:69. doi: 10.1186/1471-2172-9-69.


Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, Brennan FM, Foxwell BM.

J Immunol. 2008 Dec 1;181(11):8002-9.


Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

Sumariwalla PF, Palmer CD, Pickford LB, Feldmann M, Foxwell BM, Brennan FM.

Rheumatology (Oxford). 2009 Jan;48(1):32-8. doi: 10.1093/rheumatology/ken398. Epub 2008 Nov 16.


Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis.

Drexler SK, Kong PL, Wales J, Foxwell BM.

Arthritis Res Ther. 2008;10(5):216. doi: 10.1186/ar2481. Epub 2008 Oct 10. Review.


The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.

Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ.

J Biol Chem. 2008 Jul 4;283(27):18591-600. doi: 10.1074/jbc.M710330200. Epub 2008 May 5.


Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.

Behmoaras J, Bhangal G, Smith J, McDonald K, Mutch B, Lai PC, Domin J, Game L, Salama A, Foxwell BM, Pusey CD, Cook HT, Aitman TJ.

Nat Genet. 2008 May;40(5):553-9. doi: 10.1038/ng.137.


Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene.

Unterberger C, Staples KJ, Smallie T, Williams L, Foxwell B, Schaefer A, Kempkes B, Hofer TP, Koeppel M, Lohrum M, Stunnenberg H, Frankenberger M, Ziegler-Heitbrock L.

Mol Immunol. 2008 Jun;45(11):3230-7. doi: 10.1016/j.molimm.2008.02.020. Epub 2008 Apr 9.


Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts.

Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM.

Biochem Biophys Res Commun. 2008 Jun 13;370(4):599-602. doi: 10.1016/j.bbrc.2008.03.142. Epub 2008 Apr 8.


Targeting intracellular signaling: a novel approach to vaccination.

Wales J, Foxwell B, Feldmann M.

Expert Rev Vaccines. 2007 Dec;6(6):971-80. doi: 10.1586/14760584.6.6.971. Review.


Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

Williams LM, Lali F, Willetts K, Balague C, Godessart N, Brennan F, Feldmann M, Foxwell BM.

Mol Immunol. 2008 May;45(9):2446-54. doi: 10.1016/j.molimm.2007.12.011. Epub 2008 Feb 6. Review.


Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation.

Simmonds RE, Foxwell BM.

Rheumatology (Oxford). 2008 May;47(5):584-90. doi: 10.1093/rheumatology/kem298. Epub 2008 Jan 29. Review.


Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

Wales J, Andreakos E, Feldmann M, Foxwell B.

Biochem Soc Trans. 2007 Dec;35(Pt 6):1501-3. Review.


Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.

El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Watowich SS, Häcker H, Foxwell BM, Murray PJ.

J Immunol. 2007 Dec 1;179(11):7215-9. Erratum in: J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia [corrected to Panopoulos, Athanasia D].


Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity.

Palmer CD, Mutch BE, Workman S, McDaid JP, Horwood NJ, Foxwell BM.

Blood. 2008 Feb 15;111(4):1781-8. Epub 2007 Nov 19.


Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

Sacre SM, Drexler SK, Andreakos E, Feldmann M, Brennan FM, Foxwell BM.

Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii81-6. Review.


Adenoviral targeting of signal transduction pathways in synovial cell cultures.

Davis A, Taylor C, Willetts K, Smith C, Foxwell BM.

Methods Mol Med. 2007;136:395-419.


Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages.

Smolinska MJ, Horwood NJ, Page TH, Smallie T, Foxwell BM.

Mol Immunol. 2008 Feb;45(4):990-1000. Epub 2007 Sep 17.


Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

Lundberg AM, Drexler SK, Monaco C, Williams LM, Sacre SM, Feldmann M, Foxwell BM.

Blood. 2007 Nov 1;110(9):3245-52. Epub 2007 Jul 27.


Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Edwards CJ, Feldman JL, Beech J, Shields KM, Stover JA, Trepicchio WL, Larsen G, Foxwell BM, Brennan FM, Feldmann M, Pittman DD.

Mol Med. 2007 Jan-Feb;13(1-2):40-58.


IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3.

Staples KJ, Smallie T, Williams LM, Foey A, Burke B, Foxwell BM, Ziegler-Heitbrock L.

J Immunol. 2007 Apr 15;178(8):4779-85.


Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.

Sheryanna A, Bhangal G, McDaid J, Smith J, Manning A, Foxwell BM, Feldmann M, Cook HT, Pusey CD, Tam FW.

J Am Soc Nephrol. 2007 Apr;18(4):1167-79. Epub 2007 Feb 21.


The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.

Sacre SM, Andreakos E, Kiriakidis S, Amjadi P, Lundberg A, Giddins G, Feldmann M, Brennan F, Foxwell BM.

Am J Pathol. 2007 Feb;170(2):518-25.


Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages.

Williams LM, Sarma U, Willets K, Smallie T, Brennan F, Foxwell BM.

J Biol Chem. 2007 Mar 9;282(10):6965-75. Epub 2006 Dec 27.


A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.

Newton SM, Smith RJ, Wilkinson KA, Nicol MP, Garton NJ, Staples KJ, Stewart GR, Wain JR, Martineau AR, Fandrich S, Smallie T, Foxwell B, Al-Obaidi A, Shafi J, Rajakumar K, Kampmann B, Andrew PW, Ziegler-Heitbrock L, Barer MR, Wilkinson RJ.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15594-8. Epub 2006 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):685.


Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.

Andreakos E, Williams RO, Wales J, Foxwell BM, Feldmann M.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14459-64. Epub 2006 Sep 13.


TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells.

Patel DN, Bailey SR, Gresham JK, Schuchman DB, Shelhamer JH, Goldstein BJ, Foxwell BM, Stemerman MB, Maranchie JK, Valente AJ, Mummidi S, Chandrasekar B.

Biochem Biophys Res Commun. 2006 Sep 8;347(4):1113-20. Epub 2006 Jul 13.


Toll-like receptors: a new target in rheumatoid arthritis?

Drexler SK, Sacre SM, Foxwell BM.

Expert Rev Clin Immunol. 2006 Jul;2(4):585-99. doi: 10.1586/1744666X.2.4.585.


Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis.

Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, Pavlov VA, Gallowitsch-Puerta M, Ashok M, Czura CJ, Foxwell B, Tracey KJ, Ulloa L.

J Exp Med. 2006 Jul 10;203(7):1623-8. Epub 2006 Jun 19.


Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production.

Horwood NJ, Page TH, McDaid JP, Palmer CD, Campbell J, Mahon T, Brennan FM, Webster D, Foxwell BM.

J Immunol. 2006 Mar 15;176(6):3635-41.


Anti-TNF therapy: where have we got to in 2005?

Feldmann M, Brennan FM, Foxwell BM, Taylor PC, Williams RO, Maini RN.

J Autoimmun. 2005;25 Suppl:26-8. Epub 2005 Nov 2. Review.


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