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Items: 1 to 50 of 66

1.

Citryl Ornithine Is an Intermediate in a Three-Step Biosynthetic Pathway for Rhizoferrin in Francisella.

Ramakrishnan G, Pérez NM, Carroll C, Moore MM, Nakamoto RK, Fox TE.

ACS Chem Biol. 2019 Jul 12. doi: 10.1021/acschembio.9b00297. [Epub ahead of print]

PMID:
31260252
2.

Childhood growth and neurocognition are associated with distinct sets of metabolites.

Moreau GB, Ramakrishnan G, Cook HL, Fox TE, Nayak U, Ma JZ, Colgate ER, Kirkpatrick BD, Haque R, Petri WA Jr.

EBioMedicine. 2019 Jun;44:597-606. doi: 10.1016/j.ebiom.2019.05.043. Epub 2019 May 25.

3.

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation.

Tan SF, Dunton W, Liu X, Fox TE, Morad SAF, Desai D, Doi K, Conaway MR, Amin S, Claxton DF, Wang HG, Kester M, Cabot MC, Feith DJ, Loughran TP Jr.

J Lipid Res. 2019 Jun;60(6):1078-1086. doi: 10.1194/jlr.M091876. Epub 2019 Apr 8.

PMID:
30962310
4.

TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.

Shah A, Melhuish TA, Fox TE, Frierson HF Jr, Wotton D.

Genes Dev. 2019 Apr 1;33(7-8):388-402. doi: 10.1101/gad.320127.118. Epub 2019 Feb 26.

PMID:
30808659
5.

Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic modeling.

Kumar M, Ji B, Babaei P, Das P, Lappa D, Ramakrishnan G, Fox TE, Haque R, Petri WA, Bäckhed F, Nielsen J.

Metab Eng. 2018 Sep;49:128-142. doi: 10.1016/j.ymben.2018.07.018. Epub 2018 Jul 31.

PMID:
30075203
6.

STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia.

Doshi UA, Shaw J, Fox TE, Claxton DF, Loughran TP, Kester M.

Signal Transduct Target Ther. 2017 Oct 27;2:17051. doi: 10.1038/sigtrans.2017.51. eCollection 2017.

7.

Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo.

Shin M, Snyder HW, Donvito G, Schurman LD, Fox TE, Lichtman AH, Kester M, Hsu KL.

Mol Pharm. 2018 Mar 5;15(3):721-728. doi: 10.1021/acs.molpharmaceut.7b00657. Epub 2017 Sep 13.

8.

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.

Hengst JA, Dick TE, Sharma A, Doi K, Hegde S, Tan SF, Geffert LM, Fox TE, Sharma AK, Desai D, Amin S, Kester M, Loughran TP, Paulson RF, Claxton DF, Wang HG, Yun JK.

Cancer Transl Med. 2017 Jul-Aug;3(4):109-121. doi: 10.4103/ctm.ctm_7_17. Epub 2017 Aug 14.

9.

Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.

Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B.

J Immunol. 2017 Jul 15;199(2):677-687. doi: 10.4049/jimmunol.1601959. Epub 2017 Jun 9.

10.

A MicroRNA93-Interferon Regulatory Factor-9-Immunoresponsive Gene-1-Itaconic Acid Pathway Modulates M2-Like Macrophage Polarization to Revascularize Ischemic Muscle.

Ganta VC, Choi MH, Kutateladze A, Fox TE, Farber CR, Annex BH.

Circulation. 2017 Jun 13;135(24):2403-2425. doi: 10.1161/CIRCULATIONAHA.116.025490. Epub 2017 Mar 29.

11.

Acid ceramidase is upregulated in AML and represents a novel therapeutic target.

Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, Liao J, Yun J, Kester M, Claxton DF, Wang HG, Cabot MC, Schuchman EH, Levine RL, Feith DJ, Loughran TP Jr.

Oncotarget. 2016 Dec 13;7(50):83208-83222. doi: 10.18632/oncotarget.13079.

12.

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.

Young MM, Takahashi Y, Fox TE, Yun JK, Kester M, Wang HG.

Cell Rep. 2016 Nov 1;17(6):1532-1545. doi: 10.1016/j.celrep.2016.10.019.

13.

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia.

Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC.

J Lipid Res. 2016 Jul;57(7):1231-42. doi: 10.1194/jlr.M067389. Epub 2016 May 2.

14.

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic.

Kester M, Bassler J, Fox TE, Carter CJ, Davidson JA, Parette MR.

Biol Chem. 2015 Jun;396(6-7):737-47. doi: 10.1515/hsz-2015-0129. Review.

PMID:
25838296
15.

Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.

Morad SA, Tan SF, Feith DJ, Kester M, Claxton DF, Loughran TP Jr, Barth BM, Fox TE, Cabot MC.

Biochim Biophys Acta. 2015 Jul;1851(7):919-28. doi: 10.1016/j.bbalip.2015.03.001. Epub 2015 Mar 10.

16.

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells.

Haakenson JK, Khokhlatchev AV, Choi YJ, Linton SS, Zhang P, Zaki PM, Fu C, Cooper TK, Manni A, Zhu J, Fox TE, Dong C, Kester M.

J Biol Chem. 2015 Mar 27;290(13):8632-43. doi: 10.1074/jbc.M114.609677. Epub 2015 Feb 13.

17.

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.

Dick TE, Hengst JA, Fox TE, Colledge AL, Kale VP, Sung SS, Sharma A, Amin S, Loughran TP Jr, Kester M, Wang HG, Yun JK.

J Pharmacol Exp Ther. 2015 Mar;352(3):494-508. doi: 10.1124/jpet.114.219659. Epub 2015 Jan 6.

18.

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia.

Ryland LK, Doshi UA, Shanmugavelandy SS, Fox TE, Aliaga C, Broeg K, Baab KT, Young M, Khan O, Haakenson JK, Jarbadan NR, Liao J, Wang HG, Feith DJ, Loughran TP Jr, Liu X, Kester M.

PLoS One. 2013 Dec 19;8(12):e84648. doi: 10.1371/journal.pone.0084648. eCollection 2013.

19.

Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers.

Jones KA, Kim PD, Patel BB, Kelsen SG, Braverman A, Swinton DJ, Gafken PR, Jones LA, Lane WS, Neveu JM, Leung HE, Shaffer SA, Leszyk JD, Stanley BA, Fox TE, Stanley A, Hall MJ, Hampel H, South CD, de la Chapelle A, Burt RW, Jones DA, Kopelovich L, Yeung AT.

J Proteome Res. 2013 Oct 4;12(10):4351-65. doi: 10.1021/pr400307u. Epub 2013 Sep 19.

20.

Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.

Morad SA, Levin JC, Tan SF, Fox TE, Feith DJ, Cabot MC.

Biochim Biophys Acta. 2013 Dec;1831(12):1657-64. doi: 10.1016/j.bbalip.2013.07.016. Epub 2013 Aug 9.

PMID:
23939396
21.

Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex.

Hankins JL, Ward KE, Linton SS, Barth BM, Stahelin RV, Fox TE, Kester M.

J Biol Chem. 2013 Jul 5;288(27):19726-38. doi: 10.1074/jbc.M113.481622. Epub 2013 May 21.

22.

Zinc absorption in Brazilian subjects fed a healthy meal.

Ribeiro MA, Cominetti C, Kakazu MH, Sarkis JE, Dainty J, Fox TE, Cozzolino SM.

J Hum Nutr Diet. 2014 Apr;27 Suppl 2:313-20. doi: 10.1111/jhn.12119. Epub 2013 May 2.

PMID:
23634993
23.

PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate.

Barth BM, Shanmugavelandy SS, Kaiser JM, McGovern C, Altınoğlu Eİ, Haakenson JK, Hengst JA, Gilius EL, Knupp SA, Fox TE, Smith JP, Ritty TM, Adair JH, Kester M.

ACS Nano. 2013 Mar 26;7(3):2132-44. doi: 10.1021/nn304862b. Epub 2013 Feb 14.

24.

Altered sphingolipid metabolism in patients with metastatic pancreatic cancer.

Jiang Y, DiVittore NA, Young MM, Jia Z, Xie K, Ritty TM, Kester M, Fox TE.

Biomolecules. 2013 Jul 25;3(3):435-48. doi: 10.3390/biom3030435.

25.

Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia.

Watters RJ, Fox TE, Tan SF, Shanmugavelandy S, Choby JE, Broeg K, Liao J, Kester M, Cabot MC, Loughran TP, Liu X.

Leuk Lymphoma. 2013 Jun;54(6):1288-96. doi: 10.3109/10428194.2012.752485. Epub 2012 Dec 31.

26.

Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death.

Fox TE, Young MM, Pedersen MM, Han X, Gardner TW, Kester M.

Invest Ophthalmol Vis Sci. 2012 Oct 19;53(11):7257-67. doi: 10.1167/iovs.11-7626.

27.

Nanoliposomal minocycline for ocular drug delivery.

Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS, Unrath KA, Pedersen MM, Dai P, Freeman WM, Bronson SK, Gardner TW, Kester M.

Nanomedicine. 2013 Jan;9(1):130-40. doi: 10.1016/j.nano.2012.03.004. Epub 2012 Mar 28.

28.

Targeting sphingosine kinase-1 to inhibit melanoma.

Madhunapantula SV, Hengst J, Gowda R, Fox TE, Yun JK, Robertson GP.

Pigment Cell Melanoma Res. 2012 Mar;25(2):259-74. doi: 10.1111/j.1755-148X.2012.00970.x.

29.

Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression.

Hankins JL, Fox TE, Barth BM, Unrath KA, Kester M.

J Biol Chem. 2011 Dec 30;286(52):44357-66. doi: 10.1074/jbc.M111.264010. Epub 2011 Nov 7.

30.

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.

Jiang Y, DiVittore NA, Kaiser JM, Shanmugavelandy SS, Fritz JL, Heakal Y, Tagaram HR, Cheng H, Cabot MC, Staveley-O'Carroll KF, Tran MA, Fox TE, Barth BM, Kester M.

Cancer Biol Ther. 2011 Oct 1;12(7):574-85. Epub 2011 Oct 1.

31.

Transcriptional regulation of the human neutral ceramidase gene.

O'Neill SM, Yun JK, Fox TE, Kester M.

Arch Biochem Biophys. 2011 Jul;511(1-2):21-30. doi: 10.1016/j.abb.2011.04.012. Epub 2011 Apr 22.

32.

AP-1 binding transcriptionally regulates human neutral ceramidase.

O'Neill SM, Houck KL, Yun JK, Fox TE, Kester M.

Arch Biochem Biophys. 2011 Jul;511(1-2):31-9. doi: 10.1016/j.abb.2011.04.009. Epub 2011 Apr 21.

33.

Dysregulation of sphingolipid metabolism in cancer.

Ryland LK, Fox TE, Liu X, Loughran TP, Kester M.

Cancer Biol Ther. 2011 Jan 15;11(2):138-49. Epub 2011 Jan 15. Review.

PMID:
21209555
34.

Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.

Fox TE, Young MM, Pedersen MM, Giambuzzi-Tussey S, Kester M, Gardner TW.

Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E600-9. doi: 10.1152/ajpendo.00641.2010. Epub 2011 Jan 4.

35.

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy.

Takahashi Y, Meyerkord CL, Hori T, Runkle K, Fox TE, Kester M, Loughran TP, Wang HG.

Autophagy. 2011 Jan;7(1):61-73. Epub 2011 Jan 1.

36.

Circulating sphingolipid biomarkers in models of type 1 diabetes.

Fox TE, Bewley MC, Unrath KA, Pedersen MM, Anderson RE, Jung DY, Jefferson LS, Kim JK, Bronson SK, Flanagan JM, Kester M.

J Lipid Res. 2011 Mar;52(3):509-17. doi: 10.1194/jlr.M010595. Epub 2010 Nov 10.

37.

Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance.

Barth BM, Gustafson SJ, Young MM, Fox TE, Shanmugavelandy SS, Kaiser JM, Cabot MC, Kester M, Kuhn TB.

Cancer Biol Ther. 2010 Dec 1;10(11):1126-36. doi: 10.4161/cbt.10.11.13438. Epub 2010 Dec 1.

38.

Therapeutic strategies for diabetes and complications: a role for sphingolipids?

Fox TE, Kester M.

Adv Exp Med Biol. 2010;688:206-16. Review.

PMID:
20919656
39.

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway.

Winter JN, Fox TE, Kester M, Jefferson LS, Kimball SR.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C335-44. doi: 10.1152/ajpcell.00039.2010. Epub 2010 Apr 28.

40.

Ceramide modulates HERG potassium channel gating by translocation into lipid rafts.

Ganapathi SB, Fox TE, Kester M, Elmslie KS.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C74-86. doi: 10.1152/ajpcell.00462.2009. Epub 2010 Apr 7.

41.

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition.

Hengst JA, Guilford JM, Fox TE, Wang X, Conroy EJ, Yun JK.

Arch Biochem Biophys. 2009 Dec;492(1-2):62-73. doi: 10.1016/j.abb.2009.09.013. Epub 2009 Sep 24.

42.

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels.

Wijesinghe DS, Allegood JC, Gentile LB, Fox TE, Kester M, Chalfant CE.

J Lipid Res. 2010 Mar;51(3):641-51. doi: 10.1194/jlr.D000430. Epub 2009 Aug 4.

43.

Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling.

Houck KL, Fox TE, Sandirasegarane L, Kester M.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1657-68. doi: 10.1152/ajpheart.00141.2008. Epub 2008 Aug 22.

44.

C(6)-Ceramide-Coated Catheters Promote Re-Endothelialization of Stretch-Injured Arteries.

O'Neill SM, Olympia DK, Fox TE, Brown JT, Stover TC, Houck KL, Wilson R, Waybill P, Kozak M, Levison SW, Weber N, Karavodin LM, Kester M.

Vasc Dis Prev. 2008 Aug 1;5(3):200-210.

45.

Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli.

De Cotiis DA, Woll MP, Fox TE, Hill RB, Levenson R, Flanagan JM.

Protein Expr Purif. 2008 Oct;61(2):103-12. doi: 10.1016/j.pep.2008.06.006. Epub 2008 Jun 25.

46.

Propagation of undifferentiated human embryonic stem cells with nano-liposomal ceramide.

Salli U, Fox TE, Carkaci-Salli N, Sharma A, Robertson GP, Kester M, Vrana KE.

Stem Cells Dev. 2009 Jan-Feb;18(1):55-65. doi: 10.1089/scd.2007.0271.

PMID:
18393629
47.

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains.

Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, Unal O, Yun JK, Naides SJ, Kester M.

J Biol Chem. 2007 Apr 27;282(17):12450-7. Epub 2007 Feb 17.

48.

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy.

Fox TE, Han X, Kelly S, Merrill AH 2nd, Martin RE, Anderson RE, Gardner TW, Kester M.

Diabetes. 2006 Dec;55(12):3573-80.

49.

The clinical potential of sphingolipid-based therapeutics.

Fox TE, Finnegan CM, Blumenthal R, Kester M.

Cell Mol Life Sci. 2006 May;63(9):1017-23. Review.

PMID:
16568241
50.

Absorption of selenium from wheat, garlic, and cod intrinsically labeled with Se-77 and Se-82 stable isotopes.

Fox TE, Atherton C, Dainty JR, Lewis DJ, Langford NJ, Baxter MJ, Crews HM, Fairweather-Tait SJ.

Int J Vitam Nutr Res. 2005 May;75(3):179-86.

PMID:
16028633

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