Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 154

1.

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis.

Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, Jia S, Fox PL, Huang E, Pizarro TT, Kalady MF, Jackson MW, Bao S, Sen GC, Stark GR, Chang CJ, Li X.

Nat Commun. 2020 Feb 14;11(1):900. doi: 10.1038/s41467-020-14698-y.

PMID:
32060280
2.

Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.

Zhao S, Dejanovic D, Yao P, Bhilocha S, Sadler T, Schirbel A, West G, Doyon G, Lopez R, Mao R, Kurada S, El Ouali S, Grassl G, Fox PL, Cruise M, Worthley DL, de la Motte C, Fiocchi C, Rieder F.

Mucosal Immunol. 2020 Feb 4. doi: 10.1038/s41385-020-0259-9. [Epub ahead of print]

PMID:
32020030
3.

Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM.

Elife. 2019 Oct 17;8. pii: e49882. doi: 10.7554/eLife.49882.

4.

Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.

Singh A, Manjunath LE, Kundu P, Sahoo S, Das A, Suma HR, Fox PL, Eswarappa SM.

EMBO J. 2019 Aug 15;38(16):e100727. doi: 10.15252/embj.2018100727. Epub 2019 Jul 22.

5.

Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia.

Davuluri G, Giusto M, Chandel R, Welch N, Alsabbagh K, Kant S, Kumar A, Kim A, Gangadhariah M, Ghosh PK, Tran U, Krajcik DM, Vasu K, DiDonato AJ, DiDonato JA, Willard B, Monga SP, Wang Y, Fox PL, Stark GR, Wessely O, Esser KA, Dasarathy S.

Mol Cell Biol. 2019 Jul 29;39(16). pii: e00451-18. doi: 10.1128/MCB.00451-18. Print 2019 Aug 15.

6.

Aminoacyl-tRNA synthetases as therapeutic targets.

Kwon NH, Fox PL, Kim S.

Nat Rev Drug Discov. 2019 Aug;18(8):629-650. doi: 10.1038/s41573-019-0026-3. Review.

PMID:
31073243
7.

Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection.

Arif A, Jia J, Willard B, Li X, Fox PL.

Mol Cell. 2019 Feb 7;73(3):446-457.e6. doi: 10.1016/j.molcel.2018.11.017. Epub 2019 Jan 3.

8.

Metabolic origin of the fused aminoacyl-tRNA synthetase, glutamyl-prolyl-tRNA synthetase.

Eswarappa SM, Potdar AA, Sahoo S, Sankar S, Fox PL.

J Biol Chem. 2018 Dec 7;293(49):19148-19156. doi: 10.1074/jbc.RA118.004276. Epub 2018 Oct 11.

9.

The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4+ Th2 Differentiation.

Techasintana P, Ellis JS, Glascock J, Gubin MM, Ridenhour SE, Magee JD, Hart ML, Yao P, Zhou H, Whitney MS, Franklin CL, Martindale JL, Gorospe M, Davis WJ, Fox PL, Li X, Atasoy U.

Immunohorizons. 2017 Aug 1;1(6):109-123. doi: 10.4049/immunohorizons.1700017.

10.

Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains.

Halawani D, Gogonea V, DiDonato JA, Pipich V, Yao P, China A, Topbas C, Vasu K, Arif A, Hazen SL, Fox PL.

J Biol Chem. 2018 Jun 8;293(23):8843-8860. doi: 10.1074/jbc.M117.807503. Epub 2018 Apr 11.

11.

IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.

Herjan T, Hong L, Bubenik J, Bulek K, Qian W, Liu C, Li X, Chen X, Yang H, Ouyang S, Zhou H, Zhao J, Vasu K, Cockman E, Aronica M, Asosingh K, Licatalosi DD, Qin J, Fox PL, Hamilton TA, Driscoll D, Li X.

Nat Immunol. 2018 Apr;19(4):354-365. doi: 10.1038/s41590-018-0071-9. Epub 2018 Mar 21.

12.

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.

Thiagarajan PS, Sinyuk M, Turaga SM, Mulkearns-Hubert EE, Hale JS, Rao V, Demelash A, Saygin C, China A, Alban TJ, Hitomi M, Torre-Healy LA, Alvarado AG, Jarrar A, Wiechert A, Adorno-Cruz V, Fox PL, Calhoun BC, Guan JL, Liu H, Reizes O, Lathia JD.

Nat Commun. 2018 Feb 8;9(1):578. doi: 10.1038/s41467-018-02938-1.

13.

The GAIT translational control system.

Arif A, Yao P, Terenzi F, Jia J, Ray PS, Fox PL.

Wiley Interdiscip Rev RNA. 2018 Mar;9(2). doi: 10.1002/wrna.1441. Epub 2017 Nov 20. Review.

14.

Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.

Ward JR, Vasu K, Deutschman E, Halawani D, Larson PA, Zhang D, Willard B, Fox PL, Moran JV, Longworth MS.

PLoS Genet. 2017 Oct 13;13(10):e1007051. doi: 10.1371/journal.pgen.1007051. eCollection 2017 Oct.

15.

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.

Zhou H, Bulek K, Li X, Herjan T, Yu M, Qian W, Wang H, Zhou G, Chen X, Yang H, Hong L, Zhao J, Qin L, Fukuda K, Flotho A, Gao J, Dongre A, Carman JA, Kang Z, Su B, Kern TS, Smith JD, Hamilton TA, Melchior F, Fox PL, Li X.

Elife. 2017 Oct 9;6. pii: e29630. doi: 10.7554/eLife.29630.

16.

Unexpected metabolic function of a tRNA synthetase.

Arif A, Fox PL.

Cell Cycle. 2017;16(23):2239-2240. doi: 10.1080/15384101.2017.1324127. Epub 2017 Dec 7. No abstract available.

17.

Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis.

Yao P, Wu J, Lindner D, Fox PL.

Nucleic Acids Res. 2017 Jul 27;45(13):7950-7964. doi: 10.1093/nar/gkx440.

18.

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.

Arif A, Terenzi F, Potdar AA, Jia J, Sacks J, China A, Halawani D, Vasu K, Li X, Brown JM, Chen J, Kozma SC, Thomas G, Fox PL.

Nature. 2017 Feb 16;542(7641):357-361. doi: 10.1038/nature21380. Epub 2017 Feb 8.

19.

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease.

Zhou H, Yu M, Zhao J, Martin BN, Roychowdhury S, McMullen MR, Wang E, Fox PL, Yamasaki S, Nagy LE, Li X.

Hepatology. 2016 Dec;64(6):1978-1993. doi: 10.1002/hep.28811. Epub 2016 Oct 25.

20.

Experimental approaches for investigation of aminoacyl tRNA synthetase phosphorylation.

Arif A, Jia J, Halawani D, Fox PL.

Methods. 2017 Jan 15;113:72-82. doi: 10.1016/j.ymeth.2016.10.004. Epub 2016 Oct 8. Review.

21.

Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.

Lee EY, Lee HC, Kim HK, Jang SY, Park SJ, Kim YH, Kim JH, Hwang J, Kim JH, Kim TH, Arif A, Kim SY, Choi YK, Lee C, Lee CH, Jung JU, Fox PL, Kim S, Lee JS, Kim MH.

Nat Immunol. 2016 Nov;17(11):1252-1262. doi: 10.1038/ni.3542. Epub 2016 Sep 5.

22.

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.

Otvos B, Silver DJ, Mulkearns-Hubert EE, Alvarado AG, Turaga SM, Sorensen MD, Rayman P, Flavahan WA, Hale JS, Stoltz K, Sinyuk M, Wu Q, Jarrar A, Kim SH, Fox PL, Nakano I, Rich JN, Ransohoff RM, Finke J, Kristensen BW, Vogelbaum MA, Lathia JD.

Stem Cells. 2016 Aug;34(8):2026-39. doi: 10.1002/stem.2393. Epub 2016 May 27.

23.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.

24.

A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.

Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL.

J Biol Chem. 2016 Mar 18;291(12):6386-95. doi: 10.1074/jbc.M115.696088. Epub 2016 Jan 21.

25.

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.

Gao XH, Krokowski D, Guan BJ, Bederman I, Majumder M, Parisien M, Diatchenko L, Kabil O, Willard B, Banerjee R, Wang B, Bebek G, Evans CR, Fox PL, Gerson SL, Hoppel CL, Liu M, Arvan P, Hatzoglou M.

Elife. 2015 Nov 23;4:e10067. doi: 10.7554/eLife.10067.

26.

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

Schonberg DL, Miller TE, Wu Q, Flavahan WA, Das NK, Hale JS, Hubert CG, Mack SC, Jarrar AM, Karl RT, Rosager AM, Nixon AM, Tesar PJ, Hamerlik P, Kristensen BW, Horbinski C, Connor JR, Fox PL, Lathia JD, Rich JN.

Cancer Cell. 2015 Oct 12;28(4):441-455. doi: 10.1016/j.ccell.2015.09.002.

27.

Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.

Zhao J, Bulek K, Gulen MF, Zepp JA, Karagkounis G, Martin BN, Zhou H, Yu M, Liu X, Huang E, Fox PL, Kalady MF, Markowitz SD, Li X.

Gastroenterology. 2015 Dec;149(7):1860-1871.e8. doi: 10.1053/j.gastro.2015.08.051. Epub 2015 Sep 5.

28.

Antiangiogenic VEGF-Ax: A New Participant in Tumor Angiogenesis.

Eswarappa SM, Fox PL.

Cancer Res. 2015 Jul 15;75(14):2765-9. doi: 10.1158/0008-5472.CAN-14-3805. Epub 2015 Jun 29. Review.

29.

Translational control mechanisms in angiogenesis and vascular biology.

Yao P, Eswarappa SM, Fox PL.

Curr Atheroscler Rep. 2015 May;17(5):506. doi: 10.1007/s11883-015-0506-9. Review.

PMID:
25786748
30.

Discovery and investigation of the GAIT translational control system.

Fox PL.

RNA. 2015 Apr;21(4):615-8. doi: 10.1261/rna.050187.115. No abstract available.

31.

Target-selective protein S-nitrosylation by sequence motif recognition.

Jia J, Arif A, Terenzi F, Willard B, Plow EF, Hazen SL, Fox PL.

Cell. 2014 Oct 23;159(3):623-34. doi: 10.1016/j.cell.2014.09.032. Epub 2014 Oct 16.

32.

Ceruloplasmin has two nearly identical sites that bind myeloperoxidase.

Bakhautdin B, Goksoy Bakhautdin E, Fox PL.

Biochem Biophys Res Commun. 2014 Oct 31;453(4):722-7. doi: 10.1016/j.bbrc.2014.09.134. Epub 2014 Oct 6.

33.

Computational modeling and analysis of iron release from macrophages.

Potdar AA, Sarkar J, Das NK, Ghosh P, Gratzl M, Fox PL, Saidel GM.

PLoS Comput Biol. 2014 Jul 3;10(7):e1003701. doi: 10.1371/journal.pcbi.1003701. eCollection 2014 Jul.

34.

Origin and evolution of glutamyl-prolyl tRNA synthetase WHEP domains reveal evolutionary relationships within Holozoa.

Ray PS, Fox PL.

PLoS One. 2014 Jun 26;9(6):e98493. doi: 10.1371/journal.pone.0098493. eCollection 2014.

35.

Programmed translational readthrough generates antiangiogenic VEGF-Ax.

Eswarappa SM, Potdar AA, Koch WJ, Fan Y, Vasu K, Lindner D, Willard B, Graham LM, DiCorleto PE, Fox PL.

Cell. 2014 Jun 19;157(7):1605-18. doi: 10.1016/j.cell.2014.04.033.

36.

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.

Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X.

J Exp Med. 2014 May 5;211(5):887-907. doi: 10.1084/jem.20131314. Epub 2014 Apr 21. Erratum in: J Exp Med. 2014 May 5;211(5):1003. Ransohoff, Richard M [added].

37.

Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.

Fan Y, Potdar AA, Gong Y, Eswarappa SM, Donnola S, Lathia JD, Hambardzumyan D, Rich JN, Fox PL.

Nat Cell Biol. 2014 May;16(5):445-56. doi: 10.1038/ncb2954. Epub 2014 Apr 20.

38.

Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional.

DiDonato JA, Aulak K, Huang Y, Wagner M, Gerstenecker G, Topbas C, Gogonea V, DiDonato AJ, Tang WH, Mehl RA, Fox PL, Plow EF, Smith JD, Fisher EA, Hazen SL.

J Biol Chem. 2014 Apr 11;289(15):10276-92. doi: 10.1074/jbc.M114.556506. Epub 2014 Feb 20.

39.

An abundant dysfunctional apolipoprotein A1 in human atheroma.

Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL.

Nat Med. 2014 Feb;20(2):193-203. doi: 10.1038/nm.3459. Epub 2014 Jan 26.

40.

The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA.

Yao P, Potdar AA, Ray PS, Eswarappa SM, Flagg AC, Willard B, Fox PL.

PLoS Biol. 2013;11(8):e1001635. doi: 10.1371/journal.pbio.1001635. Epub 2013 Aug 20.

41.

Function and distribution of apolipoprotein A1 in the artery wall are markedly distinct from those in plasma.

DiDonato JA, Huang Y, Aulak KS, Even-Or O, Gerstenecker G, Gogonea V, Wu Y, Fox PL, Tang WH, Plow EF, Smith JD, Fisher EA, Hazen SL.

Circulation. 2013 Oct 8;128(15):1644-55. doi: 10.1161/CIRCULATIONAHA.113.002624. Epub 2013 Aug 22.

42.

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.

Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, Smith JD, Plow EF, Fox PL, Shih DM, Lusis AJ, Fisher EA, DiDonato JA, Landmesser U, Hazen SL.

J Clin Invest. 2013 Sep;123(9):3815-28. doi: 10.1172/JCI67478. Epub 2013 Aug 1.

43.

Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism.

Pluskota E, Ma Y, Bledzka KM, Bialkowska K, Soloviev DA, Szpak D, Podrez EA, Fox PL, Hazen SL, Dowling JJ, Ma YQ, Plow EF.

Blood. 2013 Oct 3;122(14):2491-9. doi: 10.1182/blood-2013-04-497669. Epub 2013 Jul 29.

44.

Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.

Chandrasekharan UM, Dechert L, Davidson UI, Waitkus M, Mavrakis L, Lyons K, Beach JR, Li X, Egelhoff TT, Fox PL, DiCorleto PE.

Sci Signal. 2013 Jul 16;6(284):ra60. doi: 10.1126/scisignal.2003743.

45.

HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization.

Herjan T, Yao P, Qian W, Li X, Liu C, Bulek K, Sun D, Yang WP, Zhu J, He A, Carman JA, Erzurum SC, Lipshitz HD, Fox PL, Hamilton TA, Li X.

J Immunol. 2013 Jul 15;191(2):640-9. doi: 10.4049/jimmunol.1203315. Epub 2013 Jun 14.

46.

Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases.

Yao P, Poruri K, Martinis SA, Fox PL.

Top Curr Chem. 2014;344:167-87. doi: 10.1007/128_2013_422. Review.

PMID:
23536244
47.

Aminoacyl-tRNA synthetases in medicine and disease.

Yao P, Fox PL.

EMBO Mol Med. 2013 Mar;5(3):332-43. doi: 10.1002/emmm.201100626. Epub 2013 Feb 21. Review.

48.

Citric acid cycle and the origin of MARS.

Eswarappa SM, Fox PL.

Trends Biochem Sci. 2013 May;38(5):222-8. doi: 10.1016/j.tibs.2013.01.005. Epub 2013 Feb 14.

49.

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production.

Zhou H, Yu M, Fukuda K, Im J, Yao P, Cui W, Bulek K, Zepp J, Wan Y, Kim TW, Yin W, Ma V, Thomas J, Gu J, Wang JA, DiCorleto PE, Fox PL, Qin J, Li X.

EMBO J. 2013 Feb 20;32(4):583-96. doi: 10.1038/emboj.2013.2. Epub 2013 Feb 1.

50.

Regulation and dysregulation of 3'UTR-mediated translational control.

Jia J, Yao P, Arif A, Fox PL.

Curr Opin Genet Dev. 2013 Feb;23(1):29-34. doi: 10.1016/j.gde.2012.12.004. Epub 2013 Jan 9. Review.

Supplemental Content

Support Center