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Items: 1 to 50 of 172

1.

Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.

Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Morita K, Achreja A, Popovic B, Wang Y, Handa K, Mittal A, Meurs N, Zhu Z, Weinberg F, Salomon M, Fox IJ, Deng CX, Nagrath D, Soto-Gutierrez A.

Cell Metab. 2019 Aug 6;30(2):385-401.e9. doi: 10.1016/j.cmet.2019.06.017.

PMID:
31390551
2.

Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.

Guzman-Lepe J, Cervantes-Alvarez E, Collin de l'Hortet A, Wang Y, Mars WM, Oda Y, Bekki Y, Shimokawa M, Wang H, Yoshizumi T, Maehara Y, Bell A, Fox IJ, Takeishi K, Soto-Gutierrez A.

Hepatol Commun. 2018 Mar 23;2(5):582-594. doi: 10.1002/hep4.1172. eCollection 2018 May.

3.

Clinical Hepatocyte Transplantation: What Is Next?

Squires JE, Soltys KA, McKiernan P, Squires RH, Strom SC, Fox IJ, Soto-Gutierrez A.

Curr Transplant Rep. 2017 Dec;4(4):280-289. doi: 10.1007/s40472-017-0165-6. Epub 2017 Oct 14.

4.

Host conditioning and rejection monitoring in hepatocyte transplantation in humans.

Soltys KA, Setoyama K, Tafaleng EN, Soto Gutiérrez A, Fong J, Fukumitsu K, Nishikawa T, Nagaya M, Sada R, Haberman K, Gramignoli R, Dorko K, Tahan V, Dreyzin A, Baskin K, Crowley JJ, Quader MA, Deutsch M, Ashokkumar C, Shneider BL, Squires RH, Ranganathan S, Reyes-Mugica M, Dobrowolski SF, Mazariegos G, Elango R, Stolz DB, Strom SC, Vockley G, Roy-Chowdhury J, Cascalho M, Guha C, Sindhi R, Platt JL, Fox IJ.

J Hepatol. 2017 May;66(5):987-1000. doi: 10.1016/j.jhep.2016.12.017. Epub 2016 Dec 24.

5.

Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology.

Sauer V, Tchaikovskaya T, Wang X, Li Y, Zhang W, Tar K, Polgar Z, Ding J, Guha C, Fox IJ, Roy-Chowdhury N, Roy-Chowdhury J.

Cell Transplant. 2016 Dec 13;25(12):2221-2243. doi: 10.3727/096368916X692014. Epub 2016 Jun 9.

PMID:
27512979
6.

Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes.

Chen Y, Li Y, Wang X, Zhang W, Sauer V, Chang CJ, Han B, Tchaikovskaya T, Avsar Y, Tafaleng E, Madhusudana Girija S, Tar K, Polgar Z, Strom S, Bouhassira EE, Guha C, Fox IJ, Roy-Chowdhury J, Roy-Chowdhury N.

Stem Cell Reports. 2015 Jul 14;5(1):22-30. doi: 10.1016/j.stemcr.2015.04.017. Epub 2015 Jun 11.

7.

Resetting the transcription factor network reverses terminal chronic hepatic failure.

Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ.

J Clin Invest. 2015 Apr;125(4):1533-44. doi: 10.1172/JCI73137. Epub 2015 Mar 16.

8.

Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency.

Tafaleng EN, Chakraborty S, Han B, Hale P, Wu W, Soto-Gutierrez A, Feghali-Bostwick CA, Wilson AA, Kotton DN, Nagaya M, Strom SC, Roy-Chowdhury J, Stolz DB, Perlmutter DH, Fox IJ.

Hepatology. 2015 Jul;62(1):147-57. doi: 10.1002/hep.27753. Epub 2015 Apr 13.

9.

Effects of edaravone, a radical scavenger, on hepatocyte transplantation.

Hayashi C, Ito M, Ito R, Murakumo A, Yamamoto N, Hiramatsu N, Fox IJ, Horiguchi A.

J Hepatobiliary Pancreat Sci. 2014 Dec;21(12):919-24. doi: 10.1002/jhbp.164. Epub 2014 Sep 10.

PMID:
25205207
10.

Hepatocyte Transplantation.

Fox IJ.

Gastroenterol Hepatol (N Y). 2014 Sep;10(9):594-6. No abstract available.

11.

A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression.

Dutta-Moscato J, Solovyev A, Mi Q, Nishikawa T, Soto-Gutierrez A, Fox IJ, Vodovotz Y.

Front Bioeng Biotechnol. 2014 May 30;2:18. doi: 10.3389/fbioe.2014.00018. eCollection 2014.

12.

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Fox IJ, Daley GQ, Goldman SA, Huard J, Kamp TJ, Trucco M.

Science. 2014 Aug 22;345(6199):1247391. doi: 10.1126/science.1247391. Review.

13.

Cell and tissue engineering for liver disease.

Bhatia SN, Underhill GH, Zaret KS, Fox IJ.

Sci Transl Med. 2014 Jul 16;6(245):245sr2. doi: 10.1126/scitranslmed.3005975. Review.

14.

Rapid and sensitive assessment of human hepatocyte functions.

Gramignoli R, Tahan V, Dorko K, Venkataramanan R, Fox IJ, Ellis EC, Vosough M, Strom SC.

Cell Transplant. 2014;23(12):1545-56. doi: 10.3727/096368914X680064. Epub 2014 Apr 4.

PMID:
24702711
15.

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.

Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev MI, Sehgal V, Moss TJ, Oertel M, Ram PT, Pipinos II, Soto-Gutierrez A, Fox IJ, Nagrath D.

J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26.

16.

All-human microphysical model of metastasis therapy.

Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, Wells A, Young C.

Stem Cell Res Ther. 2013;4 Suppl 1:S11. doi: 10.1186/scrt372. Epub 2013 Dec 20. Review.

17.

Liver transplantation for pediatric metabolic disease.

Mazariegos G, Shneider B, Burton B, Fox IJ, Hadzic N, Kishnani P, Morton DH, McIntire S, Sokol RJ, Summar M, White D, Chavanon V, Vockley J.

Mol Genet Metab. 2014 Apr;111(4):418-27. doi: 10.1016/j.ymgme.2014.01.006. Epub 2014 Jan 17. Review.

PMID:
24495602
18.

A nonhuman primate model of human radiation-induced venocclusive liver disease and hepatocyte injury.

Yannam GR, Han B, Setoyama K, Yamamoto T, Ito R, Brooks JM, Guzman-Lepe J, Galambos C, Fong JV, Deutsch M, Quader MA, Yamanouchi K, Kabarriti R, Mehta K, Soto-Gutierrez A, Roy-Chowdhury J, Locker J, Abe M, Enke CA, Baranowska-Kortylewicz J, Solberg TD, Guha C, Fox IJ.

Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):404-411. doi: 10.1016/j.ijrobp.2013.10.037. Epub 2013 Dec 5.

19.

Parent perspectives on decisions to participate in a phase I hepatocyte transplant trial.

Dreyzin A, Barnato AE, Soltys KA, Farris C, Sada R, Haberman K, Fox IJ.

Pediatr Transplant. 2014 Feb;18(1):112-9. doi: 10.1111/petr.12190. Epub 2013 Nov 20.

20.

Engineering liver tissue from induced pluripotent stem cells: a first step in generating new organs for transplantation?

Fox IJ, Duncan SA.

Hepatology. 2013 Dec;58(6):2198-201. doi: 10.1002/hep.26737. Epub 2013 Oct 31. No abstract available.

21.

Hypothermic storage of human hepatocytes for transplantation.

Gramignoli R, Dorko K, Tahan V, Skvorak KJ, Ellis E, Jorns C, Ericzon BG, Fox IJ, Strom SC.

Cell Transplant. 2014;23(9):1143-51. doi: 10.3727/096368913X668627.

PMID:
23768881
22.

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.

Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, Venkataramanan R, Ellis EC, Jorns C, Ericzon BG, Rosenborg S, Kuiper R, Soltys KA, Mazariegos GV, Fox IJ, Wilson EM, Grompe M, Strom SC.

Stem Cell Res. 2013 Jul;11(1):563-73. doi: 10.1016/j.scr.2013.03.002. Epub 2013 Mar 27.

23.

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions.

Hansel MC, Gramignoli R, Blake W, Davila J, Skvorak K, Dorko K, Tahan V, Lee BR, Tafaleng E, Guzman-Lepe J, Soto-Gutierrez A, Fox IJ, Strom SC.

Cell Transplant. 2014 Jan;23(1):27-38. doi: 10.3727/096368912X662453. Epub 2013 Feb 4.

24.

Single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in Gunn rats.

Zhou H, Dong X, Kabarriti R, Chen Y, Avsar Y, Wang X, Ding J, Liu L, Fox IJ, Roy-Chowdhury J, Roy-Chowdhury N, Guha C.

PLoS One. 2012;7(10):e46775. doi: 10.1371/journal.pone.0046775. Epub 2012 Oct 16.

25.

The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis.

Liu L, Yannam GR, Nishikawa T, Yamamoto T, Basma H, Ito R, Nagaya M, Dutta-Moscato J, Stolz DB, Duan F, Kaestner KH, Vodovotz Y, Soto-Gutierrez A, Fox IJ.

Hepatology. 2012 May;55(5):1529-39. doi: 10.1002/hep.24815. Epub 2012 Apr 4.

26.

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.

Ding J, Yannam GR, Roy-Chowdhury N, Hidvegi T, Basma H, Rennard SI, Wong RJ, Avsar Y, Guha C, Perlmutter DH, Fox IJ, Roy-Chowdhury J.

J Clin Invest. 2011 May;121(5):1930-4. doi: 10.1172/JCI45260. Epub 2011 Apr 18.

27.

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.

Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, Ellis EC, Nowak G, Ericzon BG, Fox IJ, Gómez-Lechón MJ, Guha C, Gupta S, Mitry RR, Ohashi K, Ott M, Reid LM, Roy-Chowdhury J, Sokal E, Weber A, Dhawan A.

Cell Transplant. 2012;21(1):1-10. doi: 10.3727/096368911X566208.

PMID:
21457616
28.

A whole-organ regenerative medicine approach for liver replacement.

Soto-Gutierrez A, Zhang L, Medberry C, Fukumitsu K, Faulk D, Jiang H, Reing J, Gramignoli R, Komori J, Ross M, Nagaya M, Lagasse E, Stolz D, Strom SC, Fox IJ, Badylak SF.

Tissue Eng Part C Methods. 2011 Jun;17(6):677-86. doi: 10.1089/ten.tec.2010.0698. Epub 2011 Apr 20.

29.

Modeling and therapy of human liver diseases using induced pluripotent stem cells: how far have we come?

Soto-Gutierrez A, Tafaleng E, Kelly V, Roy-Chowdhury J, Fox IJ.

Hepatology. 2011 Feb;53(2):708-11. doi: 10.1002/hep.24143. No abstract available.

30.

Hepatic differentiation of mouse iPS cells in vitro.

Iwamuro M, Komaki T, Kubota Y, Seita M, Kawamoto H, Yuasa T, Shahid JM, Hassan RA, Hassan WA, Nakaji S, Nishikawa Y, Kondo E, Yamamoto K, Fox IJ, Kobayashi N.

Cell Transplant. 2010;19(6):841-7. doi: 10.3727/096368910X508960.

PMID:
20955659
31.

Barriers to the successful treatment of liver disease by hepatocyte transplantation.

Soltys KA, Soto-Gutiérrez A, Nagaya M, Baskin KM, Deutsch M, Ito R, Shneider BL, Squires R, Vockley J, Guha C, Roy-Chowdhury J, Strom SC, Platt JL, Fox IJ.

J Hepatol. 2010 Oct;53(4):769-74. doi: 10.1016/j.jhep.2010.05.010. Epub 2010 Jun 30. No abstract available.

32.

Human hepatocyte transplantation.

Dhawan A, Strom SC, Sokal E, Fox IJ.

Methods Mol Biol. 2010;640:525-34. doi: 10.1007/978-1-60761-688-7_29. Review.

PMID:
20645072
33.

Patients beware: commercialized stem cell treatments on the web.

Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL.

Cell Stem Cell. 2010 Jul 2;7(1):43-9. doi: 10.1016/j.stem.2010.06.001. Epub 2010 Jun 17.

34.

Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice.

Navarro-Alvarez N, Soto-Gutierrez A, Chen Y, Caballero-Corbalan J, Hassan W, Kobayashi S, Kondo Y, Iwamuro M, Yamamoto K, Kondo E, Tanaka N, Fox IJ, Kobayashi N.

J Hepatol. 2010 Feb;52(2):211-9. doi: 10.1016/j.jhep.2009.11.019. Epub 2009 Dec 8.

PMID:
20022655
35.

Treatment of nonalbumin rats by transplantation of immortalized hepatocytes using artificial human chromosome.

Ito M, Ikeno M, Nagata H, Yamamoto T, Hiroguchi A, Fox IJ, Miyakawa S.

Transplant Proc. 2009 Jan-Feb;41(1):422-4. doi: 10.1016/j.transproceed.2008.10.023.

PMID:
19249570
36.

Embryonic and induced pluripotent stem cells as a model for liver disease.

Yagi H, Tafaleng E, Nagaya M, Hansel MC, Strom SC, Fox IJ, Soto-Gutierrez A.

Crit Rev Biomed Eng. 2009;37(4-5):377-98. Review.

37.

Review of hepatocyte transplantation.

Ito M, Nagata H, Miyakawa S, Fox IJ.

J Hepatobiliary Pancreat Surg. 2009;16(2):97-100. doi: 10.1007/s00534-008-0023-0. Epub 2008 Dec 27. Review.

PMID:
19110647
38.

New ISSCR guidelines underscore major principles for responsible translational stem cell research.

Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy-Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ.

Cell Stem Cell. 2008 Dec 4;3(6):607-9. doi: 10.1016/j.stem.2008.11.009. Review.

39.

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes.

Basma H, Soto-Gutiérrez A, Yannam GR, Liu L, Ito R, Yamamoto T, Ellis E, Carson SD, Sato S, Chen Y, Muirhead D, Navarro-Alvarez N, Wong RJ, Roy-Chowdhury J, Platt JL, Mercer DF, Miller JD, Strom SC, Kobayashi N, Fox IJ.

Gastroenterology. 2009 Mar;136(3):990-9. doi: 10.1053/j.gastro.2008.10.047. Epub 2008 Oct 29.

40.

Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation.

Yamanouchi K, Zhou H, Roy-Chowdhury N, Macaluso F, Liu L, Yamamoto T, Yannam GR, Enke C, Solberg TD, Adelson AB, Platt JL, Fox IJ, Roy-Chowdhury J, Guha C.

Hepatology. 2009 Jan;49(1):258-67. doi: 10.1002/hep.22573.

41.

Immortalized hepatocytes using human artificial chromosome.

Ito M, Ito R, Yoshihara D, Ikeno M, Kamiya M, Suzuki N, Horiguchi A, Nagata H, Yamamoto T, Kobayashi N, Fox IJ, Okazaki T, Miyakama S.

Cell Transplant. 2008;17(1-2):165-71.

PMID:
18468246
42.

Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat.

Kawashita Y, Guha C, Moitra R, Wang X, Fox IJ, Roy-Chowdhury J, Roy-Chowdhury N.

J Hepatol. 2008 Jul;49(1):99-106. doi: 10.1016/j.jhep.2008.02.020. Epub 2008 Apr 9.

PMID:
18466997
43.

To be or not to be: generation of hepatocytes from cells outside the liver.

Fox IJ, Strom SC.

Gastroenterology. 2008 Mar;134(3):878-81. doi: 10.1053/j.gastro.2008.01.065. No abstract available.

PMID:
18325397
44.

Differentiating stem cells into liver.

Soto-Gutierrez A, Basma H, Navarro-Alvarez N, Uygun BE, Yarmush ML, Kobayashi N, Fox IJ.

Biotechnol Genet Eng Rev. 2008;25:149-63. Review.

PMID:
21412354
45.

Intrasplenic hepatocyte transplantation prolonged the survival in Nagase analbuminemic rats with liver failure induced by common bile duct ligation.

Ito M, Nagata H, Yamamoto T, Yoshihara D, Fox IJ, Miyakawa S.

Cell Transplant. 2007;16(5):547-53.

PMID:
17708344
46.

Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation.

Botha JF, Thompson E, Gilroy R, Grant WJ, Mukherjee S, Lyden ER, Fox IJ, Sudan DL, Shaw BW Jr, Langnas AN.

Liver Int. 2007 Aug;27(6):758-63.

PMID:
17617118
47.

Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines.

Soto-Gutiérrez A, Navarro-Alvarez N, Zhao D, Rivas-Carrillo JD, Lebkowski J, Tanaka N, Fox IJ, Kobayashi N.

Nat Protoc. 2007;2(2):347-56.

PMID:
17406596
48.

Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells.

Mashalova EV, Guha C, Roy-Chowdhury N, Liu L, Fox IJ, Roy-Chowdhury J, Horwitz MS.

Hepatology. 2007 Mar;45(3):755-66.

PMID:
17326202
49.

Instant hepatic differentiation of human embryonic stem cells using activin A and a deleted variant of HGF.

Chen Y, Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Yamatsuji T, Shirakawa Y, Tanaka N, Basma H, Fox IJ, Kobayashi N.

Cell Transplant. 2006;15(10):865-71. Erratum in: Cell Transplant. 2007;16(1):97. Basma, Hesham [added]; Fox, Ira J [added].

PMID:
17299990
50.

Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.

Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Chen Y, Yuasa T, Tanaka K, Narushima M, Miki A, Misawa H, Tabata Y, Jun HS, Matsumoto S, Fox IJ, Tanaka N, Kobayashi N.

Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

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