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Items: 1 to 50 of 114

1.

The effects of mechanical strain on mouse eye lens capsule and cellular microstructure.

Parreno J, Cheng C, Nowak RB, Fowler VM.

Mol Biol Cell. 2018 Aug 8;29(16):1963-1974. doi: 10.1091/mbc.E18-01-0035. Epub 2018 Apr 10.

PMID:
30088796
2.

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability.

Smith AS, Nowak RB, Zhou S, Giannetto M, Gokhin DS, Papoin J, Ghiran IC, Blanc L, Wan J, Fowler VM.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4377-E4385. doi: 10.1073/pnas.1718285115. Epub 2018 Apr 2. Erratum in: Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6385.

PMID:
29610350
3.

HSPB7 is indispensable for heart development by modulating actin filament assembly.

Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961. doi: 10.1073/pnas.1713763114. Epub 2017 Oct 23.

4.

High-Resolution Fluorescence Microscope Imaging of Erythroblast Structure.

Smith AS, Nowak RB, Fowler VM.

Methods Mol Biol. 2018;1698:205-228. doi: 10.1007/978-1-4939-7428-3_12.

PMID:
29076092
5.

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome.

Nowak RB, Papoin J, Gokhin DS, Casu C, Rivella S, Lipton JM, Blanc L, Fowler VM.

Blood. 2017 Aug 31;130(9):1144-1155. doi: 10.1182/blood-2017-05-787051. Epub 2017 Jul 20.

6.

Stabilization of F-actin by tropomyosin isoforms regulates the morphology and mechanical behavior of red blood cells.

Sui Z, Gokhin DS, Nowak RB, Guo X, An X, Fowler VM.

Mol Biol Cell. 2017 Sep 15;28(19):2531-2542. doi: 10.1091/mbc.E16-10-0699. Epub 2017 Jul 18.

7.

EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens.

Cheng C, Fowler VM, Gong X.

Exp Eye Res. 2017 Sep;162:9-17. doi: 10.1016/j.exer.2017.06.016. Epub 2017 Jun 23.

8.

Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles.

Fowler VM, Dominguez R.

Biophys J. 2017 May 9;112(9):1742-1760. doi: 10.1016/j.bpj.2017.03.034. Review.

9.

Software-based measurement of thin filament lengths: an open-source GUI for Distributed Deconvolution analysis of fluorescence images.

Gokhin DS, Fowler VM.

J Microsc. 2017 Jan;265(1):11-20. doi: 10.1111/jmi.12456. Epub 2016 Sep 19.

10.

Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.

Cheng C, Nowak RB, Biswas SK, Lo WK, FitzGerald PG, Fowler VM.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4084-99. doi: 10.1167/iovs.16-19949.

11.
12.

Feisty filaments: actin dynamics in the red blood cell membrane skeleton.

Gokhin DS, Fowler VM.

Curr Opin Hematol. 2016 May;23(3):206-14. doi: 10.1097/MOH.0000000000000227. Review.

13.

The lens actin filament cytoskeleton: Diverse structures for complex functions.

Cheng C, Nowak RB, Fowler VM.

Exp Eye Res. 2017 Mar;156:58-71. doi: 10.1016/j.exer.2016.03.005. Epub 2016 Mar 10. Review.

14.

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.

Gokhin DS, Ochala J, Domenighetti AA, Fowler VM.

Development. 2015 Dec 15;142(24):4351-62. doi: 10.1242/dev.129171. Epub 2015 Nov 19.

15.

Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.

Sui Z, Nowak RB, Sanada C, Halene S, Krause DS, Fowler VM.

Blood. 2015 Jul 23;126(4):520-30. doi: 10.1182/blood-2014-09-601484. Epub 2015 May 11.

16.

Thematic Minireview Series: The State of the Cytoskeleton in 2015.

Fischer RS, Fowler VM.

J Biol Chem. 2015 Jul 10;290(28):17133-6. doi: 10.1074/jbc.R115.663716. Epub 2015 May 8. Review.

17.

Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells.

Cheng C, Nowak RB, Gao J, Sun X, Biswas SK, Lo WK, Mathias RT, Fowler VM.

Am J Physiol Cell Physiol. 2015 May 15;308(10):C835-47. doi: 10.1152/ajpcell.00372.2014. Epub 2015 Mar 4.

18.

Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane.

Gokhin DS, Nowak RB, Khoory JA, Piedra Ade L, Ghiran IC, Fowler VM.

Mol Biol Cell. 2015 May 1;26(9):1699-710. doi: 10.1091/mbc.E14-12-1583. Epub 2015 Feb 25.

19.

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF.

J Clin Invest. 2015 Jan;125(1):456-7. doi: 10.1172/JCI80057. Epub 2015 Jan 2. No abstract available.

20.

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice.

Gokhin DS, Dubuc EA, Lian KQ, Peters LL, Fowler VM.

Front Physiol. 2014 Sep 29;5:375. doi: 10.3389/fphys.2014.00375. eCollection 2014.

21.

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF.

J Clin Invest. 2014 Nov;124(11):4693-708. doi: 10.1172/JCI75199. Epub 2014 Sep 24. Erratum in: J Clin Invest. 2015 Jan;125(1):456-7.

22.

Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.

Lewis RA, Yamashiro S, Gokhin DS, Fowler VM.

Cytoskeleton (Hoboken). 2014 Jul;71(7):395-411. doi: 10.1002/cm.21179. Epub 2014 Jul 2.

23.

Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms.

Yamashiro S, Gokhin DS, Sui Z, Bergeron SE, Rubenstein PA, Fowler VM.

J Biol Chem. 2014 Apr 25;289(17):11616-29. doi: 10.1074/jbc.M114.555128. Epub 2014 Mar 18.

24.

Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo.

McKeown CR, Nowak RB, Gokhin DS, Fowler VM.

Dev Dyn. 2014 Jun;243(6):800-17. doi: 10.1002/dvdy.24115. Epub 2014 Feb 24.

25.

Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle.

Gokhin DS, Tierney MT, Sui Z, Sacco A, Fowler VM.

Mol Biol Cell. 2014 Mar;25(6):852-65. doi: 10.1091/mbc.E13-10-0608. Epub 2014 Jan 15.

26.

The human erythrocyte plasma membrane: a Rosetta Stone for decoding membrane-cytoskeleton structure.

Fowler VM.

Curr Top Membr. 2013;72:39-88. doi: 10.1016/B978-0-12-417027-8.00002-7.

PMID:
24210427
27.

Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.

Sui Z, Nowak RB, Bacconi A, Kim NE, Liu H, Li J, Wickrema A, An XL, Fowler VM.

Blood. 2014 Jan 30;123(5):758-67. doi: 10.1182/blood-2013-03-492710. Epub 2013 Oct 24.

28.

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers.

Ochala J, Gokhin DS, Iwamoto H, Fowler VM.

FASEB J. 2014 Jan;28(1):408-15. doi: 10.1096/fj.13-239640. Epub 2013 Sep 26.

29.

A two-segment model for thin filament architecture in skeletal muscle.

Gokhin DS, Fowler VM.

Nat Rev Mol Cell Biol. 2013 Feb;14(2):113-9. doi: 10.1038/nrm3510. Epub 2013 Jan 9. Review.

30.

Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens.

Gokhin DS, Nowak RB, Kim NE, Arnett EE, Chen AC, Sah RL, Clark JI, Fowler VM.

PLoS One. 2012;7(11):e48734. doi: 10.1371/journal.pone.0048734. Epub 2012 Nov 7.

31.

Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms.

Ochala J, Gokhin DS, Pénisson-Besnier I, Quijano-Roy S, Monnier N, Lunardi J, Romero NB, Fowler VM.

Hum Mol Genet. 2012 Oct 15;21(20):4473-85. Epub 2012 Jul 13.

32.

Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.

Yamashiro S, Gokhin DS, Kimura S, Nowak RB, Fowler VM.

Cytoskeleton (Hoboken). 2012 Jun;69(6):337-70. doi: 10.1002/cm.21031. Epub 2012 May 4. Review.

33.

Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex.

Nowak RB, Fowler VM.

J Histochem Cytochem. 2012 Jun;60(6):414-27. doi: 10.1369/0022155412440881. Epub 2012 Apr 3.

34.

Characterization of circulating endothelial cells in acute myocardial infarction.

Damani S, Bacconi A, Libiger O, Chourasia AH, Serry R, Gollapudi R, Goldberg R, Rapeport K, Haaser S, Topol S, Knowlton S, Bethel K, Kuhn P, Wood M, Carragher B, Schork NJ, Jiang J, Rao C, Connelly M, Fowler VM, Topol EJ.

Sci Transl Med. 2012 Mar 21;4(126):126ra33. doi: 10.1126/scitranslmed.3003451.

35.

Thin-filament length correlates with fiber type in human skeletal muscle.

Gokhin DS, Kim NE, Lewis SA, Hoenecke HR, D'Lima DD, Fowler VM.

Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C555-65. doi: 10.1152/ajpcell.00299.2011. Epub 2011 Nov 9.

36.

The sarcoplasmic reticulum: Actin and tropomodulin hit the links.

Gokhin DS, Fowler VM.

Bioarchitecture. 2011 Jul;1(4):175-179. Epub 2011 Jul 1.

37.

Tropomodulin capping of actin filaments in striated muscle development and physiology.

Gokhin DS, Fowler VM.

J Biomed Biotechnol. 2011;2011:103069. doi: 10.1155/2011/103069. Epub 2011 Oct 17. Review.

38.

Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network.

Bao N, Kodippili GC, Giger KM, Fowler VM, Low PS, Lu C.

Lab Chip. 2011 Sep 21;11(18):3053-6. doi: 10.1039/c1lc20365g. Epub 2011 Jul 25.

39.

Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers.

Gokhin DS, Fowler VM.

J Cell Biol. 2011 Jul 11;194(1):105-20. doi: 10.1083/jcb.201011128. Epub 2011 Jul 4.

40.

Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin.

Nicolaou KC, Jiang X, Lindsay-Scott PJ, Corbu A, Yamashiro S, Bacconi A, Fowler VM.

Angew Chem Int Ed Engl. 2011 Feb 1;50(5):1139-44. doi: 10.1002/anie.201006780. Epub 2011 Jan 7. No abstract available.

41.

Tropomodulins are negative regulators of neurite outgrowth.

Fath T, Fischer RS, Dehmelt L, Halpain S, Fowler VM.

Eur J Cell Biol. 2011 Apr;90(4):291-300. doi: 10.1016/j.ejcb.2010.10.014. Epub 2010 Dec 10.

42.

Modulation of N-cadherin junctions and their role as epicenters of differentiation-specific actin regulation in the developing lens.

Leonard M, Zhang L, Zhai N, Cader A, Chan Y, Nowak RB, Fowler VM, Menko AS.

Dev Biol. 2011 Jan 15;349(2):363-77. doi: 10.1016/j.ydbio.2010.10.009. Epub 2010 Oct 20.

43.

Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities.

Yamashiro S, Speicher KD, Speicher DW, Fowler VM.

J Biol Chem. 2010 Oct 22;285(43):33265-80. doi: 10.1074/jbc.M110.144873. Epub 2010 Jul 21.

44.

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.

Moyer JD, Nowak RB, Kim NE, Larkin SK, Peters LL, Hartwig J, Kuypers FA, Fowler VM.

Blood. 2010 Oct 7;116(14):2590-9. doi: 10.1182/blood-2010-02-268458. Epub 2010 Jun 28.

45.

Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

Gokhin DS, Lewis RA, McKeown CR, Nowak RB, Kim NE, Littlefield RS, Lieber RL, Fowler VM.

J Cell Biol. 2010 Apr 5;189(1):95-109. doi: 10.1083/jcb.201001125.

46.

Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens.

Nowak RB, Fischer RS, Zoltoski RK, Kuszak JR, Fowler VM.

J Cell Biol. 2009 Sep 21;186(6):915-28. doi: 10.1083/jcb.200905065. Epub 2009 Sep 14.

47.

A nebulin ruler does not dictate thin filament lengths.

Castillo A, Nowak R, Littlefield KP, Fowler VM, Littlefield RS.

Biophys J. 2009 Mar 4;96(5):1856-65. doi: 10.1016/j.bpj.2008.10.053.

48.

Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development.

McKeown CR, Nowak RB, Moyer J, Sussman MA, Fowler VM.

Circ Res. 2008 Nov 21;103(11):1241-8. doi: 10.1161/CIRCRESAHA.108.178749. Epub 2008 Oct 16.

49.

Thin filament length regulation in striated muscle sarcomeres: pointed-end dynamics go beyond a nebulin ruler.

Littlefield RS, Fowler VM.

Semin Cell Dev Biol. 2008 Dec;19(6):511-9. doi: 10.1016/j.semcdb.2008.08.009. Epub 2008 Aug 26. Review.

50.

Disease severity and thin filament regulation in M9R TPM3 nemaline myopathy.

Ilkovski B, Mokbel N, Lewis RA, Walker K, Nowak KJ, Domazetovska A, Laing NG, Fowler VM, North KN, Cooper ST.

J Neuropathol Exp Neurol. 2008 Sep;67(9):867-77. doi: 10.1097/NEN.0b013e318183a44f.

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