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A Conversation Between Joanna Fowler and Johannes Czernin.

Fowler JS, Czernin J.

J Nucl Med. 2019 Sep;60(9):1191-1193. doi: 10.2967/jnumed.119.233619. No abstract available.


Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder.

Wang GJ, Wiers CE, Shumay E, Tomasi D, Yuan K, Wong CT, Logan J, Fowler JS, Volkow ND.

Transl Psychiatry. 2019 Feb 15;9(1):93. doi: 10.1038/s41398-019-0421-x.


Preclinical Evaluation of the First Adenosine A1 Receptor Partial Agonist Radioligand for Positron Emission Tomography Imaging.

Guo M, Gao ZG, Tyler R, Stodden T, Li Y, Ramsey J, Zhao WJ, Wang GJ, Wiers CE, Fowler JS, Rice KC, Jacobson KA, Kim SW, Volkow ND.

J Med Chem. 2018 Nov 21;61(22):9966-9975. doi: 10.1021/acs.jmedchem.8b01009. Epub 2018 Nov 13.


Synthesis of l-[4-11 C]Asparagine by Ring-Opening Nucleophilic 11 C-Cyanation Reaction of a Chiral Cyclic Sulfamidate Precursor.

Xu Y, Cankaya AS, Hoque R, Lee SJ, Shea C, Kersting L, Schueller M, Fowler JS, Szalda D, Alexoff D, Riehl B, Gleede T, Ferrieri RA, Qu W.

Chemistry. 2018 May 7;24(26):6848-6853. doi: 10.1002/chem.201801029. Epub 2018 Apr 19.


New Repeat Polymorphism in the AKT1 Gene Predicts Striatal Dopamine D2/D3 Receptor Availability and Stimulant-Induced Dopamine Release in the Healthy Human Brain.

Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang GJ, Fowler JS, Volkow ND.

J Neurosci. 2017 May 10;37(19):4982-4991. doi: 10.1523/JNEUROSCI.3155-16.2017. Epub 2017 Apr 17. Erratum in: J Neurosci. 2017 Aug 16;37(33):8043.


A mild, rapid synthesis of freebase [11C]nicotine from [11C]methyl triflate.

Xu Y, Kim SW, Kim D, Alexoff D, Schueller MJ, Fowler JS.

Appl Radiat Isot. 2016 Dec;118:62-66. doi: 10.1016/j.apradiso.2016.08.020. Epub 2016 Aug 29.


Dynamic Precision Phenotyping Reveals Mechanism of Crop Tolerance to Root Herbivory.

Qu W, Robert CA, Erb M, Hibbard BE, Paven M, Gleede T, Riehl B, Kersting L, Cankaya AS, Kunert AT, Xu Y, Schueller MJ, Shea C, Alexoff D, Lee SJ, Fowler JS, Ferrieri RA.

Plant Physiol. 2016 Oct;172(2):776-788. Epub 2016 Jul 12.


The high frequency relationship: implications for torsadogenic hERG blockers.

Champeroux P, Le Guennec JY, Jude S, Laigot C, Maurin A, Sola ML, Fowler JS, Richard S, Thireau J.

Br J Pharmacol. 2016 Feb;173(3):601-12. doi: 10.1111/bph.13391. Epub 2016 Jan 14.


An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization.

Lee SJ, Fowler JS, Alexoff D, Schueller M, Kim D, Nauth A, Weber C, Kim SW, Hooker JM, Ma L, Qu W.

Org Biomol Chem. 2015 Dec 14;13(46):11235-43. doi: 10.1039/c5ob01654a.


Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.

Wang H, Liu L, Lu Y, Pan P, Hooker JM, Fowler JS, Tonge PJ.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4782-4786. doi: 10.1016/j.bmcl.2015.07.019. Epub 2015 Jul 14.


Recovery of dopamine transporters with methamphetamine detoxification is not linked to changes in dopamine release.

Volkow ND, Wang GJ, Smith L, Fowler JS, Telang F, Logan J, Tomasi D.

Neuroimage. 2015 Nov 1;121:20-8. doi: 10.1016/j.neuroimage.2015.07.035. Epub 2015 Jul 21.


Total cyanide mass measurement with micro-ion selective electrode for determination of specific activity of carbon-11 cyanide.

Shea C, Alexoff DL, Kim D, Hoque R, Schueller MJ, Fowler JS, Qu W.

Appl Radiat Isot. 2015 Aug;102:48-54. doi: 10.1016/j.apradiso.2015.04.014. Epub 2015 Apr 25.


Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain.

Volkow ND, Wang GJ, Logan J, Alexoff D, Fowler JS, Thanos PK, Wong C, Casado V, Ferre S, Tomasi D.

Transl Psychiatry. 2015 Apr 14;5:e549. doi: 10.1038/tp.2015.46.


Aromatase imaging with [N-methyl-11C]vorozole PET in healthy men and women.

Biegon A, Alexoff DL, Kim SW, Logan J, Pareto D, Schlyer D, Wang GJ, Fowler JS.

J Nucl Med. 2015 Apr;56(4):580-5. doi: 10.2967/jnumed.114.150383. Epub 2015 Feb 19.


Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases.

Volkow ND, Wang GJ, Shokri Kojori E, Fowler JS, Benveniste H, Tomasi D.

J Neurosci. 2015 Feb 18;35(7):3248-55. doi: 10.1523/JNEUROSCI.4877-14.2015.


Monoamine oxidase: radiotracer chemistry and human studies.

Fowler JS, Logan J, Shumay E, Alia-Klein N, Wang GJ, Volkow ND.

J Labelled Comp Radiopharm. 2015 Mar;58(3):51-64. doi: 10.1002/jlcr.3247. Epub 2015 Feb 10. Review.


Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations.

Champeroux P, Thireau J, Judé S, Laigot-Barbé C, Maurin A, Sola ML, Fowler JS, Richard S, Le Guennec JY.

Br J Pharmacol. 2015 Jun;172(11):2878-91. doi: 10.1111/bph.13093. Epub 2015 Mar 26.


Investigation of SN2 [11C]cyanation for base-sensitive substrates: an improved radiosynthesis of L-[5-11C]-glutamine.

Gleede T, Riehl B, Shea C, Kersting L, Cankaya AS, Alexoff D, Schueller M, Fowler JS, Qu W.

Amino Acids. 2015 Mar;47(3):525-33. doi: 10.1007/s00726-014-1883-z. Epub 2014 Dec 10.


The design and performance of a portable handheld (11)CO2 delivery system.

Kim D, Alexoff DL, Schueller M, Babst B, Ferrieri R, Fowler JS, Schlyer DJ.

Appl Radiat Isot. 2014 Dec;94:338-343. doi: 10.1016/j.apradiso.2014.09.008. Epub 2014 Sep 22.


Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain.

Fowler JS, Logan J, Volkow ND, Shumay E, McCall-Perez F, Jayne M, Wang GJ, Alexoff DL, Apelskog-Torres K, Hubbard B, Carter P, King P, Fahn S, Gilmor M, Telang F, Shea C, Xu Y, Muench L.

Neuropsychopharmacology. 2015 Feb;40(3):650-7. doi: 10.1038/npp.2014.214. Epub 2014 Sep 24.


Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus.

Wang H, Lu Y, Liu L, Kim SW, Hooker JM, Fowler JS, Tonge PJ.

Eur J Med Chem. 2014 Dec 17;88:66-73. doi: 10.1016/j.ejmech.2014.09.008. Epub 2014 Sep 6.


Reactions to media violence: it's in the brain of the beholder.

Alia-Klein N, Wang GJ, Preston-Campbell RN, Moeller SJ, Parvaz MA, Zhu W, Jayne MC, Wong C, Tomasi D, Goldstein RZ, Fowler JS, Volkow ND.

PLoS One. 2014 Sep 10;9(9):e107260. doi: 10.1371/journal.pone.0107260. eCollection 2014.


Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity.

Volkow ND, Wang GJ, Telang F, Fowler JS, Alexoff D, Logan J, Jayne M, Wong C, Tomasi D.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3149-56. doi: 10.1073/pnas.1411228111. Epub 2014 Jul 14.


BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake.

Wang GJ, Tomasi D, Convit A, Logan J, Wong CT, Shumay E, Fowler JS, Volkow ND.

PLoS One. 2014 Jul 7;9(7):e101585. doi: 10.1371/journal.pone.0101585. eCollection 2014.


Radiosynthesis of 3-indolyl[1-¹¹C]acetic acid for phyto-PET-imaging: an improved production procedure and formulation method.

Xu Y, Alexoff DL, Kunert AT, Qu W, Kim D, Paven M, Babst BA, Ferrieri RA, Schueller MJ, Fowler JS.

Appl Radiat Isot. 2014 Sep;91:155-60. doi: 10.1016/j.apradiso.2014.05.017. Epub 2014 May 27.


Dynamic functional imaging of brain glucose utilization using fPET-FDG.

Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM.

Neuroimage. 2014 Oct 15;100:192-9. doi: 10.1016/j.neuroimage.2014.06.025. Epub 2014 Jun 14.


Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers.

Volkow ND, Tomasi D, Wang GJ, Logan J, Alexoff DL, Jayne M, Fowler JS, Wong C, Yin P, Du C.

Mol Psychiatry. 2014 Sep;19(9):1037-43. doi: 10.1038/mp.2014.58. Epub 2014 Jun 10.


Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography.

Logan J, Kim SW, Pareto D, Telang F, Wang GJ, Fowler JS, Biegon A.

Mol Imaging. 2014;13:1-12.


Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

Seo YJ, Kang Y, Muench L, Reid A, Caesar S, Jean L, Wagner F, Holson E, Haggarty SJ, Weiss P, King P, Carter P, Volkow ND, Fowler JS, Hooker JM, Kim SW.

ACS Chem Neurosci. 2014 Jul 16;5(7):588-96. doi: 10.1021/cn500021p. Epub 2014 May 21.


Therapeutic doses of buspirone block D3 receptors in the living primate brain.

Kim SW, Fowler JS, Skolnick P, Muench L, Kang Y, Shea C, Logan J, Kim D, Carter P, King P, Alexoff D, Volkow ND.

Int J Neuropsychopharmacol. 2014 Aug;17(8):1257-67. doi: 10.1017/S1461145714000194. Epub 2014 Mar 28. Erratum in: Int J Neuropsychopharmacol. 2014 Aug;17(8):1354.


In vivo imaging of brain aromatase in female baboons: [11C]vorozole kinetics and effect of the menstrual cycle.

Pareto D, Biegon A, Alexoff D, Carter P, Shea C, Muench L, Xu Y, Fowler JS, Kim SW, Logan J.

Mol Imaging. 2013 Nov-Dec;12(8). doi: 10.2310/7290.2013.00068.


Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain.

Seo YJ, Muench L, Reid A, Chen J, Kang Y, Hooker JM, Volkow ND, Fowler JS, Kim SW.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6700-5. doi: 10.1016/j.bmcl.2013.10.038. Epub 2013 Oct 30.


Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET.

Kim SW, Hooker JM, Otto N, Win K, Muench L, Shea C, Carter P, King P, Reid AE, Volkow ND, Fowler JS.

Nucl Med Biol. 2013 Oct;40(7):912-8. doi: 10.1016/j.nucmedbio.2013.06.007. Epub 2013 Jul 29.


Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism.

Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Goldstein RZ, Klein N, Wong C, Swanson JM, Shumay E.

PLoS One. 2013 May 22;8(5):e63492. doi: 10.1371/journal.pone.0063492. Print 2013.


Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder.

Wang GJ, Volkow ND, Wigal T, Kollins SH, Newcorn JH, Telang F, Logan J, Jayne M, Wong CT, Han H, Fowler JS, Zhu W, Swanson JM.

PLoS One. 2013 May 15;8(5):e63023. doi: 10.1371/journal.pone.0063023. Print 2013.


A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity.

Yu K, Soares JM, Mandal MK, Wang C, Chanda B, Gifford AN, Fowler JS, Navarre D, Kachroo A, Kachroo P.

Cell Rep. 2013 Apr 25;3(4):1266-78. doi: 10.1016/j.celrep.2013.03.030. Epub 2013 Apr 18.


Predominance of D2 receptors in mediating dopamine's effects in brain metabolism: effects of alcoholism.

Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Logan J, Maynard LJ, Wong CT.

J Neurosci. 2013 Mar 6;33(10):4527-35. doi: 10.1523/JNEUROSCI.5261-12.2013.


Power spectral analysis of heart rate variability in cynomolgus monkeys in safety pharmacology studies: comparative study with beagle dogs.

Champeroux P, Martel E, Jude S, Laigot C, Laveissière A, Weyn-Marotte AA, Fowler JS, Maurin A, Richard S, Babuty D.

J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):166-74. doi: 10.1016/j.vascn.2013.02.005. Epub 2013 Feb 19.


Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain.

Biegon A, Alia-Klein N, Fowler JS.

Front Pharmacol. 2012 Nov 6;3:185. doi: 10.3389/fphar.2012.00185. eCollection 2012.


Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men.

Shumay E, Logan J, Volkow ND, Fowler JS.

Epigenetics. 2012 Oct;7(10):1151-60. doi: 10.4161/epi.21976. Epub 2012 Sep 4.


Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain.

Volkow ND, Kim SW, Wang GJ, Alexoff D, Logan J, Muench L, Shea C, Telang F, Fowler JS, Wong C, Benveniste H, Tomasi D.

Neuroimage. 2013 Jan 1;64:277-83. doi: 10.1016/j.neuroimage.2012.08.057. Epub 2012 Aug 28.


Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability.

Shumay E, Fowler JS, Wang GJ, Logan J, Alia-Klein N, Goldstein RZ, Maloney T, Wong C, Volkow ND.

Transl Psychiatry. 2012 Mar 6;2:e86. doi: 10.1038/tp.2012.11.


Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.

Logan J, Carruthers NI, Letavic MA, Sands S, Jiang X, Shea C, Muench L, Xu Y, Carter P, King P, Fowler JS.

Psychopharmacology (Berl). 2012 Oct;223(4):447-55. Epub 2012 May 22.


Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain.

Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Logan J, Benveniste H, Kim R, Thanos PK, Ferré S.

J Neurosci. 2012 May 9;32(19):6711-7. doi: 10.1523/JNEUROSCI.0045-12.2012.


Evaluation of positron emission tomography as a method to visualize subsurface microbial processes.

Kinsella K, Schlyer DJ, Fowler JS, Martinez RJ, Sobecky PA.

J Hazard Mater. 2012 Apr 30;213-214:498-501. doi: 10.1016/j.jhazmat.2012.01.037. Epub 2012 Jan 18.


Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder.

Volkow ND, Wang GJ, Tomasi D, Kollins SH, Wigal TL, Newcorn JH, Telang FW, Fowler JS, Logan J, Wong CT, Swanson JM.

J Neurosci. 2012 Jan 18;32(3):841-9. doi: 10.1523/JNEUROSCI.4461-11.2012.


Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.

Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):679-82. doi: 10.1016/j.bmcl.2011.10.053. Epub 2011 Oct 25.


Food and drug reward: overlapping circuits in human obesity and addiction.

Volkow ND, Wang GJ, Fowler JS, Tomasi D, Baler R.

Curr Top Behav Neurosci. 2012;11:1-24. doi: 10.1007/7854_2011_169. Review.


Addiction circuitry in the human brain.

Volkow ND, Wang GJ, Fowler JS, Tomasi D.

Annu Rev Pharmacol Toxicol. 2012;52:321-36. doi: 10.1146/annurev-pharmtox-010611-134625. Epub 2011 Sep 27. Review.


Genotype and ancestry modulate brain's DAT availability in healthy humans.

Shumay E, Chen J, Fowler JS, Volkow ND.

PLoS One. 2011;6(8):e22754. doi: 10.1371/journal.pone.0022754. Epub 2011 Aug 3.

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