Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 40

1.

Biophysical and Mechanistic Models for Disease-Causing Protein Variants.

Stein A, Fowler DM, Hartmann-Petersen R, Lindorff-Larsen K.

Trends Biochem Sci. 2019 Jan 31. pii: S0968-0004(19)30003-9. doi: 10.1016/j.tibs.2019.01.003. [Epub ahead of print] Review.

PMID:
30712981
2.

Multiplex assessment of protein variant abundance by massively parallel sequencing.

Matreyek KA, Starita LM, Stephany JJ, Martin B, Chiasson MA, Gray VE, Kircher M, Khechaduri A, Dines JN, Hause RJ, Bhatia S, Evans WE, Relling MV, Yang W, Shendure J, Fowler DM.

Nat Genet. 2018 Jun;50(6):874-882. doi: 10.1038/s41588-018-0122-z. Epub 2018 May 21.

3.

Correction to: A statistical framework for analyzing deep mutational scanning data.

Rubin AF, Gelman H, Lucas N, Bajjalieh SM, Papenfuss AT, Speed TP, Fowler DM.

Genome Biol. 2018 Feb 7;19(1):17. doi: 10.1186/s13059-018-1391-7.

4.

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations.

Daly AK, Rettie AE, Fowler DM, Miners JO.

J Pers Med. 2017 Dec 28;8(1). pii: E1. doi: 10.3390/jpm8010001. Review.

5.

A framework for exhaustively mapping functional missense variants.

Weile J, Sun S, Cote AG, Knapp J, Verby M, Mellor JC, Wu Y, Pons C, Wong C, van Lieshout N, Yang F, Tasan M, Tan G, Yang S, Fowler DM, Nussbaum R, Bloom JD, Vidal M, Hill DE, Aloy P, Roth FP.

Mol Syst Biol. 2017 Dec 21;13(12):957. doi: 10.15252/msb.20177908.

6.

Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data.

Gray VE, Hause RJ, Luebeck J, Shendure J, Fowler DM.

Cell Syst. 2018 Jan 24;6(1):116-124.e3. doi: 10.1016/j.cels.2017.11.003. Epub 2017 Dec 6.

7.

Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.

McDonald MG, Ray S, Amorosi CJ, Sitko KA, Kowalski JP, Paco L, Nath A, Gallis B, Totah RA, Dunham MJ, Fowler DM, Rettie AE.

Drug Metab Dispos. 2017 Dec;45(12):1364-1371. doi: 10.1124/dmd.117.078188. Epub 2017 Oct 10.

8.

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase.

Taskinen B, Ferrada E, Fowler DM.

J Biol Chem. 2017 Nov 10;292(45):18518-18529. doi: 10.1074/jbc.M117.811174. Epub 2017 Sep 22.

9.

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing.

Rose JC, Stephany JJ, Wei CT, Fowler DM, Maly DJ.

ACS Chem Biol. 2018 Feb 16;13(2):438-442. doi: 10.1021/acschembio.7b00652. Epub 2017 Sep 15.

10.

Variant Interpretation: Functional Assays to the Rescue.

Starita LM, Ahituv N, Dunham MJ, Kitzman JO, Roth FP, Seelig G, Shendure J, Fowler DM.

Am J Hum Genet. 2017 Sep 7;101(3):315-325. doi: 10.1016/j.ajhg.2017.07.014.

11.

New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.

Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM.

Clin Pharmacol Ther. 2017 Dec;102(6):897-902. doi: 10.1002/cpt.755. Epub 2017 Aug 10.

12.

A statistical framework for analyzing deep mutational scanning data.

Rubin AF, Gelman H, Lucas N, Bajjalieh SM, Papenfuss AT, Speed TP, Fowler DM.

Genome Biol. 2017 Aug 7;18(1):150. doi: 10.1186/s13059-017-1272-5. Erratum in: Genome Biol. 2018 Feb 7;19(1):17.

13.

Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions.

Gray VE, Hause RJ, Fowler DM.

Genetics. 2017 Sep;207(1):53-61. doi: 10.1534/genetics.117.300064. Epub 2017 Jul 27.

14.

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

Rose JC, Stephany JJ, Valente WJ, Trevillian BM, Dang HV, Bielas JH, Maly DJ, Fowler DM.

Nat Methods. 2017 Sep;14(9):891-896. doi: 10.1038/nmeth.4368. Epub 2017 Jul 24.

15.

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research.

Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, Cox NJ, Herman GE, Kingsmore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang H, Westerfield M, Bult C.

Cell. 2017 Mar 23;169(1):6-12. doi: 10.1016/j.cell.2017.03.005.

16.

A platform for functional assessment of large variant libraries in mammalian cells.

Matreyek KA, Stephany JJ, Fowler DM.

Nucleic Acids Res. 2017 Jun 20;45(11):e102. doi: 10.1093/nar/gkx183.

17.

Novel Rhizosphere Soil Alleles for the Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase Queried for Function with an In Vivo Competition Assay.

Jin Z, Di Rienzi SC, Janzon A, Werner JJ, Angenent LT, Dangl JL, Fowler DM, Ley RE.

Appl Environ Microbiol. 2015 Dec 4;82(4):1050-9. doi: 10.1128/AEM.03074-15. Print 2016 Feb 15.

18.

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.

Starita LM, Young DL, Islam M, Kitzman JO, Gullingsrud J, Hause RJ, Fowler DM, Parvin JD, Shendure J, Fields S.

Genetics. 2015 Jun;200(2):413-22. doi: 10.1534/genetics.115.175802. Epub 2015 Mar 30. Erratum in: Genetics. 2017 Dec;207 (4):1713.

19.

Contrasting patterns of genetic and phenotypic differentiation in two invasive salmonids in the southern hemisphere.

Monzón-Argüello C, Consuegra S, Gajardo G, Marco-Rius F, Fowler DM, DeFaveri J, Garcia de Leaniz C.

Evol Appl. 2014 Sep;7(8):921-36. doi: 10.1111/eva.12188. Epub 2014 Jul 23.

20.

Measuring the activity of protein variants on a large scale using deep mutational scanning.

Fowler DM, Stephany JJ, Fields S.

Nat Protoc. 2014 Sep;9(9):2267-84. doi: 10.1038/nprot.2014.153. Epub 2014 Aug 28.

21.

Deep mutational scanning: a new style of protein science.

Fowler DM, Fields S.

Nat Methods. 2014 Aug;11(8):801-7. doi: 10.1038/nmeth.3027.

22.

Contemporary, yeast-based approaches to understanding human genetic variation.

Dunham MJ, Fowler DM.

Curr Opin Genet Dev. 2013 Dec;23(6):658-64. doi: 10.1016/j.gde.2013.10.001. Epub 2013 Nov 16. Review.

23.

Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection.

Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD.

J Biol Chem. 2013 Jun 14;288(24):17111-21. doi: 10.1074/jbc.M112.447326. Epub 2013 Apr 26.

24.

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

Starita LM, Pruneda JN, Lo RS, Fowler DM, Kim HJ, Hiatt JB, Shendure J, Brzovic PS, Fields S, Klevit RE.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1263-72. doi: 10.1073/pnas.1303309110. Epub 2013 Mar 18.

25.

Functional amyloidogenesis and cytotoxicity-insights into biology and pathology.

Fowler DM, Kelly JW.

PLoS Biol. 2012;10(12):e1001459. doi: 10.1371/journal.pbio.1001459. Epub 2012 Dec 27.

26.

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function.

Araya CL, Fowler DM, Chen W, Muniez I, Kelly JW, Fields S.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16858-63. doi: 10.1073/pnas.1209751109. Epub 2012 Oct 3.

27.

Enrich: software for analysis of protein function by enrichment and depletion of variants.

Fowler DM, Araya CL, Gerard W, Fields S.

Bioinformatics. 2011 Dec 15;27(24):3430-1. doi: 10.1093/bioinformatics/btr577. Epub 2011 Oct 17.

28.

Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.

Lo HY, Nemoto PA, Kim JM, Hao MH, Qian KC, Farrow NA, Albaugh DR, Fowler DM, Schneiderman RD, Michael August E, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H, De Lombaert S.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4533-9. doi: 10.1016/j.bmcl.2011.05.126. Epub 2011 Jun 17.

PMID:
21733690
29.

Deep mutational scanning: assessing protein function on a massive scale.

Araya CL, Fowler DM.

Trends Biotechnol. 2011 Sep;29(9):435-42. doi: 10.1016/j.tibtech.2011.04.003. Epub 2011 May 10. Review.

30.

Suppression of statin effectiveness by copper and zinc in yeast and human cells.

Fowler DM, Cooper SJ, Stephany JJ, Hendon N, Nelson S, Fields S.

Mol Biosyst. 2011 Feb;7(2):533-44. doi: 10.1039/c0mb00166j. Epub 2010 Nov 17.

31.

High-resolution mapping of protein sequence-function relationships.

Fowler DM, Araya CL, Fleishman SJ, Kellogg EH, Stephany JJ, Baker D, Fields S.

Nat Methods. 2010 Sep;7(9):741-6. doi: 10.1038/nmeth.1492. Epub 2010 Aug 15.

32.

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils.

Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS.

J Biol Chem. 2009 Dec 18;284(51):35543-55. doi: 10.1074/jbc.M109.047449.

33.

Aggregating knowledge about prions and amyloid.

Fowler DM, Kelly JW.

Cell. 2009 Apr 3;137(1):20-2. doi: 10.1016/j.cell.2009.03.030.

34.
35.

Semen-derived amyloid fibrils drastically enhance HIV infection.

Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F.

Cell. 2007 Dec 14;131(6):1059-71.

36.

Functional amyloid--from bacteria to humans.

Fowler DM, Koulov AV, Balch WE, Kelly JW.

Trends Biochem Sci. 2007 May;32(5):217-24. Epub 2007 Apr 6. Review.

PMID:
17412596
37.

The dynamin middle domain is critical for tetramerization and higher-order self-assembly.

Ramachandran R, Surka M, Chappie JS, Fowler DM, Foss TR, Song BD, Schmid SL.

EMBO J. 2007 Jan 24;26(2):559-66. Epub 2006 Dec 14.

38.

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.

Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P Jr, Lerner RA, Kelly JW.

Nat Chem Biol. 2006 May;2(5):249-53. Epub 2006 Mar 26. Erratum in: Nat Chem Biol. 2006 Jun;2(6):346.

PMID:
16565714
39.

Structure of the Sec13/31 COPII coat cage.

Stagg SM, Gürkan C, Fowler DM, LaPointe P, Foss TR, Potter CS, Carragher B, Balch WE.

Nature. 2006 Jan 12;439(7073):234-8. Erratum in: Nature. 2006 Aug 17;442(7104):840.

PMID:
16407955
40.

Functional amyloid formation within mammalian tissue.

Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW.

PLoS Biol. 2006 Jan;4(1):e6.

Supplemental Content

Loading ...
Support Center