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Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.

Gaylo-Moynihan A, Prizant H, Popović M, Fernandes NRJ, Anderson CS, Chiou KK, Bell H, Schrock DC, Schumacher J, Capece T, Walling BL, Topham DJ, Miller J, Smrcka AV, Kim M, Hughson A, Fowell DJ.

Immunity. 2019 Aug 20;51(2):298-309.e6. doi: 10.1016/j.immuni.2019.06.026. Epub 2019 Aug 6.


Pivotal role for αV integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation.

Schrock DC, Leddon SA, Hughson A, Miller J, Lacy-Hulbert A, Fowell DJ.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4462-4470. doi: 10.1073/pnas.1809329116. Epub 2019 Feb 15.


CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection.

Ford J, Hughson A, Lim K, Bardina SV, Lu W, Charo IF, Lim JK, Fowell DJ.

Front Immunol. 2019 Jan 8;9:3063. doi: 10.3389/fimmu.2018.03063. eCollection 2018.


Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.

Batchu SN, Dugbartey GJ, Wadosky KM, Mickelsen DM, Ko KA, Wood RW, Zhao Y, Yang X, Fowell DJ, Korshunov VA.

Am J Pathol. 2018 Aug;188(8):1794-1806. doi: 10.1016/j.ajpath.2018.04.013.


CCR7 fuels and LFA-1 grips.

Oakes PW, Fowell DJ.

Nat Immunol. 2018 Jun;19(6):516-518. doi: 10.1038/s41590-018-0118-y. No abstract available.


T Cell Interstitial Migration: Motility Cues from the Inflamed Tissue for Micro- and Macro-Positioning.

Gaylo A, Schrock DC, Fernandes NR, Fowell DJ.

Front Immunol. 2016 Oct 14;7:428. eCollection 2016. Review.


The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.

Meli AP, Fontés G, Avery DT, Leddon SA, Tam M, Elliot M, Ballesteros-Tato A, Miller J, Stevenson MM, Fowell DJ, Tangye SG, King IL.

Immunity. 2016 Oct 18;45(4):831-846. doi: 10.1016/j.immuni.2016.09.018.


Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation.

Billroth-MacLurg AC, Ford J, Rosenberg A, Miller J, Fowell DJ.

J Immunol. 2016 Sep 15;197(6):2208-18. doi: 10.4049/jimmunol.1502575. Epub 2016 Aug 10.


Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.

Batchu N, Hughson A, Wadosky KM, Morrell CN, Fowell DJ, Korshunov VA.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1638-1646. doi: 10.1161/ATVBAHA.116.307848. Epub 2016 Jun 30.


Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis.

Gaylo A, Overstreet MG, Fowell DJ.

J Vis Exp. 2016 Mar 25;(109):e53585. doi: 10.3791/53585.


Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.

Shi G, Field DJ, Ko KA, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, Morrell CN.

J Clin Invest. 2014 Feb;124(2):543-52. doi: 10.1172/JCI71858. Epub 2014 Jan 27.


IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance.

Lazarski CA, Ford J, Katzman SD, Rosenberg AF, Fowell DJ.

PLoS One. 2013 Aug 26;8(8):e71949. doi: 10.1371/journal.pone.0071949. eCollection 2013.


Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV.

Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ.

Nat Immunol. 2013 Sep;14(9):949-58. doi: 10.1038/ni.2682. Epub 2013 Aug 11.


Role of Axl in early kidney inflammation and progression of salt-dependent hypertension.

Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA.

Hypertension. 2013 Aug;62(2):302-9. doi: 10.1161/HYPERTENSIONAHA.113.01382. Epub 2013 Jun 17.


Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.

Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M.

J Exp Med. 2012 Jul 2;209(7):1349-62. doi: 10.1084/jem.20111426. Epub 2012 Jun 18.


Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection.

Mock DJ, Hollenbaugh JA, Daddacha W, Overstreet MG, Lazarski CA, Fowell DJ, Kim B.

PLoS Pathog. 2012;8(4):e1002635. doi: 10.1371/journal.ppat.1002635. Epub 2012 Apr 5.


Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells.

Huang YH, Sojka DK, Fowell DJ.

J Immunol. 2012 Feb 1;188(3):947-51. doi: 10.4049/jimmunol.1101027. Epub 2012 Jan 6.


Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10.

Sojka DK, Fowell DJ.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18336-41. doi: 10.1073/pnas.1110566108. Epub 2011 Oct 24.


Itk controls the spatiotemporal organization of T cell activation.

Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C.

Sci Signal. 2011 Oct 4;4(193):ra66. doi: 10.1126/scisignal.2001821.


Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.

Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell DJ.

Diabetes. 2011 Aug;60(8):2125-33. doi: 10.2337/db10-1661. Epub 2011 Jun 29.


Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function.

Morales-Tirado V, Sojka DK, Katzman SD, Lazarski CA, Finkelman FD, Urban JF, Fowell DJ.

Blood. 2010 Apr 29;115(17):3498-507. doi: 10.1182/blood-2009-07-235754. Epub 2009 Dec 23.


CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.

Sojka DK, Hughson A, Fowell DJ.

Eur J Immunol. 2009 Jun;39(6):1544-51. doi: 10.1002/eji.200838603.


Signals for the execution of Th2 effector function.

Fowell DJ.

Cytokine. 2009 Apr;46(1):1-6. doi: 10.1016/j.cyto.2008.12.023. Epub 2009 Feb 23. Review.


Regulation of immunity at tissue sites of inflammation.

Sojka DK, Lazarski CA, Huang YH, Bromberg I, Hughson A, Fowell DJ.

Immunol Res. 2009 Dec;45(2-3):239-50. doi: 10.1007/s12026-009-8105-x. Epub 2009 Jan 31. Review.


Regulating Treg cells at sites of inflammation.

Lazarski CA, Hughson A, Sojka DK, Fowell DJ.

Immunity. 2008 Oct 17;29(4):511; author reply 512. doi: 10.1016/j.immuni.2008.09.012. No abstract available.


Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target.

Sojka DK, Huang YH, Fowell DJ.

Immunology. 2008 May;124(1):13-22. doi: 10.1111/j.1365-2567.2008.02813.x. Epub 2008 Mar 14. Review.


Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site.

Katzman SD, Fowell DJ.

J Clin Invest. 2008 Feb;118(2):801-11. doi: 10.1172/JCI33174.


A key role for Itk in both IFN gamma and IL-4 production by NKT cells.

Au-Yeung BB, Fowell DJ.

J Immunol. 2007 Jul 1;179(1):111-9.


Distinct molecular program imposed on CD4+ T cell targets by CD4+CD25+ regulatory T cells.

Sukiennicki TL, Fowell DJ.

J Immunol. 2006 Nov 15;177(10):6952-61.


Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activity.

Sojka DK, Hughson A, Sukiennicki TL, Fowell DJ.

J Immunol. 2005 Dec 1;175(11):7274-80.


Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells.

Morales-Tirado V, Johannson S, Hanson E, Howell A, Zhang J, Siminovitch KA, Fowell DJ.

J Immunol. 2004 Jul 15;173(2):726-30.


Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells.

Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA.

J Immunol. 2000 Jul 15;165(2):915-24. Erratum in: J Immunol 2000 Sep 15;165(6):following 3526.


Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).

Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N.

J Immunol. 1999 Dec 15;163(12):6520-9.


Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells.

Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM.

Immunity. 1999 Oct;11(4):399-409.


Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.

Fowell DJ, Locksley RM.

Bioessays. 1999 Jun;21(6):510-8. Review.


Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.

Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM.

J Exp Med. 1999 Apr 5;189(7):1111-20.


Susceptibility to infectious diseases: Leishmania as a paradigm.

Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ.

J Infect Dis. 1999 Mar;179 Suppl 2:S305-8. Review.


Development of CD4+ effector T cells and susceptibility to infectious diseases.

Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M.

Adv Exp Med Biol. 1998;452:45-52. Review.


Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.

Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM.

Eur Cytokine Netw. 1998 Sep;9(3 Suppl):102-6. Review.


Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.

Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM.

J Exp Med. 1998 Nov 2;188(9):1651-6.


Control of Leishmania major by a monoclonal alpha beta T cell repertoire.

Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM.

J Immunol. 1998 Jan 15;160(2):884-9.


Altered immune responses in interleukin 10 transgenic mice.

Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M.

J Exp Med. 1997 Jun 16;185(12):2101-10.


Impaired Th2 subset development in the absence of CD4.

Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM.

Immunity. 1997 May;6(5):559-69.


Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL.

J Exp Med. 1996 Oct 1;184(4):1295-304.


Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro.

Ramírez F, Fowell DJ, Puklavec M, Simmonds S, Mason D.

J Immunol. 1996 Apr 1;156(7):2406-12.


The role of the thymus in the control of autoimmunity.

Heath VL, Saoudi A, Seddon BP, Moore NC, Fowell DJ, Mason DW.

J Autoimmun. 1996 Apr;9(2):241-6. Review.


Interleukin-12 in murine leishmaniasis--match, flame or fuel?

Fowell DJ, Wakil AE, Locksley RM.

Res Immunol. 1995 Sep-Oct;146(7-8):566-75. Review. No abstract available.


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