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Items: 36


TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection.

Yang H, Yu HB, Bhinder G, Ryz NR, Lee J, Yang H, Fotovati A, Gibson DL, Turvey SE, Reid GS, Vallance BA.

Cell Microbiol. 2019 Jul;21(7):e13026. doi: 10.1111/cmi.13026. Epub 2019 May 7.


HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.

Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA.

Elife. 2017 Oct 10;6. pii: e28672. doi: 10.7554/eLife.28672.


Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A.

Chu TLH, Connell M, Zhou L, He Z, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielsen TO, Pante N, Maxwell CA.

Mol Cancer Res. 2018 Jan;16(1):16-31. doi: 10.1158/1541-7786.MCR-17-0417. Epub 2017 Oct 9.


EZH2 expression is a prognostic factor in childhood intracranial ependymoma: a Canadian Pediatric Brain Tumor Consortium study.

Li AM, Dunham C, Tabori U, Carret AS, McNeely PD, Johnston D, Lafay-Cousin L, Wilson B, Eisenstat DD, Jabado N, Zelcer S, Silva M, Scheinemann K, Fryer C, Hendson G, Fotovati A, Hawkins C, Yip S, Dunn SE, Hukin J.

Cancer. 2015 May 1;121(9):1499-507. doi: 10.1002/cncr.29198. Epub 2015 Jan 13.


YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.

Davies AH, Reipas KM, Pambid MR, Berns R, Stratford AL, Fotovati A, Firmino N, Astanehe A, Hu K, Maxwell C, Mills GB, Dunn SE.

Stem Cells. 2014 Jun;32(6):1437-50. doi: 10.1002/stem.1707.


Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.

Triscott J, Lee C, Foster C, Manoranjan B, Pambid MR, Berns R, Fotovati A, Venugopal C, O'Halloran K, Narendran A, Hawkins C, Ramaswamy V, Bouffet E, Taylor MD, Singhal A, Hukin J, Rassekh R, Yip S, Northcott P, Singh SK, Dunham C, Dunn SE.

Cancer Res. 2013 Nov 15;73(22):6734-44. doi: 10.1158/0008-5472.CAN-12-4331. Epub 2013 Sep 9.


Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.

Triscott J, Lee C, Hu K, Fotovati A, Berns R, Pambid M, Luk M, Kast RE, Kong E, Toyota E, Yip S, Toyota B, Dunn SE.

Oncotarget. 2012 Oct;3(10):1112-23.


Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.

Stratford AL, Reipas K, Hu K, Fotovati A, Brough R, Frankum J, Takhar M, Watson P, Ashworth A, Lord CJ, Lasham A, Print CG, Dunn SE.

Stem Cells. 2012 Jul;30(7):1338-48. doi: 10.1002/stem.1128.


Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

Lee C, Fotovati A, Triscott J, Chen J, Venugopal C, Singhal A, Dunham C, Kerr JM, Verreault M, Yip S, Wakimoto H, Jones C, Jayanthan A, Narendran A, Singh SK, Dunn SE.

Stem Cells. 2012 Jun;30(6):1064-75. doi: 10.1002/stem.1081.


MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition.

Astanehe A, Finkbeiner MR, Krzywinski M, Fotovati A, Dhillon J, Berquin IM, Mills GB, Marra MA, Dunn SE.

Oncogene. 2012 Oct 11;31(41):4434-46. doi: 10.1038/onc.2011.617. Epub 2012 Jan 16.


Expression of N-myc downstream regulated gene 1 (NDRG1) in central neurocytoma.

Fotovati A, Abu-Ali S, Sugita Y, Nakamura Y.

J Clin Neurosci. 2011 Oct;18(10):1383-5. doi: 10.1016/j.jocn.2011.02.021. Epub 2011 Jul 23.


YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.

Fotovati A, Abu-Ali S, Wang PS, Deleyrolle LP, Lee C, Triscott J, Chen JY, Franciosi S, Nakamura Y, Sugita Y, Uchiumi T, Kuwano M, Leavitt BR, Singh SK, Jury A, Jones C, Wakimoto H, Reynolds BA, Pallen CJ, Dunn SE.

Cancer Res. 2011 Aug 15;71(16):5569-78. doi: 10.1158/0008-5472.CAN-10-2805. Epub 2011 Jul 5.


Impaired ovarian development and reduced fertility in female mice deficient in Skp2.

Fotovati A, Abu-Ali S, Nakayama K, Nakayama KI.

J Anat. 2011 Jun;218(6):668-77. doi: 10.1111/j.1469-7580.2011.01370.x. Epub 2011 Mar 31.


N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer.

Fotovati A, Abu-Ali S, Kage M, Shirouzu K, Yamana H, Kuwano M.

Pathol Oncol Res. 2011 Sep;17(3):525-33. doi: 10.1007/s12253-010-9342-y. Epub 2011 Jan 9.


The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells.

Dhillon J, Astanehe A, Lee C, Fotovati A, Hu K, Dunn SE.

Oncogene. 2010 Nov 25;29(47):6294-300. doi: 10.1038/onc.2010.365. Epub 2010 Aug 30.


Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.

To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ, Dunn SE.

Cancer Res. 2010 Apr 1;70(7):2840-51. doi: 10.1158/0008-5472.CAN-09-3155. Epub 2010 Mar 23. Erratum in: Cancer Res. 2018 Jul 15;78(14):4102.


Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase.

Gao Y, Fotovati A, Lee C, Wang M, Cote G, Guns E, Toyota B, Faury D, Jabado N, Dunn SE.

Mol Cancer Ther. 2009 Dec;8(12):3276-84. doi: 10.1158/1535-7163.MCT-09-0478.


Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.

Hu K, Lee C, Qiu D, Fotovati A, Davies A, Abu-Ali S, Wai D, Lawlor ER, Triche TJ, Pallen CJ, Dunn SE.

Mol Cancer Ther. 2009 Nov;8(11):3024-35. doi: 10.1158/1535-7163.MCT-09-0365. Epub 2009 Nov 3.


The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1.

Astanehe A, Finkbeiner MR, Hojabrpour P, To K, Fotovati A, Shadeo A, Stratford AL, Lam WL, Berquin IM, Duronio V, Dunn SE.

Oncogene. 2009 Jun 25;28(25):2406-18. doi: 10.1038/onc.2009.81. Epub 2009 May 11.


Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite- and titanium-coated rough-surfaced implants in ovariectomized rats.

Hayashi K, Fotovati A, Abu Ali S, Nakamura Y, Inagaki M, Naito M.

J Biomed Mater Res A. 2010 Mar 1;92(3):1202-9. doi: 10.1002/jbm.a.32444.


Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells.

Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE.

Oncogene. 2009 Mar 19;28(11):1421-31. doi: 10.1038/onc.2008.485. Epub 2009 Jan 19.


Effect of combined treatment with alendronate and calcitriol on femoral neck strength in osteopenic rats.

Nakamura Y, Naito M, Hayashi K, Fotovati A, Abu-Ali S.

J Orthop Surg Res. 2008 Dec 17;3:51. doi: 10.1186/1749-799X-3-51.


Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation.

Watari K, Nakao S, Fotovati A, Basaki Y, Hosoi F, Bereczky B, Higuchi R, Miyamoto T, Kuwano M, Ono M.

Biochem Biophys Res Commun. 2008 Dec 19;377(3):826-31. doi: 10.1016/j.bbrc.2008.10.077. Epub 2008 Oct 23.


Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.

Hiraoka K, Zenmyo M, Watari K, Iguchi H, Fotovati A, Kimura YN, Hosoi F, Shoda T, Nagata K, Osada H, Ono M, Kuwano M.

Cancer Sci. 2008 Aug;99(8):1595-602. doi: 10.1111/j.1349-7006.2008.00880.x.


Effect of preoperative combined treatment with alendronate and calcitriol on fixation of hydroxyapatite-coated implants in ovariectomized rats.

Nakamura Y, Hayashi K, Abu-Ali S, Naito M, Fotovati A.

J Bone Joint Surg Am. 2008 Apr;90(4):824-32. doi: 10.2106/JBJS.G.00635.


Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.

Kimura YN, Watari K, Fotovati A, Hosoi F, Yasumoto K, Izumi H, Kohno K, Umezawa K, Iguchi H, Shirouzu K, Takamori S, Kuwano M, Ono M.

Cancer Sci. 2007 Dec;98(12):2009-18. Epub 2007 Oct 9.


YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation.

Uchiumi T, Fotovati A, Sasaguri T, Shibahara K, Shimada T, Fukuda T, Nakamura T, Izumi H, Tsuzuki T, Kuwano M, Kohno K.

J Biol Chem. 2006 Dec 29;281(52):40440-9. Epub 2006 Nov 2.


Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells.

Basaki Y, Hosoi F, Oda Y, Fotovati A, Maruyama Y, Oie S, Ono M, Izumi H, Kohno K, Sakai K, Shimoyama T, Nishio K, Kuwano M.

Oncogene. 2007 Apr 26;26(19):2736-46. Epub 2006 Oct 30.


High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma.

Aishima S, Basaki Y, Oda Y, Kuroda Y, Nishihara Y, Taguchi K, Taketomi A, Maehara Y, Hosoi F, Maruyama Y, Fotovati A, Oie S, Ono M, Ueno T, Sata M, Yano H, Kojiro M, Kuwano M, Tsuneyoshi M.

Cancer Sci. 2006 Nov;97(11):1182-90. Epub 2006 Sep 12.


17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells.

Fotovati A, Fujii T, Yamaguchi M, Kage M, Shirouzu K, Oie S, Basaki Y, Ono M, Yamana H, Kuwano M.

Clin Cancer Res. 2006 May 15;12(10):3010-8.


Prostaglandin EP4 receptor agonist augments fixation of hydroxyapatite-coated implants in a rat model of osteoporosis.

Hayashi K, Fotovati A, Ali SA, Oda K, Oida H, Naito M.

J Bone Joint Surg Br. 2005 Aug;87(8):1150-6.


S-myotrophin promotes the hypertrophy of myotube as insulin-like growth factor-I does.

Hayashi T, Ogawa T, Sato M, Tsuchida N, Fotovati A, Iwamoto H, Ikeuchi Y, Cassens RG, Ito T.

Int J Biochem Cell Biol. 2001 Aug;33(8):831-8.


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