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Items: 1 to 50 of 143

1.

Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers.

Ladebo L, Foster DJR, Abuhelwa AY, Upton RN, Kongstad KT, Drewes AM, Christrup LL, Olesen AE.

Basic Clin Pharmacol Toxicol. 2019 Oct 9. doi: 10.1111/bcpt.13330. [Epub ahead of print]

PMID:
31597014
2.

Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice.

Hughes JH, Upton RN, Reuter SE, Rozewski DM, Phelps MA, Foster DJR.

Cancer Chemother Pharmacol. 2019 Nov;84(5):1073-1087. doi: 10.1007/s00280-019-03941-z. Epub 2019 Sep 6.

PMID:
31493176
3.

Pharmacometrics in Australasia-Twenty Years of Population Approach Group of Australia and New Zealand.

Hennig S, Hannam JA, Kirkpatrick CMJ, Staatz CE, Holford S, Duffull SB, Al-Sallami HS, Charles BG, Holford N, Foster DJR.

CPT Pharmacometrics Syst Pharmacol. 2019 Oct;8(10):701-704. doi: 10.1002/psp4.12460. Epub 2019 Sep 16. No abstract available.

4.

Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis.

Hughes JH, Upton RN, Reuter SE, Phelps MA, Foster DJR.

J Pharm Pharmacol. 2019 Nov;71(11):1635-1644. doi: 10.1111/jphp.13154. Epub 2019 Aug 14.

PMID:
31412422
5.

5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger.

Kumar P, Parmar RG, Brown CR, Willoughby JLS, Foster DJ, Babu IR, Schofield S, Jadhav V, Charisse K, Nair JK, Rajeev KG, Maier MA, Egli M, Manoharan M.

Chem Commun (Camb). 2019 Apr 25;55(35):5139-5142. doi: 10.1039/c9cc00977a.

PMID:
30977478
6.

High density is a property of slow-cycling and treatment-resistant human glioblastoma cells.

Sabelström H, Quigley DA, Fenster T, Foster DJ, Fuchshuber CAM, Saxena S, Yuan E, Li N, Paterno F, Phillips JJ, James CD, Norling B, Berger MS, Persson AI.

Exp Cell Res. 2019 May 1;378(1):76-86. doi: 10.1016/j.yexcr.2019.03.003. Epub 2019 Mar 5.

7.

Population pharmacokinetics of lenalidomide in patients with B-cell malignancies.

Hughes JH, Phelps MA, Upton RN, Reuter SE, Gao Y, Byrd JC, Grever MR, Hofmeister CC, Marcucci G, Blum W, Blum KA, Foster DJR.

Br J Clin Pharmacol. 2019 May;85(5):924-934. doi: 10.1111/bcp.13873. Epub 2019 Feb 27.

PMID:
30672004
8.

Acute silencing of hippocampal CA3 reveals a dominant role in place field responses.

Davoudi H, Foster DJ.

Nat Neurosci. 2019 Mar;22(3):337-342. doi: 10.1038/s41593-018-0321-z. Epub 2019 Jan 21.

9.

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties.

Petito ES, Foster DJR, Ward MB, Sykes MJ.

Curr Top Med Chem. 2018;18(26):2230-2238. doi: 10.2174/1568026619666181220105726. Review.

PMID:
30569859
10.

Spoiled for choice, pressed for time.

Widloski J, Foster DJ.

Nat Neurosci. 2018 Nov;21(11):1501-1503. doi: 10.1038/s41593-018-0260-8. No abstract available.

PMID:
30349108
11.

Mechanistic Assessment of the Effect of Omeprazole on the In Vivo Pharmacokinetics of Itraconazole in Healthy Volunteers.

Abuhelwa AY, Mudge S, Upton RN, Foster DJR.

Eur J Drug Metab Pharmacokinet. 2019 Apr;44(2):201-215. doi: 10.1007/s13318-018-0519-1.

PMID:
30328059
12.

Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators.

Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ.

Mol Psychiatry. 2018 Aug 16. doi: 10.1038/s41380-018-0206-2. [Epub ahead of print]

PMID:
30116027
13.

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.

Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M.

Nucleic Acids Res. 2018 Sep 19;46(16):8090-8104. doi: 10.1093/nar/gky703.

14.

Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward.

Reddy IA, Smith NK, Erreger K, Ghose D, Saunders C, Foster DJ, Turner B, Poe A, Albaugh VL, McGuinness O, Hackett TA, Grueter BA, Abumrad NN, Flynn CR, Galli A.

PLoS Biol. 2018 Jul 26;16(7):e2006682. doi: 10.1371/journal.pbio.2006682. eCollection 2018 Jul.

15.

Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome.

Boone CE, Davoudi H, Harrold JB, Foster DJ.

Neuroscience. 2018 Aug 1;384:275-289. doi: 10.1016/j.neuroscience.2018.05.012. Epub 2018 May 22.

PMID:
29775702
16.

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.

Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S.

Mol Ther. 2018 Mar 7;26(3):708-717. doi: 10.1016/j.ymthe.2017.12.021. Epub 2018 Jan 4.

17.

Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG.

J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27.

PMID:
29376650
18.

lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

Jiao AL, Foster DJ, Dixon J, Slack FJ.

PLoS One. 2018 Jan 11;13(1):e0190766. doi: 10.1371/journal.pone.0190766. eCollection 2018.

19.

Population in vitro-in vivo pharmacokinetic model of first-pass metabolism: itraconazole and hydroxy-itraconazole.

Abuhelwa AY, Mudge S, Upton RN, Foster DJR.

J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):181-197. doi: 10.1007/s10928-017-9555-8. Epub 2017 Nov 17.

PMID:
29150770
20.

Activity in LIP, But not V4, Matches Performance When Attention is Spread.

Arcizet F, Mirpour K, Foster DJ, Bisley JW.

Cereb Cortex. 2018 Dec 1;28(12):4195-4209. doi: 10.1093/cercor/bhx274.

21.

4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ.

J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6.

PMID:
28937776
22.

Replay Comes of Age.

Foster DJ.

Annu Rev Neurosci. 2017 Jul 25;40:581-602. doi: 10.1146/annurev-neuro-072116-031538. Review.

PMID:
28772098
23.

Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.

Walker AG, Sheffler DJ, Lewis AS, Dickerson JW, Foster DJ, Senter RK, Moehle MS, Lv X, Stansley BJ, Xiang Z, Rook JM, Emmitte KA, Lindsley CW, Conn PJ.

Neuropsychopharmacology. 2017 Dec;42(13):2553-2566. doi: 10.1038/npp.2017.136. Epub 2017 Jun 30.

24.

Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats.

Leshinsky J, McLachlan A, Foster DJR, Norris R, Barrs VR.

PLoS One. 2017 Jun 2;12(6):e0178783. doi: 10.1371/journal.pone.0178783. eCollection 2017.

25.

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charissé K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M.

J Am Chem Soc. 2017 Jun 28;139(25):8537-8546. doi: 10.1021/jacs.7b02694. Epub 2017 Jun 19.

PMID:
28570818
26.

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.

Foster DJ, Conn PJ.

Neuron. 2017 May 3;94(3):431-446. doi: 10.1016/j.neuron.2017.03.016. Review.

27.

Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example for In Silico Assessment of Adaptive Dosing Strategies.

Wojciechowski J, Upton RN, Mould DR, Wiese MD, Foster DJR.

AAPS J. 2017 Jul;19(4):1136-1147. doi: 10.1208/s12248-017-0082-8. Epub 2017 Apr 25.

PMID:
28444562
28.

Comparison of non-compartmental and mixed effect modelling methods for establishing bioequivalence for the case of two compartment kinetics and censored concentrations.

Hughes JH, Upton RN, Foster DJR.

J Pharmacokinet Pharmacodyn. 2017 Jun;44(3):233-244. doi: 10.1007/s10928-017-9511-7. Epub 2017 Feb 13.

PMID:
28194623
29.

Rosiglitazone Metabolism in Human Liver Microsomes Using a Substrate Depletion Method.

Bazargan M, Foster DJ, Davey AK, Muhlhausler BS.

Drugs R D. 2017 Mar;17(1):189-198. doi: 10.1007/s40268-016-0166-4.

30.

Population Pharmacokinetic Model of Doxycycline Plasma Concentrations Using Pooled Study Data.

Hopkins AM, Wojciechowski J, Abuhelwa AY, Mudge S, Upton RN, Foster DJ.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02401-16. doi: 10.1128/AAC.02401-16. Print 2017 Mar.

31.

Food, gastrointestinal pH, and models of oral drug absorption.

Abuhelwa AY, Williams DB, Upton RN, Foster DJ.

Eur J Pharm Biopharm. 2017 Mar;112:234-248. doi: 10.1016/j.ejpb.2016.11.034. Epub 2016 Nov 30. Review.

PMID:
27914234
32.

Single-dose pharmacokinetics and cardiovascular effects of oral pimobendan in healthy cats.

Yata M, McLachlan AJ, Foster DJ, Hanzlicek AS, Beijerink NJ.

J Vet Cardiol. 2016 Dec;18(4):310-325. doi: 10.1016/j.jvc.2016.07.001. Epub 2016 Sep 6.

PMID:
27613648
33.

Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration.

Hopkins AM, Moghaddami M, Foster DJ, Proudman SM, Upton RN, Wiese MD.

Drug Metab Dispos. 2017 Jan;45(1):8-16. Epub 2016 Oct 14.

PMID:
27742727
34.

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.

Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ.

Neuron. 2016 Sep 21;91(6):1244-1252. doi: 10.1016/j.neuron.2016.08.017. Epub 2016 Sep 8.

35.

Reverse Replay of Hippocampal Place Cells Is Uniquely Modulated by Changing Reward.

Ambrose RE, Pfeiffer BE, Foster DJ.

Neuron. 2016 Sep 7;91(5):1124-1136. doi: 10.1016/j.neuron.2016.07.047. Epub 2016 Aug 25.

36.

An introduction to physiologically-based pharmacokinetic models.

Upton RN, Foster DJ, Abuhelwa AY.

Paediatr Anaesth. 2016 Nov;26(11):1036-1046. doi: 10.1111/pan.12995. Epub 2016 Aug 23. Review.

PMID:
27550716
37.

A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption-Part I: Gastrointestinal pH.

Abuhelwa AY, Foster DJR, Upton RN.

AAPS J. 2016 Sep;18(5):1309-1321. doi: 10.1208/s12248-016-9952-8. Epub 2016 Aug 5. Review.

PMID:
27495120
38.

A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.

Abuhelwa AY, Foster DJR, Upton RN.

AAPS J. 2016 Sep;18(5):1322-1333. doi: 10.1208/s12248-016-9953-7. Epub 2016 Jul 20. Review.

PMID:
27439620
39.

Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model.

Knøsgaard KR, Foster DJ, Kreilgaard M, Sverrisdóttir E, Upton RN, van den Anker JN.

Eur J Pharm Sci. 2016 Sep 20;92:117-30. doi: 10.1016/j.ejps.2016.06.026. Epub 2016 Jul 1.

40.

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28.

PMID:
27121751
41.

Population In Vitro-In Vivo Correlation Model Linking Gastrointestinal Transit Time, pH, and Pharmacokinetics: Itraconazole as a Model Drug.

Abuhelwa AY, Mudge S, Hayes D, Upton RN, Foster DJ.

Pharm Res. 2016 Jul;33(7):1782-94. doi: 10.1007/s11095-016-1917-1. Epub 2016 Apr 27.

PMID:
27119846
42.

Limited fetal metabolism of rosiglitazone: Elimination via the maternal compartment in the pregnant ewe.

Bazargan M, Foster DJ, Muhlhausler BS, Morrison JL, McMillen I, Davey AK.

Reprod Toxicol. 2016 Jun;61:162-8. doi: 10.1016/j.reprotox.2016.04.008. Epub 2016 Apr 8.

PMID:
27067916
43.

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.

Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, Manoharan M, Fitzgerald K, Meyers RE, Nochur SV, Saraiva MJ, Zimmermann TS.

Amyloid. 2016 Jun;23(2):109-18. doi: 10.3109/13506129.2016.1160882. Epub 2016 Mar 31.

44.

Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.

Olsen R, Foster DJ, Upton RN, Olesen AE, Ross JR, Droney J, Sato H, Drewes AM, Kreilgaard M.

Eur J Pharm Sci. 2016 Apr 30;86:41-9. doi: 10.1016/j.ejps.2016.02.021. Epub 2016 Mar 2.

PMID:
26946441
45.

A model-based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity.

Wojciechowski J, Wiese MD, Proudman SM, Foster DJ, Upton RN.

Br J Clin Pharmacol. 2016 Jun;81(6):1046-57. doi: 10.1111/bcp.12891. Epub 2016 Apr 7.

46.

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M.

ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13.

PMID:
26675211
47.

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14078-83. doi: 10.1073/pnas.1512812112. Epub 2015 Oct 27.

48.

Trajectory events across hippocampal place cells require previous experience.

Silva D, Feng T, Foster DJ.

Nat Neurosci. 2015 Dec;18(12):1772-9. doi: 10.1038/nn.4151. Epub 2015 Oct 26.

49.

Memory and Space: Towards an Understanding of the Cognitive Map.

Schiller D, Eichenbaum H, Buffalo EA, Davachi L, Foster DJ, Leutgeb S, Ranganath C.

J Neurosci. 2015 Oct 14;35(41):13904-11. doi: 10.1523/JNEUROSCI.2618-15.2015. Erratum in: J Neurosci. 2015 Nov 18;35(46):15477.

50.

Extrahepatic biliary duct obstruction as a result of involuntary transcavitary implantation of hair in a cat.

Linton M, Buffa E, Simon A, Ashton J, McGregor R, Foster DJ.

JFMS Open Rep. 2015 Oct 12;1(2):2055116915610359. doi: 10.1177/2055116915610359. eCollection 2015 Jul-Dec.

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