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Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators.

Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ.

Mol Psychiatry. 2018 Aug 16. doi: 10.1038/s41380-018-0206-2. [Epub ahead of print]


Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.

Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M.

Nucleic Acids Res. 2018 Sep 19;46(16):8090-8104. doi: 10.1093/nar/gky703.


Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward.

Reddy IA, Smith NK, Erreger K, Ghose D, Saunders C, Foster DJ, Turner B, Poe A, Albaugh VL, McGuinness O, Hackett TA, Grueter BA, Abumrad NN, Flynn CR, Galli A.

PLoS Biol. 2018 Jul 26;16(7):e2006682. doi: 10.1371/journal.pbio.2006682. eCollection 2018 Jul.


Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome.

Boone CE, Davoudi H, Harrold JB, Foster DJ.

Neuroscience. 2018 Aug 1;384:275-289. doi: 10.1016/j.neuroscience.2018.05.012. Epub 2018 May 22.


Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.

Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S.

Mol Ther. 2018 Mar 7;26(3):708-717. doi: 10.1016/j.ymthe.2017.12.021. Epub 2018 Jan 4.


Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG.

J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27.


lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

Jiao AL, Foster DJ, Dixon J, Slack FJ.

PLoS One. 2018 Jan 11;13(1):e0190766. doi: 10.1371/journal.pone.0190766. eCollection 2018.


Population in vitro-in vivo pharmacokinetic model of first-pass metabolism: itraconazole and hydroxy-itraconazole.

Abuhelwa AY, Mudge S, Upton RN, Foster DJR.

J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):181-197. doi: 10.1007/s10928-017-9555-8. Epub 2017 Nov 17.


Activity in LIP, But not V4, Matches Performance When Attention is Spread.

Arcizet F, Mirpour K, Foster DJ, Bisley JW.

Cereb Cortex. 2017 Oct 23:1-15. doi: 10.1093/cercor/bhx274. [Epub ahead of print]


4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ.

J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6.


Replay Comes of Age.

Foster DJ.

Annu Rev Neurosci. 2017 Jul 25;40:581-602. doi: 10.1146/annurev-neuro-072116-031538. Review.


Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.

Walker AG, Sheffler DJ, Lewis AS, Dickerson JW, Foster DJ, Senter RK, Moehle MS, Lv X, Stansley BJ, Xiang Z, Rook JM, Emmitte KA, Lindsley CW, Conn PJ.

Neuropsychopharmacology. 2017 Dec;42(13):2553-2566. doi: 10.1038/npp.2017.136. Epub 2017 Jun 30.


Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats.

Leshinsky J, McLachlan A, Foster DJR, Norris R, Barrs VR.

PLoS One. 2017 Jun 2;12(6):e0178783. doi: 10.1371/journal.pone.0178783. eCollection 2017.


Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charissé K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M.

J Am Chem Soc. 2017 Jun 28;139(25):8537-8546. doi: 10.1021/jacs.7b02694. Epub 2017 Jun 19.


Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.

Foster DJ, Conn PJ.

Neuron. 2017 May 3;94(3):431-446. doi: 10.1016/j.neuron.2017.03.016. Review.


Infliximab Maintenance Dosing in Inflammatory Bowel Disease: an Example for In Silico Assessment of Adaptive Dosing Strategies.

Wojciechowski J, Upton RN, Mould DR, Wiese MD, Foster DJR.

AAPS J. 2017 Jul;19(4):1136-1147. doi: 10.1208/s12248-017-0082-8. Epub 2017 Apr 25.


Comparison of non-compartmental and mixed effect modelling methods for establishing bioequivalence for the case of two compartment kinetics and censored concentrations.

Hughes JH, Upton RN, Foster DJR.

J Pharmacokinet Pharmacodyn. 2017 Jun;44(3):233-244. doi: 10.1007/s10928-017-9511-7. Epub 2017 Feb 13.


Rosiglitazone Metabolism in Human Liver Microsomes Using a Substrate Depletion Method.

Bazargan M, Foster DJ, Davey AK, Muhlhausler BS.

Drugs R D. 2017 Mar;17(1):189-198. doi: 10.1007/s40268-016-0166-4.


Population Pharmacokinetic Model of Doxycycline Plasma Concentrations Using Pooled Study Data.

Hopkins AM, Wojciechowski J, Abuhelwa AY, Mudge S, Upton RN, Foster DJ.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02401-16. doi: 10.1128/AAC.02401-16. Print 2017 Mar.


Food, gastrointestinal pH, and models of oral drug absorption.

Abuhelwa AY, Williams DB, Upton RN, Foster DJ.

Eur J Pharm Biopharm. 2017 Mar;112:234-248. doi: 10.1016/j.ejpb.2016.11.034. Epub 2016 Nov 30. Review.


Single-dose pharmacokinetics and cardiovascular effects of oral pimobendan in healthy cats.

Yata M, McLachlan AJ, Foster DJ, Hanzlicek AS, Beijerink NJ.

J Vet Cardiol. 2016 Dec;18(4):310-325. doi: 10.1016/j.jvc.2016.07.001. Epub 2016 Sep 6.


Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration.

Hopkins AM, Moghaddami M, Foster DJ, Proudman SM, Upton RN, Wiese MD.

Drug Metab Dispos. 2017 Jan;45(1):8-16. Epub 2016 Oct 14.


Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.

Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ.

Neuron. 2016 Sep 21;91(6):1244-1252. doi: 10.1016/j.neuron.2016.08.017. Epub 2016 Sep 8.


Reverse Replay of Hippocampal Place Cells Is Uniquely Modulated by Changing Reward.

Ambrose RE, Pfeiffer BE, Foster DJ.

Neuron. 2016 Sep 7;91(5):1124-1136. doi: 10.1016/j.neuron.2016.07.047. Epub 2016 Aug 25.


An introduction to physiologically-based pharmacokinetic models.

Upton RN, Foster DJ, Abuhelwa AY.

Paediatr Anaesth. 2016 Nov;26(11):1036-1046. doi: 10.1111/pan.12995. Epub 2016 Aug 23. Review.


A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption-Part I: Gastrointestinal pH.

Abuhelwa AY, Foster DJ, Upton RN.

AAPS J. 2016 Sep;18(5):1309-21. doi: 10.1208/s12248-016-9952-8. Epub 2016 Aug 5. Review.


A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time.

Abuhelwa AY, Foster DJ, Upton RN.

AAPS J. 2016 Sep;18(5):1322-33. doi: 10.1208/s12248-016-9953-7. Epub 2016 Jul 20. Review.


Pharmacokinetic models of morphine and its metabolites in neonates:: Systematic comparisons of models from the literature, and development of a new meta-model.

Knøsgaard KR, Foster DJ, Kreilgaard M, Sverrisdóttir E, Upton RN, van den Anker JN.

Eur J Pharm Sci. 2016 Sep 20;92:117-30. doi: 10.1016/j.ejps.2016.06.026. Epub 2016 Jul 1.


5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28.


Population In Vitro-In Vivo Correlation Model Linking Gastrointestinal Transit Time, pH, and Pharmacokinetics: Itraconazole as a Model Drug.

Abuhelwa AY, Mudge S, Hayes D, Upton RN, Foster DJ.

Pharm Res. 2016 Jul;33(7):1782-94. doi: 10.1007/s11095-016-1917-1. Epub 2016 Apr 27.


Limited fetal metabolism of rosiglitazone: Elimination via the maternal compartment in the pregnant ewe.

Bazargan M, Foster DJ, Muhlhausler BS, Morrison JL, McMillen I, Davey AK.

Reprod Toxicol. 2016 Jun;61:162-8. doi: 10.1016/j.reprotox.2016.04.008. Epub 2016 Apr 8.


Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.

Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, Manoharan M, Fitzgerald K, Meyers RE, Nochur SV, Saraiva MJ, Zimmermann TS.

Amyloid. 2016 Jun;23(2):109-18. doi: 10.3109/13506129.2016.1160882. Epub 2016 Mar 31.


Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.

Olsen R, Foster DJ, Upton RN, Olesen AE, Ross JR, Droney J, Sato H, Drewes AM, Kreilgaard M.

Eur J Pharm Sci. 2016 Apr 30;86:41-9. doi: 10.1016/j.ejps.2016.02.021. Epub 2016 Mar 2.


A model-based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity.

Wojciechowski J, Wiese MD, Proudman SM, Foster DJ, Upton RN.

Br J Clin Pharmacol. 2016 Jun;81(6):1046-57. doi: 10.1111/bcp.12891. Epub 2016 Apr 7.


5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M.

ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13.


Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

Pancani T, Foster DJ, Moehle MS, Bichell TJ, Bradley E, Bridges TM, Klar R, Poslusney M, Rook JM, Daniels JS, Niswender CM, Jones CK, Wood MR, Bowman AB, Lindsley CW, Xiang Z, Conn PJ.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14078-83. doi: 10.1073/pnas.1512812112. Epub 2015 Oct 27.


Trajectory events across hippocampal place cells require previous experience.

Silva D, Feng T, Foster DJ.

Nat Neurosci. 2015 Dec;18(12):1772-9. doi: 10.1038/nn.4151. Epub 2015 Oct 26.


Memory and Space: Towards an Understanding of the Cognitive Map.

Schiller D, Eichenbaum H, Buffalo EA, Davachi L, Foster DJ, Leutgeb S, Ranganath C.

J Neurosci. 2015 Oct 14;35(41):13904-11. doi: 10.1523/JNEUROSCI.2618-15.2015. Erratum in: J Neurosci. 2015 Nov 18;35(46):15477.


Extrahepatic biliary duct obstruction as a result of involuntary transcavitary implantation of hair in a cat.

Linton M, Buffa E, Simon A, Ashton J, McGregor R, Foster DJ.

JFMS Open Rep. 2015 Oct 12;1(2):2055116915610359. doi: 10.1177/2055116915610359. eCollection 2015 Jul-Dec.


Disordered ripples are a common feature of genetically distinct mouse models relevant to schizophrenia.

Altimus C, Harrold J, Jaaro-Peled H, Sawa A, Foster DJ.

Mol Neuropsychiatry. 2015 May;1(1):52-59.


LIP activity in the interstimulus interval of a change detection task biases the behavioral response.

Arcizet F, Mirpour K, Foster DJ, Charpentier CJ, Bisley JW.

J Neurophysiol. 2015 Nov;114(5):2637-48. doi: 10.1152/jn.00604.2015. Epub 2015 Sep 2.


Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis.

Hopkins AM, Wiese MD, Proudman SM, O'Doherty CE, Upton RN, Foster DJ.

Br J Clin Pharmacol. 2016 Jan;81(1):113-23. doi: 10.1111/bcp.12760. Epub 2015 Oct 28.


PLACE CELLS. Autoassociative dynamics in the generation of sequences of hippocampal place cells.

Pfeiffer BE, Foster DJ.

Science. 2015 Jul 10;349(6244):180-3. doi: 10.1126/science.aaa9633.


Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in fed and fasted states.

Abuhelwa AY, Foster DJ, Mudge S, Hayes D, Upton RN.

Antimicrob Agents Chemother. 2015 Sep;59(9):5681-96. doi: 10.1128/AAC.00973-15. Epub 2015 Jul 6.


Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs.

Yata M, McLachlan AJ, Foster DJ, Page SW, Beijerink NJ.

J Vet Pharmacol Ther. 2016 Feb;39(1):45-53. doi: 10.1111/jvp.12243. Epub 2015 May 21.


Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.

Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ.

Neuron. 2015 May 20;86(4):1029-1040. doi: 10.1016/j.neuron.2015.03.063. Epub 2015 Apr 30.


ADVAN-style analytical solutions for common pharmacokinetic models.

Abuhelwa AY, Foster DJ, Upton RN.

J Pharmacol Toxicol Methods. 2015 May-Jun;73:42-8. doi: 10.1016/j.vascn.2015.03.004. Epub 2015 Apr 2.


Dissociation between the experience-dependent development of hippocampal theta sequences and single-trial phase precession.

Feng T, Silva D, Foster DJ.

J Neurosci. 2015 Mar 25;35(12):4890-902. doi: 10.1523/JNEUROSCI.2614-14.2015.


Discovering the brain's cognitive map.

Pfeiffer BE, Foster DJ.

JAMA Neurol. 2015 Mar;72(3):257-8. doi: 10.1001/jamaneurol.2014.4141. Review. No abstract available.


A population model of early rheumatoid arthritis disease activity during treatment with methotrexate, sulfasalazine and hydroxychloroquine.

Wojciechowski J, Wiese MD, Proudman SM, Foster DJ, Upton RN.

Br J Clin Pharmacol. 2015 May;79(5):777-88. doi: 10.1111/bcp.12553.

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