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Items: 1 to 50 of 255

1.

Novel Benzohydroxamate-based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis and Biological Evaluation.

Vergani B, Sandrone G, Marchini M, Ripamonti C, Cellupica E, Galbiati E, Caprini G, Pavich G, Porro G, Rocchio I, Lattanzio M, Pezzuto M, Skorupska M, Cordella P, Pagani P, Pozzi P, Pomarico R, Modena D, Leoni F, Perego R, Fossati G, Steinkühler C, Stevenazzi A.

J Med Chem. 2019 Nov 11. doi: 10.1021/acs.jmedchem.9b01194. [Epub ahead of print]

PMID:
31710483
2.

HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis.

Lagosz KB, Bysiek A, Macina JM, Bereta GP, Kantorowicz M, Lipska W, Sochalska M, Gawron K, Kaczmarzyk T, Chomyszyn-Gajewska M, Fossati G, Potempa J, Grabiec AM.

J Dent Res. 2019 Nov 6:22034519885088. doi: 10.1177/0022034519885088. [Epub ahead of print]

PMID:
31693860
3.

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.

Ranđelović I, Schuster S, Kapuvári B, Fossati G, Steinkühler C, Mező G, Tóvári J.

Int J Mol Sci. 2019 Sep 25;20(19). pii: E4763. doi: 10.3390/ijms20194763.

4.

Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.

Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, Mosher DF, Garlanda C, Bottazzi B, Taraboletti G, Mantovani A, Matteoli M, Menna E.

EMBO J. 2019 Jan 3;38(1). pii: e99529. doi: 10.15252/embj.201899529. Epub 2018 Nov 5.

5.

Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions.

Rowley TF, Peters SJ, Aylott M, Griffin R, Davies NL, Healy LJ, Cutler RM, Eddleston A, Pither TL, Sopp JM, Zaccheo O, Fossati G, Cain K, Ventom AM, Hailu H, Ward EJ, Sherington J, Brennan FR, Fallah-Arani F, Humphreys DP.

Commun Biol. 2018 Sep 14;1:146. doi: 10.1038/s42003-018-0149-9. eCollection 2018.

6.

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation.

Angiolilli C, Kabala PA, Grabiec AM, Rossato M, Lai WS, Fossati G, Mascagni P, Steinkühler C, Blackshear PJ, Reedquist KA, Baeten DL, Radstake TRDJ.

Arthritis Res Ther. 2018 Jul 20;20(1):148. doi: 10.1186/s13075-018-1638-4.

7.

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.

Pinazza M, Ghisi M, Minuzzo S, Agnusdei V, Fossati G, Ciminale V, Pezzè L, Ciribilli Y, Pilotto G, Venturoli C, Amadori A, Indraccolo S.

Oncogene. 2018 Jul;37(28):3839-3851. doi: 10.1038/s41388-018-0234-z. Epub 2018 Apr 12.

8.

The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.

Savino AM, Sarno J, Trentin L, Vieri M, Fazio G, Bardini M, Bugarin C, Fossati G, Davis KL, Gaipa G, Izraeli S, Meyer LH, Nolan GP, Biondi A, Te Kronnie G, Palmi C, Cazzaniga G.

Leukemia. 2017 Nov;31(11):2365-2375. doi: 10.1038/leu.2017.93. Epub 2017 Mar 23.

PMID:
28331226
9.

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells.

Angeletti F, Fossati G, Pattarozzi A, Würth R, Solari A, Daga A, Masiello I, Barbieri F, Florio T, Comincini S.

Front Mol Neurosci. 2016 Oct 27;9:107. eCollection 2016.

10.

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.

Angiolilli C, Kabala PA, Grabiec AM, Van Baarsen IM, Ferguson BS, García S, Malvar Fernandez B, McKinsey TA, Tak PP, Fossati G, Mascagni P, Baeten DL, Reedquist KA.

Ann Rheum Dis. 2017 Jan;76(1):277-285. doi: 10.1136/annrheumdis-2015-209064. Epub 2016 Jul 25.

11.

SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions.

Antonucci F, Corradini I, Fossati G, Tomasoni R, Menna E, Matteoli M.

Front Synaptic Neurosci. 2016 Mar 24;8:7. doi: 10.3389/fnsyn.2016.00007. eCollection 2016. Review.

12.

An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts.

Pinazza M, Borga C, Agnusdei V, Minuzzo S, Fossati G, Paganin M, Michielotto B, De Paoli A, Basso G, Amadori A, te Kronnie G, Indraccolo S.

Cell Death Dis. 2016 Jan 14;6:e2047. doi: 10.1038/cddis.2015.394.

13.

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.

Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, Ziv NE, Menna E, Matteoli M.

Cell Death Differ. 2015 Sep;22(9):1425-36. doi: 10.1038/cdd.2014.227. Epub 2015 Feb 13.

14.

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response.

Mensah AA, Kwee I, Gaudio E, Rinaldi A, Ponzoni M, Cascione L, Fossati G, Stathis A, Zucca E, Caprini G, Bertoni F.

Oncotarget. 2015 Mar 10;6(7):5059-71.

15.

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases.

Cleophas MC, Crişan TO, Lemmers H, Toenhake-Dijkstra H, Fossati G, Jansen TL, Dinarello CA, Netea MG, Joosten LA.

Ann Rheum Dis. 2016 Mar;75(3):593-600. doi: 10.1136/annrheumdis-2014-206258. Epub 2015 Jan 14.

PMID:
25589513
16.

Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo.

Li S, Fossati G, Marchetti C, Modena D, Pozzi P, Reznikov LL, Moras ML, Azam T, Abbate A, Mascagni P, Dinarello CA.

J Biol Chem. 2015 Jan 23;290(4):2368-78. doi: 10.1074/jbc.M114.618454. Epub 2014 Dec 1.

17.

Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.

Ronzoni L, Sonzogni L, Fossati G, Modena D, Trombetta E, Porretti L, Cappellini MD.

Br J Haematol. 2014 Jun;165(5):714-21. doi: 10.1111/bjh.12814. Epub 2014 Mar 7.

PMID:
24606390
18.

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.

Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9. doi: 10.1073/pnas.1320850111. Epub 2014 Jan 6.

19.

Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses.

Antonucci F, Corradini I, Morini R, Fossati G, Menna E, Pozzi D, Pacioni S, Verderio C, Bacci A, Matteoli M.

EMBO Rep. 2013 Jul;14(7):645-51. doi: 10.1038/embor.2013.75. Epub 2013 Jun 4.

20.

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.

Menna E, Zambetti S, Morini R, Donzelli A, Disanza A, Calvigioni D, Braida D, Nicolini C, Orlando M, Fossati G, Cristina Regondi M, Pattini L, Frassoni C, Francolini M, Scita G, Sala M, Fahnestock M, Matteoli M.

EMBO J. 2013 Jun 12;32(12):1730-44. doi: 10.1038/emboj.2013.107. Epub 2013 May 17.

21.

From filopodia to synapses: the role of actin-capping and anti-capping proteins.

Menna E, Fossati G, Scita G, Matteoli M.

Eur J Neurosci. 2011 Nov;34(10):1655-62. doi: 10.1111/j.1460-9568.2011.07897.x. Review.

22.

Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer.

Dinarello CA, Fossati G, Mascagni P.

Mol Med. 2011 May-Jun;17(5-6):333-52. doi: 10.2119/molmed.2011.00116. Epub 2011 May 5.

23.

Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).

Furlan A, Monzani V, Reznikov LL, Leoni F, Fossati G, Modena D, Mascagni P, Dinarello CA.

Mol Med. 2011 May-Jun;17(5-6):353-62. doi: 10.2119/molmed.2011.00020. Epub 2011 Feb 22.

24.

The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.

Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA.

J Acquir Immune Defic Syndr. 2010 May 1;54(1):1-9. doi: 10.1097/QAI.0b013e3181d3dca3.

25.

Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b.

Todoerti K, Barbui V, Pedrini O, Lionetti M, Fossati G, Mascagni P, Rambaldi A, Neri A, Introna M, Lombardi L, Golay J.

Haematologica. 2010 Feb;95(2):260-9. doi: 10.3324/haematol.2009.012088. Epub 2009 Aug 27.

26.

Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo.

Faraco G, Pittelli M, Cavone L, Fossati S, Porcu M, Mascagni P, Fossati G, Moroni F, Chiarugi A.

Neurobiol Dis. 2009 Nov;36(2):269-79. doi: 10.1016/j.nbd.2009.07.019. Epub 2009 Jul 25.

PMID:
19635561
27.

Low-grade fibromatosis-like spindle cell metaplastic carcinoma: a basal-like tumor with a favorable clinical outcome. Report of two cases.

Podetta M, D'Ambrosio G, Ferrari A, Sgarella A, Dal Bello B, Fossati GS, Zonta S, Silini E, Dionigi P.

Tumori. 2009 Mar-Apr;95(2):264-7.

PMID:
19579879
28.

[Ultrasonic videolaparoscopic cholecystectomy: evolution of a revolutionary technique].

Faccini M, Martellosio V, Marzo V, Viezzoli A, Gatti V, Abbiati F, Fossati GS.

Minerva Chir. 2009 Apr;64(2):205-10. Italian.

PMID:
19365321
29.
30.

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way.

Piccini A, Carta S, Tassi S, Lasiglié D, Fossati G, Rubartelli A.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8067-72. doi: 10.1073/pnas.0709684105. Epub 2008 Jun 3.

31.

ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation.

Bertuglia S, Ichimura H, Fossati G, Parthasarathi K, Leoni F, Modena D, Cremonesi P, Bhattacharya J, Mascagni P.

Mol Med. 2007 Nov-Dec;13(11-12):615-24.

32.

Selective anti-leukaemic activity of low-dose histone deacetylase inhibitor ITF2357 on AML1/ETO-positive cells.

Barbetti V, Gozzini A, Rovida E, Morandi A, Spinelli E, Fossati G, Mascagni P, Lübbert M, Dello Sbarba P, Santini V.

Oncogene. 2008 Mar 13;27(12):1767-78. Epub 2007 Sep 24.

PMID:
17891169
33.

The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells.

Golay J, Cuppini L, Leoni F, Micò C, Barbui V, Domenghini M, Lombardi L, Neri A, Barbui AM, Salvi A, Pozzi P, Porro G, Pagani P, Fossati G, Mascagni P, Introna M, Rambaldi A.

Leukemia. 2007 Sep;21(9):1892-900. Epub 2007 Jul 19.

PMID:
17637810
34.

Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents.

Nesbitt A, Fossati G, Bergin M, Stephens P, Stephens S, Foulkes R, Brown D, Robinson M, Bourne T.

Inflamm Bowel Dis. 2007 Nov;13(11):1323-32.

PMID:
17636564
35.

Total synthesis of tubulysins U and V.

Sani M, Fossati G, Huguenot F, Zanda M.

Angew Chem Int Ed Engl. 2007;46(19):3526-9. No abstract available.

PMID:
17397123
36.

Limited effect of rituximab on thrombocytopaenia and anticardiolipin antibodies in a patient with primary antiphospholipid syndrome.

Ames PR, Tommasino C, Fossati G, Scenna G, Brancaccio V, Ferrara F.

Ann Hematol. 2007 Mar;86(3):227-8. Epub 2006 Nov 21. No abstract available.

PMID:
17119963
37.

Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.

Faraco G, Pancani T, Formentini L, Mascagni P, Fossati G, Leoni F, Moroni F, Chiarugi A.

Mol Pharmacol. 2006 Dec;70(6):1876-84. Epub 2006 Aug 31.

PMID:
16946032
38.

Efforts toward the total synthesis of tubulysins: new hopes for a more effective targeted drug delivery to tumors.

Neri D, Fossati G, Zanda M.

ChemMedChem. 2006 Feb;1(2):175-80. Review. No abstract available.

PMID:
16892348
39.

Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules.

Carta S, Tassi S, Semino C, Fossati G, Mascagni P, Dinarello CA, Rubartelli A.

Blood. 2006 Sep 1;108(5):1618-26. Epub 2006 May 9.

40.

Short term palindromic rheumatism after clopidogrel use.

Ames PR, Fossati G, Tommasino C.

Ann Rheum Dis. 2006 May;65(5):700. No abstract available.

41.

The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.

Leoni F, Fossati G, Lewis EC, Lee JK, Porro G, Pagani P, Modena D, Moras ML, Pozzi P, Reznikov LL, Siegmund B, Fantuzzi G, Dinarello CA, Mascagni P.

Mol Med. 2005 Jan-Dec;11(1-12):1-15.

42.

Lymphocyte subpopulations and intima media thickness in primary antiphospholipd syndrome.

Ames PR, Tommasino C, Fossati G, Matsuura E, Margarita A, Saulino A, Lopez L, Scenna G, Brancaccio V.

Lupus. 2005;14(10):809-13.

PMID:
16302675
43.

Characterization of the folding landscape of monomeric lactose repressor: quantitative comparison of theory and experiment.

Das P, Wilson CJ, Fossati G, Wittung-Stafshede P, Matthews KS, Clementi C.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14569-74. Epub 2005 Oct 3.

44.

The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticity.

Fossati G, Cremonesi P, Izzo G, Rizzi E, Sandrone G, Harding S, Errington N, Walters C, Henderson B, Roberts MM, Coates AR, Mascagni P.

Biopolymers. 2004 Oct 5;75(2):148-62.

PMID:
15356869
45.

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W Jr, Alber T, Rupp B.

Tuberculosis (Edinb). 2003;83(4):223-49. Review.

PMID:
12906835
46.

Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane?

Fossati G, Izzo G, Rizzi E, Gancia E, Modena D, Moras ML, Niccolai N, Giannozzi E, Spiga O, Bono L, Marone P, Leone E, Mangili F, Harding S, Errington N, Walters C, Henderson B, Roberts MM, Coates AR, Casetta B, Mascagni P.

J Bacteriol. 2003 Jul;185(14):4256-67.

47.

Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops.

Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP.

J Bacteriol. 2003 Jul;185(14):4172-85.

48.

The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis.

Fossati G, Moulding DA, Spiller DG, Moots RJ, White MR, Edwards SW.

J Immunol. 2003 Feb 15;170(4):1964-72.

49.
50.

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.

Leoni F, Zaliani A, Bertolini G, Porro G, Pagani P, Pozzi P, Donà G, Fossati G, Sozzani S, Azam T, Bufler P, Fantuzzi G, Goncharov I, Kim SH, Pomerantz BJ, Reznikov LL, Siegmund B, Dinarello CA, Mascagni P.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2995-3000. Epub 2002 Feb 26.

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