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Items: 16


Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.

Chan PF, Srikannathasan V, Huang J, Cui H, Fosberry AP, Gu M, Hann MM, Hibbs M, Homes P, Ingraham K, Pizzollo J, Shen C, Shillings AJ, Spitzfaden CE, Tanner R, Theobald AJ, Stavenger RA, Bax BD, Gwynn MN.

Nat Commun. 2015 Dec 7;6:10048. doi: 10.1038/ncomms10048.


Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.

Srikannathasan V, Wohlkonig A, Shillings A, Singh O, Chan PF, Huang J, Gwynn MN, Fosberry AP, Homes P, Hibbs M, Theobald AJ, Spitzfaden C, Bax BD.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1242-6. doi: 10.1107/S2053230X15015290. Epub 2015 Sep 23.


Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance.

Wohlkonig A, Chan PF, Fosberry AP, Homes P, Huang J, Kranz M, Leydon VR, Miles TJ, Pearson ND, Perera RL, Shillings AJ, Gwynn MN, Bax BD.

Nat Struct Mol Biol. 2010 Sep;17(9):1152-3. doi: 10.1038/nsmb.1892. Epub 2010 Aug 29.


The dodecameric vanadium-dependent haloperoxidase from the marine algae Corallina officinalis: cloning, expression, and refolding of the recombinant enzyme.

Coupe EE, Smyth MG, Fosberry AP, Hall RM, Littlechild JA.

Protein Expr Purif. 2007 Apr;52(2):265-72. Epub 2006 Aug 30.


Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A.

Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9.


Potential of real-time measurement of GFP-fusion proteins.

Jones JJ, Bridges AM, Fosberry AP, Gardner S, Lowers RR, Newby RR, James PJ, Hall RM, Jenkins O.

J Biotechnol. 2004 Apr 8;109(1-2):201-11.


Nuclear magnetic resonance spectroscopy reveals the functional state of the signalling protein CheY in vivo in Escherichia coli.

Hubbard JA, MacLachlan LK, King GW, Jones JJ, Fosberry AP.

Mol Microbiol. 2003 Sep;49(5):1191-200.


The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Brown MJ, Carter PS, Fenwick AS, Fosberry AP, Hamprecht DW, Hibbs MJ, Jarvest RL, Mensah L, Milner PH, O'Hanlon PJ, Pope AJ, Richardson CM, West A, Witty DR.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3171-4.


Discovery of a novel and potent class of FabI-directed antibacterial agents.

Payne DJ, Miller WH, Berry V, Brosky J, Burgess WJ, Chen E, DeWolf WE Jr, Fosberry AP, Greenwood R, Head MS, Heerding DA, Janson CA, Jaworski DD, Keller PM, Manley PJ, Moore TD, Newlander KA, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Salyers KL, Seefeld MA, Smyth MG, Takata DT, Uzinskas IN, Vaidya K, Wallis NG, Winram SB, Yuan CC, Huffman WF.

Antimicrob Agents Chemother. 2002 Oct;46(10):3118-24.


Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A.

J Med Chem. 2002 May 9;45(10):1959-62.


A method for identification of inhibitors of the phosphorylation reactions of bacterial response regulator proteins using (31)P nuclear magnetic resonance spectroscopy.

Hubbard JA, MacLachlan LK, Johnson P, Findlow SC, Ladds JC, Lewis CJ, Carter PS, Jones JJ, Fosberry AP.

Anal Biochem. 2001 Dec 1;299(1):31-6.


Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.

Seefeld MA, Miller WH, Newlander KA, Burgess WJ, Payne DJ, Rittenhouse SF, Moore TD, DeWolf WE Jr, Keller PM, Qiu X, Janson CA, Vaidya K, Fosberry AP, Smyth MG, Jaworski DD, Slater-Radosti C, Huffman WF.

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2241-4.


1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5.


Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.

Hodgson JE, Fosberry AP, Rawlinson NS, Ross HN, Neal RJ, Arnell JC, Earl AJ, Lawlor EJ.

Gene. 1995 Dec 1;166(1):49-55.


Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BS.

Fosberry AP, Payne DJ, Lawlor EJ, Hodgson JE.

Antimicrob Agents Chemother. 1994 May;38(5):1182-5.


Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase.

Chalker AF, Ward JM, Fosberry AP, Hodgson JE.

Gene. 1994 Apr 8;141(1):103-8.


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