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Items: 36


Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi.

Souza ACO, Al Abdallah Q, DeJarnette K, Martin-Vicente A, Nywening AV, DeJarnette C, Sansevere EA, Ge W, Palmer GE, Fortwendel JR.

Virulence. 2019 Dec;10(1):511-526. doi: 10.1080/21505594.2019.1620063.


Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus.

Rybak JM, Ge W, Wiederhold NP, Parker JE, Kelly SL, Rogers PD, Fortwendel JR.

mBio. 2019 Apr 2;10(2). pii: e00437-19. doi: 10.1128/mBio.00437-19.


SH3-class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth.

Martin-Vicente A, Souza ACO, Al Abdallah Q, Ge W, Fortwendel JR.

Cell Microbiol. 2019 Jun;21(6):e13013. doi: 10.1111/cmi.13013. Epub 2019 Feb 15.


Emerging threat of triazole-resistant Aspergillus fumigatus.

Rybak JM, Fortwendel JR, Rogers PD.

J Antimicrob Chemother. 2019 Apr 1;74(4):835-842. doi: 10.1093/jac/dky517.


Whole-genome sequencing reveals highly specific gene targeting by in vitro assembled Cas9-ribonucleoprotein complexes in Aspergillus fumigatus.

Al Abdallah Q, Souza ACO, Martin-Vicente A, Ge W, Fortwendel JR.

Fungal Biol Biotechnol. 2018 Jun 5;5:11. doi: 10.1186/s40694-018-0057-2. eCollection 2018.


Commonly Used Oncology Drugs Decrease Antifungal Effectiveness against Candida and Aspergillus Species.

Butts A, Reitler P, Ge W, Fortwendel JR, Palmer GE.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00504-18. doi: 10.1128/AAC.00504-18. Print 2018 Jul.


C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus.

Al Abdallah Q, Martin-Vicente A, Souza ACO, Ge W, Fortwendel JR.

Front Microbiol. 2018 Mar 26;9:562. doi: 10.3389/fmicb.2018.00562. eCollection 2018.


A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus: In Vitro-Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates.

Al Abdallah Q, Ge W, Fortwendel JR.

mSphere. 2017 Nov 22;2(6). pii: e00446-17. doi: 10.1128/mSphere.00446-17. eCollection 2017 Nov-Dec.


The Aspergillus fumigatus farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility.

Norton TS, Al Abdallah Q, Hill AM, Lovingood RV, Fortwendel JR.

Virulence. 2017 Oct 3;8(7):1401-1416. doi: 10.1080/21505594.2017.1328343. Epub 2017 May 10.


A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus.

Al Abdallah Q, Norton TS, Hill AM, LeClaire LL, Fortwendel JR.

mSphere. 2016 Nov 30;1(6). pii: e00234-16. eCollection 2016 Nov-Dec.


Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice.

Ferretti A, Fortwendel JR, Gebb SA, Barrington RA.

J Immunol. 2016 Jul 15;197(2):470-9. doi: 10.4049/jimmunol.1502248. Epub 2016 Jun 8.


Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.

LeClaire LL, Fortwendel JR.

PLoS One. 2015 Nov 10;10(11):e0142535. doi: 10.1371/journal.pone.0142535. eCollection 2015.


Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets.

Al Abdallah Q, Fortwendel JR.

Front Microbiol. 2015 Feb 26;6:128. doi: 10.3389/fmicb.2015.00128. eCollection 2015.


Control of Ras-mediated signaling in Aspergillus fumigatus.

Norton TS, Fortwendel JR.

Mycopathologia. 2014 Dec;178(5-6):325-30. doi: 10.1007/s11046-014-9765-1. Epub 2014 Jun 22. Review.


Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus.

Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ.

PLoS Pathog. 2013;9(8):e1003564. doi: 10.1371/journal.ppat.1003564. Epub 2013 Aug 22.


Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Fortwendel JR, Steinbach WJ.

Eukaryot Cell. 2012 Nov;11(11):1324-32. doi: 10.1128/EC.00032-12. Epub 2012 Jul 20.


Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus.

Fortwendel JR, Juvvadi PR, Rogg LE, Asfaw YG, Burns KA, Randell SH, Steinbach WJ.

Eukaryot Cell. 2012 Aug;11(8):966-77. doi: 10.1128/EC.00091-12. Epub 2012 May 4.


Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.

Juvvadi PR, Fortwendel JR, Rogg LE, Burns KA, Randell SH, Steinbach WJ.

Mol Microbiol. 2011 Dec;82(5):1235-59. doi: 10.1111/j.1365-2958.2011.07886.x. Epub 2011 Nov 8.


The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus.

Rogg LE, Fortwendel JR, Juvvadi PR, Lilley A, Steinbach WJ.

Biochem Biophys Res Commun. 2011 Aug 5;411(3):549-54. doi: 10.1016/j.bbrc.2011.06.180. Epub 2011 Jul 5.


Regulation of expression, activity and localization of fungal chitin synthases.

Rogg LE, Fortwendel JR, Juvvadi PR, Steinbach WJ.

Med Mycol. 2012 Jan;50(1):2-17. doi: 10.3109/13693786.2011.577104. Epub 2011 Apr 28. Review.


Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.

Fortwendel JR, Juvvadi PR, Rogg LE, Steinbach WJ.

Eukaryot Cell. 2011 Apr;10(4):611-5. doi: 10.1128/EC.00315-10. Epub 2011 Jan 28.


Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions.

Juvvadi PR, Fortwendel JR, Rogg LE, Steinbach WJ.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):238-43. doi: 10.1016/j.bbrc.2011.01.017. Epub 2011 Jan 8.


Newer combination antifungal therapies for invasive aspergillosis.

Steinbach WJ, Juvvadi PR, Fortwendel JR, Rogg LE.

Med Mycol. 2011 Apr;49 Suppl 1:S77-81. doi: 10.3109/13693786.2010.499374. Epub 2010 Jul 7. Review.


Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.

Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ.

Antimicrob Agents Chemother. 2010 Apr;54(4):1555-63. doi: 10.1128/AAC.00854-09. Epub 2010 Feb 1.


The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis.

Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ.

Eukaryot Cell. 2010 Mar;9(3):472-6. doi: 10.1128/EC.00378-09. Epub 2010 Jan 22.


Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.

Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA Jr, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ.

Eukaryot Cell. 2009 Apr;8(4):511-9. doi: 10.1128/EC.00336-08. Epub 2009 Feb 27.


Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.

Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ.

Antimicrob Agents Chemother. 2009 Feb;53(2):476-82. doi: 10.1128/AAC.01154-08. Epub 2008 Nov 17.


Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.

Juvvadi PR, Fortwendel JR, Pinchai N, Perfect BZ, Heitman J, Steinbach WJ.

Eukaryot Cell. 2008 Sep;7(9):1606-10. doi: 10.1128/EC.00200-08. Epub 2008 Jul 7.


Aspergillus fumigatus RasA regulates asexual development and cell wall integrity.

Fortwendel JR, Fuller KK, Stephens TJ, Bacon WC, Askew DS, Rhodes JC.

Eukaryot Cell. 2008 Sep;7(9):1530-9. doi: 10.1128/EC.00080-08. Epub 2008 Jul 7.


Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence.

Zhao W, Panepinto JC, Fortwendel JR, Fox L, Oliver BG, Askew DS, Rhodes JC.

Infect Immun. 2006 Aug;74(8):4865-74.


A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus.

Fortwendel JR, Zhao W, Bhabhra R, Park S, Perlin DS, Askew DS, Rhodes JC.

Eukaryot Cell. 2005 Dec;4(12):1982-9. Erratum in: Eukaryot Cell. 2007 Jan;6(1):117.


Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development.

Fortwendel JR, Panepinto JC, Seitz AE, Askew DS, Rhodes JC.

Fungal Genet Biol. 2004 Feb;41(2):129-39.


Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis.

Panepinto JC, Oliver BG, Fortwendel JR, Smith DL, Askew DS, Rhodes JC.

Infect Immun. 2003 May;71(5):2819-26.


Cloning and expression of pkaC and pkaR, the genes encoding the cAMP-dependent protein kinase of Aspergillus fumigatus.

Oliver BG, Panepinto JC, Fortwendel JR, Smith DL, Askew DS, Rhodes JC.

Mycopathologia. 2002;154(2):85-91.


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