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Items: 29


Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death.

Secinaro MA, Fortner KA, Collins C, Rincón M, Budd RC.

Front Cell Dev Biol. 2019 Mar 11;7:28. doi: 10.3389/fcell.2019.00028. eCollection 2019.


Glycolysis promotes caspase-3 activation in lipid rafts in T cells.

Secinaro MA, Fortner KA, Dienz O, Logan A, Murphy MP, Anathy V, Boyson JE, Budd RC.

Cell Death Dis. 2018 Jan 19;9(2):62. doi: 10.1038/s41419-017-0099-z.


The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.

Fortner KA, Bond JP, Austin JW, Boss JM, Budd RC.

J Autoimmun. 2017 Aug;82:47-61. doi: 10.1016/j.jaut.2017.05.003. Epub 2017 May 24.


IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.

Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-Casás N, Silberger DJ, Weaver CT, Haynes L, Rincon M.

J Exp Med. 2016 Oct 17;213(11):2281-2291. Epub 2016 Sep 26.


Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

Collins CC, Bashant K, Erikson C, Thwe PM, Fortner KA, Wang H, Morita CT, Budd RC.

J Innate Immun. 2016;8(5):479-92. doi: 10.1159/000446498. Epub 2016 Jul 19.


Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus.

Champagne DP, Hatle KM, Fortner KA, D'Alessandro A, Thornton TM, Yang R, Torralba D, Tomás-Cortázar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M.

Immunity. 2016 Jun 21;44(6):1299-311. doi: 10.1016/j.immuni.2016.02.018. Epub 2016 May 24.


Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V.

J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4.


Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest.

Long PM, Tighe SW, Driscoll HE, Fortner KA, Viapiano MS, Jaworski DM.

J Cell Physiol. 2015 Aug;230(8):1929-43. doi: 10.1002/jcp.24927.


IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3.

Saligrama PT, Fortner KA, Secinaro MA, Collins CC, Russell JQ, Budd RC.

Cell Death Differ. 2014 Jun;21(6):904-14. doi: 10.1038/cdd.2014.10. Epub 2014 Feb 7.


The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.

Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC.

J Biol Chem. 2014 Jan 10;289(2):1183-91. doi: 10.1074/jbc.M113.506428. Epub 2013 Nov 25.


Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells.

Ather JL, Fortner KA, Budd RC, Anathy V, Poynter ME.

Cell Death Dis. 2013 Sep 5;4:e786. doi: 10.1038/cddis.2013.327.


Proliferating γδ T cells manifest high and spatially confined caspase-3 activity.

Koenig A, Fortner KA, King BR, Madden J, Buskiewicz IA, Budd RC.

Immunology. 2012 Apr;135(4):276-86. doi: 10.1111/j.1365-2567.2011.03540.x.


Increased caspase activity primes human Lyme arthritis synovial γδ T cells for proliferation and death.

Thai PT, Collins CC, Fortner KA, Koenig A, Hayes SM, Budd RC.

Hum Immunol. 2011 Dec;72(12):1168-75. doi: 10.1016/j.humimm.2011.08.019. Epub 2011 Sep 22.


Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells.

Shi C, Sahay B, Russell JQ, Fortner KA, Hardin N, Sellati TJ, Budd RC.

Infect Immun. 2011 Oct;79(10):3940-6. doi: 10.1128/IAI.00148-11. Epub 2011 Jul 18.


Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.

Fortner KA, Lees RK, MacDonald HR, Budd RC.

Int Immunol. 2011 Feb;23(2):75-88. doi: 10.1093/intimm/dxq466. Epub 2011 Jan 25.


Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation.

Fortner KA, Bouillet P, Strasser A, Budd RC.

Eur J Immunol. 2010 Nov;40(11):3043-53. doi: 10.1002/eji.201040577. Epub 2010 Oct 27.


Evidence that CD8 T-cell homeostasis and function remain intact during murine pregnancy.

Norton MT, Fortner KA, Oppenheimer KH, Bonney EA.

Immunology. 2010 Nov;131(3):426-37. doi: 10.1111/j.1365-2567.2010.03316.x.


Pregnancy alters the proliferation and apoptosis of mouse splenic erythroid lineage cells and leukocytes.

Norton MT, Fortner KA, Bizargity P, Bonney EA.

Biol Reprod. 2009 Sep;81(3):457-64. doi: 10.1095/biolreprod.109.076976. Epub 2009 Apr 15.


Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway.

Collins C, Shi C, Russell JQ, Fortner KA, Budd RC.

J Immunol. 2008 Aug 15;181(4):2392-8.


Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.

Hughes PD, Belz GT, Fortner KA, Budd RC, Strasser A, Bouillet P.

Immunity. 2008 Feb;28(2):197-205. doi: 10.1016/j.immuni.2007.12.017.


c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.

Hinshaw-Makepeace J, Huston G, Fortner KA, Russell JQ, Holoch D, Swain S, Budd RC.

Eur J Immunol. 2008 Jan;38(1):54-63.


Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation.

Wu W, Rinaldi L, Fortner KA, Russell JQ, Tschopp J, Irvin C, Budd RC.

J Immunol. 2004 Apr 15;172(8):4724-32.


The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.

Lens SM, Kataoka T, Fortner KA, Tinel A, Ferrero I, MacDonald RH, Hahne M, Beermann F, Attinger A, Orbea HA, Budd RC, Tschopp J.

Mol Cell Biol. 2002 Aug;22(15):5419-33.


Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?

Rincón M, Conze D, Weiss L, Diehl NL, Fortner KA, Yang D, Flavell RA, Enslen H, Whitmarsh A, Davis RJ.

Immunol Cell Biol. 2000 Apr;78(2):166-75. Review.


Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo.

Diehl NL, Enslen H, Fortner KA, Merritt C, Stetson N, Charland C, Flavell RA, Davis RJ, Rincón M.

J Exp Med. 2000 Jan 17;191(2):321-34.


Down-modulation of CD2 delays deletion of superantigen-responsive T cells.

Fortner KA, Russell JQ, Budd RC.

Eur J Immunol. 1998 Jan;28(1):70-9.


JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells.

Wilson DJ, Fortner KA, Lynch DH, Mattingly RR, Macara IG, Posada JA, Budd RC.

Eur J Immunol. 1996 May;26(5):989-94.


Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A.

Brondyk WH, McKiernan CJ, Fortner KA, Stabila P, Holz RW, Macara IG.

Mol Cell Biol. 1995 Mar;15(3):1137-43.

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