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Items: 1 to 50 of 60

1.

Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-β Precursor-Like Protein Activity.

Khanna MR, Fortini ME.

J Alzheimers Dis. 2015;46(4):913-28. doi: 10.3233/JAD-141491.

PMID:
26402626
2.

Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling.

Sasamura T, Matsuno K, Fortini ME.

PLoS Genet. 2013 Nov;9(11):e1003917. doi: 10.1371/journal.pgen.1003917. Epub 2013 Nov 7.

3.

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.

Groth C, Sasamura T, Khanna MR, Whitley M, Fortini ME.

Development. 2013 Jul;140(14):3018-27. doi: 10.1242/dev.088336. Epub 2013 Jun 19.

4.

Introduction--Notch in development and disease.

Fortini ME.

Semin Cell Dev Biol. 2012 Jun;23(4):419-20. doi: 10.1016/j.semcdb.2012.03.001. Epub 2012 Mar 7. No abstract available.

PMID:
22425963
5.

Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.

Groth C, Fortini ME.

Semin Cell Dev Biol. 2012 Jun;23(4):465-72. doi: 10.1016/j.semcdb.2012.01.016. Epub 2012 Jan 30. Review.

6.

Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila.

Yamakawa T, Yamada K, Sasamura T, Nakazawa N, Kanai M, Suzuki E, Fortini ME, Matsuno K.

Development. 2012 Feb;139(3):558-67. doi: 10.1242/dev.073858. Epub 2011 Dec 21.

7.

Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function.

McBride SM, Choi CH, Schoenfeld BP, Bell AJ, Liebelt DA, Ferreiro D, Choi RJ, Hinchey P, Kollaros M, Terlizzi AM, Ferrick NJ, Koenigsberg E, Rudominer RL, Sumida A, Chiorean S, Siwicki KK, Nguyen HT, Fortini ME, McDonald TV, Jongens TA.

J Neurosci. 2010 Jul 14;30(28):9510-22. doi: 10.1523/JNEUROSCI.1017-10.2010.

8.

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G.

Mol Cell Biol. 2010 Jul;30(13):3165-75. doi: 10.1128/MCB.00030-10. Epub 2010 Apr 26.

9.

Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.

Groth C, Alvord WG, Quiñones OA, Fortini ME.

Mol Pharmacol. 2010 Apr;77(4):567-74. doi: 10.1124/mol.109.062471. Epub 2010 Jan 11.

10.

Generation and characterization of monoclonal antibodies specific to Drosophila presenilin.

Cuc HT, Seo JB, Choi JK, Kim WT, Park SJ, Lee DW, Kim YS, Fortini ME, Koh YH.

Hybridoma (Larchmt). 2009 Jun;28(3):215-20. doi: 10.1089/hyb.2008.0086.

11.

Notch signaling: the core pathway and its posttranslational regulation.

Fortini ME.

Dev Cell. 2009 May;16(5):633-47. doi: 10.1016/j.devcel.2009.03.010. Review.

12.

Endocytic regulation of Notch signaling.

Fortini ME, Bilder D.

Curr Opin Genet Dev. 2009 Aug;19(4):323-8. doi: 10.1016/j.gde.2009.04.005. Epub 2009 May 15. Review.

13.

Inheritance of susceptibility to induction of nephroblastomas in the Noble rat.

Diwan BA, Timofeeva O, Rice JM, Yang Y, Sharma N, Fortini ME, Wang H, Perantoni AO.

Differentiation. 2009 Apr;77(4):424-32. doi: 10.1016/j.diff.2008.12.003. Epub 2009 Jan 29.

14.

Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006.

Tountas NA, Fortini ME.

Fly (Austin). 2007 Jan-Feb;1(1):47-54. Epub 2007 Jan 23. No abstract available.

PMID:
18690062
15.

The big brain aquaporin is required for endosome maturation and notch receptor trafficking.

Kanwar R, Fortini ME.

Cell. 2008 May 30;133(5):852-63. doi: 10.1016/j.cell.2008.04.038. Retraction in: Cell. 2010 Jul 9;142(1):170.

16.

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.

Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D.

J Cell Biol. 2008 Feb 25;180(4):755-62. doi: 10.1083/jcb.200708127.

17.

A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila.

Lu Y, Lv Y, Ye Y, Wang Y, Hong Y, Fortini ME, Zhong Y, Xie Z.

FASEB J. 2007 Aug;21(10):2368-78. Epub 2007 Apr 11.

PMID:
17428965
18.

Medicine. Anticipating trouble from gene transcription.

Fortini ME.

Science. 2007 Mar 30;315(5820):1800-1. No abstract available.

PMID:
17395816
19.
20.

Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila.

Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME.

Curr Biol. 2006 May 23;16(10):1026-33.

21.

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.

Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, Dotti CG, Fortini ME, Feiguin F.

Neuron. 2006 May 4;50(3):359-75. Retraction in: Dotti CG, Feiguin F, Fortini ME. Neuron. 2007 Feb 1;53(3):463.

22.

Notch signaling: a different sort makes the cut.

Kanwar R, Fortini ME.

Curr Biol. 2004 Dec 29;14(24):R1043-5. Review.

23.
24.

PAR-1 for the course of neurodegeneration.

Fortini ME.

Cell. 2004 Mar 5;116(5):631-2.

25.

Neurobiology: double trouble for neurons.

Fortini ME.

Nature. 2003 Oct 9;425(6958):565-6. No abstract available.

PMID:
14534567
26.
27.

Human neurodegenerative disease modeling using Drosophila.

Bonini NM, Fortini ME.

Annu Rev Neurosci. 2003;26:627-56. Epub 2003 Apr 10.

PMID:
12704223
28.

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.

Fortini ME.

Nat Rev Mol Cell Biol. 2002 Sep;3(9):673-84. Review.

PMID:
12209127
29.
30.

Applications of the Drosophila retina to human disease modeling.

Bonini NM, Fortini ME.

Results Probl Cell Differ. 2002;37:257-75. Review. No abstract available.

PMID:
25707079
31.

Sugar-coated pathways for developmental patterning.

Fortini ME.

Nat Cell Biol. 2001 Oct;3(10):E229-31. No abstract available.

PMID:
11584283
32.

Identification and characterization of the Drosophila tau homolog.

Heidary G, Fortini ME.

Mech Dev. 2001 Oct;108(1-2):171-8.

33.

Notch and presenilin: a proteolytic mechanism emerges.

Fortini ME.

Curr Opin Cell Biol. 2001 Oct;13(5):627-34. Review. Erratum in: Curr Opin Cell Biol 2001 Dec;13(6):785.

PMID:
11544033
34.

Proteolysis in Alzheimer's disease. Can plasmin tip the balance?

Periz G, Fortini ME.

EMBO Rep. 2000 Dec;1(6):477-8. No abstract available.

35.

Fringe benefits to carbohydrates.

Fortini ME.

Nature. 2000 Jul 27;406(6794):357-8. No abstract available.

PMID:
10935619
36.

A survey of human disease gene counterparts in the Drosophila genome.

Fortini ME, Skupski MP, Boguski MS, Hariharan IK.

J Cell Biol. 2000 Jul 24;150(2):F23-30. Review. No abstract available.

37.

Proteolysis and developmental signal transduction.

Ye Y, Fortini ME.

Semin Cell Dev Biol. 2000 Jun;11(3):211-21. Review.

PMID:
10906278
38.

Comparative genomics of the eukaryotes.

Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S.

Science. 2000 Mar 24;287(5461):2204-15.

39.

Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer.

Fortini ME, Bonini NM.

Trends Genet. 2000 Apr;16(4):161-7. Review.

PMID:
10729831
40.
41.
42.

Genetic analysis of the role of the drosophila fat facets gene in the ubiquitin pathway.

Wu Z, Li Q, Fortini ME, Fischer JA.

Dev Genet. 1999;25(4):312-20.

PMID:
10570463
43.
44.
45.
46.

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

Ye Y, Lukinova N, Fortini ME.

Nature. 1999 Apr 8;398(6727):525-9.

PMID:
10206647
47.

Analysis of dominant enhancers and suppressors of activated Notch in Drosophila.

Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S.

Genetics. 1996 Nov;144(3):1127-41.

48.

Notch signaling.

Artavanis-Tsakonas S, Matsuno K, Fortini ME.

Science. 1995 Apr 14;268(5208):225-32. Review.

PMID:
7716513
49.

The suppressor of hairless protein participates in notch receptor signaling.

Fortini ME, Artavanis-Tsakonas S.

Cell. 1994 Oct 21;79(2):273-82.

PMID:
7954795
50.

Notch: neurogenesis is only part of the picture.

Fortini ME, Artavanis-Tsakonas S.

Cell. 1993 Dec 31;75(7):1245-7. Review. No abstract available.

PMID:
8269507

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