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Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4.

Nalawade SA, Ji N, Raphael I, Pratt A 3rd, Kraig E, Forsthuber TG.

Cell Immunol. 2018 May 14. pii: S0008-8749(18)30202-8. doi: 10.1016/j.cellimm.2018.05.003. [Epub ahead of print]


Emerging drugs for primary progressive multiple sclerosis.

Narayan RN, Forsthuber T, Stüve O.

Expert Opin Emerg Drugs. 2018 Jun;23(2):97-110. doi: 10.1080/14728214.2018.1463370. Epub 2018 Apr 24.


B cell-based therapies in CNS autoimmunity: differentiating CD19 and CD20 as therapeutic targets.

Forsthuber TG, Cimbora DM, Ratchford JN, Katz E, Stüve O.

Ther Adv Neurol Disord. 2018 Mar 21;11:1756286418761697. doi: 10.1177/1756286418761697. eCollection 2018. Review.


Targeting "Retired Antigens" for Cancer Immunoprevention.

Shoemaker RH, Forsthuber TG.

Cancer Prev Res (Phila). 2017 Nov;10(11):607-608. doi: 10.1158/1940-6207.CAPR-17-0188.


B-cell-targeted therapies in relapsing forms of MS.

Dubey D, Forsthuber T, Flanagan EP, Pittock SJ, Stüve O.

Neurol Neuroimmunol Neuroinflamm. 2017 Oct 23;4(6):e405. doi: 10.1212/NXI.0000000000000405. eCollection 2017 Nov. Review.


Serum Neuroinflammatory Disease-Induced Central Nervous System Proteins Predict Clinical Onset of Experimental Autoimmune Encephalomyelitis.

Raphael I, Webb J, Gomez-Rivera F, Chase Huizar CA, Gupta R, Arulanandam BP, Wang Y, Haskins WE, Forsthuber TG.

Front Immunol. 2017 Jul 17;8:812. doi: 10.3389/fimmu.2017.00812. eCollection 2017.


Early response index: a statistic to discover potential early stage disease biomarkers.

Salekin S, Bari MG, Raphael I, Forsthuber TG, Zhang JM.

BMC Bioinformatics. 2017 Jun 23;18(1):313. doi: 10.1186/s12859-017-1712-y.


Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential.

Bloom J, Metz C, Nalawade S, Casabar J, Cheng KF, He M, Sherry B, Coleman T, Forsthuber T, Al-Abed Y.

J Biol Chem. 2016 Dec 16;291(51):26502-26514. Epub 2016 Oct 28.


Targeting "bad" B cells in multiple sclerosis: Could laquinimod be part of the armamentarium?

Forsthuber TG, Stuve O.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 21;3(5):e283. eCollection 2016 Oct. No abstract available.


M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis.

Cunningham AL, Guentzel MN, Yu JJ, Hung CY, Forsthuber TG, Navara CS, Yagita H, Williams IR, Klose KE, Eaves-Pyles TD, Arulanandam BP.

PLoS One. 2016 Apr 21;11(4):e0153402. doi: 10.1371/journal.pone.0153402. eCollection 2016.


Pentraxin 3: an immune modulator of infection and useful marker for disease severity assessment in sepsis.

Ketter P, Yu JJ, Cap AP, Forsthuber T, Arulanandam B.

Expert Rev Clin Immunol. 2016;12(5):501-7. doi: 10.1586/1744666X.2016.1166957. Epub 2016 Mar 31. Review.


IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.

Sosa RA, Murphey C, Robinson RR, Forsthuber TG.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5038-47. doi: 10.1073/pnas.1505955112. Epub 2015 Aug 24.


Macrophage migration inhibitory factor promotes resistance to glucocorticoid treatment in EAE.

Ji N, Kovalovsky A, Fingerle-Rowson G, Guentzel MN, Forsthuber TG.

Neurol Neuroimmunol Neuroinflamm. 2015 Aug 6;2(5):e139. doi: 10.1212/NXI.0000000000000139. eCollection 2015 Oct.


Antivirus immune activity in multiple sclerosis correlates with MRI activity.

Latham LB, Lee MJ, Lincoln JA, Ji N, Forsthuber TG, Lindsey JW.

Acta Neurol Scand. 2016 Jan;133(1):17-24. doi: 10.1111/ane.12417. Epub 2015 May 4.


Expert Review of Clinical Immunology 10-year anniversary issue. Foreword.

Forsthuber TG, Radstake TR.

Expert Rev Clin Immunol. 2015 Jan;11(1):1-3. doi: 10.1586/1744666X.2015.997215. No abstract available.


Body fluid biomarkers in multiple sclerosis: how far we have come and how they could affect the clinic now and in the future.

Raphael I, Webb J, Stuve O, Haskins W, Forsthuber T.

Expert Rev Clin Immunol. 2015 Jan;11(1):69-91. doi: 10.1586/1744666X.2015.991315. Epub 2014 Dec 18. Review.


T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.

Raphael I, Nalawade S, Eagar TN, Forsthuber TG.

Cytokine. 2015 Jul;74(1):5-17. doi: 10.1016/j.cyto.2014.09.011. Epub 2014 Oct 30. Review.


Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.

Shetty A, Gupta SG, Varrin-Doyer M, Weber MS, Prod'homme T, Molnarfi N, Ji N, Nelson PA, Patarroyo JC, Schulze-Topphoff U, Fogal SE, Forsthuber T, Sobel RA, Bernard CC, Slavin AJ, Zamvil SS.

Neurol Neuroimmunol Neuroinflamm. 2014 Aug 14;1(2):e22. doi: 10.1212/NXI.0000000000000022. eCollection 2014 Aug.


MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.

Varrin-Doyer M, Shetty A, Spencer CM, Schulze-Topphoff U, Weber MS, Bernard CC, Forsthuber T, Cree BA, Slavin AJ, Zamvil SS.

Neurol Neuroimmunol Neuroinflamm. 2014 Aug 14;1(2):e20. doi: 10.1212/NXI.0000000000000020. eCollection 2014 Aug.


Microwave & magnetic (M2) proteomics reveals CNS-specific protein expression waves that precede clinical symptoms of experimental autoimmune encephalomyelitis.

Raphael I, Mahesula S, Purkar A, Black D, Catala A, Gelfond JA, Forsthuber TG, Haskins WE.

Sci Rep. 2014 Sep 3;4:6210. doi: 10.1038/srep06210.


ELISPOT Techniques.

Ji N, Forsthuber TG.

Methods Mol Biol. 2016;1304:63-71. doi: 10.1007/7651_2014_111.


CD19 as a molecular target in CNS autoimmunity.

Stüve O, Warnke C, Deason K, Stangel M, Kieseier BC, Hartung HP, von Büdingen HC, Centonze D, Forsthuber TG, Knappertz V.

Acta Neuropathol. 2014 Aug;128(2):177-90. doi: 10.1007/s00401-014-1313-z. Epub 2014 Jul 4. Review.


The kinetics of myelin antigen uptake by myeloid cells in the central nervous system during experimental autoimmune encephalomyelitis.

Sosa RA, Murphey C, Ji N, Cardona AE, Forsthuber TG.

J Immunol. 2013 Dec 15;191(12):5848-57. doi: 10.4049/jimmunol.1300771. Epub 2013 Nov 13.


Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis.

Ji N, Somanaboeina A, Dixit A, Kawamura K, Hayward NJ, Self C, Olson GL, Forsthuber TG.

J Immunol. 2013 Nov 15;191(10):5074-84. doi: 10.4049/jimmunol.1300407. Epub 2013 Oct 11.


A T cell epitope-based vaccine protects against chlamydial infection in HLA-DR4 transgenic mice.

Li W, Murthy AK, Lanka GK, Chetty SL, Yu JJ, Chambers JP, Zhong G, Forsthuber TG, Guentzel MN, Arulanandam BP.

Vaccine. 2013 Nov 19;31(48):5722-8. doi: 10.1016/j.vaccine.2013.09.036. Epub 2013 Oct 1.


Anti-CRLF2 Antibody-Armored Biodegradable Nanoparticles for Childhood B-ALL.

Raghunathan R, Mahesula S, Kancharla K, Janardhanan P, Jadhav YL, Nadeau R, Villa GP, Cook RL, Witt CM, Gelfond JA, Forsthuber TG, Haskins WE.

Part Part Syst Charact. 2013 Apr;30(4):355-364.


Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation.

Garcia JA, Pino PA, Mizutani M, Cardona SM, Charo IF, Ransohoff RM, Forsthuber TG, Cardona AE.

J Immunol. 2013 Aug 1;191(3):1063-72. doi: 10.4049/jimmunol.1300040. Epub 2013 Jul 1.


Mast cells: multitalented facilitators of protection against bacterial pathogens.

Trivedi NH, Guentzel MN, Rodriguez AR, Yu JJ, Forsthuber TG, Arulanandam BP.

Expert Rev Clin Immunol. 2013 Feb;9(2):129-38. doi: 10.1586/eci.12.95. Review.


Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

Raphael I, Mahesula S, Kalsaria K, Kotagiri V, Purkar AB, Anjanappa M, Shah D, Pericherla V, Jadhav YL, Raghunathan R, Vaynberg M, Noriega D, Grimaldo NH, Wenk C, Gelfond JA, Forsthuber TG, Haskins WE.

Electrophoresis. 2012 Dec;33(24):3810-9. doi: 10.1002/elps.201200200. Erratum in: Electrophoresis. 2013 Nov;34(20-21):3100.


Immunoenrichment microwave and magnetic proteomics for quantifying CD47 in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

Mahesula S, Raphael I, Raghunathan R, Kalsaria K, Kotagiri V, Purkar AB, Anjanappa M, Shah D, Pericherla V, Jadhav YL, Gelfond JA, Forsthuber TG, Haskins WE.

Electrophoresis. 2012 Dec;33(24):3820-9. doi: 10.1002/elps.201200515.


Human aquaporin 4281-300 is the immunodominant linear determinant in the context of HLA-DRB1*03:01: relevance for diagnosing and monitoring patients with neuromyelitis optica.

Arellano B, Hussain R, Zacharias T, Yoon J, David C, Zein S, Steinman L, Forsthuber T, Greenberg BM, Lambracht-Washington D, Ritchie AM, Bennett JL, Stüve O.

Arch Neurol. 2012 Sep;69(9):1125-31. doi: 10.1001/archneurol.2012.1300.


Stability of T-cell lineages in autoimmune diseases.

Raphael I, Forsthuber TG.

Expert Rev Clin Immunol. 2012 May;8(4):299-301. doi: 10.1586/eci.12.22. No abstract available.


Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis.

Rodriguez AR, Yu JJ, Guentzel MN, Navara CS, Klose KE, Forsthuber TG, Chambers JP, Berton MT, Arulanandam BP.

J Immunol. 2012 Jun 1;188(11):5604-11. doi: 10.4049/jimmunol.1200039. Epub 2012 Apr 23.


The critical role of antigen-presentation-induced cytokine crosstalk in the central nervous system in multiple sclerosis and experimental autoimmune encephalomyelitis.

Sosa RA, Forsthuber TG.

J Interferon Cytokine Res. 2011 Oct;31(10):753-68. doi: 10.1089/jir.2011.0052. Epub 2011 Sep 15. Review.


Non-FcεR bearing mast cells secrete sufficient interleukin-4 to control Francisella tularensis replication within macrophages.

Thathiah P, Sanapala S, Rodriguez AR, Yu JJ, Murthy AK, Guentzel MN, Forsthuber TG, Chambers JP, Arulanandam BP.

Cytokine. 2011 Aug;55(2):211-20. doi: 10.1016/j.cyto.2011.04.009. Epub 2011 May 12.


Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection.

Murthy AK, Li W, Chaganty BK, Kamalakaran S, Guentzel MN, Seshu J, Forsthuber TG, Zhong G, Arulanandam BP.

Infect Immun. 2011 Jul;79(7):2928-35. doi: 10.1128/IAI.05022-11. Epub 2011 May 2.


More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases.

Ji N, Sosa RA, Forsthuber TG.

Immunotherapy. 2011 Mar;3(3):435-41. doi: 10.2217/imt.10.111. Review.


Anaphylaxis and mortality induced by treatment of mice with anti-VLA-4 antibody and pertussis toxin.

Ji N, Rao N, Guentzel NM, Arulanandam BP, Forsthuber TG.

J Immunol. 2011 Mar 1;186(5):2750-6. doi: 10.4049/jimmunol.1000907. Epub 2011 Jan 26.


Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift.

Cantor JR, Yoo TH, Dixit A, Iverson BL, Forsthuber TG, Georgiou G.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1272-7. doi: 10.1073/pnas.1014739108. Epub 2011 Jan 5.


Induction of polyclonal CD8+ T cell activation and effector function by Pertussis toxin.

Murphey C, Chang S, Zhang X, Arulanandam B, Forsthuber TG.

Cell Immunol. 2011;267(1):50-5. doi: 10.1016/j.cellimm.2010.11.003. Epub 2010 Nov 13.


Mast cell/IL-4 control of Francisella tularensis replication and host cell death is associated with increased ATP production and phagosomal acidification.

Rodriguez AR, Yu JJ, Murthy AK, Guentzel MN, Klose KE, Forsthuber TG, Chambers JP, Berton MT, Arulanandam BP.

Mucosal Immunol. 2011 Mar;4(2):217-26. doi: 10.1038/mi.2010.59. Epub 2010 Sep 22.


Immunization with a combination of integral chlamydial antigens and a defined secreted protein induces robust immunity against genital chlamydial challenge.

Li W, Murthy AK, Guentzel MN, Chambers JP, Forsthuber TG, Seshu J, Zhong G, Arulanandam BP.

Infect Immun. 2010 Sep;78(9):3942-9. doi: 10.1128/IAI.00346-10. Epub 2010 Jul 6.


Kinetics of IL-17- and interferon-gamma-producing PLPp-specific CD4 T cells in EAE induced by coinjection of PLPp/IFA with pertussis toxin in SJL mice.

Hofstetter HH, Forsthuber TG.

Neurosci Lett. 2010 Jun 7;476(3):150-5. doi: 10.1016/j.neulet.2010.04.018. Epub 2010 Apr 14.


The contribution of interleukin-12/interferon-gamma axis in protection against neonatal pulmonary Chlamydia muridarum challenge.

Jupelli M, Selby DM, Guentzel MN, Chambers JP, Forsthuber TG, Zhong G, Murthy AK, Arulanandam BP.

J Interferon Cytokine Res. 2010 Jun;30(6):407-15. doi: 10.1089/jir.2009.0083.


Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice.

Yu JJ, Goluguri T, Guentzel MN, Chambers JP, Murthy AK, Klose KE, Forsthuber TG, Arulanandam BP.

Clin Vaccine Immunol. 2010 Feb;17(2):215-22. doi: 10.1128/CVI.00361-09. Epub 2009 Dec 16.


Prosurvival and proapoptotic functions of ERK1/2 activation in murine thymocytes in vitro.

Smirnova IS, Chang S, Forsthuber TG.

Cell Immunol. 2010;261(1):29-36. doi: 10.1016/j.cellimm.2009.10.008. Epub 2009 Oct 19.


Is there a place for 'immuno' in the immunotherapy of multiple sclerosis?

Forsthuber TG, Muraro P.

Immunotherapy. 2009 May;1(3):329-31. doi: 10.2217/imt.09.15. No abstract available.


Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4.

Ketavarapu JM, Rodriguez AR, Yu JJ, Cong Y, Murthy AK, Forsthuber TG, Guentzel MN, Klose KE, Berton MT, Arulanandam BP.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9313-8. doi: 10.1073/pnas.0707636105. Epub 2008 Jun 30.


Trends in HLA antibody screening and identification and their role in transplantation.

Murphey CL, Forsthuber TG.

Expert Rev Clin Immunol. 2008 May;4(3):391-9. doi: 10.1586/1744666X.4.3.391.


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