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Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia.

Doostparast Torshizi A, Armoskus C, Zhang H, Forrest MP, Zhang S, Souaiaia T, Evgrafov OV, Knowles JA, Duan J, Wang K.

Sci Adv. 2019 Sep 11;5(9):eaau4139. doi: 10.1126/sciadv.aau4139. eCollection 2019 Sep.


Proteolysis and Oxidation of Therapeutic Proteins After Intradermal or Subcutaneous Administration.

Varkhede N, Bommana R, Schöneich C, Forrest ML.

J Pharm Sci. 2019 Aug 10. pii: S0022-3549(19)30499-X. doi: 10.1016/j.xphs.2019.08.005. [Epub ahead of print] Review.


Effect of hands-on interprofessional simulation training for local emergencies in Scotland: the THISTLE stepped-wedge design randomised controlled trial.

Lenguerrand E, Winter C, Siassakos D, MacLennan G, Innes K, Lynch P, Cameron A, Crofts J, McDonald A, McCormack K, Forrest M, Norrie J, Bhattacharya S, Draycott T.

BMJ Qual Saf. 2019 Jul 13. pii: bmjqs-2018-008625. doi: 10.1136/bmjqs-2018-008625. [Epub ahead of print]


Effect of Iron Oxide Nanoparticles on the Oxidation and Secondary Structure of Growth Hormone.

Varkhede N, Peters BH, Wei Y, Middaugh CR, Schöneich C, Forrest ML.

J Pharm Sci. 2019 Oct;108(10):3372-3381. doi: 10.1016/j.xphs.2019.06.007. Epub 2019 Jun 16.


Formulation and preclinical evaluation of a toll-like receptor 7/8 agonist as an anti-tumoral immunomodulator.

Lu R, Groer C, Kleindl PA, Moulder KR, Huang A, Hunt JR, Cai S, Aires DJ, Berkland C, Forrest ML.

J Control Release. 2019 Jul 28;306:165-176. doi: 10.1016/j.jconrel.2019.06.003. Epub 2019 Jun 4.


Protocol for a Randomised controlled trial to Evaluate the effectiveness and cost benefit of prescribing high dose FLuoride toothpaste in preventing and treating dEntal Caries in high-risk older adulTs (reflect trial).

Tickle M, Ricketts DJN, Duncan A, O'Malley L, Donaldson PM, Clarkson JE, Black M, Boyers D, Donaldson M, Floate R, Forrest MM, Fraser A, Glenny AM, Goulao B, McDonald A, Ramsay CR, Ross C, Walsh T, Worthington HV, Young L, Bonetti DL, Gouick J, Mitchell FE, Macpherson LE, Lin YL, Pretty IA, Birch S.

BMC Oral Health. 2019 May 24;19(1):88. doi: 10.1186/s12903-019-0749-x.


Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization.

Donneys A, Yang Q, Forrest ML, Nelson NS, Zhang T, Ettinger R, Ranganathan K, Snider A, Deshpande SS, Cohen MS, Buchman SR.

NPJ Regen Med. 2019 May 21;4:11. doi: 10.1038/s41536-019-0072-9. eCollection 2019.


A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling.

Schürmann B, Bermingham DP, Kopeikina KJ, Myczek K, Yoon S, Horan KE, Kelly CJ, Martin-de-Saavedra MD, Forrest MP, Fawcett-Patel JM, Smith KR, Gao R, Bach A, Burette AC, Rappoport JZ, Weinberg RJ, Martina M, Penzes P.

Mol Psychiatry. 2019 Apr 9. doi: 10.1038/s41380-019-0407-3. [Epub ahead of print]


Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer.

Li C, He C, Xu Y, Xu H, Tang Y, Chavan H, Duan S, Artigues A, Forrest ML, Krishnamurthy P, Han S, Holzbeierlein JM, Li B.

Prostate. 2019 May;79(6):628-639. doi: 10.1002/pros.23767. Epub 2019 Jan 20.


Convergent Evidence That ZNF804A Is a Regulator of Pre-messenger RNA Processing and Gene Expression.

Chapman RM, Tinsley CL, Hill MJ, Forrest MP, Tansey KE, Pardiñas AF, Rees E, Doyle AM, Wilkinson LS, Owen MJ, O'Donovan MC, Blake DJ.

Schizophr Bull. 2018 Dec 29. doi: 10.1093/schbul/sby183. [Epub ahead of print]


Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation.

Song JY, Larson NR, Thati S, Torres-Vazquez I, Martinez-Rivera N, Subelzu NJ, Leon MA, Rosa-Molinar E, Schöneich C, Forrest ML, Middaugh CR, Berkland CJ.

J Control Release. 2019 Jan 10;293:36-47. doi: 10.1016/j.jconrel.2018.11.007. Epub 2018 Nov 7.


Injectable Chemotherapy Downstaged Oral Squamous Cell Carcinoma from Nonresectable to Resectable in a Rescue Dog: Diagnosis, Treatment, and Outcome.

Cai S, Zhang T, Groer C, Forrest M, Aires D, Otte V, Barchman S, Faerber A, Forrest ML.

Case Rep Vet Med. 2018 Oct 8;2018:9078537. doi: 10.1155/2018/9078537. eCollection 2018.


The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer.

Somasundaram S, Forrest ME, Moinova H, Cohen A, Varadan V, LaFramboise T, Markowitz S, Khalil AM.

Clin Epigenetics. 2018 Oct 22;10(1):127. doi: 10.1186/s13148-018-0555-3.


DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways.

Maayah ZH, Zhang T, Forrest ML, Alrushaid S, Doschak MR, Davies NM, El-Kadi AOS.

Pharmaceutics. 2018 Sep 4;10(3). pii: E144. doi: 10.3390/pharmaceutics10030144.


Injury Prevention Strategies for Adolescent Cricket Pace Bowlers.

Forrest MRL, Scott BR, Hebert JJ, Dempsey AR.

Sports Med. 2018 Nov;48(11):2449-2461. doi: 10.1007/s40279-018-0981-6. Review.


PrimedRPA: primer design for recombinase polymerase amplification assays.

Higgins M, Ravenhall M, Ward D, Phelan J, Ibrahim A, Forrest MS, Clark TG, Campino S.

Bioinformatics. 2019 Feb 15;35(4):682-684. doi: 10.1093/bioinformatics/bty701.


Correction to: Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.

Alrushaid S, Zhao Y, Sayre CL, Maayah ZH, Forrest ML, Senadheera SN, Chaboyer K, Anderson HD, El-Kadi AOS, Davies NM.

Drug Deliv Transl Res. 2018 Oct;8(5):1592. doi: 10.1007/s13346-018-0569-6.


Exercise Timing in Type 2 Diabetes Mellitus: A Systematic Review.

Teo SYM, Kanaley JA, Guelfi KJ, Cook SB, Hebert JJ, Forrest MRL, Fairchild TJ.

Med Sci Sports Exerc. 2018 Dec;50(12):2387-2397. doi: 10.1249/MSS.0000000000001732.


Correction to: A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice.

Varkhede N, Patel N, Chang W, Ruterbories K, Forrest ML.

Pharm Res. 2018 Jul 25;35(9):180. doi: 10.1007/s11095-018-2463-9.


Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multicentre cross-sectional preclinical evaluation.

Harding-Esch EM, Fuller SS, Chow SC, Nori AV, Harrison MA, Parker M, Piepenburg O, Forrest MS, Brooks DG, Patel R, Hay PE, Fearnley N, Pond MJ, Dunbar JK, Butcher PD, Planche T, Lowndes CM, Sadiq ST.

Clin Microbiol Infect. 2019 Mar;25(3):380.e1-380.e7. doi: 10.1016/j.cmi.2018.06.003. Epub 2018 Jun 12.


Colon Cancer-Upregulated Long Non-Coding RNA lincDUSP Regulates Cell Cycle Genes and Potentiates Resistance to Apoptosis.

Forrest ME, Saiakhova A, Beard L, Buchner DA, Scacheri PC, LaFramboise T, Markowitz S, Khalil AM.

Sci Rep. 2018 May 9;8(1):7324. doi: 10.1038/s41598-018-25530-5.


CNTNAP2 stabilizes interneuron dendritic arbors through CASK.

Gao R, Piguel NH, Melendez-Zaidi AE, Martin-de-Saavedra MD, Yoon S, Forrest MP, Myczek K, Zhang G, Russell TA, Csernansky JG, Surmeier DJ, Penzes P.

Mol Psychiatry. 2018 Sep;23(9):1832-1850. doi: 10.1038/s41380-018-0027-3. Epub 2018 Apr 9.


Dendritic structural plasticity and neuropsychiatric disease.

Forrest MP, Parnell E, Penzes P.

Nat Rev Neurosci. 2018 Mar 16;19(4):215-234. doi: 10.1038/nrn.2018.16. Review.


Olaparib-induced Adaptive Response Is Disrupted by FOXM1 Targeting that Enhances Sensitivity to PARP Inhibition.

Fang P, Madden JA, Neums L, Moulder RK, Forrest ML, Chien J.

Mol Cancer Res. 2018 Jun;16(6):961-973. doi: 10.1158/1541-7786.MCR-17-0607. Epub 2018 Mar 15.


Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): study protocol for a randomised controlled trial.

Constable L, Cotterill N, Cooper D, Glazener C, Drake MJ, Forrest M, Harding C, Kilonzo M, MacLennan G, McCormack K, McDonald A, Mundy A, Norrie J, Pickard R, Ramsay C, Smith R, Wileman S, Abrams P; (Chief Investigator) for the MASTER Study Group.

Trials. 2018 Feb 21;19(1):131. doi: 10.1186/s13063-018-2501-2.


Duplex recombinase polymerase amplification assays incorporating competitive internal controls for bacterial meningitis detection.

Higgins O, Clancy E, Forrest MS, Piepenburg O, Cormican M, Boo TW, O'Sullivan N, McGuinness C, Cafferty D, Cunney R, Smith TJ.

Anal Biochem. 2018 Apr 1;546:10-16. doi: 10.1016/j.ab.2018.01.016. Epub 2018 Jan 31.


HEALTH: laparoscopic supracervical hysterectomy versus second-generation endometrial ablation for the treatment of heavy menstrual bleeding: study protocol for a randomised controlled trial.

Cooper K, McCormack K, Breeman S, Wood J, Scott NW, Clark J, Hawe J, Hawthorn R, Phillips K, Hyde A, McDonald A, Forrest M, Wileman S, Scotland G, Norrie J, Bhattacharya S; HEALTH Study Group.

Trials. 2018 Jan 24;19(1):63. doi: 10.1186/s13063-017-2374-9.


A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.

Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P.

Biol Psychiatry. 2018 Mar 15;83(6):499-508. doi: 10.1016/j.biopsych.2017.10.024. Epub 2017 Nov 7.


The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability.

Forrest MP, Hill MJ, Kavanagh DH, Tansey KE, Waite AJ, Blake DJ.

Schizophr Bull. 2018 Aug 20;44(5):1100-1110. doi: 10.1093/schbul/sbx164.


Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.

Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P.

J Neurosci. 2017 Nov 15;37(46):11127-11139. doi: 10.1523/JNEUROSCI.1153-17.2017. Epub 2017 Oct 13.


A pragmatic group sequential, placebo-controlled, randomised trial to determine the effectiveness of glyceryl trinitrate for retained placenta (GOT-IT): a study protocol.

Denison FC, Norrie J, Lawton J, Norman JE, Scotland G, McPherson GC, McDonald A, Forrest M, Hudson J, Brewin J, Peace M, Clarkson C, Brook-Smith S, Morrow S, Hallowell N, Hodges L, Carruthers KF.

BMJ Open. 2017 Sep 18;7(9):e017134. doi: 10.1136/bmjopen-2017-017134.


Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative.

Alrushaid S, Sayre CL, Yáñez JA, Forrest ML, Senadheera SN, Burczynski FJ, Löbenberg R, Davies NM.

Pharmaceutics. 2017 Sep 13;9(3). pii: E35. doi: 10.3390/pharmaceutics9030035.


THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial.

Lenguerrand E, Winter C, Innes K, MacLennan G, Siassakos D, Lynch P, Cameron A, Crofts J, McDonald A, McCormack K, Forrest M, Norrie J, Bhattacharya S, Draycott T; Thistle group.

BMC Pregnancy Childbirth. 2017 Sep 7;17(1):294. doi: 10.1186/s12884-017-1455-9.


Risk Factors for Non-Contact Injury in Adolescent Cricket Pace Bowlers: A Systematic Review.

Forrest MRL, Hebert JJ, Scott BR, Brini S, Dempsey AR.

Sports Med. 2017 Dec;47(12):2603-2619. doi: 10.1007/s40279-017-0778-z. Review.


Profiling the Photochemical-Induced Degradation of Rat Growth Hormone with Extreme Ultra-pressure Chromatography-Mass Spectrometry Utilizing Meter-Long Microcapillary Columns Packed with Sub-2-μm Particles.

Mozziconacci O, Stobaugh JT, Bommana R, Woods J, Franklin E, Jorgenson JW, Forrest ML, Schöneich C, Stobaugh JF.

Chromatographia. 2017 Sep;80(9):1299-1318. doi: 10.1007/s10337-017-3344-9. Epub 2017 Jul 4.


Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J.

Cell Stem Cell. 2017 Sep 7;21(3):305-318.e8. doi: 10.1016/j.stem.2017.07.008. Epub 2017 Aug 10.


Comparative Characterization of Crofelemer Samples Using Data Mining and Machine Learning Approaches With Analytical Stability Data Sets.

Nariya MK, Kim JH, Xiong J, Kleindl PA, Hewarathna A, Fisher AC, Joshi SB, Schöneich C, Forrest ML, Middaugh CR, Volkin DB, Deeds EJ.

J Pharm Sci. 2017 Nov;106(11):3270-3279. doi: 10.1016/j.xphs.2017.07.013. Epub 2017 Jul 22.


The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs.

Kleindl PA, Xiong J, Hewarathna A, Mozziconacci O, Nariya MK, Fisher AC, Deeds EJ, Joshi SB, Middaugh CR, Schöneich C, Volkin DB, Forrest ML.

J Pharm Sci. 2017 Nov;106(11):3242-3256. doi: 10.1016/j.xphs.2017.07.012. Epub 2017 Jul 22.


Chemical Stability of the Botanical Drug Substance Crofelemer: A Model System for Comparative Characterization of Complex Mixture Drugs.

Hewarathna A, Mozziconacci O, Nariya MK, Kleindl PA, Xiong J, Fisher AC, Joshi SB, Middaugh CR, Forrest ML, Volkin DB, Deeds EJ, Schöneich C.

J Pharm Sci. 2017 Nov;106(11):3257-3269. doi: 10.1016/j.xphs.2017.06.022. Epub 2017 Jul 5.


A human-driven decline in global burned area.

Andela N, Morton DC, Giglio L, Chen Y, van der Werf GR, Kasibhatla PS, DeFries RS, Collatz GJ, Hantson S, Kloster S, Bachelet D, Forrest M, Lasslop G, Li F, Mangeon S, Melton JR, Yue C, Randerson JT.

Science. 2017 Jun 30;356(6345):1356-1362. doi: 10.1126/science.aal4108.


Characterization of a novel p110β-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells.

He C, Duan S, Dong L, Wang Y, Hu Q, Liu C, Forrest ML, Holzbeierlein JM, Han S, Li B.

Prostate. 2017 Aug;77(11):1187-1198. doi: 10.1002/pros.23377. Epub 2017 Jun 20.


Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage.

Somoza RA, Correa D, Labat I, Sternberg H, Forrest ME, Khalil AM, West MD, Tesar P, Caplan AI.

Tissue Eng Part A. 2018 Feb;24(3-4):335-350. doi: 10.1089/ten.TEA.2016.0559. Epub 2017 Jul 28.


Formation of platinum (II) as a six member ring for sustained polymeric delivery.

Senadheera SN, Zhang T, Groer CE, Forrest ML.

Eur J Med Chem. 2017 Aug 18;136:452-456. doi: 10.1016/j.ejmech.2017.05.020. Epub 2017 May 6.


Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.

Alrushaid S, Zhao Y, Sayre CL, Maayah ZH, Forrest ML, Senadheera SN, Chaboyer K, Anderson HD, El-Kadi AOS, Davies NM.

Drug Deliv Transl Res. 2017 Aug;7(4):582-597. doi: 10.1007/s13346-017-0379-2. Erratum in: Drug Deliv Transl Res. 2018 Oct;8(5):1592.


Batrachochytrium dendrobatidis and the Decline and Survival of the Relict Leopard Frog.

Jaeger JR, Waddle AW, Rivera R, Harrison DT, Ellison S, Forrest MJ, Vredenburg VT, van Breukelen F.

Ecohealth. 2017 Jun;14(2):285-295. doi: 10.1007/s10393-017-1240-2. Epub 2017 Apr 24.


Review: Regulation of the cancer epigenome by long non-coding RNAs.

Forrest ME, Khalil AM.

Cancer Lett. 2017 Oct 28;407:106-112. doi: 10.1016/j.canlet.2017.03.040. Epub 2017 Apr 9. Review.


Incentivised chronic disease management and the inverse equity hypothesis: findings from a longitudinal analysis of Scottish primary care practice-level data.

Lowrie R, McConnachie A, Williamson AE, Kontopantelis E, Forrest M, Lannigan N, Mercer SW, Mair FS.

BMC Med. 2017 Apr 11;15(1):77. doi: 10.1186/s12916-017-0833-5.


Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats.

Zhou X, Forrest MJ, Sharif-Rodriguez W, Forrest G, Szeto D, Urosevic-Price O, Zhu Y, Stevenson AS, Zhou Y, Stribling S, Dajee M, Walsh SP, Pasternak A, Sullivan KA.

Hypertension. 2017 Feb;69(2):332-338. doi: 10.1161/HYPERTENSIONAHA.116.08358. Epub 2016 Dec 5.


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