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Items: 1 to 50 of 336

1.

Global metabolomic responses in urine from atm deficient mice in response to LD50/30 gamma irradiation doses.

Laiakis EC, Mak TD, Strawn SJ, Wang YW, Moon BH, Ake P, Fornace AJ Jr.

Environ Mol Mutagen. 2018 Aug 10. doi: 10.1002/em.22202. [Epub ahead of print]

PMID:
30095186
2.

A Metabolomic Serum Signature from Nonhuman Primates Treated with a Radiation Countermeasure, Gamma-tocotrienol, and Exposed to Ionizing Radiation.

Pannkuk EL, Laiakis EC, Fornace AJ Jr, Fatanmi OO, Singh VK.

Health Phys. 2018 Jul;115(1):3-11. doi: 10.1097/HP.0000000000000776.

PMID:
29787425
3.

Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays.

Suresh Kumar MA, Laiakis EC, Ghandhi SA, Morton SR, Fornace AJ Jr, Amundson SA.

Radiat Res. 2018 Jul;190(1):53-62. doi: 10.1667/RR14990.1. Epub 2018 May 10.

PMID:
29746213
4.

Differential Mobility Spectrometry-Mass Spectrometry (DMS-MS) in Radiation Biodosimetry: Rapid and High-Throughput Quantitation of Multiple Radiation Biomarkers in Nonhuman Primate Urine.

Chen Z, Coy SL, Pannkuk EL, Laiakis EC, Fornace AJ Jr, Vouros P.

J Am Soc Mass Spectrom. 2018 May 7. doi: 10.1007/s13361-018-1977-z. [Epub ahead of print]

PMID:
29736597
5.

Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non-human primates (NHPs) exposed to radiation.

Vera NB, Chen Z, Pannkuk E, Laiakis EC, Fornace AJ Jr, Erion DM, Coy SL, Pfefferkorn JA, Vouros P.

J Mass Spectrom. 2018 Jul;53(7):548-559. doi: 10.1002/jms.4085.

PMID:
29596720
6.

The effect of carbon irradiation is associated with greater oxidative stress in mouse intestine and colon relative to γ-rays.

Suman S, Kumar S, Fornace AJ Jr, Datta K.

Free Radic Res. 2018 May;52(5):556-567. doi: 10.1080/10715762.2018.1452204.

PMID:
29544379
7.

Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation.

Rudqvist N, Laiakis EC, Ghandhi SA, Kumar S, Knotts JD, Chowdhury M, Fornace AJ Jr, Amundson SA.

Radiat Res. 2018 Apr;189(4):337-344. doi: 10.1667/RR14862.1. Epub 2018 Jan 19.

PMID:
29351057
8.

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs.

Li HH, Chen R, Hyduke DR, Williams A, Frötschl R, Ellinger-Ziegelbauer H, O'Lone R, Yauk CL, Aubrecht J, Fornace AJ Jr.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10881-E10889. doi: 10.1073/pnas.1714109114. Epub 2017 Dec 4.

9.

Prior irradiation results in elevated programmed cell death protein 1 (PD-1) in T cells.

Li D, Chen R, Wang YW, Fornace AJ Jr, Li HH.

Int J Radiat Biol. 2018 May;94(5):488-494. doi: 10.1080/09553002.2017.1400192. Epub 2017 Nov 29.

PMID:
29108460
10.

Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells.

Buick JK, Williams A, Kuo B, Wills JW, Swartz CD, Recio L, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Mutat Res. 2017 Dec;806:51-62. doi: 10.1016/j.mrfmmm.2017.09.002. Epub 2017 Sep 13.

PMID:
29017062
11.

Lipidomic Signatures of Nonhuman Primates with Radiation-Induced Hematopoietic Syndrome.

Pannkuk EL, Laiakis EC, Singh VK, Fornace AJ.

Sci Rep. 2017 Aug 29;7(1):9777. doi: 10.1038/s41598-017-10299-w.

12.

A Serum Small Molecule Biosignature of Radiation Exposure from Total Body Irradiated Patients.

Laiakis EC, Pannkuk EL, Chauthe SK, Wang YW, Lian M, Mak TD, Barker CA, Astarita G, Fornace AJ Jr.

J Proteome Res. 2017 Oct 6;16(10):3805-3815. doi: 10.1021/acs.jproteome.7b00468. Epub 2017 Aug 31.

PMID:
28825479
13.

Increased Transgenerational Intestinal Tumorigenesis in Offspring of Ionizing Radiation Exposed Parent APC1638N/+ Mice.

Suman S, Kumar S, Moon BH, Fornace AJ Jr, Kallakury BVS, Datta K.

J Cancer. 2017 Jul 1;8(10):1769-1773. doi: 10.7150/jca.17803. eCollection 2017.

14.

Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N/+ mice.

Suman S, Kumar S, Moon BH, Fornace AJ Jr, Datta K.

Life Sci Space Res (Amst). 2017 May;13:45-50. doi: 10.1016/j.lssr.2017.04.003. Epub 2017 Apr 29.

PMID:
28554509
15.

Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device.

Laiakis EC, Wang YW, Young EF, Harken AD, Xu Y, Smilenov L, Garty GY, Brenner DJ, Fornace AJ Jr.

Radiat Res. 2017 Jul;188(1):21-34. doi: 10.1667/RR14656.1. Epub 2017 May 5.

16.

Gas Chromatography/Mass Spectrometry Metabolomics of Urine and Serum from Nonhuman Primates Exposed to Ionizing Radiation: Impacts on the Tricarboxylic Acid Cycle and Protein Metabolism.

Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ Jr.

J Proteome Res. 2017 May 5;16(5):2091-2100. doi: 10.1021/acs.jproteome.7b00064. Epub 2017 Apr 4.

17.

A Lipidomic and Metabolomic Serum Signature from Nonhuman Primates Exposed to Ionizing Radiation.

Pannkuk EL, Laiakis EC, Mak TD, Astarita G, Authier S, Wong K, Fornace AJ Jr.

Metabolomics. 2016 May;12(5). pii: 80. doi: 10.1007/s11306-016-1010-0. Epub 2016 Mar 15.

18.

Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex.

Shuryak I, Fornace AJ Jr, Datta K, Suman S, Kumar S, Sachs RK, Brenner DJ.

Radiat Res. 2017 Apr;187(4):476-482. doi: 10.1667/RR009CC.1. Epub 2017 Feb 20.

PMID:
28218889
19.

Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development.

Cho SJ, Cha BS, Kwon OS, Lim J, Shin DM, Han DW, Ishitani T, Jho EH, Fornace AJ, Cha HJ.

Biochim Biophys Acta. 2017 Apr;1863(4):1013-1022. doi: 10.1016/j.bbadis.2017.01.028. Epub 2017 Feb 7.

20.

A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients.

Jacobs JP, Goudarzi M, Singh N, Tong M, McHardy IH, Ruegger P, Asadourian M, Moon BH, Ayson A, Borneman J, McGovern DP, Fornace AJ Jr, Braun J, Dubinsky M.

Cell Mol Gastroenterol Hepatol. 2016 Jul 2;2(6):750-766. doi: 10.1016/j.jcmgh.2016.06.004. eCollection 2016 Nov.

21.

Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.

Pannkuk EL, Fornace AJ Jr, Laiakis EC.

Int J Radiat Biol. 2017 Oct;93(10):1151-1176. doi: 10.1080/09553002.2016.1269218. Epub 2017 Jan 12. Review.

PMID:
28067089
22.

Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.

Jacobs JP, Lin L, Goudarzi M, Ruegger P, McGovern DP, Fornace AJ Jr, Borneman J, Xia L, Braun J.

Gut Microbes. 2017 Jan 2;8(1):1-16. doi: 10.1080/19490976.2016.1257469. Epub 2016 Nov 22.

23.

Impairment of the Intrinsic Capability of Th1 Polarization in Irradiated Mice: A Close Look at the Imbalanced Th1/Th2 Response after Irradiation.

Chen R, Wang YW, Fornace AJ Jr, Li HH.

Radiat Res. 2016 Dec;186(6):559-567. doi: 10.1667/RR14401.1. Epub 2016 Nov 16.

PMID:
27849436
24.

Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.

Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ Jr, Peters JM.

J Biol Chem. 2016 Nov 25;291(48):25255-25263. Epub 2016 Oct 20.

25.

Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T.

Sci Rep. 2016 Sep 14;6:33011. doi: 10.1038/srep33011. No abstract available.

26.

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity.

Pendse SN, Maertens A, Rosenberg M, Roy D, Fasani RA, Vantangoli MM, Madnick SJ, Boekelheide K, Fornace AJ, Odwin SA, Yager JD, Hartung T, Andersen ME, McMullen PD.

Arch Toxicol. 2017 Apr;91(4):1749-1762. doi: 10.1007/s00204-016-1824-6. Epub 2016 Sep 3.

27.
28.

An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis.

Goudarzi M, Mak TD, Jacobs JP, Moon BH, Strawn SJ, Braun J, Brenner DJ, Fornace AJ Jr, Li HH.

Radiat Res. 2016 Sep;186(3):219-34. doi: 10.1667/RR14306.1. Epub 2016 Aug 11.

29.

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Kleensang A, Vantangoli MM, Odwin-DaCosta S, Andersen ME, Boekelheide K, Bouhifd M, Fornace AJ Jr, Li HH, Livi CB, Madnick S, Maertens A, Rosenberg M, Yager JD, Zhao L, Hartung T.

Sci Rep. 2016 Jul 26;6:28994. doi: 10.1038/srep28994. Erratum in: Sci Rep. 2016 Sep 14;6:33011.

30.

Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry.

Chen Z, Coy SL, Pannkuk EL, Laiakis EC, Hall AB, Fornace AJ Jr, Vouros P.

J Am Soc Mass Spectrom. 2016 Oct;27(10):1626-36. doi: 10.1007/s13361-016-1438-5. Epub 2016 Jul 8.

31.

Assessment of Saliva as a Potential Biofluid for Biodosimetry: A Pilot Metabolomics Study in Mice.

Laiakis EC, Strawn SJ, Brenner DJ, Fornace AJ Jr.

Radiat Res. 2016 Jul;186(1):92-7. doi: 10.1667/RR14433.1. Epub 2016 Jun 22.

32.

Quantitative Metabolomic Analysis of Urinary Citrulline and Calcitroic Acid in Mice after Exposure to Various Types of Ionizing Radiation.

Goudarzi M, Chauthe S, Strawn SJ, Weber WM, Brenner DJ, Fornace AJ.

Int J Mol Sci. 2016 May 20;17(5). pii: E782. doi: 10.3390/ijms17050782.

33.

Induction of MiR-21 by Stereotactic Body Radiotherapy Contributes to the Pulmonary Fibrotic Response.

Kwon OS, Kim KT, Lee E, Kim M, Choi SH, Li H, Fornace AJ Jr, Cho JH, Lee YS, Lee JS, Lee YJ, Cha HJ.

PLoS One. 2016 May 12;11(5):e0154942. doi: 10.1371/journal.pone.0154942. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0160137.

34.

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis.

Cheema AK, Maier I, Dowdy T, Wang Y, Singh R, Ruegger PM, Borneman J, Fornace AJ Jr, Schiestl RH.

PLoS One. 2016 Apr 13;11(4):e0151190. doi: 10.1371/journal.pone.0151190. eCollection 2016.

35.

Implications of genotypic differences in the generation of a urinary metabolomics radiation signature.

Laiakis EC, Pannkuk EL, Diaz-Rubio ME, Wang YW, Mak TD, Simbulan-Rosenthal CM, Brenner DJ, Fornace AJ Jr.

Mutat Res. 2016 Jun;788:41-9. doi: 10.1016/j.mrfmmm.2016.03.003. Epub 2016 Mar 25.

36.

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9.

Yauk CL, Buick JK, Williams A, Swartz CD, Recio L, Li HH, Fornace AJ Jr, Thomson EM, Aubrecht J.

Environ Mol Mutagen. 2016 May;57(4):243-60. doi: 10.1002/em.22004. Epub 2016 Mar 4.

37.

Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway.

Datta K, Suman S, Kumar S, Fornace AJ Jr.

J Cancer. 2016 Jan 1;7(2):174-83. doi: 10.7150/jca.13387. eCollection 2016. Review.

38.

Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice.

Suman S, Kumar S, Moon BH, Strawn SJ, Thakor H, Fan Z, Shay JW, Fornace AJ Jr, Datta K.

Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):131-8. doi: 10.1016/j.ijrobp.2015.10.057. Epub 2015 Oct 31.

PMID:
26725728
39.

Targeted Metabolomics of Nonhuman Primate Serum after Exposure to Ionizing Radiation: Potential Tools for High-throughput Biodosimetry.

Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ Jr.

RSC Adv. 2016;6(56):51192-51202. doi: 10.1039/C6RA07757A. Epub 2016 May 20.

40.

Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat.

Mak TD, Tyburski JB, Krausz KW, Kalinich JF, Gonzalez FJ, Fornace AJ Jr.

Metabolomics. 2015 Oct 1;11(5):1082-1094. Epub 2014 Dec 20.

41.

Decreased RXRα is Associated with Increased β-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors.

Suman S, Kumar S, Fornace AJ Jr, Datta K.

Front Oncol. 2015 Oct 8;5:218. doi: 10.3389/fonc.2015.00218. eCollection 2015.

42.

A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells.

Williams A, Buick JK, Moffat I, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Data Brief. 2015 Aug 24;5:77-83. doi: 10.1016/j.dib.2015.08.013. eCollection 2015 Dec.

43.

Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography-Mass Spectrometry Approach.

Goudarzi M, Weber WM, Chung J, Doyle-Eisele M, Melo DR, Mak TD, Strawn SJ, Brenner DJ, Guilmette R, Fornace AJ Jr.

J Proteome Res. 2015 Sep 4;14(9):4039-49. doi: 10.1021/acs.jproteome.5b00576. Epub 2015 Aug 18.

44.

Concepts and challenges in cancer risk prediction for the space radiation environment.

Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ Jr, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM.

Life Sci Space Res (Amst). 2015 Jul;6:92-103. doi: 10.1016/j.lssr.2015.07.006. Epub 2015 Jul 17. Review.

45.

Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation.

Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ Jr.

Radiat Res. 2015 Aug;184(2):121-33. Epub 2015 Jul 31.

46.

Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming.

Li HH, Wang YW, Chen R, Zhou B, Ashwell JD, Fornace AJ Jr.

Int J Biol Sci. 2015 May 15;11(7):726-36. doi: 10.7150/ijbs.12009. eCollection 2015.

47.

A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90.

Goudarzi M, Weber WM, Mak TD, Chung J, Doyle-Eisele M, Melo DR, Strawn SJ, Brenner DJ, Guilmette RA, Fornace AJ Jr.

Radiat Res. 2015 Jun;183(6):665-74. Epub 2015 May 26.

48.

Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma.

LaConti JJ, Laiakis EC, Mays AD, Peran I, Kim SE, Shay JW, Riegel AT, Fornace AJ Jr, Wellstein A.

BMC Genomics. 2015;16 Suppl 1:S1. doi: 10.1186/1471-2164-16-S1-S1. Epub 2015 Jan 15.

49.

Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis.

Zhang L, Kim S, Jia G, Buhmeida A, Dallol A, Wright WE, Fornace AJ, Al-Qahtani M, Shay JW.

BMC Genomics. 2015;16 Suppl 1:S8. doi: 10.1186/1471-2164-16-S1-S8. Epub 2015 Jan 15.

50.

Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences.

Laiakis EC, Trani D, Moon BH, Strawn SJ, Fornace AJ Jr.

Radiat Res. 2015 Apr;183(4):382-90. doi: 10.1667/RR3967.1. Epub 2015 Mar 13.

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