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Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment.

Joseph B, Marchetti P, Formstecher P, Kroemer G, Lewensohn R, Zhivotovsky B.

Oncogene. 2017 Aug 17;36(33):4818. doi: 10.1038/onc.2017.78. Epub 2017 Apr 10.


Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse.

Corvaisier M, Bauzone M, Corfiotti F, Renaud F, El Amrani M, Monté D, Truant S, Leteurtre E, Formstecher P, Van Seuningen I, Gespach C, Huet G.

Oncotarget. 2016 Aug 30;7(35):56699-56712. doi: 10.18632/oncotarget.11057.


Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A-dependent quiescence of disseminated stem-like cells.

Touil Y, Segard P, Ostyn P, Begard S, Aspord C, El Machhour R, Masselot B, Vandomme J, Flamenco P, Idziorek T, Figeac M, Formstecher P, Quesnel B, Polakowska R.

Sci Rep. 2016 Jul 28;6:30405. doi: 10.1038/srep30405.


[Reply to « Why is it difficult to implement biomedical policy? The ase of the Cancéropôles, the French cancer organizations », by Audrey Vézian, Med Sci (Paris) 2014 Aug-Sep; 30 (8-9) : 803-7].

Chabannon C, Bougnoux P, Favre G, Formstecher P, Laurent-Puig P, Oudet P, Trillet-Lenoir V.

Med Sci (Paris). 2014 Oct;30(10):925. doi: 10.1051/medsci/20143010022. Epub 2014 Oct 14. French.


Transient TNF regulates the self-renewing capacity of stem-like label-retaining cells in sphere and skin equivalent models of melanoma.

Ostyn P, El Machhour R, Begard S, Kotecki N, Vandomme J, Flamenco P, Segard P, Masselot B, Formstecher P, Touil Y, Polakowska R.

Cell Commun Signal. 2014 Sep 17;12:52. doi: 10.1186/s12964-014-0052-z.


Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production.

Ballot C, Martoriati A, Jendoubi M, Buche S, Formstecher P, Mortier L, Kluza J, Marchetti P.

Mar Drugs. 2014 Jan 27;12(2):779-98. doi: 10.3390/md12020779.


Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

Touil Y, Igoudjil W, Corvaisier M, Dessein AF, Vandomme J, Monté D, Stechly L, Skrypek N, Langlois C, Grard G, Millet G, Leteurtre E, Dumont P, Truant S, Pruvot FR, Hebbar M, Fan F, Ellis LM, Formstecher P, Van Seuningen I, Gespach C, Polakowska R, Huet G.

Clin Cancer Res. 2014 Feb 15;20(4):837-46. doi: 10.1158/1078-0432.CCR-13-1854. Epub 2013 Dec 9.


Insulin-like growth factor 1 receptor and p38 mitogen-activated protein kinase signals inversely regulate signal transducer and activator of transcription 3 activity to control human dental pulp stem cell quiescence, propagation, and differentiation.

Vandomme J, Touil Y, Ostyn P, Olejnik C, Flamenco P, El Machhour R, Segard P, Masselot B, Bailliez Y, Formstecher P, Polakowska R.

Stem Cells Dev. 2014 Apr 15;23(8):839-51. doi: 10.1089/scd.2013.0400. Epub 2014 Jan 17.


A structural explanation of the effects of dissociated glucocorticoids on glucocorticoid receptor transactivation.

Dezitter X, Fagart J, Taront S, Fay M, Masselot B, Hétuin D, Formstecher P, Rafestin-Oblin ME, Idziorek T.

Mol Pharmacol. 2014 Feb;85(2):226-36. doi: 10.1124/mol.113.085860. Epub 2013 Nov 13.


Mitochondrial oxidative stress is the Achille's heel of melanoma cells resistant to Braf-mutant inhibitor.

Corazao-Rozas P, Guerreschi P, Jendoubi M, André F, Jonneaux A, Scalbert C, Garçon G, Malet-Martino M, Balayssac S, Rocchi S, Savina A, Formstecher P, Mortier L, Kluza J, Marchetti P.

Oncotarget. 2013 Nov;4(11):1986-98.


Patient-derived tumor xenograft model to guide the use of BRAF inhibitors in metastatic melanoma.

Guerreschi P, Scalbert C, Qassemyar A, Kluza J, Ravasi L, Huglo D, Martinot-Duquennoy V, Formstecher P, Marchetti P, Mortier L.

Melanoma Res. 2013 Oct;23(5):373-80. doi: 10.1097/CMR.0b013e328363ed92.


The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity.

Touil Y, Zuliani T, Wolowczuk I, Kuranda K, Prochazkova J, Andrieux J, Le Roy H, Mortier L, Vandomme J, Jouy N, Masselot B, Ségard P, Quesnel B, Formstecher P, Polakowska R.

Stem Cells. 2013 Apr;31(4):641-51. doi: 10.1002/stem.1333.


Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

Kluza J, Corazao-Rozas P, Touil Y, Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac S, Valable S, Corroyer-Dulmont A, Bernaudin M, Malet-Martino M, de Lassalle EM, Maboudou P, Formstecher P, Polakowska R, Mortier L, Marchetti P.

Cancer Res. 2012 Oct 1;72(19):5035-47. doi: 10.1158/0008-5472.CAN-12-0979. Epub 2012 Aug 3.


Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.

Ballot C, Jendoubi M, Kluza J, Jonneaux A, Laine W, Formstecher P, Bailly C, Marchetti P.

Apoptosis. 2012 Apr;17(4):364-76. doi: 10.1007/s10495-011-0681-2.


Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

Kluza J, Jendoubi M, Ballot C, Dammak A, Jonneaux A, Idziorek T, Joha S, Dauphin V, Malet-Martino M, Balayssac S, Maboudou P, Briand G, Formstecher P, Quesnel B, Marchetti P.

PLoS One. 2011;6(7):e21924. doi: 10.1371/journal.pone.0021924. Epub 2011 Jul 18.


Macromolecular synthesis inhibitors perturb glucocorticoid receptor trafficking.

Dezitter X, Masselot B, Tardivel M, Mereau-Richard C, Formstecher P, Idziorek T.

J Steroid Biochem Mol Biol. 2011 Sep;126(3-5):104-12. doi: 10.1016/j.jsbmb.2011.04.008. Epub 2011 May 5.


Human umbilical cord blood cells form epidermis in the skin equivalent model.

Mortier L, Delesalle F, Formstecher P, Polakowska R.

Exp Dermatol. 2010 Oct;19(10):929-30. doi: 10.1111/j.1600-0625.2010.01131.x. Epub 2010 Aug 31.


Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D.

Ballot C, Kluza J, Lancel S, Martoriati A, Hassoun SM, Mortier L, Vienne JC, Briand G, Formstecher P, Bailly C, Nevière R, Marchetti P.

Apoptosis. 2010 Jul;15(7):769-81. doi: 10.1007/s10495-010-0471-2.


Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.

Ballot C, Kluza J, Martoriati A, Nyman U, Formstecher P, Joseph B, Bailly C, Marchetti P.

Mol Cancer Ther. 2009 Dec;8(12):3307-17. doi: 10.1158/1535-7163.MCT-09-0639.


Asymmetric distribution of epidermal growth factor receptor directs the fate of normal and cancer keratinocytes in vitro.

Le Roy H, Zuliani T, Wolowczuk I, Faivre N, Jouy N, Masselot B, Kerkaert JP, Formstecher P, Polakowska R.

Stem Cells Dev. 2010 Feb;19(2):209-20. doi: 10.1089/scd.2009.0150.


Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities.

Castera L, Hatzfeld-Charbonnier AS, Ballot C, Charbonnel F, Dhuiege E, Velu T, Formstecher P, Mortier L, Marchetti P.

J Cell Mol Med. 2009 Jul;13(7):1321-35. doi: 10.1111/j.1582-4934.2008.00358.x. Epub 2008 May 3.


Human dental pulp stem cells differentiate into neural crest-derived melanocytes and have label-retaining and sphere-forming abilities.

Stevens A, Zuliani T, Olejnik C, LeRoy H, Obriot H, Kerr-Conte J, Formstecher P, Bailliez Y, Polakowska RR.

Stem Cells Dev. 2008 Dec;17(6):1175-84. doi: 10.1089/scd.2008.0012.


Variable Bax antigenicity is linked to keratinocyte position within epidermal strata and UV-induced apoptosis.

Zuliani T, Obriot H, Tual M, Lachman-Weber N, Dumas M, Formstecher P, Polakowska R, Ratinaud MH.

Exp Dermatol. 2008 Feb;17(2):125-32. doi: 10.1111/j.1600-0625.2007.00660.x. Epub 2007 Dec 31.


[Translational research and Cancer Plan].

Vassal G, Borella L, Pierre A, Pamphile R, Bourrie B, Meflah K, Amalric F, Pauporte I, Caillot JL, Formstecher P, Demers B, Dumontet C, Grégoire M, Lethiec F, Boue AM, Tonelli D, Pilsudski R, Van Hijfte L, Cailliot C, Vrignaud P, Merlin JL, Oudet P, Arnoux PY, Lassale C.

Bull Cancer. 2007 Dec;94(12):1107-11. French.


Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway.

Gallego MA, Ballot C, Kluza J, Hajji N, Martoriati A, Castéra L, Cuevas C, Formstecher P, Joseph B, Kroemer G, Bailly C, Marchetti P.

Oncogene. 2008 Mar 27;27(14):1981-92. Epub 2007 Oct 1.


S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.

Carmona MC, Louche K, Lefebvre B, Pilon A, Hennuyer N, Audinot-Bouchez V, Fievet C, Torpier G, Formstecher P, Renard P, Lefebvre P, Dacquet C, Staels B, Casteilla L, Pénicaud L; Consortium of the French Ministry of Research and Technology.

Diabetes. 2007 Nov;56(11):2797-808. Epub 2007 Aug 17.


Proteomics unveil corticoid-induced S100A11 shuttling in keratinocyte differentiation.

Dezitter X, Hammoudi F, Belverge N, Deloulme JC, Drobecq H, Masselot B, Formstecher P, Mendy D, Idziorek T.

Biochem Biophys Res Commun. 2007 Aug 31;360(3):627-32. Epub 2007 Jul 2.


[Activation of cardiac caspases: a double-edged weapon implicated in cardiac dysfunction].

Lancel S, Fauvel H, Formstecher P, Marchetti P, Nevière R.

Arch Mal Coeur Vaiss. 2007 Apr;100(4):265-72. Review. French.


Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway.

Szczesny RJ, Obriot H, Paczkowska A, Jedrzejczak R, Dmochowska A, Bartnik E, Formstecher P, Polakowska R, Stepien PP.

Biol Cell. 2007 Jun;99(6):323-32.


Influence of heat stress on human monocyte-derived dendritic cell functions with immunotherapeutic potential for antitumor vaccines.

Hatzfeld-Charbonnier AS, Lasek A, Castera L, Gosset P, Velu T, Formstecher P, Mortier L, Marchetti P.

J Leukoc Biol. 2007 May;81(5):1179-87. Epub 2007 Feb 20.


Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.

Eeckhoute J, Briche I, Kurowska M, Formstecher P, Laine B.

J Mol Biol. 2006 Dec 8;364(4):567-81. Epub 2006 Sep 12.


Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation.

Tamiji S, Beauvillain JC, Mortier L, Jouy N, Tual M, Delaporte E, Formstecher P, Marchetti P, Polakowska R.

J Invest Dermatol. 2005 Oct;125(4):647-58.


Ventricular myocyte caspases are directly responsible for endotoxin-induced cardiac dysfunction.

Lancel S, Joulin O, Favory R, Goossens JF, Kluza J, Chopin C, Formstecher P, Marchetti P, Neviere R.

Circulation. 2005 May 24;111(20):2596-604. Epub 2005 May 16.


Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas.

Gallego MA, Joseph B, Hemström TH, Tamiji S, Mortier L, Kroemer G, Formstecher P, Zhivotovsky B, Marchetti P.

Oncogene. 2004 Aug 19;23(37):6282-91.


Comparison of four fluorochromes for the detection of the inner mitochondrial membrane potential in human spermatozoa and their correlation with sperm motility.

Marchetti C, Jouy N, Leroy-Martin B, Defossez A, Formstecher P, Marchetti P.

Hum Reprod. 2004 Oct;19(10):2267-76. Epub 2004 Jul 15.


Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription.

Eeckhoute J, Formstecher P, Laine B.

Nucleic Acids Res. 2004 May 11;32(8):2586-93. Print 2004.


[Micro-array based technologies to study the proteome: technological progress and applications].

Mortuaire G, Marchetti P, Formstecher P, Danzé PM.

Ann Biol Clin (Paris). 2004 Mar-Apr;62(2):139-48. Review. French.


Staining of human sperm with fluorochrome-labeled inhibitor of caspases to detect activated caspases: correlation with apoptosis and sperm parameters.

Marchetti C, Gallego MA, Defossez A, Formstecher P, Marchetti P.

Hum Reprod. 2004 May;19(5):1127-34. Epub 2004 Mar 25.


Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production.

Favory R, Lancel S, Marchetti P, Mordon S, Chopin C, Formstecher P, Neviere R.

Crit Care Med. 2004 Feb;32(2):495-501.


Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 non-small cell lung carcinoma cells.

Ekedahl J, Joseph B, Marchetti P, Fauvel H, Formstecher P, Lewensohn R, Zhivotovsky B.

Cancer Biol Ther. 2003 Nov-Dec;2(6):663-9.


PLZF is a negative regulator of retinoic acid receptor transcriptional activity.

Martin PJ, Delmotte MH, Formstecher P, Lefebvre P.

Nucl Recept. 2003 Sep 6;1(1):6.


Terminal differentiation of human epidermal keratinocytes involves mitochondria- and caspase-dependent cell death pathway.

Allombert-Blaise C, Tamiji S, Mortier L, Fauvel H, Tual M, Delaporte E, Piette F, DeLassale EM, Formstecher P, Marchetti P, Polakowska R.

Cell Death Differ. 2003 Jul;10(7):850-2. No abstract available.


Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

Eeckhoute J, Moerman E, Bouckenooghe T, Lukoviak B, Pattou F, Formstecher P, Kerr-Conte J, Vandewalle B, Laine B.

Endocrinology. 2003 May;144(5):1686-94.


The novel retinoid AHPN/CD437 induces a rapid but incomplete apoptotic response in human myeloma cells.

Joseph B, Marchetti P, Lefebvre O, Schraen-Maschke S, Méreau-Richard C, Formstecher P.

Biochim Biophys Acta. 2003 Feb 17;1593(2-3):277-82.


[Are mitochondria targets of anticancer drugs responsible for apoptosis?].

Marchetti P, Mortier L, Beauvillain V, Formstecher P.

Ann Biol Clin (Paris). 2002 Jul-Aug;60(4):391-403. Review. French.


Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors.

Sacchetti P, Dwornik H, Formstecher P, Rachez C, Lefebvre P.

J Biol Chem. 2002 Sep 20;277(38):35088-96. Epub 2002 Jul 16.


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