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Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo.

Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S.

Mol Cell Biol. 2019 Jul 16;39(15). pii: e00602-18. doi: 10.1128/MCB.00602-18. Print 2019 Aug 1.


FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics.

Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C.

Elife. 2019 Jan 25;8. pii: e40988. doi: 10.7554/eLife.40988.


Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae.

McCullough LL, Pham TH, Parnell TJ, Connell Z, Chandrasekharan MB, Stillman DJ, Formosa T.

Genetics. 2019 Mar;211(3):877-892. doi: 10.1534/genetics.118.301853. Epub 2019 Jan 24.


FACT Inhibition Blocks Induction But Not Maintenance of Pluripotency.

Shen Z, Formosa T, Tantin D.

Stem Cells Dev. 2018 Dec 15;27(24):1693-1701. doi: 10.1089/scd.2018.0150. Epub 2018 Nov 28.


Functional roles of the DNA-binding HMGB domain in the histone chaperone FACT in nucleosome reorganization.

McCullough LL, Connell Z, Xin H, Studitsky VM, Feofanov AV, Valieva ME, Formosa T.

J Biol Chem. 2018 Apr 20;293(16):6121-6133. doi: 10.1074/jbc.RA117.000199. Epub 2018 Mar 7.


A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription.

Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP.

Elife. 2017 Aug 16;6. pii: e28723. doi: 10.7554/eLife.28723.


Large-scale ATP-independent nucleosome unfolding by a histone chaperone.

Valieva ME, Armeev GA, Kudryashova KS, Gerasimova NS, Shaytan AK, Kulaeva OI, McCullough LL, Formosa T, Georgiev PG, Kirpichnikov MP, Studitsky VM, Feofanov AV.

Nat Struct Mol Biol. 2016 Dec;23(12):1111-1116. doi: 10.1038/nsmb.3321. Epub 2016 Nov 7.


FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.

Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP.

Mol Cell. 2015 Oct 15;60(2):294-306. doi: 10.1016/j.molcel.2015.09.008. Epub 2015 Oct 8.


The Abundant Histone Chaperones Spt6 and FACT Collaborate to Assemble, Inspect, and Maintain Chromatin Structure in Saccharomyces cerevisiae.

McCullough L, Connell Z, Petersen C, Formosa T.

Genetics. 2015 Nov;201(3):1031-45. doi: 10.1534/genetics.115.180794. Epub 2015 Sep 28.


Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.

Lee M, Lee CH, Demin AA, Munashingha PR, Amangyeld T, Kwon B, Formosa T, Seo YS.

J Biol Chem. 2014 May 23;289(21):15064-79. doi: 10.1074/jbc.M114.548388. Epub 2014 Apr 7.


The role of FACT in making and breaking nucleosomes.

Formosa T.

Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):247-55. Review.


The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae.

McCullough L, Poe B, Connell Z, Xin H, Formosa T.

Genetics. 2013 Sep;195(1):101-13. doi: 10.1534/genetics.113.153080. Epub 2013 Jul 5.


Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT.

Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP.

J Biol Chem. 2013 Apr 12;288(15):10188-94. doi: 10.1074/jbc.C113.451369. Epub 2013 Feb 15.


Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function.

Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP.

J Biol Chem. 2012 Oct 26;287(44):37371-82. doi: 10.1074/jbc.M112.367003. Epub 2012 Aug 28.


The role of FACT in making and breaking nucleosomes.

Formosa T.

Biochim Biophys Acta. 2012 Mar;1819(3-4):247-55. doi: 10.1016/j.bbagrm.2011.07.009. Epub 2011 Jul 23.


Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.

McCullough L, Rawlins R, Olsen A, Xin H, Stillman DJ, Formosa T.

Genetics. 2011 Aug;188(4):835-46. doi: 10.1534/genetics.111.128769. Epub 2011 May 30.


Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.

Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP.

J Mol Biol. 2011 May 13;408(4):697-713. doi: 10.1016/j.jmb.2011.03.002. Epub 2011 Mar 17.


A kinase's work is never done: Rad53 monitors chromatin near replication origins.

Formosa T.

Cell Cycle. 2011 Feb 15;10(4):573-4. Epub 2011 Feb 15. No abstract available.


Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding.

McDonald SM, Close D, Xin H, Formosa T, Hill CP.

Mol Cell. 2010 Dec 10;40(5):725-35. doi: 10.1016/j.molcel.2010.11.014. Epub 2010 Nov 25.


Ubiquitylation of FACT by the cullin-E3 ligase Rtt101 connects FACT to DNA replication.

Han J, Li Q, McCullough L, Kettelkamp C, Formosa T, Zhang Z.

Genes Dev. 2010 Jul 15;24(14):1485-90. doi: 10.1101/gad.1887310.


Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Sadre-Bazzaz K, Whitby FG, Robinson H, Formosa T, Hill CP.

Mol Cell. 2010 Mar 12;37(5):728-35. doi: 10.1016/j.molcel.2010.02.002.


yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement.

Xin H, Takahata S, Blanksma M, McCullough L, Stillman DJ, Formosa T.

Mol Cell. 2009 Aug 14;35(3):365-76. doi: 10.1016/j.molcel.2009.06.024.


FACT and the reorganized nucleosome.

Formosa T.

Mol Biosyst. 2008 Nov;4(11):1085-93. doi: 10.1039/b812136b. Epub 2008 Sep 19. Review.


A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae.

Biswas D, Takahata S, Xin H, Dutta-Biswas R, Yu Y, Formosa T, Stillman DJ.

Genetics. 2008 Feb;178(2):649-59. doi: 10.1534/genetics.107.084202. Epub 2008 Feb 1.


Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits.

VanDemark AP, Xin H, McCullough L, Rawlins R, Bentley S, Heroux A, Stillman DJ, Hill CP, Formosa T.

J Biol Chem. 2008 Feb 22;283(8):5058-68. Epub 2007 Dec 18.


blm3-1 is an allele of UBP3, a ubiquitin protease that appears to act during transcription of damaged DNA.

McCullock S, Kinard T, McCullough L, Formosa T.

J Mol Biol. 2006 Oct 27;363(3):660-72. Epub 2006 Aug 30.


Opposing roles for Set2 and yFACT in regulating TBP binding at promoters.

Biswas D, Dutta-Biswas R, Mitra D, Shibata Y, Strahl BD, Formosa T, Stillman DJ.

EMBO J. 2006 Oct 4;25(19):4479-89. Epub 2006 Sep 14.


Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.

Iwanczyk J, Sadre-Bazzaz K, Ferrell K, Kondrashkina E, Formosa T, Hill CP, Ortega J.

J Mol Biol. 2006 Oct 27;363(3):648-59. Epub 2006 Aug 9.


The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.

VanDemark AP, Blanksma M, Ferris E, Heroux A, Hill CP, Formosa T.

Mol Cell. 2006 May 5;22(3):363-74. Erratum in: Mol Cell. 2007 Jul 6;27(1):171-2.


The yeast FACT complex has a role in transcriptional initiation.

Biswas D, Yu Y, Prall M, Formosa T, Stillman DJ.

Mol Cell Biol. 2005 Jul;25(14):5812-22.


Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6.

Rhoades AR, Ruone S, Formosa T.

Mol Cell Biol. 2004 May;24(9):3907-17.


Multiple Nhp6 molecules are required to recruit Spt16-Pob3 to form yFACT complexes and to reorganize nucleosomes.

Ruone S, Rhoades AR, Formosa T.

J Biol Chem. 2003 Nov 14;278(46):45288-95. Epub 2003 Sep 1.


Changing the DNA landscape: putting a SPN on chromatin.

Formosa T.

Curr Top Microbiol Immunol. 2003;274:171-201. Review.


Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.

Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, Rhoades AR, Kaufman PD, Stillman DJ.

Genetics. 2002 Dec;162(4):1557-71.


Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.

Formosa T, Eriksson P, Wittmeyer J, Ginn J, Yu Y, Stillman DJ.

EMBO J. 2001 Jul 2;20(13):3506-17.


Identifying DNA replication complex components using protein affinity chromatography.

Wittmeyer J, Formosa T.

Methods Enzymol. 1995;262:415-30. No abstract available.


Using protein affinity chromatography to probe structure of protein machines.

Formosa T, Barry J, Alberts BM, Greenblatt J.

Methods Enzymol. 1991;208:24-45. No abstract available.


Purification and characterization of the T4 bacteriophage uvsX protein.

Formosa T, Alberts BM.

J Biol Chem. 1986 May 5;261(13):6107-18.

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