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Items: 22


ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.

Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP.

Nat Commun. 2019 Jan 8;10(1):87. doi: 10.1038/s41467-018-07729-2.


XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data.

Kluin RJC, Kemper K, Kuilman T, de Ruiter JR, Iyer V, Forment JV, Cornelissen-Steijger P, de Rink I, Ter Brugge P, Song JY, Klarenbeek S, McDermott U, Jonkers J, Velds A, Adams DJ, Peeper DS, Krijgsman O.

BMC Bioinformatics. 2018 Oct 4;19(1):366. doi: 10.1186/s12859-018-2353-5.


Detection of functional protein domains by unbiased genome-wide forward genetic screening.

Herzog M, Puddu F, Coates J, Geisler N, Forment JV, Jackson SP.

Sci Rep. 2018 Apr 18;8(1):6161. doi: 10.1038/s41598-018-24400-4.


Targeting the replication stress response in cancer.

Forment JV, O'Connor MJ.

Pharmacol Ther. 2018 Aug;188:155-167. doi: 10.1016/j.pharmthera.2018.03.005. Epub 2018 Mar 24. Review.


Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.

Asim M, Tarish F, Zecchini HI, Sanjiv K, Gelali E, Massie CE, Baridi A, Warren AY, Zhao W, Ogris C, McDuffus LA, Mascalchi P, Shaw G, Dev H, Wadhwa K, Wijnhoven P, Forment JV, Lyons SR, Lynch AG, O'Neill C, Zecchini VR, Rennie PS, Baniahmad A, Tavaré S, Mills IG, Galanty Y, Crosetto N, Schultz N, Neal D, Helleday T.

Nat Commun. 2017 Aug 29;8(1):374. doi: 10.1038/s41467-017-00393-y.


Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells.

Forment JV, Herzog M, Coates J, Konopka T, Gapp BV, Nijman SM, Adams DJ, Keane TM, Jackson SP.

Nat Chem Biol. 2017 Jan;13(1):12-14. doi: 10.1038/nchembio.2226. Epub 2016 Oct 31.


When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.

Forment JV, Jackson SP, Pellegrini L.

Nucleus. 2015;6(5):344-8. doi: 10.1080/19491034.2015.1086050.


A flow cytometry-based method to simplify the analysis and quantification of protein association to chromatin in mammalian cells.

Forment JV, Jackson SP.

Nat Protoc. 2015 Sep;10(9):1297-307. doi: 10.1038/nprot.2015.066. Epub 2015 Jul 30.


CtIP tetramer assembly is required for DNA-end resection and repair.

Davies OR, Forment JV, Sun M, Belotserkovskaya R, Coates J, Galanty Y, Demir M, Morton CR, Rzechorzek NJ, Jackson SP, Pellegrini L.

Nat Struct Mol Biol. 2015 Feb;22(2):150-157. doi: 10.1038/nsmb.2937. Epub 2015 Jan 5.


Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP.

Nat Cell Biol. 2014 Oct;16(10):1016-26, 1-8. doi: 10.1038/ncb3028. Epub 2014 Sep 7.


High-affinity glucose transport in Aspergillus nidulans is mediated by the products of two related but differentially expressed genes.

Forment JV, Flipphi M, Ventura L, González R, Ramón D, Maccabe AP.

PLoS One. 2014 Apr 21;9(4):e94662. doi: 10.1371/journal.pone.0094662. eCollection 2014.


Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ.

PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15.


Chromothripsis and cancer: causes and consequences of chromosome shattering.

Forment JV, Kaidi A, Jackson SP.

Nat Rev Cancer. 2012 Oct;12(10):663-70. doi: 10.1038/nrc3352. Epub 2012 Sep 13. Review.


A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells.

Forment JV, Walker RV, Jackson SP.

Cytometry A. 2012 Oct;81(10):922-8. doi: 10.1002/cyto.a.22155. Epub 2012 Aug 14.


CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination.

Falck J, Forment JV, Coates J, Mistrik M, Lukas J, Bartek J, Jackson SP.

EMBO Rep. 2012 Jun;13(6):561-8. doi: 10.1038/embor.2012.58.


Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.

Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S, Jackson SP.

Nat Chem Biol. 2012 Feb 5;8(3):301-10. doi: 10.1038/nchembio.780.


Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.

Forment JV, Blasius M, Guerini I, Jackson SP.

PLoS One. 2011;6(8):e23517. doi: 10.1371/journal.pone.0023517. Epub 2011 Aug 17.


A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1.

Blasius M, Forment JV, Thakkar N, Wagner SA, Choudhary C, Jackson SP.

Genome Biol. 2011 Aug 18;12(8):R78. doi: 10.1186/gb-2011-12-8-r78.


Use of Saccharomyces cerevisiae and Caenorhabditis elegans as model organisms to study the effect of cocoa polyphenols in the resistance to oxidative stress.

Martorell P, Forment JV, de Llanos R, Montón F, Llopis S, González N, Genovés S, Cienfuegos E, Monzó H, Ramón D.

J Agric Food Chem. 2011 Mar 9;59(5):2077-85. doi: 10.1021/jf104217g. Epub 2011 Feb 2.


Concentration dependent effects of commonly used pesticides on activation versus inhibition of the quince (Cydonia Oblonga) polyphenol oxidase.

Fattouch S, Raboudi-Fattouch F, Ponce JV, Forment JV, Lukovic D, Marzouki N, Vidal DR.

Food Chem Toxicol. 2010 Mar;48(3):957-63. doi: 10.1016/j.fct.2010.01.006. Epub 2010 Jan 12.


Consecutive gene deletions in Aspergillus nidulans: application of the Cre/loxP system.

Forment JV, Ramón D, MacCabe AP.

Curr Genet. 2006 Sep;50(3):217-24. Epub 2006 Jun 17.


Identification of the mstE gene encoding a glucose-inducible, low affinity glucose transporter in Aspergillus nidulans.

Forment JV, Flipphi M, Ramón D, Ventura L, Maccabe AP.

J Biol Chem. 2006 Mar 31;281(13):8339-46. Epub 2006 Jan 17.

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