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Items: 1 to 50 of 80

1.

Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate.

Forkert PG.

Drug Metab Rev. 2010 May;42(2):355-78. doi: 10.3109/03602531003611915. Review.

PMID:
20205516
2.

Inhibition of vinyl carbamate-induced lung tumors and Kras2 mutations by the garlic derivative diallyl sulfone.

Hernandez LG, Forkert PG.

Mutat Res. 2009 Mar 9;662(1-2):16-21. doi: 10.1016/j.mrfmmm.2008.11.013. Epub 2008 Dec 3.

PMID:
19101575
3.

Trichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in mice.

Kan FW, Forkert PG, Wade MG.

Histol Histopathol. 2007 Sep;22(9):977-88. doi: 10.14670/HH-22.977.

PMID:
17523075
4.
5.

Oxidation of vinyl carbamate and formation of 1,N6-ethenodeoxyadenosine in murine lung.

Forkert PG, Kaufmann M, Black G, Bowers R, Chen H, Collins K, Sharma A, Jones G.

Drug Metab Dispos. 2007 May;35(5):713-20. Epub 2007 Feb 12.

PMID:
17296623
7.

Formation of N-alkylprotoporphyrin IX from metabolism of diallyl sulfone in lung and liver.

Black GP, Collins KS, Blacquiere DP, Forkert PG.

Drug Metab Dispos. 2006 Jun;34(6):895-900. Epub 2006 Mar 1.

PMID:
16510538
8.

Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.

Forkert PG, Millen B, Lash LH, Putt DA, Ghanayem BI.

J Pharmacol Exp Ther. 2006 Feb;316(2):520-9. Epub 2005 Nov 3.

PMID:
16269531
9.

Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.

Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.

Drug Metab Dispos. 2005 Oct;33(10):1429-37. Epub 2005 Jun 29.

PMID:
15987776
10.

1,1-Dichloroethylene-induced mitochondrial damage precedes apoptotic cell death of bronchiolar epithelial cells in murine lung.

Martin EJ, Forkert PG.

J Pharmacol Exp Ther. 2005 Apr;313(1):95-103. Epub 2004 Dec 30.

PMID:
15626720
11.

Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice.

Xu H, Tanphaichitr N, Forkert PG, Anupriwan A, Weerachatyanukul W, Vincent R, Leader A, Wade MG.

Toxicol Sci. 2004 Dec;82(2):590-7. Epub 2004 Sep 16.

PMID:
15375293
12.

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.

Drug Metab Dispos. 2004 Sep;32(9):1032-9.

PMID:
15319346
13.

Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung.

Simmonds AC, Ghanayem BI, Sharma A, Reilly CA, Millen B, Yost GS, Forkert PG.

J Pharmacol Exp Ther. 2004 Sep;310(3):855-64. Epub 2004 May 3. Erratum in: J Pharmacol Exp Ther. 2004 Nov;311(2):853.

PMID:
15123768
14.

Evidence that 1,1-dichloroethylene induces apoptotic cell death in murine liver.

Martin EJ, Forkert PG.

J Pharmacol Exp Ther. 2004 Jul;310(1):33-42. Epub 2004 Mar 17.

PMID:
15028783
15.

Gap junctional intercellular communication in cells isolated from urethane-induced tumors in A/J mice.

Vultur A, Tomai E, Peebles K, Malkinson AM, Grammatikakis N, Forkert PG, Raptis L.

DNA Cell Biol. 2003 Jan;22(1):33-40.

PMID:
12590735
16.

Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.

Forkert PG, Lash L, Tardif R, Tanphaichitr N, Vandevoort C, Moussa M.

Drug Metab Dispos. 2003 Mar;31(3):306-11.

PMID:
12584157
17.

Mitochondrial dysfunction is an early manifestation of 1,1-dichloroethylene-induced hepatotoxicity in mice.

Martin EJ, Racz WJ, Forkert PG.

J Pharmacol Exp Ther. 2003 Jan;304(1):121-9.

PMID:
12490582
18.

Metabolism and toxicity of trichloroethylene in epididymis and testis.

Forkert PG, Lash LH, Nadeau V, Tardif R, Simmonds A.

Toxicol Appl Pharmacol. 2002 Aug 1;182(3):244-54.

PMID:
12183104
19.

Differential metabolism of 1,1-dichloroethylene in livers of A/J, CD-1, and C57BL/6 mice.

Forkert PG, Boyd SM.

Drug Metab Dispos. 2001 Nov;29(11):1396-402.

PMID:
11602514
20.

Pulmonary bioactivation of 1,1-dichloroethylene is associated with CYP2E1 levels in A/J, CD-1, and C57BL/6 mice.

Forkert PG, Boyd SM, Ulreich JB.

J Pharmacol Exp Ther. 2001 Jun;297(3):1193-200.

PMID:
11356946
21.

Mechanisms of 1,1-dichloroethylene-induced cytotoxicity in lung and liver.

Forkert PG.

Drug Metab Rev. 2001 Feb;33(1):49-80. Review.

PMID:
11270662
22.

Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes.

Forkert PG, Lee RP, Reid K.

Drug Metab Dispos. 2001 Mar;29(3):258-63.

PMID:
11181492
24.

Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs.

Forkert PG, Premdas PD, Bowers RJ.

Am J Respir Cell Mol Biol. 2000 Nov;23(5):687-95.

PMID:
11062148
25.

Improved procedure for examination of gap junctional intercellular communication by in situ electroporation on a partly conductive slide.

Raptis L, Firth KL, Tomai E, Forkert PG.

Biotechniques. 2000 Aug;29(2):222-4, 226. No abstract available.

26.

Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone.

Premdas PD, Bowers RJ, Forkert PG.

J Pharmacol Exp Ther. 2000 Jun;293(3):1112-20.

PMID:
10869417
29.

Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes.

Dowsley TF, Reid K, Petsikas D, Ulreich JB, Fisher RL, Forkert PG.

J Pharmacol Exp Ther. 1999 May;289(2):641-8.

PMID:
10215634
31.
32.

Expression and inducibility of alpha, pi, and Mu glutathione S-transferase protein and mRNA in murine lung.

Forkert PG, D'Costa D, El-Mestrah M.

Am J Respir Cell Mol Biol. 1999 Jan;20(1):143-52.

PMID:
9870928
34.
35.
36.

Immunochemical assay for recognition of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene-epoxide.

Forkert PG, Collins KS, Dowsley TF, Ross GM.

J Pharmacol Exp Ther. 1997 Jun;281(3):1422-30.

PMID:
9190879
37.
38.

Coexpression of Ah receptor and CYP1A1 in hepatocytes of C57BL/6J and DBA/2J mice.

Forkert PG.

Toxicol Appl Pharmacol. 1997 Jan;142(1):69-78.

PMID:
9007035
39.
40.

Detection of early stages of carcinogenesis in adenomas of murine lung by 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.

Campbell DL, Gudgin-Dickson EF, Forkert PG, Pottier RH, Kennedy JC.

Photochem Photobiol. 1996 Oct;64(4):676-82.

PMID:
8863473
41.

CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates.

Dowsley TF, Ulreich JB, Bolton JL, Park SS, Forkert PG.

Toxicol Appl Pharmacol. 1996 Jul;139(1):42-8.

PMID:
8685907
42.

Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.

Forkert PG, Lee RP, Dowsley TF, Hong JY, Ulreich JB.

J Pharmacol Exp Ther. 1996 Jun;277(3):1665-71.

PMID:
8667236
43.
44.
45.
47.

Phase II enzymes and bioactivation.

Hinson JA, Forkert PG.

Can J Physiol Pharmacol. 1995 Oct;73(10):1407-13.

PMID:
8748931
49.

Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene.

Dowsley TF, Forkert PG, Benesch LA, Bolton JL.

Chem Biol Interact. 1995 Apr 14;95(3):227-44.

PMID:
7728894
50.

Pulmonary CYP2E1 bioactivates 1,1-dichloroethylene in male and female mice.

Lee RP, Forkert PG.

J Pharmacol Exp Ther. 1995 Apr;273(1):561-7.

PMID:
7714813

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