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Localized disorganization of the cochlear inner hair cell synaptic region after noise exposure.

Bullen A, Anderson L, Bakay W, Forge A.

Biol Open. 2019 Jan 7;8(1). pii: bio038547. doi: 10.1242/bio.038547.


Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.

Corns LF, Johnson SL, Roberts T, Ranatunga KM, Hendry A, Ceriani F, Safieddine S, Steel KP, Forge A, Petit C, Furness DN, Kros CJ, Marcotti W.

Nat Commun. 2018 Oct 1;9(1):4015. doi: 10.1038/s41467-018-06307-w.


Regenerating hair cells in vestibular sensory epithelia from humans.

Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A.

Elife. 2018 Jul 18;7. pii: e34817. doi: 10.7554/eLife.34817.


Gαi Proteins are Indispensable for Hearing.

Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C, Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L.

Cell Physiol Biochem. 2018;47(4):1509-1532. doi: 10.1159/000490867. Epub 2018 Jun 21.


Author Correction: Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.

Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Gezer A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M.

Nat Commun. 2018 May 25;9:16188. doi: 10.1038/ncomms16188.


Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.

Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M.

Nat Commun. 2017 Apr 7;8:14907. doi: 10.1038/ncomms14907. Erratum in: Nat Commun. 2018 May 25;9:16188.


Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear.

Forge A, Taylor RR, Dawson SJ, Lovett M, Jagger DJ.

PLoS Genet. 2017 Mar 27;13(3):e1006692. doi: 10.1371/journal.pgen.1006692. eCollection 2017 Mar.


A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH.

Nat Biotechnol. 2017 Mar;35(3):280-284. doi: 10.1038/nbt.3781. Epub 2017 Feb 6.


The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.

Sexton JE, Desmonds T, Quick K, Taylor R, Abramowitz J, Forge A, Kros CJ, Birnbaumer L, Wood JN.

Neurosci Lett. 2016 Jan 1;610:36-42. doi: 10.1016/j.neulet.2015.10.052. Epub 2015 Oct 28.


Association of intracellular and synaptic organization in cochlear inner hair cells revealed by 3D electron microscopy.

Bullen A, West T, Moores C, Ashmore J, Fleck RA, MacLellan-Gibson K, Forge A.

J Cell Sci. 2015 Jul 15;128(14):2529-40. doi: 10.1242/jcs.170761. Epub 2015 Jun 4.


Junctions in human health and inherited disease.

Getsios S, Kelsell DP, Forge A.

Cell Tissue Res. 2015 Jun;360(3):435-8. doi: 10.1007/s00441-015-2171-2. Epub 2015 Apr 11. No abstract available.


Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing.

Taylor RR, Jagger DJ, Saeed SR, Axon P, Donnelly N, Tysome J, Moffatt D, Irving R, Monksfield P, Coulson C, Freeman SR, Lloyd SK, Forge A.

Neurobiol Aging. 2015 Jun;36(6):2068-84. doi: 10.1016/j.neurobiolaging.2015.02.013. Epub 2015 Feb 17.


Gap junctional coupling is essential for epithelial repair in the avian cochlea.

Jagger DJ, Nickel R, Forge A.

J Neurosci. 2014 Nov 26;34(48):15851-60. doi: 10.1523/JNEUROSCI.1932-14.2014.


Connexins and gap junctions in the inner ear--it's not just about K⁺ recycling.

Jagger DJ, Forge A.

Cell Tissue Res. 2015 Jun;360(3):633-44. doi: 10.1007/s00441-014-2029-z. Epub 2014 Nov 9. Review.


Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss.

Chen J, Ingham N, Kelly J, Jadeja S, Goulding D, Pass J, Mahajan VB, Tsang SH, Nijnik A, Jackson IJ, White JK, Forge A, Jagger D, Steel KP.

PLoS Genet. 2014 Oct 30;10(10):e1004688. doi: 10.1371/journal.pgen.1004688. eCollection 2014 Oct.


ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.

Morozko EL, Nishio A, Ingham NJ, Chandra R, Fitzgerald T, Martelletti E, Borck G, Wilson E, Riordan GP, Wangemann P, Forge A, Steel KP, Liddle RA, Friedman TB, Belyantseva IA.

Hum Mol Genet. 2015 Feb 1;24(3):609-24. doi: 10.1093/hmg/ddu474. Epub 2014 Sep 12.


Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.

Taylor R, Bullen A, Johnson SL, Grimm-Günter EM, Rivero F, Marcotti W, Forge A, Daudet N.

Hum Mol Genet. 2015 Jan 1;24(1):37-49. doi: 10.1093/hmg/ddu417. Epub 2014 Aug 14.


Inner ear tissue preservation by rapid freezing: improving fixation by high-pressure freezing and hybrid methods.

Bullen A, Taylor RR, Kachar B, Moores C, Fleck RA, Forge A.

Hear Res. 2014 Sep;315:49-60. doi: 10.1016/j.heares.2014.06.006. Epub 2014 Jul 10.


Cochlear implantation in the mouse via the round window: effects of array insertion.

Mistry N, Nolan LS, Saeed SR, Forge A, Taylor RR.

Hear Res. 2014 Jun;312:81-90. doi: 10.1016/j.heares.2014.03.005. Epub 2014 Mar 18.


Hearing loss in a mouse model of 22q11.2 Deletion Syndrome.

Fuchs JC, Zinnamon FA, Taylor RR, Ivins S, Scambler PJ, Forge A, Tucker AS, Linden JF.

PLoS One. 2013 Nov 14;8(11):e80104. doi: 10.1371/journal.pone.0080104. eCollection 2013.


Tricellulin deficiency affects tight junction architecture and cochlear hair cells.

Nayak G, Lee SI, Yousaf R, Edelmann SE, Trincot C, Van Itallie CM, Sinha GP, Rafeeq M, Jones SM, Belyantseva IA, Anderson JM, Forge A, Frolenkov GI, Riazuddin S.

J Clin Invest. 2013 Sep;123(9):4036-49. doi: 10.1172/JCI69031. Epub 2013 Aug 27.


Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea.

Forge A, Jagger DJ, Kelly JJ, Taylor RR.

J Cell Sci. 2013 Apr 1;126(Pt 7):1703-12. doi: 10.1242/jcs.125476. Epub 2013 Feb 19.


Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice.

Mellado Lagarde MM, Cox BC, Fang J, Taylor R, Forge A, Zuo J.

J Neurosci. 2013 Jan 23;33(4):1564-76. doi: 10.1523/JNEUROSCI.3088-12.2013.


The enigmatic root cell - emerging roles contributing to fluid homeostasis within the cochlear outer sulcus.

Jagger DJ, Forge A.

Hear Res. 2013 Sep;303:1-11. doi: 10.1016/j.heares.2012.10.010. Epub 2012 Nov 11. Review.


Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport.

Steinberg G, Schuster M, Theisen U, Kilaru S, Forge A, Martin-Urdiroz M.

J Cell Biol. 2012 Aug 6;198(3):343-55. doi: 10.1083/jcb.201201087. Epub 2012 Jul 30.


TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.

Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN.

Open Biol. 2012 May;2(5):120068. doi: 10.1098/rsob.120068.


Contractility in type III cochlear fibrocytes is dependent on non-muscle myosin II and intercellular gap junctional coupling.

Kelly JJ, Forge A, Jagger DJ.

J Assoc Res Otolaryngol. 2012 Aug;13(4):473-84. doi: 10.1007/s10162-012-0322-7. Epub 2012 Apr 5.


β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear.

Brunetta I, Casalotti SO, Hart IR, Forge A, Reynolds LE.

BMC Cell Biol. 2012 Mar 17;13:5. doi: 10.1186/1471-2121-13-5.


Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ.

Goodyear RJ, Jones SM, Sharifi L, Forge A, Richardson GP.

J Neurosci. 2012 Feb 22;32(8):2762-72. doi: 10.1523/JNEUROSCI.3635-11.2012.


Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea.

Taylor RR, Jagger DJ, Forge A.

PLoS One. 2012;7(1):e30577. doi: 10.1371/journal.pone.0030577. Epub 2012 Jan 27.


Hearing in 44-45 year olds with m.1555A>G, a genetic mutation predisposing to aminoglycoside-induced deafness: a population based cohort study.

Rahman S, Ecob R, Costello H, Sweeney MG, Duncan AJ, Pearce K, Strachan D, Forge A, Davis A, Bitner-Glindzicz M.

BMJ Open. 2012 Jan 5;2:e000411. doi: 10.1136/bmjopen-2011-000411. Print 2012.


Assessing PCP in the cochlea of mammalian ciliopathy models.

Jagger DJ, Forge A.

Methods Mol Biol. 2012;839:239-48. doi: 10.1007/978-1-61779-510-7_19.


The aneurogenic limb identifies developmental cell interactions underlying vertebrate limb regeneration.

Kumar A, Delgado JP, Gates PB, Neville G, Forge A, Brockes JP.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13588-93. doi: 10.1073/pnas.1108472108. Epub 2011 Aug 8.


Development of gap junctional intercellular communication within the lateral wall of the rat cochlea.

Kelly JJ, Forge A, Jagger DJ.

Neuroscience. 2011 Apr 28;180:360-9. doi: 10.1016/j.neuroscience.2011.02.011. Epub 2011 Feb 12.


Alström Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity.

Jagger D, Collin G, Kelly J, Towers E, Nevill G, Longo-Guess C, Benson J, Halsey K, Dolan D, Marshall J, Naggert J, Forge A.

Hum Mol Genet. 2011 Feb 1;20(3):466-81. doi: 10.1093/hmg/ddq493. Epub 2010 Nov 11.


Asymmetric distribution of cadherin 23 and protocadherin 15 in the kinocilial links of avian sensory hair cells.

Goodyear RJ, Forge A, Legan PK, Richardson GP.

J Comp Neurol. 2010 Nov 1;518(21):4288-97. doi: 10.1002/cne.22456.


A comparative study of gland cells implicated in the nerve dependence of salamander limb regeneration.

Kumar A, Nevill G, Brockes JP, Forge A.

J Anat. 2010 Jul;217(1):16-25. doi: 10.1111/j.1469-7580.2010.01239.x. Epub 2010 Apr 26.


The Membrane Properties of Cochlear Root Cells are Consistent with Roles in Potassium Recirculation and Spatial Buffering.

Jagger DJ, Nevill G, Forge A.

J Assoc Res Otolaryngol. 2010 Sep;11(3):435-48. doi: 10.1007/s10162-010-0218-3. Epub 2010 Apr 15.


A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes.

Burns SO, Killock DJ, Moulding DA, Metelo J, Nunes J, Taylor RR, Forge A, Thrasher AJ, Ivetic A.

Blood. 2010 Jul 1;115(26):5355-65. doi: 10.1182/blood-2009-08-236174. Epub 2010 Mar 30.


Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions.

May-Simera HL, Ross A, Rix S, Forge A, Beales PL, Jagger DJ.

J Comp Neurol. 2009 May 10;514(2):174-88. doi: 10.1002/cne.22001.


Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

Lelli A, Asai Y, Forge A, Holt JR, Géléoc GS.

J Neurophysiol. 2009 Jun;101(6):2961-73. doi: 10.1152/jn.00136.2009. Epub 2009 Apr 1.


Gap junctions and connexins in the inner ear: their roles in homeostasis and deafness.

Nickel R, Forge A.

Curr Opin Otolaryngol Head Neck Surg. 2008 Oct;16(5):452-7. doi: 10.1097/MOO.0b013e32830e20b0. Review.


Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses.

Johnson SL, Forge A, Knipper M, Münkner S, Marcotti W.

J Neurosci. 2008 Jul 23;28(30):7670-8. doi: 10.1523/JNEUROSCI.0785-08.2008.


Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.

Oesterle EC, Campbell S, Taylor RR, Forge A, Hume CR.

J Assoc Res Otolaryngol. 2008 Mar;9(1):65-89. Epub 2007 Dec 22.


Rapid hair cell loss: a mouse model for cochlear lesions.

Taylor RR, Nevill G, Forge A.

J Assoc Res Otolaryngol. 2008 Mar;9(1):44-64. Epub 2007 Dec 4.


MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt.

Tsonis PA, Call MK, Grogg MW, Sartor MA, Taylor RR, Forge A, Fyffe R, Goldenberg R, Cowper-Sal-lari R, Tomlinson CR.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):940-5. Epub 2007 Aug 27.


Tricellulin is a tight-junction protein necessary for hearing.

Riazuddin S, Ahmed ZM, Fanning AS, Lagziel A, Kitajiri S, Ramzan K, Khan SN, Chattaraj P, Friedman PL, Anderson JM, Belyantseva IA, Forge A, Riazuddin S, Friedman TB.

Am J Hum Genet. 2006 Dec;79(6):1040-51. Epub 2006 Oct 31.


Relationship of opioid receptors with GABAergic neurons in the rat inferior colliculus.

Tongjaroenbuangam W, Jongkamonwiwat N, Phansuwan-Pujito P, Casalotti SO, Forge A, Dodson H, Govitrapong P.

Eur J Neurosci. 2006 Oct;24(7):1987-94. Epub 2006 Oct 16.


The existence of opioid receptors in the cochlea of guinea pigs.

Jongkamonwiwat N, Phansuwan-Pujito P, Casalotti SO, Forge A, Dodson H, Govitrapong P.

Eur J Neurosci. 2006 May;23(10):2701-11.


Molecular and functional characterization of gap junctions in the avian inner ear.

Nickel R, Becker D, Forge A.

J Neurosci. 2006 Jun 7;26(23):6190-9. Erratum in: J Neurosci. 2006 Jun 21;26(25):table of contents.

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