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Items: 1 to 50 of 161

1.

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus.

Foretz M, Guigas B, Viollet B.

Nat Rev Endocrinol. 2019 Oct;15(10):569-589. doi: 10.1038/s41574-019-0242-2. Epub 2019 Aug 22. Review.

PMID:
31439934
2.

Salt-inducible kinases dictate parathyroid hormone receptor action in bone development and remodeling.

Nishimori S, O'Meara MJ, Castro C, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, Jüppner H, Kronenberg HM, Wein MN.

J Clin Invest. 2019 Aug 20. pii: 130126. doi: 10.1172/JCI130126. [Epub ahead of print]

3.

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.

Collodet C, Foretz M, Deak M, Bultot L, Metairon S, Viollet B, Lefebvre G, Raymond F, Parisi A, Civiletto G, Gut P, Descombes P, Sakamoto K.

FASEB J. 2019 Aug 19:fj201900841R. doi: 10.1096/fj.201900841R. [Epub ahead of print]

4.

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sallé D, Aksoy E, Staels B, Dombrowicz D.

Cell. 2019 Jun 27;178(1):263. doi: 10.1016/j.cell.2019.06.017. No abstract available.

PMID:
31251916
5.

Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells.

Shum M, Houde VP, Bellemare V, Junges Moreira R, Bellmann K, St-Pierre P, Viollet B, Foretz M, Marette A.

J Biol Chem. 2019 Aug 9;294(32):12250-12260. doi: 10.1074/jbc.RA119.008488. Epub 2019 Jun 26.

PMID:
31243102
6.

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sallé D, Aksoy E, Staels B, Dombrowicz D.

Cell. 2019 May 16;177(5):1201-1216.e19. doi: 10.1016/j.cell.2019.03.018. Epub 2019 Apr 25. Erratum in: Cell. 2019 Jun 27;178(1):263.

PMID:
31031005
7.

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction.

Kjøbsted R, Roll JLW, Jørgensen NO, Birk JB, Foretz M, Viollet B, Chadt A, Al-Hasani H, Wojtaszewski JFP.

Diabetes. 2019 Jul;68(7):1427-1440. doi: 10.2337/db19-0050. Epub 2019 Apr 22.

PMID:
31010958
8.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Vara-Ciruelos D, Dandapani M, Russell FM, Grzes KM, Atrih A, Foretz M, Viollet B, Lamont DJ, Cantrell DA, Hardie DG.

Cell Rep. 2019 Apr 16;27(3):690-698.e4. doi: 10.1016/j.celrep.2019.03.067.

9.

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018).

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM.

Trends Endocrinol Metab. 2019 Jun;30(6):407. doi: 10.1016/j.tem.2019.01.009. Epub 2019 Mar 2. No abstract available.

PMID:
30837108
10.

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates.

Ducommun S, Deak M, Zeigerer A, Göransson O, Seitz S, Collodet C, Madsen AB, Jensen TE, Viollet B, Foretz M, Gut P, Sumpton D, Sakamoto K.

Cell Signal. 2019 May;57:45-57. doi: 10.1016/j.cellsig.2019.02.001. Epub 2019 Feb 14.

11.

Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction.

Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF Jr, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E.

Basic Res Cardiol. 2019 Jan 14;114(2):8. doi: 10.1007/s00395-019-0717-2.

PMID:
30643968
12.

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation.

Nadeau L, Patten DA, Caron A, Garneau L, Pinault-Masson E, Foretz M, Haddad P, Anderson BG, Quinn LS, Jardine K, McBurney MW, Pistilli EE, Harper ME, Aguer C.

Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):395-407. doi: 10.1016/j.bbagen.2018.10.021. Epub 2018 Nov 15.

PMID:
30448294
13.

A functional role for AMPK in female fertility and endometrial regeneration

McCallum ML, Pru CA, Smith AR, Kelp NC, Foretz M, Viollet B, Du M, Pru JK.

Reproduction. 2018 Sep 12. pii: REP-18-0372. doi: 10.1530/REP-18-0372. [Epub ahead of print]

PMID:
30328345
14.

Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis.

Ladli M, Richard C, Aguilar LC, Ducamp S, Bondu S, Sujobert P, Tamburini J, Lacombe C, Azar N, Foretz M, Zermati Y, Mayeux P, Viollet B, Verdier F.

Haematologica. 2019 May;104(5):907-918. doi: 10.3324/haematol.2018.191403. Epub 2018 Oct 11.

15.

The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria.

Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M, Moran C, Hardie DG, Evans AM.

Sci Signal. 2018 Oct 2;11(550). pii: eaau0296. doi: 10.1126/scisignal.aau0296.

PMID:
30279167
16.

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo.

Foretz M, Even PC, Viollet B.

Int J Mol Sci. 2018 Sep 19;19(9). pii: E2826. doi: 10.3390/ijms19092826.

17.

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM.

Trends Endocrinol Metab. 2018 Oct;29(10):723-735. doi: 10.1016/j.tem.2018.08.004. Epub 2018 Aug 24. Review. Erratum in: Trends Endocrinol Metab. 2019 Mar 2;:.

18.

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Hingst JR, Bruhn L, Hansen MB, Rosschou MF, Birk JB, Fentz J, Foretz M, Viollet B, Sakamoto K, Færgeman NJ, Havelund JF, Parker BL, James DE, Kiens B, Richter EA, Jensen J, Wojtaszewski JFP.

Mol Metab. 2018 Oct;16:24-34. doi: 10.1016/j.molmet.2018.07.001. Epub 2018 Jul 25.

19.

α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.

Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF Jr, Münzel T, Wenzel P, Schulz E.

Cardiovasc Res. 2018 Dec 1;114(14):1883-1893. doi: 10.1093/cvr/cvy172.

PMID:
29982418
20.

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol.

Foretz M, Viollet B.

EBioMedicine. 2018 May;31:15-16. doi: 10.1016/j.ebiom.2018.05.009. Epub 2018 May 10. No abstract available.

21.

Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells.

Foretz M, Viollet B.

Methods Mol Biol. 2018;1732:363-371. doi: 10.1007/978-1-4939-7598-3_23.

22.

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration.

Maillet V, Boussetta N, Leclerc J, Fauveau V, Foretz M, Viollet B, Couty JP, Celton-Morizur S, Perret C, Desdouets C.

Cell Rep. 2018 Feb 20;22(8):1994-2005. doi: 10.1016/j.celrep.2018.01.086.

23.

Promise and challenges for direct small molecule AMPK activators.

Olivier S, Foretz M, Viollet B.

Biochem Pharmacol. 2018 Jul;153:147-158. doi: 10.1016/j.bcp.2018.01.049. Epub 2018 Feb 3. Review.

24.

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

Boudaba N, Marion A, Huet C, Pierre R, Viollet B, Foretz M.

EBioMedicine. 2018 Feb;28:194-209. doi: 10.1016/j.ebiom.2018.01.008. Epub 2018 Jan 9.

25.

AMPK in skeletal muscle function and metabolism.

Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L.

FASEB J. 2018 Apr;32(4):1741-1777. doi: 10.1096/fj.201700442R. Epub 2018 Jan 5. Review.

26.

Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.

Martin KR, Pederzoli-Ribeil M, Pacreau E, Burgener SS, Dahdah A, Candalh C, Lauret E, Foretz M, Mouthon L, Lucas B, Thieblemont N, Benarafa C, Launay P, Witko-Sarsat V.

J Immunol. 2017 Dec 1;199(11):3914-3924. doi: 10.4049/jimmunol.1601522. Epub 2017 Oct 27.

27.

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2017 Dec 8;292(49):20125-20140. doi: 10.1074/jbc.M117.811547. Epub 2017 Oct 16.

28.

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes.

Deschemin JC, Foretz M, Viollet B, Vaulont S.

Sci Rep. 2017 Oct 4;7(1):12679. doi: 10.1038/s41598-017-12976-2.

29.

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Wall ML, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Aug 16;12(8):e0183601. doi: 10.1371/journal.pone.0183601. eCollection 2017.

30.

Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice.

Chalvon-Demersay T, Even PC, Chaumontet C, Piedcoq J, Viollet B, Gaudichon C, Tomé D, Foretz M, Azzout-Marniche D.

J Nutr. 2017 Sep;147(9):1669-1676. doi: 10.3945/jn.117.250803. Epub 2017 Jul 26.

PMID:
28747486
31.

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.

Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R.

EMBO J. 2017 Jul 3;36(13):1946-1962. doi: 10.15252/embj.201695273. Epub 2017 May 17.

32.

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA.

Cell Metab. 2017 May 2;25(5):1147-1159.e10. doi: 10.1016/j.cmet.2017.04.010.

33.

Corrigendum: SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

Nat Commun. 2017 Feb 22;8:14745. doi: 10.1038/ncomms14745. No abstract available.

34.

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling.

Vauthier V, Roujeau C, Chen P, Sarkis C, Migrenne S, Hosoi T, Ozawa K, Rouillé Y, Foretz M, Mallet J, Launay JM, Magnan C, Jockers R, Dam J.

Mol Metab. 2016 Nov 3;6(1):159-172. doi: 10.1016/j.molmet.2016.10.009. eCollection 2017 Jan.

35.

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Jan 20;12(1):e0170382. doi: 10.1371/journal.pone.0170382. eCollection 2017. Erratum in: PLoS One. 2017 Aug 16;12 (8):e0183601.

36.

Animal Models to Study AMPK.

Viollet B, Foretz M.

Exp Suppl. 2016;107:441-469. Review.

37.

Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk.

Chakhtoura Z, Laki F, Bernadet M, Cherifi I, Chiche A, Pigat N, Bernichtein S, Courtillot C, Boutillon F, Bièche I, Vacher S, Tanguy ML, Bissery A, Grouthier V, Camparo P, Foretz M, Do Cruzeiro M, Pierre R, Rakotozafy F, Tichet J, Tejedor I, Guidotti JE, Sigal-Zafrani B, Goffin V, Touraine P.

J Clin Endocrinol Metab. 2016 Nov;101(11):4449-4460. Epub 2016 Aug 30.

PMID:
27575941
38.

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Kjøbsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Björnholm M, Zierath JR, Treebak JT, Wojtaszewski JF.

Diabetes. 2017 Mar;66(3):598-612. doi: 10.2337/db16-0530. Epub 2016 Oct 26.

39.

SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176.

40.

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis.

Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M.

Cell Metab. 2016 Oct 11;24(4):542-554. doi: 10.1016/j.cmet.2016.08.010. Epub 2016 Sep 15.

41.

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.

Bultot L, Jensen TE, Lai YC, Madsen AL, Collodet C, Kviklyte S, Deak M, Yavari A, Foretz M, Ghaffari S, Bellahcene M, Ashrafian H, Rider MH, Richter EA, Sakamoto K.

Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719. doi: 10.1152/ajpendo.00237.2016. Epub 2016 Aug 30.

42.

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJ, Savinko T, Wong AK, Viollet B, Sakamoto K, Fagerholm SC, Foretz M, Lang CC, Rena G.

Circ Res. 2016 Aug 19;119(5):652-65. doi: 10.1161/CIRCRESAHA.116.308445. Epub 2016 Jul 14.

43.

Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection.

Nieves W, Hung LY, Oniskey TK, Boon L, Foretz M, Viollet B, Herbert DR.

J Immunol. 2016 Jun 1;196(11):4632-40. doi: 10.4049/jimmunol.1502218. Epub 2016 Apr 20.

44.

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug.

Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, Sakamoto K, McDougall G, Foretz M, Rena G.

Biochim Biophys Acta. 2016 Aug;1862(8):1412-22. doi: 10.1016/j.bbadis.2016.04.015. Epub 2016 Apr 27.

45.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA.

PLoS One. 2016 Mar 24;11(3):e0149549. doi: 10.1371/journal.pone.0149549. eCollection 2016.

46.

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH.

Nat Commun. 2016 Mar 8;7:10856. doi: 10.1038/ncomms10856.

47.

Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality.

Bertoldo MJ, Guibert E, Faure M, Guillou F, Ramé C, Nadal-Desbarats L, Foretz M, Viollet B, Dupont J, Froment P.

Mol Cell Endocrinol. 2016 Mar 5;423:96-112. doi: 10.1016/j.mce.2016.01.001. Epub 2016 Jan 7.

PMID:
26772142
48.

AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea.

Mahmoud AD, Lewis S, Juričić L, Udoh UA, Hartmann S, Jansen MA, Ogunbayo OA, Puggioni P, Holmes AP, Kumar P, Navarro-Dorado J, Foretz M, Viollet B, Dutia MB, Marshall I, Evans AM.

Am J Respir Crit Care Med. 2016 May 1;193(9):1032-43. doi: 10.1164/rccm.201508-1667OC.

49.

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

Fentz J, Kjøbsted R, Kristensen CM, Hingst JR, Birk JB, Gudiksen A, Foretz M, Schjerling P, Viollet B, Pilegaard H, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2015 Dec 1;309(11):E900-14. doi: 10.1152/ajpendo.00157.2015. Epub 2015 Sep 29.

50.

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK.

Fu X, Zhu M, Zhang S, Foretz M, Viollet B, Du M.

Diabetes. 2016 Jan;65(1):188-200. doi: 10.2337/db15-0647. Epub 2015 Sep 17.

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