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Light on the cell cycle of the non-photosynthetic bacterium Ramlibacter tataouinensis.

De Luca G, Fochesato S, Lavergne J, Forest KT, Barakat M, Ortet P, Achouak W, Heulin T, Verméglio A.

Sci Rep. 2019 Nov 11;9(1):16505. doi: 10.1038/s41598-019-52927-7.


Retention of Native Quaternary Structure in Racemic Melittin Crystals.

Kurgan KW, Kleman AF, Bingman CA, Kreitler DF, Weisblum B, Forest KT, Gellman SH.

J Am Chem Soc. 2019 May 15;141(19):7704-7708. doi: 10.1021/jacs.9b02691. Epub 2019 May 6.


Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin α3 Toxicity.

Yao Z, Cary BP, Bingman CA, Wang C, Kreitler DF, Satyshur KA, Forest KT, Gellman SH.

J Am Chem Soc. 2019 May 15;141(19):7660-7664. doi: 10.1021/jacs.9b00349. Epub 2019 May 2.


Type IV pili: dynamics, biophysics and functional consequences.

Craig L, Forest KT, Maier B.

Nat Rev Microbiol. 2019 Jul;17(7):429-440. doi: 10.1038/s41579-019-0195-4. Review.


A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation.

Kreitler DF, Yao Z, Steinkruger JD, Mortenson DE, Huang L, Mittal R, Travis BR, Forest KT, Gellman SH.

J Am Chem Soc. 2019 Jan 30;141(4):1583-1592. doi: 10.1021/jacs.8b11246. Epub 2019 Jan 15.


Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid.

Windsor IW, Palte MJ, Lukesh JC 3rd, Gold B, Forest KT, Raines RT.

J Am Chem Soc. 2018 Oct 31;140(43):14015-14018. doi: 10.1021/jacs.8b07366. Epub 2018 Oct 22.


acI Actinobacteria Assemble a Functional Actinorhodopsin with Natively Synthesized Retinal.

Dwulit-Smith JR, Hamilton JJ, Stevenson DM, He S, Oyserman BO, Moya-Flores F, Garcia SL, Amador-Noguez D, McMahon KD, Forest KT.

Appl Environ Microbiol. 2018 Nov 30;84(24). pii: e01678-18. doi: 10.1128/AEM.01678-18. Print 2018 Dec 15.


Evaluation of β-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure.

Mortenson DE, Kreitler DF, Thomas NC, Guzei IA, Gellman SH, Forest KT.

Chembiochem. 2018 Mar 16;19(6):604-612. doi: 10.1002/cbic.201700580. Epub 2018 Feb 13.


Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics.

Douzi B, Trinh NTT, Michel-Souzy S, Desmyter A, Ball G, Barbier P, Kosta A, Durand E, Forest KT, Cambillau C, Roussel A, Voulhoux R.

mBio. 2017 Oct 17;8(5). pii: e01185-17. doi: 10.1128/mBio.01185-17.


Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.

Smith TP, Windsor IW, Forest KT, Raines RT.

J Med Chem. 2017 Sep 28;60(18):7820-7834. doi: 10.1021/acs.jmedchem.7b00952. Epub 2017 Sep 18.


Metabolic Network Analysis and Metatranscriptomics Reveal Auxotrophies and Nutrient Sources of the Cosmopolitan Freshwater Microbial Lineage acI.

Hamilton JJ, Garcia SL, Brown BS, Oyserman BO, Moya-Flores F, Bertilsson S, Malmstrom RR, Forest KT, McMahon KD.

mSystems. 2017 Aug 29;2(4). pii: e00091-17. doi: 10.1128/mSystems.00091-17. eCollection 2017 Jul-Aug.


Shearing and Enrichment of Extracellular Type IV Pili.

Gonzalez Rivera AK, Forest KT.

Methods Mol Biol. 2017;1615:311-320. doi: 10.1007/978-1-4939-7033-9_25.


Conformational Control of UDP-Galactopyranose Mutase Inhibition.

Wangkanont K, Winton VJ, Forest KT, Kiessling LL.

Biochemistry. 2017 Aug 1;56(30):3983-3992. doi: 10.1021/acs.biochem.7b00189. Epub 2017 Jul 20.


Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili.

Goosens VJ, Busch A, Georgiadou M, Castagnini M, Forest KT, Waksman G, Pelicic V.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4978-E4986. doi: 10.1073/pnas.1618539114. Epub 2017 Jun 6.


Effects of Single α-to-β Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization.

Kreitler DF, Mortenson DE, Forest KT, Gellman SH.

J Am Chem Soc. 2016 May 25;138(20):6498-505. doi: 10.1021/jacs.6b01454. Epub 2016 May 12.


Classic Spotlight: Crowd Sourcing Provided Penicillium Strains for the War Effort.

Forest KT, Stock AM.

J Bacteriol. 2016 Feb 29;198(6):877. doi: 10.1128/JB.00903-15. Print 2016 Mar. No abstract available.


Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction.

Baker AW, Satyshur KA, Moreno Morales N, Forest KT.

J Bacteriol. 2016 Mar 31;198(8):1218-29. doi: 10.1128/JB.00872-15. Print 2016 Apr.


Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.

Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT.

J Biol Chem. 2016 Mar 11;291(11):5596-610. doi: 10.1074/jbc.M115.709212. Epub 2016 Jan 11.


Removal of Chromophore-Proximal Polar Atoms Decreases Water Content and Increases Fluorescence in a Near Infrared Phytofluor.

Lehtivuori H, Bhattacharya S, Angenent-Mari NM, Satyshur KA, Forest KT.

Front Mol Biosci. 2015 Nov 25;2:65. doi: 10.3389/fmolb.2015.00065. eCollection 2015.


High-resolution structures of a heterochiral coiled coil.

Mortenson DE, Steinkruger JD, Kreitler DF, Perroni DV, Sorenson GP, Huang L, Mittal R, Yun HG, Travis BR, Mahanthappa MK, Forest KT, Gellman SH.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13144-9. doi: 10.1073/pnas.1507918112. Epub 2015 Oct 12.


Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif.

Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, Gellman SH.

J Am Chem Soc. 2015 Sep 23;137(37):11884-7. doi: 10.1021/jacs.5b07206. Epub 2015 Sep 10.


Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.

Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL.

ACS Chem Biol. 2015 Oct 16;10(10):2209-18. doi: 10.1021/acschembio.5b00370. Epub 2015 Aug 17.


Recognition of microbial glycans by human intelectin-1.

Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL.

Nat Struct Mol Biol. 2015 Aug;22(8):603-10. doi: 10.1038/nsmb.3053. Epub 2015 Jul 6.


The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain.

Wangkanont K, Forest KT, Kiessling LL.

Protein Expr Purif. 2015 Nov;115:19-25. doi: 10.1016/j.pep.2015.06.001. Epub 2015 Jun 11.


Editorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level.

Forest KT, Hill CP.

Curr Opin Struct Biol. 2015 Apr;31:vii-viii. doi: 10.1016/ Epub 2015 May 29. No abstract available.


Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold.

Checco JW, Kreitler DF, Thomas NC, Belair DG, Rettko NJ, Murphy WL, Forest KT, Gellman SH.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4552-7. doi: 10.1073/pnas.1420380112. Epub 2015 Mar 30.


A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate.

Park H, Kevany BM, Dyer DH, Thomas MG, Forest KT.

PLoS One. 2014 Oct 23;9(10):e110965. doi: 10.1371/journal.pone.0110965. eCollection 2014.


Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV.

Hastie JL, Williams KB, Sepúlveda C, Houtman JC, Forest KT, Ellermeier CD.

PLoS Genet. 2014 Oct 2;10(10):e1004643. doi: 10.1371/journal.pgen.1004643. eCollection 2014 Oct.


Origins of fluorescence in evolved bacteriophytochromes.

Bhattacharya S, Auldridge ME, Lehtivuori H, Ihalainen JA, Forest KT.

J Biol Chem. 2014 Nov 14;289(46):32144-52. doi: 10.1074/jbc.M114.589739. Epub 2014 Sep 24.


Comparative single-cell genomics reveals potential ecological niches for the freshwater acI Actinobacteria lineage.

Ghylin TW, Garcia SL, Moya F, Oyserman BO, Schwientek P, Forest KT, Mutschler J, Dwulit-Smith J, Chan LK, Martinez-Garcia M, Sczyrba A, Stepanauskas R, Grossart HP, Woyke T, Warnecke F, Malmstrom R, Bertilsson S, McMahon KD.

ISME J. 2014 Dec;8(12):2503-16. doi: 10.1038/ismej.2014.135. Epub 2014 Aug 5.


Structural biology: Action at a distance in a light receptor.

Baker AW, Forest KT.

Nature. 2014 May 8;509(7499):174-5. doi: 10.1038/nature13331. Epub 2014 Apr 30. No abstract available.


Vivid watercolor paintbox for eukaryotic algae.

Forest KT.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5448-9. doi: 10.1073/pnas.1403530111. Epub 2014 Apr 8. No abstract available.


Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain.

Mortenson DE, Kreitler DF, Yun HG, Gellman SH, Forest KT.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2506-12. doi: 10.1107/S090744491302444X. Epub 2013 Nov 19.


Pigment-protein interactions in phytochromes probed by fluorescence line narrowing spectroscopy.

Nieder JB, Stojković EA, Moffat K, Forest KT, Lamparter T, Bittl R, Kennis JT.

J Phys Chem B. 2013 Dec 5;117(48):14940-50. doi: 10.1021/jp409110q. Epub 2013 Nov 22.


Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue.

Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH.

J Am Chem Soc. 2013 Oct 23;135(42):15738-15741. doi: 10.1021/ja409082w. Epub 2013 Oct 8.


Differential impact of β and γ residue preorganization on α/β/γ-peptide helix stability in water.

Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH.

J Am Chem Soc. 2013 Jun 5;135(22):8149-52. doi: 10.1021/ja403319q. Epub 2013 May 23.


Enterotoxigenic Escherichia coli CS1 pilus: not one structure but several.

Forest KT.

J Bacteriol. 2013 Apr;195(7):1357-9. doi: 10.1128/JB.00053-13. Epub 2013 Jan 25. No abstract available.


Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the Pseudomonas aeruginosa prepilin peptidase PilD.

Aly KA, Beebe ET, Chan CH, Goren MA, Sepúlveda C, Makino S, Fox BG, Forest KT.

Microbiologyopen. 2013 Feb;2(1):94-104. doi: 10.1002/mbo3.51. Epub 2012 Dec 17.


Structural insights into the Type II secretion nanomachine.

McLaughlin LS, Haft RJ, Forest KT.

Curr Opin Struct Biol. 2012 Apr;22(2):208-16. doi: 10.1016/ Epub 2012 Mar 16. Review.


Quasiracemic crystallization as a tool to assess the accommodation of noncanonical residues in nativelike protein conformations.

Mortenson DE, Satyshur KA, Guzei IA, Forest KT, Gellman SH.

J Am Chem Soc. 2012 Feb 8;134(5):2473-6. doi: 10.1021/ja210045s. Epub 2012 Jan 18.


Structure-guided engineering enhances a phytochrome-based infrared fluorescent protein.

Auldridge ME, Satyshur KA, Anstrom DM, Forest KT.

J Biol Chem. 2012 Mar 2;287(10):7000-9. doi: 10.1074/jbc.M111.295121. Epub 2011 Dec 30.


Crystal structure of the Pseudomonas aeruginosa virulence factor regulator.

Cordes TJ, Worzalla GA, Ginster AM, Forest KT.

J Bacteriol. 2011 Aug;193(16):4069-74. doi: 10.1128/JB.00666-10. Epub 2011 Jun 10.


Bacterial phytochromes: more than meets the light.

Auldridge ME, Forest KT.

Crit Rev Biochem Mol Biol. 2011 Feb;46(1):67-88. doi: 10.3109/10409238.2010.546389. Review.


Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system.

Franz LP, Douzi B, Durand E, Dyer DH, Voulhoux R, Forest KT.

Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):124-30. doi: 10.1107/S0907444910051954. Epub 2011 Jan 15.


P. aeruginosa PilT structures with and without nucleotide reveal a dynamic type IV pilus retraction motor.

Misic AM, Satyshur KA, Forest KT.

J Mol Biol. 2010 Jul 30;400(5):1011-21. doi: 10.1016/j.jmb.2010.05.066. Epub 2010 Jun 1.


Stereoelectronic and steric effects in side chains preorganize a protein main chain.

Shoulders MD, Satyshur KA, Forest KT, Raines RT.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):559-64. doi: 10.1073/pnas.0909592107. Epub 2009 Dec 31.


X-ray crystallography reveals a reduced substrate complex of UDP-galactopyranose mutase poised for covalent catalysis by flavin.

Gruber TD, Westler WM, Kiessling LL, Forest KT.

Biochemistry. 2009 Oct 6;48(39):9171-3. doi: 10.1021/bi901437v.


Ligand binding and substrate discrimination by UDP-galactopyranose mutase.

Gruber TD, Borrok MJ, Westler WM, Forest KT, Kiessling LL.

J Mol Biol. 2009 Aug 14;391(2):327-40. doi: 10.1016/j.jmb.2009.05.081. Epub 2009 Jun 3.


Structure-based design of a periplasmic binding protein antagonist that prevents domain closure.

Borrok MJ, Zhu Y, Forest KT, Kiessling LL.

ACS Chem Biol. 2009 Jun 19;4(6):447-56. doi: 10.1021/cb900021q.


Extracellular bacterial pathogen induces host cell surface reorganization to resist shear stress.

Mikaty G, Soyer M, Mairey E, Henry N, Dyer D, Forest KT, Morand P, Guadagnini S, Prévost MC, Nassif X, Duménil G.

PLoS Pathog. 2009 Feb;5(2):e1000314. doi: 10.1371/journal.ppat.1000314. Epub 2009 Feb 27.

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