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CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions.

Easley-Neal C, Foreman O, Sharma N, Zarrin AA, Weimer RM.

Front Immunol. 2019 Sep 20;10:2199. doi: 10.3389/fimmu.2019.02199. eCollection 2019.


Applications and considerations for the use of genetically engineered mouse models in drug development.

Webster JD, Santagostino SF, Foreman O.

Cell Tissue Res. 2019 Sep 5. doi: 10.1007/s00441-019-03101-y. [Epub ahead of print] Review.


Corrigendum to "Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS" Neurobiology of Disease 124 (2019) 340-352.

Sengupta-Ghosh A, Dominguez SL, Xie L, Barck KH, Jiang Z, Earr T, Imperio J, Phu L, Budayeva HG, Kirkpatrick DS, Cai H, He D, Eastham-Anderson J, Ngu H, Foreman O, Hedehus M, Reichelt M, Hotzel I, Shang Y, Carano RAD, Ayalon G, Easton A.

Neurobiol Dis. 2019 Aug 27:104558. doi: 10.1016/j.nbd.2019.104558. [Epub ahead of print] No abstract available.


Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.

Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, Barck KH, Stark M, Ngu H, Foreman O, Meilandt WJ, Elstrott J, Chang MC, Hansen DV, Carano RAD, Sheng M, Hanson JE.

Cell Rep. 2019 Aug 20;28(8):2111-2123.e6. doi: 10.1016/j.celrep.2019.07.060.


Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation.

Long JE, Wongchenko MJ, Nickles D, Chung WJ, Wang BE, Riegler J, Li J, Li Q, Sandoval W, Eastham-Anderson J, Modrusan Z, Junttila T, Carano RAD, Foreman O, Yan Y, Junttila MR.

Cell Death Differ. 2019 Nov;26(11):2416-2429. doi: 10.1038/s41418-019-0310-0. Epub 2019 Mar 1.


Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS.

Sengupta-Ghosh A, Dominguez SL, Xie L, Barck KH, Jiang Z, Earr T, Imperio J, Phu L, Budayeva HG, Kirkpatrick DS, Cai H, Eastham-Anderson J, Ngu H, Foreman O, Hedehus M, Reichelt M, Hotzel I, Shang Y, Carano RAD, Ayalon G, Easton A.

Neurobiol Dis. 2019 Apr;124:340-352. doi: 10.1016/j.nbd.2018.12.002. Epub 2018 Dec 4. Erratum in: Neurobiol Dis. 2019 Aug 27;:104558.


Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.

Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, Carano RAD, Chih B, Klumperman J, Bakalarski C, Hanson JE, Sheng M.

Neuron. 2018 Dec 19;100(6):1322-1336.e7. doi: 10.1016/j.neuron.2018.10.014. Epub 2018 Nov 1.


Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade.

Zheng J, Sha Y, Roof L, Foreman O, Lazarchick J, Venkta JK, Kozlowski C, Gasparetto C, Chao N, Ebens A, Hu J, Kang Y.

Cancer Lett. 2019 Jan;440-441:1-10. doi: 10.1016/j.canlet.2018.10.003. Epub 2018 Oct 9.


Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors.

Shields SD, Deng L, Reese RM, Dourado M, Tao J, Foreman O, Chang JH, Hackos DH.

J Neurosci. 2018 Nov 21;38(47):10180-10201. doi: 10.1523/JNEUROSCI.1049-18.2018. Epub 2018 Oct 9.


Micro-CT imaging and structural analysis of glomeruli in a model of Adriamycin-induced nephropathy.

Xie L, Koukos G, Barck K, Foreman O, Lee WP, Brendza R, Eastham-Anderson J, McKenzie BS, Peterson A, Carano RAD.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F76-F89. doi: 10.1152/ajprenal.00331.2018. Epub 2018 Sep 26.


CD8+ T cell infiltration in breast and colon cancer: A histologic and statistical analysis.

Ziai J, Gilbert HN, Foreman O, Eastham-Anderson J, Chu F, Huseni M, Kim JM.

PLoS One. 2018 Jan 10;13(1):e0190158. doi: 10.1371/journal.pone.0190158. eCollection 2018.


Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous.

Chung WJ, Daemen A, Cheng JH, Long JE, Cooper JE, Wang BE, Tran C, Singh M, Gnad F, Modrusan Z, Foreman O, Junttila MR.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10947-E10955. doi: 10.1073/pnas.1708391114. Epub 2017 Dec 4.


Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394. doi: 10.1126/scitranslmed.aag0394.


Mice deficient in NRROS show abnormal microglial development and neurological disorders.

Wong K, Noubade R, Manzanillo P, Ota N, Foreman O, Hackney JA, Friedman BA, Pappu R, Scearce-Levie K, Ouyang W.

Nat Immunol. 2017 Jun;18(6):633-641. doi: 10.1038/ni.3743. Epub 2017 May 1.


BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.

Weber M, Wu T, Meilandt WJ, Dominguez SL, Solanoy HO, Maloney JA, Ngu H, Baca M, Kung C, Lima L, Earr TK, Fleck D, Shields SD, Forrest WF, Foreman O, Warming S, Watts RJ, Scearce-Levie K.

Sci Rep. 2017 Mar 10;7:44249. doi: 10.1038/srep44249.


A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis.

Castro-Jorge LA, Pretto CD, Smith AB, Foreman O, Carnahan KE, Spindler KR.

J Virol. 2017 Jan 31;91(4). pii: e02106-16. doi: 10.1128/JVI.02106-16. Print 2017 Feb 15.


Development and Application of a Microfluidics-Based Panel in the Basal/Luminal Transcriptional Characterization of Archival Bladder Cancers.

Kim D, Choi Y, Ireland J, Foreman O, Tam RN, Patel R, Schleifman EB, Motlhabi M, French D, Wong CV, Peters E, Molinero L, Raja R, Amler LC, Hampton GM, Lackner MR, Kabbarah O.

PLoS One. 2016 Nov 15;11(11):e0165856. doi: 10.1371/journal.pone.0165856. eCollection 2016.


Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.

Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, Hansen DV, Atwal J, Lu Y, Bumbaca D, Pfeifer A, Watts RJ, Muhs A, Scearce-Levie K, Ayalon G.

Cell Rep. 2016 Aug 9;16(6):1690-1700. doi: 10.1016/j.celrep.2016.06.099. Epub 2016 Jul 28.


Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.

Zhang S, Matsunaga S, Lin YF, Sishc B, Shang Z, Sui J, Shih HY, Zhao Y, Foreman O, Story MD, Chen DJ, Chen BP.

Oncogene. 2016 Jul 28;35(30):3909-18. doi: 10.1038/onc.2015.459. Epub 2015 Nov 30.


Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.

Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ.

Neuron. 2015 Oct 21;88(2):289-97. doi: 10.1016/j.neuron.2015.09.036.


Cognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3).

Weber M, Wu T, Hanson JE, Alam NM, Solanoy H, Ngu H, Lauffer BE, Lin HH, Dominguez SL, Reeder J, Tom J, Steiner P, Foreman O, Prusky GT, Scearce-Levie K.

eNeuro. 2015 Oct 15;2(5). pii: ENEURO.0047-15.2015. doi: 10.1523/ENEURO.0047-15.2015. eCollection 2015 Sep.


Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.

Rudhard Y, Sengupta Ghosh A, Lippert B, Böcker A, Pedaran M, Krämer J, Ngu H, Foreman O, Liu Y, Lewcock JW.

J Neurosci. 2015 Feb 18;35(7):2927-41. doi: 10.1523/JNEUROSCI.2936-14.2015.


A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M; Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR.

Nat Med. 2014 Dec;20(12):1452-7. doi: 10.1038/nm.3736. Epub 2014 Nov 24.


Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process.

Galvao RP, Kasina A, McNeill RS, Harbin JE, Foreman O, Verhaak RG, Nishiyama A, Miller CR, Zong H.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4214-23. doi: 10.1073/pnas.1414389111. Epub 2014 Sep 22.


The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.

Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M.

Nature. 2014 Jun 19;510(7505):370-5. doi: 10.1038/nature13418. Epub 2014 Jun 4.


T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs.

Melillo AA, Foreman O, Bosio CM, Elkins KL.

Infect Immun. 2014 Apr;82(4):1477-90. doi: 10.1128/IAI.01545-13. Epub 2014 Jan 13.


Helicase-like transcription factor (Hltf) regulates G2/M transition, Wt1/Gata4/Hif-1a cardiac transcription networks, and collagen biogenesis.

Helmer RA, Martínez-Zaguilán R, Dertien JS, Fulford C, Foreman O, Peiris V, Chilton BS.

PLoS One. 2013 Nov 20;8(11):e80461. doi: 10.1371/journal.pone.0080461. eCollection 2013.


Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models.

Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, Palmer KE.

Antimicrob Agents Chemother. 2014;58(1):120-7. doi: 10.1128/AAC.01407-13. Epub 2013 Oct 21.


G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.

Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP.

J Leukoc Biol. 2013 Dec;94(6):1243-51. doi: 10.1189/jlb.0213097. Epub 2013 Aug 9.


Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain.

Helmer RA, Foreman O, Dertien JS, Panchoo M, Bhakta SM, Chilton BS.

PLoS One. 2013 Jun 24;8(6):e66799. doi: 10.1371/journal.pone.0066799. Print 2013.


Clinical manifestations, response to treatment, and clinical outcome for Weimaraners with hypertrophic osteodystrophy: 53 cases (2009-2011).

Safra N, Johnson EG, Lit L, Foreman O, Wolf ZT, Aguilar M, Karmi N, Finno CJ, Bannasch DL.

J Am Vet Med Assoc. 2013 May 1;242(9):1260-6. doi: 10.2460/javma.242.9.1260.


IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.

Melillo AA, Foreman O, Elkins KL.

J Leukoc Biol. 2013 May;93(5):657-67. doi: 10.1189/jlb.1012485. Epub 2013 Feb 25.


Epicutaneous model of community-acquired Staphylococcus aureus skin infections.

Prabhakara R, Foreman O, De Pascalis R, Lee GM, Plaut RD, Kim SY, Stibitz S, Elkins KL, Merkel TJ.

Infect Immun. 2013 Apr;81(4):1306-15. doi: 10.1128/IAI.01304-12. Epub 2013 Feb 4.


G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.

Giguère PM, Billard MJ, Laroche G, Buckley BK, Timoshchenko RG, McGinnis MW, Esserman D, Foreman O, Liu P, Siderovski DP, Tarrant TK.

Mol Immunol. 2013 Jun;54(2):193-8. doi: 10.1016/j.molimm.2012.12.001. Epub 2012 Dec 29.


Interleukin-6 is essential for primary resistance to Francisella tularensis live vaccine strain infection.

Kurtz SL, Foreman O, Bosio CM, Anver MR, Elkins KL.

Infect Immun. 2013 Feb;81(2):585-97. doi: 10.1128/IAI.01249-12. Epub 2012 Dec 10.


USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.

Zhang Y, Foreman O, Wigle DA, Kosari F, Vasmatzis G, Salisbury JL, van Deursen J, Galardy PJ.

J Clin Invest. 2012 Dec;122(12):4362-74. doi: 10.1172/JCI63084. Epub 2012 Nov 26.


Inflammatory dilated cardiomyopathy in Abcg5-deficient mice.

Wilson DW, Oslund KL, Lyons B, Foreman O, Burzenski L, Svenson KL, Chase TH, Shultz LD.

Toxicol Pathol. 2013 Aug;41(6):880-92. doi: 10.1177/0192623312466191. Epub 2012 Nov 5.


Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis.

Hsu TH, Althaus IW, Foreman O, Spindler KR.

MBio. 2012 May 29;3(3). pii: e00131-12. doi: 10.1128/mBio.00131-12. Print 2012.


Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models.

Singh M, Couto SS, Forrest WF, Lima A, Cheng JH, Molina R, Long JE, Hamilton P, McNutt A, Kasman I, Nannini MA, Reslan HB, Cao TC, Ho CC, Barck KH, Carano RA, Foreman O, Eastham-Anderson J, Jubb AM, Ferrara N, Johnson L.

J Pathol. 2012 Aug;227(4):417-30. doi: 10.1002/path.4053. Epub 2012 Jun 28.


Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice.

Cummins NW, Weaver EA, May SM, Croatt AJ, Foreman O, Kennedy RB, Poland GA, Barry MA, Nath KA, Badley AD.

FASEB J. 2012 Jul;26(7):2911-8. doi: 10.1096/fj.11-190017. Epub 2012 Apr 6.


T-cell chronic lymphocytic leukemia in a double yellow-headed Amazon parrot (Amazona ochrocephala oratrix).

Osofsky A, Hawkins MG, Foreman O, Kent MS, Vernau W, Lowenstine LJ.

J Avian Med Surg. 2011 Dec;25(4):286-94.


Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis.

Wu L, Yan C, Czader M, Foreman O, Blum JS, Kapur R, Du H.

Blood. 2012 Jan 5;119(1):115-26. doi: 10.1182/blood-2011-06-363093. Epub 2011 Nov 3.


Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice.

Ding L, Lu Z, Foreman O, Tatum R, Lu Q, Renegar R, Cao J, Chen YH.

Gastroenterology. 2012 Feb;142(2):305-15. doi: 10.1053/j.gastro.2011.10.025. Epub 2011 Oct 29.


Anti-inflammatory and immunomodulatory effects of bortezomib in various in vivo models.

Tung D, Cheung PH, Kaur P, Foreman O, Kavirayani A, Hain HS, Saha S.

Pharmacology. 2011;88(1-2):100-13. doi: 10.1159/000330067. Epub 2011 Aug 25.


Deficiency of scavenger receptor BI leads to impaired lymphocyte homeostasis and autoimmune disorders in mice.

Feng H, Guo L, Wang D, Gao H, Hou G, Zheng Z, Ai J, Foreman O, Daugherty A, Li XA.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2543-51. doi: 10.1161/ATVBAHA.111.234716.


Mosaic analysis with double markers reveals tumor cell of origin in glioma.

Liu C, Sage JC, Miller MR, Verhaak RG, Hippenmeyer S, Vogel H, Foreman O, Bronson RT, Nishiyama A, Luo L, Zong H.

Cell. 2011 Jul 22;146(2):209-21. doi: 10.1016/j.cell.2011.06.014. Epub 2011 Jul 7.


Advancing translational research.

Bolon B, Altrock B, Barthold SW, Baumgarth N, Besselsen D, Boivin G, Boyd KL, Brayton C, Cardiff RD, Couto S, Eaton KA, Foreman O, Griffey SM, La Perle K, Lairmore MD, Liu C, Meyerholz DK, Nikitin AY, Schoeb TR, Schwahn D, Sellers RS, Sundberg JP, Tolwani R, Valli VE, Zink MC.

Science. 2011 Mar 25;331(6024):1516-7. doi: 10.1126/science.331.6024.1516-b. No abstract available.


TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection.

Fei M, Bhatia S, Oriss TB, Yarlagadda M, Khare A, Akira S, Saijo S, Iwakura Y, Fallert Junecko BA, Reinhart TA, Foreman O, Ray P, Kolls J, Ray A.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5360-5. doi: 10.1073/pnas.1015476108. Epub 2011 Mar 14.


Primary neoplasms of bones in mice: retrospective study and review of literature.

Kavirayani AM, Sundberg JP, Foreman O.

Vet Pathol. 2012 Jan;49(1):182-205. doi: 10.1177/0300985811398252. Epub 2011 Feb 22. Review.


Host genetic variation in susceptibility to Punta Toro virus.

Ashley SL, Ameres SM, Gerrard SR, Foreman O, Eaton KA, Weinberg JB, Spindler KR.

Virus Res. 2011 Apr;157(1):71-5. doi: 10.1016/j.virusres.2011.02.008. Epub 2011 Feb 12.

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