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Floral Odors and the Interaction between Pollinating Ceratopogonid Midges and Cacao.

Arnold SEJ, Forbes SJ, Hall DR, Farman DI, Bridgemohan P, Spinelli GR, Bray DP, Perry GB, Grey L, Belmain SR, Stevenson PC.

J Chem Ecol. 2019 Nov 18. doi: 10.1007/s10886-019-01118-9. [Epub ahead of print]


Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.

Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M.

Nat Cell Biol. 2019 Nov;21(11):1321-1333. doi: 10.1038/s41556-019-0402-6. Epub 2019 Nov 4.


Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1.

Kendall TJ, Duff CM, Boulter L, Wilson DH, Freyer E, Aitken S, Forbes SJ, Iredale JP, Hastie ND.

Nat Commun. 2019 Oct 15;10(1):4688. doi: 10.1038/s41467-019-12701-9.


Safety profile of autologous macrophage therapy for liver cirrhosis.

Moroni F, Dwyer BJ, Graham C, Pass C, Bailey L, Ritchie L, Mitchell D, Glover A, Laurie A, Doig S, Hargreaves E, Fraser AR, Turner ML, Campbell JDM, McGowan NWA, Barry J, Moore JK, Hayes PC, Leeming DJ, Nielsen MJ, Musa K, Fallowfield JA, Forbes SJ.

Nat Med. 2019 Oct;25(10):1560-1565. doi: 10.1038/s41591-019-0599-8. Epub 2019 Oct 7.


Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis.

Carpino G, Nevi L, Overi D, Cardinale V, Lu WY, Di Matteo S, Safarikia S, Berloco PB, Venere R, Onori P, Franchitto A, Forbes SJ, Alvaro D, Gaudio E.

Hepatology. 2019 Jul 22. doi: 10.1002/hep.30871. [Epub ahead of print]


Macrophages as a Cell-Based Therapy for Liver Disease.

Starkey Lewis PJ, Moroni F, Forbes SJ.

Semin Liver Dis. 2019 Nov;39(4):442-451. doi: 10.1055/s-0039-1688502. Epub 2019 Jun 26.


Beneficial Noncancerous Mutations in Liver Disease.

Müller M, Forbes SJ, Bird TG.

Trends Genet. 2019 Jul;35(7):475-477. doi: 10.1016/j.tig.2019.05.002. Epub 2019 May 28.


Biliary-derived hepatocytes in chronic liver injury: Bringing new troops to the battlefield?

Aleksieva N, Forbes SJ.

J Hepatol. 2019 Jun;70(6):1051-1053. doi: 10.1016/j.jhep.2019.03.015. Epub 2019 Apr 10. No abstract available.


Quantifying changes in innate immune function following liver transplantation for chronic liver disease.

Stutchfield BM, Bodingbauer MW, Adair A, Wakelin S, Schindl M, Forbes SJ, Wigmore SJ.

HPB (Oxford). 2019 Oct;21(10):1322-1326. doi: 10.1016/j.hpb.2019.02.004. Epub 2019 Mar 6.


An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.

Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SEM, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pedersen A, Gravelle L, Tantawi S, Schambye H, Sethi T, MacKinnon AC.

Cancer Res. 2019 Apr 1;79(7):1480-1492. doi: 10.1158/0008-5472.CAN-18-2244. Epub 2019 Jan 23.


Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice.

Watanabe Y, Tsuchiya A, Seino S, Kawata Y, Kojima Y, Ikarashi S, Starkey Lewis PJ, Lu WY, Kikuta J, Kawai H, Yamagiwa S, Forbes SJ, Ishii M, Terai S.

Stem Cells Transl Med. 2019 Mar;8(3):271-284. doi: 10.1002/sctm.18-0105. Epub 2018 Nov 5.


Hepatic progenitors in liver regeneration.

Raven A, Forbes SJ.

J Hepatol. 2018 Dec;69(6):1394-1395. doi: 10.1016/j.jhep.2018.03.004. Epub 2018 Nov 1. No abstract available.


Cellular Plasticity in Liver Regeneration: Spotlight on Cholangiocytes.

Tirnitz-Parker JEE, Forbes SJ, Olynyk JK, Ramm GA.

Hepatology. 2019 May;69(5):2286-2289. doi: 10.1002/hep.30340. Epub 2019 Feb 19. No abstract available.


Telomerase Activity Links to Regenerative Capacity of Hepatocytes.

Lu WY, Forbes SJ.

Transplantation. 2018 Oct;102(10):1587-1588. doi: 10.1097/TP.0000000000002346. No abstract available.


Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes.

Russell JO, Lu WY, Okabe H, Abrams M, Oertel M, Poddar M, Singh S, Forbes SJ, Monga SP.

Hepatology. 2019 Feb;69(2):742-759. doi: 10.1002/hep.30270. Epub 2019 Jan 4.


3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Rashidi H, Luu NT, Alwahsh SM, Ginai M, Alhaque S, Dong H, Tomaz RA, Vernay B, Vigneswara V, Hallett JM, Chandrashekran A, Dhawan A, Vallier L, Bradley M, Callanan A, Forbes SJ, Newsome PN, Hay DC.

Arch Toxicol. 2018 Oct;92(10):3117-3129. doi: 10.1007/s00204-018-2280-2. Epub 2018 Aug 28.


TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.


Haematopoietic stem cells in cirrhosis - Authors' reply.

Newsome PN, Fox R, Forbes SJ.

Lancet Gastroenterol Hepatol. 2018 May;3(5):298-299. doi: 10.1016/S2468-1253(18)30035-9. Epub 2018 Apr 6. No abstract available.


Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2018 Mar 14;555(7696):402. doi: 10.1038/nature25996.


Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.

Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ.

Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5.


Studies of macrophage therapy for cirrhosis - From mice to men.

Thomas JA, Ramachandran P, Forbes SJ.

J Hepatol. 2018 May;68(5):1090-1091. doi: 10.1016/j.jhep.2017.11.043. Epub 2018 Jan 6. No abstract available.


Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma.

Guest RV, Boulter L, Dwyer BJ, Forbes SJ.

NPJ Regen Med. 2017 May 22;2:13. doi: 10.1038/s41536-017-0018-z. eCollection 2017.


Raman spectroscopy and regenerative medicine: a review.

Ember KJI, Hoeve MA, McAughtrie SL, Bergholt MS, Dwyer BJ, Stevens MM, Faulds K, Forbes SJ, Campbell CJ.

NPJ Regen Med. 2017 May 15;2:12. doi: 10.1038/s41536-017-0014-3. eCollection 2017. Review.


GADD45β Loss Ablates Innate Immunosuppression in Cancer.

Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes SJ, Sica A, Alesse E, Zazzeroni F, Franzoso G.

Cancer Res. 2018 Mar 1;78(5):1275-1292. doi: 10.1158/0008-5472.CAN-17-1833. Epub 2017 Dec 26.


The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzalez S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP.

J Immunol. 2018 Feb 1;200(3):1169-1187. doi: 10.4049/jimmunol.1701247. Epub 2017 Dec 20.


11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z.

Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22.


Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial.

Newsome PN, Fox R, King AL, Barton D, Than NN, Moore J, Corbett C, Townsend S, Thomas J, Guo K, Hull D, Beard HA, Thompson J, Atkinson A, Bienek C, McGowan N, Guha N, Campbell J, Hollyman D, Stocken D, Yap C, Forbes SJ.

Lancet Gastroenterol Hepatol. 2018 Jan;3(1):25-36. doi: 10.1016/S2468-1253(17)30326-6. Epub 2017 Nov 7.


Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2017 Jul 20;547(7663):350-354. doi: 10.1038/nature23015. Epub 2017 Jul 12. Erratum in: Nature. 2018 Mar 14;555(7696):402.


Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis.

Fraser AR, Pass C, Burgoyne P, Atkinson A, Bailey L, Laurie A, W A McGowan N, Hamid A, Moore JK, Dwyer BJ, Turner ML, Forbes SJ, Campbell JDM.

Cytotherapy. 2017 Sep;19(9):1113-1124. doi: 10.1016/j.jcyt.2017.05.009. Epub 2017 Jun 30.


Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells.

Forbes SJ.

Gastroenterology. 2017 Apr;152(5):943-946. doi: 10.1053/j.gastro.2017.02.032. Epub 2017 Mar 1. No abstract available.


Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.

Sharkey J, Starkey Lewis PJ, Barrow M, Alwahsh SM, Noble J, Livingstone E, Lennen RJ, Jansen MA, Carrion JG, Liptrott N, Forbes S, Adams DJ, Chadwick AE, Forbes SJ, Murray P, Rosseinsky MJ, Goldring CE, Park BK.

Cytotherapy. 2017 Apr;19(4):555-569. doi: 10.1016/j.jcyt.2017.01.003. Epub 2017 Feb 15.


Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.

Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ.

J Gastrointest Oncol. 2016 Dec;7(6):819-827. doi: 10.21037/jgo.2016.11.11. No abstract available.


Increased pollinator habitat enhances cacao fruit set and predator conservation.

Forbes SJ, Northfield TD.

Ecol Appl. 2017 Apr;27(3):887-899. doi: 10.1002/eap.1491. Epub 2017 Mar 15.


Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.

Moore JK, MacKinnon AC, Man TY, Manning JR, Forbes SJ, Simpson KJ.

Aliment Pharmacol Ther. 2017 Feb;45(3):443-454. doi: 10.1111/apt.13878. Epub 2016 Nov 28.


Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells.

Oosthuyzen W, Scullion KM, Ivy JR, Morrison EE, Hunter RW, Starkey Lewis PJ, O'Duibhir E, Street JM, Caporali A, Gregory CD, Forbes SJ, Webb DJ, Bailey MA, Dear JW.

J Am Soc Nephrol. 2016 Nov;27(11):3345-3355. Epub 2016 Mar 28.


Notch3 drives development and progression of cholangiocarcinoma.

Guest RV, Boulter L, Dwyer BJ, Kendall TJ, Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, Wojtacha D, Morton JP, Komuta M, Roskams T, Wigmore SJ, Sansom OJ, Forbes SJ.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12250-12255. Epub 2016 Oct 10.


Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS.

Nat Cell Biol. 2016 Oct 27;18(11):1260. doi: 10.1038/ncb3428. No abstract available.


Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L, Hahne JC, Ridgway R, Jamieson T, Athineos D, Veronese A, Visone R, Murgia C, Ferrari G, Guzzardo V, Evans TRJ, MacLeod M, Feng GJ, Dale T, Negrini M, Forbes SJ, Terracciano L, Scarpa A, Patel T, Valeri N, Workman P, Sansom O, Braconi C.

Gut. 2017 Jul;66(7):1268-1277. doi: 10.1136/gutjnl-2016-312278. Epub 2016 Sep 12.


Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck RL 3rd, Ramalingam TR, Hart KM, Vannella KM, Cantu DA, Lu WY, Ferreira-González S, Forbes SJ, Vallier L, Wynn TA.

Immunity. 2016 Jul 19;45(1):145-58. doi: 10.1016/j.immuni.2016.06.009. Epub 2016 Jul 12.


Liver regeneration - mechanisms and models to clinical application.

Forbes SJ, Newsome PN.

Nat Rev Gastroenterol Hepatol. 2016 Aug;13(8):473-85. doi: 10.1038/nrgastro.2016.97. Epub 2016 Jun 29. Review.


Corrigendum to "Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma" [J Hepatol 2015;62:607-616].

Yeung OW, Lo CM, Ling CC, Qi X, Geng W, Li CX, Ng KT, Forbes SJ, Guan XY, Poon RT, Fan ST, Man K.

J Hepatol. 2016 Jun;64(6):1461. doi: 10.1016/j.jhep.2016.02.038. Epub 2016 Mar 16. No abstract available.


Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).

Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D.

Nat Rev Gastroenterol Hepatol. 2016 May;13(5):261-80. doi: 10.1038/nrgastro.2016.51. Epub 2016 Apr 20.


The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, Xie Y, Roma G, Donovan A, Marti P, Beckmann N, Dill MT, Carbone W, Bergling S, Isken A, Mueller M, Kinzel B, Yang Y, Mao X, Nicholson TB, Zamponi R, Capodieci P, Valdez R, Rivera D, Loew A, Ukomadu C, Terracciano LM, Bouwmeester T, Cong F, Heim MH, Forbes SJ, Ruffner H, Tchorz JS.

Nat Cell Biol. 2016 May;18(5):467-79. doi: 10.1038/ncb3337. Epub 2016 Apr 18. Erratum in: Nat Cell Biol. 2016 Oct 27;18(11):1260.


Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.

Szkolnicka D, Lucendo-Villarin B, Moore JK, Simpson KJ, Forbes SJ, Hay DC.

Stem Cells Transl Med. 2016 Jun;5(6):764-72. doi: 10.5966/sctm.2015-0117. Epub 2016 Apr 7.


Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes.

Cameron K, Tan R, Schmidt-Heck W, Campos G, Lyall MJ, Wang Y, Lucendo-Villarin B, Szkolnicka D, Bates N, Kimber SJ, Hengstler JG, Godoy P, Forbes SJ, Hay DC.

Stem Cell Reports. 2015 Dec 8;5(6):1250-1262. doi: 10.1016/j.stemcr.2015.10.016. Epub 2015 Nov 25.


Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture.

Muir KR, Lima MJ, Docherty HM, McGowan NW, Forbes S, Heremans Y, Forbes SJ, Heimberg H, Casey J, Docherty K.

PLoS One. 2015 Oct 12;10(10):e0140352. doi: 10.1371/journal.pone.0140352. eCollection 2015.


Two Fresh Streams to Fill the Liver's Hepatocyte Pool.

Bird TG, Forbes SJ.

Cell Stem Cell. 2015 Oct 1;17(4):377-8. doi: 10.1016/j.stem.2015.09.007.


CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.

Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ.

Gastroenterology. 2015 Dec;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053. Epub 2015 Sep 5.


Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study.

Moore JK, Mackinnon AC, Wojtacha D, Pope C, Fraser AR, Burgoyne P, Bailey L, Pass C, Atkinson A, Mcgowan NW, Manson L, Turner ML, Campbell JD, Forbes SJ.

Cytotherapy. 2015 Nov;17(11):1604-16. doi: 10.1016/j.jcyt.2015.07.016. Epub 2015 Sep 3.


Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).

Villarin BL, Cameron K, Szkolnicka D, Rashidi H, Bates N, Kimber SJ, Flint O, Forbes SJ, Iredale JP, Bradley M, Hay DC.

Adv Healthc Mater. 2015 Aug 26;4(12):1819. doi: 10.1002/adhm.201570072.


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