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Items: 44

1.

Detection of tumors with fluoromarker-releasing bacteria.

Panteli JT, Van Dessel N, Forbes NS.

Int J Cancer. 2019 May 16. doi: 10.1002/ijc.32414. [Epub ahead of print]

PMID:
31093970
2.

The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella.

Raman V, Van Dessel N, O'Connor OM, Forbes NS.

J Immunother Cancer. 2019 Feb 12;7(1):44. doi: 10.1186/s40425-018-0490-z.

3.

White paper on microbial anti-cancer therapy and prevention.

Forbes NS, Coffin RS, Deng L, Evgin L, Fiering S, Giacalone M, Gravekamp C, Gulley JL, Gunn H, Hoffman RM, Kaur B, Liu K, Lyerly HK, Marciscano AE, Moradian E, Ruppel S, Saltzman DA, Tattersall PJ, Thorne S, Vile RG, Zhang HH, Zhou S, McFadden G.

J Immunother Cancer. 2018 Aug 6;6(1):78. doi: 10.1186/s40425-018-0381-3.

4.

Tissue transport affects how treatment scheduling increases the efficacy of chemotherapeutic drugs.

Ganz DE, Sexton-Stallone B, Brackett EL, Forbes NS.

J Theor Biol. 2018 Feb 7;438:21-33. doi: 10.1016/j.jtbi.2017.10.022. Epub 2017 Oct 21.

PMID:
29066114
5.

Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses.

Panteli JT, Forbes NS.

Biotechnol Bioeng. 2016 Nov;113(11):2474-84. doi: 10.1002/bit.26006. Epub 2016 Sep 20.

6.

Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue.

Brackett EL, Swofford CA, Forbes NS.

Methods Mol Biol. 2016;1409:35-48. doi: 10.1007/978-1-4939-3515-4_4.

7.

Persistent enhancement of bacterial motility increases tumor penetration.

Thornlow DN, Brackett EL, Gigas JM, Van Dessel N, Forbes NS.

Biotechnol Bioeng. 2015 Nov;112(11):2397-405. doi: 10.1002/bit.25645. Epub 2015 Sep 4.

8.

Potent and tumor specific: arming bacteria with therapeutic proteins.

Van Dessel N, Swofford CA, Forbes NS.

Ther Deliv. 2015 Mar;6(3):385-99. doi: 10.4155/tde.14.113. Review.

9.

Quorum-sensing Salmonella selectively trigger protein expression within tumors.

Swofford CA, Van Dessel N, Forbes NS.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3457-62. doi: 10.1073/pnas.1414558112. Epub 2015 Mar 3.

10.

Genetically modified bacteria as a tool to detect microscopic solid tumor masses with triggered release of a recombinant biomarker.

Panteli JT, Forkus BA, Van Dessel N, Forbes NS.

Integr Biol (Camb). 2015 Apr;7(4):423-34. doi: 10.1039/c5ib00047e.

11.

Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating.

Zhang M, Forbes NS.

J Control Release. 2015 Feb 10;199:180-9. doi: 10.1016/j.jconrel.2014.12.014. Epub 2014 Dec 15.

12.

Bacterial delivery of Staphylococcus aureus α-hemolysin causes regression and necrosis in murine tumors.

St Jean AT, Swofford CA, Panteli JT, Brentzel ZJ, Forbes NS.

Mol Ther. 2014 Jul;22(7):1266-1274. doi: 10.1038/mt.2014.36. Epub 2014 Mar 4.

13.

Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture.

Kasinskas RW, Venkatasubramanian R, Forbes NS.

Integr Biol (Camb). 2014 Apr;6(4):399-410. doi: 10.1039/c4ib00001c. Epub 2014 Feb 6.

14.

Identification of Staphylococcus aureus α-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells.

Swofford CA, St Jean AT, Panteli JT, Brentzel ZJ, Forbes NS.

Biotechnol Bioeng. 2014 Jun;111(6):1233-45. doi: 10.1002/bit.25184. Epub 2014 Feb 24.

PMID:
24415346
15.

Lipid A controls the robustness of intratumoral accumulation of attenuated Salmonella in mice.

Zhang M, Swofford CA, Forbes NS.

Int J Cancer. 2014 Aug 1;135(3):647-57. doi: 10.1002/ijc.28700. Epub 2014 Jan 10.

16.

Microfluidic technique to measure intratumoral transport and calculate drug efficacy shows that binding is essential for doxorubicin and release hampers Doxil.

Toley BJ, Tropeano Lovatt ZG, Harrington JL, Forbes NS.

Integr Biol (Camb). 2013 Sep;5(9):1184-96. doi: 10.1039/c3ib40021b.

17.

Construction of an inducible cell-communication system that amplifies Salmonella gene expression in tumor tissue.

Dai Y, Toley BJ, Swofford CA, Forbes NS.

Biotechnol Bioeng. 2013 Jun;110(6):1769-81. doi: 10.1002/bit.24816. Epub 2013 Jan 17.

PMID:
23280328
18.

Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro.

Toley BJ, Park J, Kim BJ, Venkatasubramanian R, Maharbiz MM, Forbes NS.

Biotechnol Prog. 2012 Mar-Apr;28(2):515-25. doi: 10.1002/btpr.1510. Epub 2012 Jan 6.

PMID:
22228537
19.

Motility is critical for effective distribution and accumulation of bacteria in tumor tissue.

Toley BJ, Forbes NS.

Integr Biol (Camb). 2012 Feb;4(2):165-76. doi: 10.1039/c2ib00091a. Epub 2011 Dec 22.

20.

Microfluidic device for recreating a tumor microenvironment in vitro.

Toley BJ, Ganz DE, Walsh CL, Forbes NS.

J Vis Exp. 2011 Nov 20;(57). pii: 2425. doi: 10.3791/2425.

21.

In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis.

Ganai S, Arenas RB, Sauer JP, Bentley B, Forbes NS.

Cancer Gene Ther. 2011 Jul;18(7):457-66. doi: 10.1038/cgt.2011.10. Epub 2011 Mar 25.

22.

Engineering the perfect (bacterial) cancer therapy.

Forbes NS.

Nat Rev Cancer. 2010 Nov;10(11):785-94. doi: 10.1038/nrc2934. Epub 2010 Oct 14. Review.

23.

Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response.

Venkatasubramanian R, Arenas RB, Henson MA, Forbes NS.

Br J Cancer. 2010 Aug 10;103(4):486-97. doi: 10.1038/sj.bjc.6605773. Epub 2010 Jul 13.

24.

Tuning payload delivery in tumour cylindroids using gold nanoparticles.

Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS.

Nat Nanotechnol. 2010 Jun;5(6):465-72. doi: 10.1038/nnano.2010.58. Epub 2010 Apr 11.

25.

Active and inactive metabolic pathways in tumor spheroids: determination by GC-MS.

Hunnewell MG, Forbes NS.

Biotechnol Prog. 2010 May-Jun;26(3):789-96. doi: 10.1002/btpr.360.

26.

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice.

Ganai S, Arenas RB, Forbes NS.

Br J Cancer. 2009 Nov 17;101(10):1683-91. doi: 10.1038/sj.bjc.6605403. Epub 2009 Oct 27.

27.

Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles.

Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM.

ACS Nano. 2008 Nov 25;2(11):2213-8. doi: 10.1021/nn800507t.

28.

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics.

Walsh CL, Babin BM, Kasinskas RW, Foster JA, McGarry MJ, Forbes NS.

Lab Chip. 2009 Feb 21;9(4):545-54. doi: 10.1039/b810571e. Epub 2008 Nov 21.

29.
30.

Bacterial therapies: completing the cancer treatment toolbox.

St Jean AT, Zhang M, Forbes NS.

Curr Opin Biotechnol. 2008 Oct;19(5):511-7. doi: 10.1016/j.copbio.2008.08.004. Epub 2008 Sep 18. Review.

31.

Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies.

Venkatasubramanian R, Henson MA, Forbes NS.

J Theor Biol. 2008 Jul 7;253(1):98-117. doi: 10.1016/j.jtbi.2008.02.016. Epub 2008 Feb 21.

32.
33.

Profile of a bacterial tumor killer.

Forbes NS.

Nat Biotechnol. 2006 Dec;24(12):1484-5. No abstract available.

PMID:
17160044
34.
35.

Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis.

Forbes NS, Meadows AL, Clark DS, Blanch HW.

Metab Eng. 2006 Nov;8(6):639-52. Epub 2006 Jun 30.

PMID:
16904360
36.

Incorporating energy metabolism into a growth model of multicellular tumor spheroids.

Venkatasubramanian R, Henson MA, Forbes NS.

J Theor Biol. 2006 Sep 21;242(2):440-53. Epub 2006 May 2.

PMID:
16650438
37.

Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles.

Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM.

Angew Chem Int Ed Engl. 2006 May 5;45(19):3165-9. No abstract available.

PMID:
16572498
38.

Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro.

Kasinskas RW, Forbes NS.

Biotechnol Bioeng. 2006 Jul 5;94(4):710-21.

PMID:
16470601
39.

Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers.

Hong R, Han G, Fernández JM, Kim BJ, Forbes NS, Rotello VM.

J Am Chem Soc. 2006 Feb 1;128(4):1078-9.

PMID:
16433515
40.
41.

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.

Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK.

Clin Cancer Res. 2002 Apr;8(4):1284-91.

42.

Can engineered bacteria help control cancer?

Jain RK, Forbes NS.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14748-50. No abstract available.

43.

Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions.

Forbes NS, Clark DS, Blanch HW.

Biotechnol Bioeng. 2001 Aug 5;74(3):196-211.

PMID:
11400093
44.

Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.

Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS.

Pharmacogenetics. 1999 Dec;9(6):669-82.

PMID:
10634130

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