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Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond.

Ong SC, Belgi A, van Lierop B, Delaine C, Andrikopoulos S, MacRaild CA, Norton RS, Haworth NL, Robinson AJ, Forbes BE.

J Biol Chem. 2018 Jun 13. pii: jbc.RA118.002486. doi: 10.1074/jbc.RA118.002486. [Epub ahead of print]


Glycerol Solvates DPPC Headgroups and Localizes in the Interfacial Regions of Model Pulmonary Interfaces Altering Bilayer Structure.

Terakosolphan W, Trick JL, Royall PG, Rogers SE, Lamberti O, Lorenz CD, Forbes B, Harvey RD.

Langmuir. 2018 Jun 12;34(23):6941-6954. doi: 10.1021/acs.langmuir.8b00866. Epub 2018 May 30.


The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): verification of nasal allergen challenge procedures in a study utilizing an investigational immunotherapy for cat allergy.

Neighbour H, Soliman M, Steacy LM, Hickey P, Forbes B, Larché M, Ellis AK.

Clin Transl Allergy. 2018 Apr 12;8:15. doi: 10.1186/s13601-018-0198-7. eCollection 2018.


Response to Letter to the Editor: Do we have to redefine lameness in the era of quantitative gait analysis.

Adair S, Baus M, Belknap J, Bell R, Boero M, Bussy C, Cardenas F, Casey T, Castro J, Davis W, Erskine M, Farr R, Fischer T, Forbes B, Ford T, Genovese R, Gottschalk R, Hoge M, Honnas C, Hunter G, Joyce J, Kaneps A, Keegan K, Kramer J, Lischer C, Marshall J, Oosterlinck M, Radue P, Redding R, Reed SK, Rick M, Santschi E, Schoonover M, Schramme M, Schumacher J, Stephenson R, Thaler R, Vedding Neilsen J, Wilson DA.

Equine Vet J. 2018 May;50(3):415-417. doi: 10.1111/evj.12820. No abstract available.


How ligand binds to the type 1 insulin-like growth factor receptor.

Xu Y, Kong GK, Menting JG, Margetts MB, Delaine CA, Jenkin LM, Kiselyov VV, De Meyts P, Forbes BE, Lawrence MC.

Nat Commun. 2018 Feb 26;9(1):821. doi: 10.1038/s41467-018-03219-7.


A novel method for studying airway hyperresponsiveness in allergic guinea pigs in vivo using the PreciseInhale system for delivery of dry powder aerosols.

Lexmond AJ, Keir S, Terakosolphan W, Page CP, Forbes B.

Drug Deliv Transl Res. 2018 Jun;8(3):760-769. doi: 10.1007/s13346-018-0490-z.


Linking hospital patient records for suspected or established acute coronary syndrome in a complex secondary care system: a proof-of-concept e-registry in NHS Scotland.

Findlay I, Morris T, Zhang R, McCowan C, Shield S, Forbes B, McConnachie A, Mangion K, Berry C.

Eur Heart J Qual Care Clin Outcomes. 2018 Feb 16. doi: 10.1093/ehjqcco/qcy007. [Epub ahead of print]


Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth).

Malallah OS, Garcia CMA, Proctor GB, Forbes B, Royall PG.

Int J Pharm. 2018 Apr 25;541(1-2):157-166. doi: 10.1016/j.ijpharm.2018.02.004. Epub 2018 Feb 6. Review.


Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.

Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS.

EMBO Rep. 2018 Mar;19(3). pii: e45009. doi: 10.15252/embr.201745009. Epub 2018 Feb 2.


Practice Guidelines for Clinical Microbiology Laboratories: Mycobacteria.

Forbes BA, Hall GS, Miller MB, Novak SM, Rowlinson MC, Salfinger M, Somoskövi A, Warshauer DM, Wilson ML.

Clin Microbiol Rev. 2018 Jan 31;31(2). pii: e00038-17. doi: 10.1128/CMR.00038-17. Print 2018 Apr. Review.


Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs.

Lexmond AJ, Singh D, Frijlink HW, Clarke GW, Page CP, Forbes B, van den Berge M.

Pulm Pharmacol Ther. 2018 Apr;49:27-35. doi: 10.1016/j.pupt.2018.01.004. Epub 2018 Jan 10. Review.


Ion-Pairing with Spermine Targets Theophylline To the Lungs via the Polyamine Transport System.

Benaouda F, Jones SA, Chana J, Dal Corno BM, Barlow DJ, Hider RC, Page CP, Forbes B.

Mol Pharm. 2018 Mar 5;15(3):861-870. doi: 10.1021/acs.molpharmaceut.7b00715. Epub 2018 Feb 9.


Repeatability of gait analysis measurements in Thoroughbreds in training.

Sepulveda Caviedes MF, Forbes BS, Pfau T.

Equine Vet J. 2018 Jul;50(4):513-518. doi: 10.1111/evj.12802. Epub 2018 Jan 22.


Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.

van Lierop B, Ong SC, Belgi A, Delaine C, Andrikopoulos S, Haworth NL, Menting JG, Lawrence MC, Robinson AJ, Forbes BE.

Sci Rep. 2017 Dec 8;7(1):17239. doi: 10.1038/s41598-017-16876-3.


A quantum mechanical exploration of phonon energy-loss spectroscopy using electrons in the aloof beam geometry.

Allen LJ, Brown HG, Findlay SD, Forbes BD.

Microscopy (Oxf). 2018 Mar 1;67(suppl_1):i24-i29. doi: 10.1093/jmicro/dfx038.


Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.

Carhart-Harris RL, Bolstridge M, Day CMJ, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S, Rickard JA, Forbes B, Feilding A, Taylor D, Curran HV, Nutt DJ.

Psychopharmacology (Berl). 2018 Feb;235(2):399-408. doi: 10.1007/s00213-017-4771-x. Epub 2017 Nov 8.


Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs.

Bäckman P, Arora S, Couet W, Forbes B, de Kruijf W, Paudel A.

Eur J Pharm Sci. 2018 Feb 15;113:41-52. doi: 10.1016/j.ejps.2017.10.030. Epub 2017 Oct 25.


A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture.

Bosquillon C, Madlova M, Patel N, Clear N, Forbes B.

Pharm Res. 2017 Dec;34(12):2532-2540. doi: 10.1007/s11095-017-2251-y. Epub 2017 Sep 18.


Biographical Feature: William Michael Dunne, Jr., Ph.D.

Forbes BA.

J Clin Microbiol. 2017 Nov;55(11):3162-3166. doi: 10.1128/JCM.01404-17. Epub 2017 Sep 6. No abstract available.


Disentangling the coupling between sea ice and tundra productivity in Svalbard.

Macias-Fauria M, Karlsen SR, Forbes BC.

Sci Rep. 2017 Aug 17;7(1):8586. doi: 10.1038/s41598-017-06218-8.


Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine.

Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S.

J Immunol. 2017 Aug 15;199(4):1319-1332. doi: 10.4049/jimmunol.1601873. Epub 2017 Jul 14.


In Silico and in Vitro Screening for P-Glycoprotein Interaction with Tenofovir, Darunavir, and Dapivirine: An Antiretroviral Drug Combination for Topical Prevention of Colorectal HIV Transmission.

Swedrowska M, Jamshidi S, Kumar A, Kelly C, Rahman KM, Forbes B.

Mol Pharm. 2017 Aug 7;14(8):2660-2669. doi: 10.1021/acs.molpharmaceut.7b00133. Epub 2017 Jul 20.


Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans.

Kumar A, Bicer EM, Pfeffer P, Monopoli MP, Dawson KA, Eriksson J, Edwards K, Lynham S, Arno M, Behndig AF, Blomberg A, Somers G, Hassall D, Dailey LA, Forbes B, Mudway I.

Nanomedicine. 2017 Nov;13(8):2517-2521. doi: 10.1016/j.nano.2017.06.008. Epub 2017 Jun 22.


Atomic resolution elemental mapping using energy-filtered imaging scanning transmission electron microscopy with chromatic aberration correction.

Krause FF, Rosenauer A, Barthel J, Mayer J, Urban K, Dunin-Borkowski RE, Brown HG, Forbes BD, Allen LJ.

Ultramicroscopy. 2017 Oct;181:173-177. doi: 10.1016/j.ultramic.2017.06.004. Epub 2017 Jun 2.


A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.

Kumar A, Terakosolphan W, Hassoun M, Vandera KK, Novicky A, Harvey R, Royall PG, Bicer EM, Eriksson J, Edwards K, Valkenborg D, Nelissen I, Hassall D, Mudway IS, Forbes B.

Pharm Res. 2017 Dec;34(12):2454-2465. doi: 10.1007/s11095-017-2169-4. Epub 2017 May 30.


Head, withers and pelvic movement asymmetry and their relative timing in trot in racing Thoroughbreds in training.

Pfau T, Noordwijk K, Sepulveda Caviedes MF, Persson-Sjodin E, Barstow A, Forbes B, Rhodin M.

Equine Vet J. 2018 Jan;50(1):117-124. doi: 10.1111/evj.12705. Epub 2017 Jul 3.


Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis.

Hoffman E, Patel A, Ball D, Klapwijk J, Millar V, Kumar A, Martin A, Mahendran R, Dailey LA, Forbes B, Hutter V.

Pharm Res. 2017 Dec;34(12):2466-2476. doi: 10.1007/s11095-017-2176-5. Epub 2017 May 24.


Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis.

Clifford V, Tebruegge M, Zufferey C, Germano S, Forbes B, Cosentino L, McBryde E, Eisen D, Robins-Browne R, Street A, Denholm J, Curtis N.

J Infect. 2017 Aug;75(2):132-145. doi: 10.1016/j.jinf.2017.04.011. Epub 2017 May 5.


Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

Ehrhardt C, Bäckman P, Couet W, Edwards C, Forbes B, Fridén M, Gumbleton M, Hosoya KI, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R.

J Pharm Sci. 2017 Sep;106(9):2234-2244. doi: 10.1016/j.xphs.2017.04.011. Epub 2017 Apr 15. Review.


Mixed micelles of lipoic acid-chitosan-poly(ethylene glycol) and distearoylphosphatidylethanolamine-poly(ethylene glycol) for tumor delivery.

Elsaid Z, Taylor KM, Puri S, Eberlein CA, Al-Jamal K, Bai J, Klippstein R, Wang JT, Forbes B, Chana J, Somavarapu S.

Eur J Pharm Sci. 2017 Apr 1;101:228-242. doi: 10.1016/j.ejps.2017.02.001. Epub 2017 Feb 3.


Patterns of retinal hemorrhage associated with pediatric cerebral sinovenous thrombosis.

Binenbaum G, Reid JE, Rogers DL, Jensen AK, Billinghurst LL, Forbes BJ.

J AAPOS. 2017 Feb;21(1):23-27. doi: 10.1016/j.jaapos.2016.10.004. Epub 2017 Jan 11.


Mycobacterial Taxonomy.

Forbes BA.

J Clin Microbiol. 2017 Feb;55(2):380-383. doi: 10.1128/JCM.01287-16. Epub 2016 Dec 7. Review.


Biographical Feature: Lynne S. Garcia, M.S., F(AAM).

Forbes BA.

J Clin Microbiol. 2017 Feb;55(2):356-359. doi: 10.1128/JCM.02210-16. Epub 2016 Dec 7. No abstract available.


Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery.

Martinelli F, Balducci AG, Kumar A, Sonvico F, Forbes B, Bettini R, Buttini F.

Int J Pharm. 2017 Jan 30;517(1-2):286-295. doi: 10.1016/j.ijpharm.2016.12.002. Epub 2016 Dec 5.


Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions.

Tsend-Ayush E, He C, Myers MA, Andrikopoulos S, Wong N, Sexton PM, Wootten D, Forbes BE, Grutzner F.

Sci Rep. 2016 Nov 29;6:37744. doi: 10.1038/srep37744.


Sea ice, rain-on-snow and tundra reindeer nomadism in Arctic Russia.

Forbes BC, Kumpula T, Meschtyb N, Laptander R, Macias-Fauria M, Zetterberg P, Verdonen M, Skarin A, Kim KY, Boisvert LN, Stroeve JC, Bartsch A.

Biol Lett. 2016 Nov;12(11). pii: 20160466.


Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks.

Muddle J, Kirton SB, Parisini I, Muddle A, Murnane D, Ali J, Brown M, Page C, Forbes B.

J Pharm Sci. 2017 Jan;106(1):313-321. doi: 10.1016/j.xphs.2016.10.002. Epub 2016 Nov 9.


Drug Delivery Devices for Inhaled Medicines.

Lexmond A, Forbes B.

Handb Exp Pharmacol. 2017;237:265-280. doi: 10.1007/164_2016_67. Review.


Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability.

Karas JA, Patil NA, Tailhades J, Sani MA, Scanlon DB, Forbes BE, Gardiner J, Separovic F, Wade JD, Hossain MA.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14743-14747. doi: 10.1002/anie.201607101. Epub 2016 Oct 20.


Two years in IGF research.

Forbes BE.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:70-74. doi: 10.1016/j.ghir.2016.09.006. Epub 2016 Sep 30. Review.


A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.


Cumulative Instructional Time and Relative Effectiveness Conclusions: Extending Research on Response Intervals, Learning, and Measurement Scale.

Black MP, Skinner CH, Forbes BE, McCurdy M, Coleman MB, Davis K, Gettelfinger M.

Behav Anal Pract. 2016 Feb 16;9(1):58-62. doi: 10.1007/s40617-016-0114-3. eCollection 2016 Mar.


Controlled drug release from lung-targeted nanocarriers via chemically mediated shell permeabilisation.

Chen H, Woods A, Forbes B, Jones S.

Int J Pharm. 2016 Sep 25;511(2):1033-41. doi: 10.1016/j.ijpharm.2016.08.012. Epub 2016 Aug 6.


Sources and magnitude of error in preparing morphine infusions for nurse-patient controlled analgesia in a UK paediatric hospital.

Rashed AN, Tomlin S, Aguado V, Forbes B, Whittlesea C.

Int J Clin Pharm. 2016 Oct;38(5):1069-74. doi: 10.1007/s11096-016-0369-3. Epub 2016 Aug 8.


Long-Term Trends and Role of Climate in the Population Dynamics of Eurasian Reindeer.

Uboni A, Horstkotte T, Kaarlejärvi E, Sévêque A, Stammler F, Olofsson J, Forbes BC, Moen J.

PLoS One. 2016 Jun 30;11(6):e0158359. doi: 10.1371/journal.pone.0158359. eCollection 2016.


Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study.

Carhart-Harris RL, Bolstridge M, Rucker J, Day CM, Erritzoe D, Kaelen M, Bloomfield M, Rickard JA, Forbes B, Feilding A, Taylor D, Pilling S, Curran VH, Nutt DJ.

Lancet Psychiatry. 2016 Jul;3(7):619-27. doi: 10.1016/S2215-0366(16)30065-7. Epub 2016 May 17.


Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration.

Patel A, Woods A, Riffo-Vasquez Y, Babin-Morgan A, Jones MC, Jones S, Sunassee K, Clark S, T M de Rosales R, Page C, Spina D, Forbes B, Dailey LA.

J Control Release. 2016 Aug 10;235:24-33. doi: 10.1016/j.jconrel.2016.05.024. Epub 2016 May 13.


Ocular findings associated with chromosome 22q11.2 duplication.

Forbes BJ, McDonald-McGinn DM, Wootton G, Dawson L, Zackai E, Binenbaum G.

J AAPOS. 2016 Jun;20(3):278-80. doi: 10.1016/j.jaapos.2016.02.003. Epub 2016 Apr 22.


The natural history of retinal hemorrhage in pediatric head trauma.

Binenbaum G, Chen W, Huang J, Ying GS, Forbes BJ.

J AAPOS. 2016 Apr;20(2):131-5. doi: 10.1016/j.jaapos.2015.12.008.


Defining the Clinical Significance of Alloscardovia omnincolens in the Urinary Tract.

Brown MK, Forbes BA, Stitley K, Doern CD.

J Clin Microbiol. 2016 Jun;54(6):1552-1556. doi: 10.1128/JCM.03084-15. Epub 2016 Apr 6.

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