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Items: 38


Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease.

Kim H, Worsley O, Yang E, Purbojati RW, Liang AL, Tan W, Moses DID, Hartono S, Fan V, Lim TKH, Schuster SC, Foo RS, Chow PKH, Pettersson S.

Cell Mol Life Sci. 2019 May 22. doi: 10.1007/s00018-019-03114-4. [Epub ahead of print]


Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy.

Lim TB, Aliwarga E, Luu TDA, Li YP, Ng SL, Annadoray L, Sian S, Ackers-Johnson MA, Foo RS.

Cardiovasc Res. 2019 May 22. pii: cvz130. doi: 10.1093/cvr/cvz130. [Epub ahead of print]


Toll-like Receptor 7 Deficiency Promotes Survival and Reduces Adverse Left Ventricular Remodeling After Myocardial Infarction.

de Kleijn DPV, Chong SY, Wang X, Yatim SMJM, Fairhurst AM, Vernooij F, Zharkova O, Chan M, Foo RSY, Timmers L, Lam CSP, Wang JW.

Cardiovasc Res. 2019 Mar 4. pii: cvz057. doi: 10.1093/cvr/cvz057. [Epub ahead of print]


Langendorff-Free Isolation and Propagation of Adult Mouse Cardiomyocytes.

Ackers-Johnson M, Foo RS.

Methods Mol Biol. 2019;1940:193-204. doi: 10.1007/978-1-4939-9086-3_14.


Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress-Gene Response.

Lee DP, Tan WLW, Anene-Nzelu CG, Lee CJM, Li PY, Luu TDA, Chan CX, Tiang Z, Ng SL, Huang X, Efthymios M, Autio MI, Jiang J, Fullwood MJ, Prabhakar S, Lieberman Aiden E, Foo RS.

Circulation. 2019 Apr 16;139(16):1937-1956. doi: 10.1161/CIRCULATIONAHA.118.036726.


Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease.

Ackers-Johnson M, Tan WLW, Foo RS.

Nat Commun. 2018 Oct 30;9(1):4434. doi: 10.1038/s41467-018-06894-8.


Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.

Stenzig J, Schneeberger Y, Löser A, Peters BS, Schaefer A, Zhao RR, Ng SL, Höppner G, Geertz B, Hirt MN, Tan W, Wong E, Reichenspurner H, Foo RS, Eschenhagen T.

J Mol Cell Cardiol. 2018 Jul;120:53-63. doi: 10.1016/j.yjmcc.2018.05.012. Epub 2018 May 21.


Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling.

Zhao RR, Ackers-Johnson M, Stenzig J, Chen C, Ding T, Zhou Y, Wang P, Ng SL, Li PY, Teo G, Rudd PM, Fawcett JW, Foo RSY.

Circulation. 2018 Jun 5;137(23):2497-2513. doi: 10.1161/CIRCULATIONAHA.117.030353. Epub 2018 Jan 25.


Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo.

See K, Tan WLW, Lim EH, Tiang Z, Lee LT, Li PYQ, Luu TDA, Ackers-Johnson M, Foo RS.

Nat Commun. 2017 Aug 9;8(1):225. doi: 10.1038/s41467-017-00319-8.


Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts.

Mohamed Suhaimi NA, Phyo WM, Yap HY, Choy SHY, Wei X, Choudhury Y, Tan WJ, Tan LAPY, Foo RSY, Tan SHS, Tiang Z, Wong CF, Koh PK, Tan MH.

Mol Cancer Ther. 2017 Sep;16(9):2035-2044. doi: 10.1158/1535-7163.MCT-16-0793. Epub 2017 May 22.


The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma.

Zhai W, Lim TK, Zhang T, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS, Chow PK.

Nat Commun. 2017 Feb 27;8:4565. doi: 10.1038/ncomms14565.


A landscape of circular RNA expression in the human heart.

Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS.

Cardiovasc Res. 2017 Mar 1;113(3):298-309. doi: 10.1093/cvr/cvw250. Erratum in: Cardiovasc Res. 2017 May 1;113(6):704.


A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts.

Jonsson MKB, Hartman RJG, Ackers-Johnson M, Tan WLW, Lim B, van Veen TAB, Foo RS.

JACC Basic Transl Sci. 2016 Nov 30;1(7):590-602. doi: 10.1016/j.jacbts.2016.07.007. eCollection 2016 Dec. Review.


A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse Heart.

Ackers-Johnson M, Li PY, Holmes AP, O'Brien SM, Pavlovic D, Foo RS.

Circ Res. 2016 Sep 30;119(8):909-20. doi: 10.1161/CIRCRESAHA.116.309202. Epub 2016 Aug 8.


AAV9 Delivery of shRNA to the Mouse Heart.

Wakimoto H, Seidman JG, Foo RS, Jiang J.

Curr Protoc Mol Biol. 2016 Jul 1;115:23.16.1-9. doi: 10.1002/cpmb.9.


FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy.

Rachmin I, Amsalem E, Golomb E, Beeri R, Gilon D, Fang P, Nechushtan H, Kay G, Guo M, Yiqing PL, Foo RS, Fisher DE, Razin E, Tshori S.

Int J Cardiol. 2015 Sep 15;195:85-94. doi: 10.1016/j.ijcard.2015.05.108. Epub 2015 May 20.


Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B.

Vujic A, Robinson EL, Ito M, Haider S, Ackers-Johnson M, See K, Methner C, Figg N, Brien P, Roderick HL, Skepper J, A Ferguson-Smith, Foo RS.

J Mol Cell Cardiol. 2015 May;82:174-83. doi: 10.1016/j.yjmcc.2015.03.007. Epub 2015 Mar 14.


Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100.

Wong LL, Wee AS, Lim JY, Ng JY, Chong JP, Liew OW, Lilyanna S, Martinez EC, Ackers-Johnson MA, Vardy LA, Armugam A, Jeyaseelan K, Ng TP, Lam CS, Foo RS, Richards AM, Chen YT.

J Mol Cell Cardiol. 2015 May;82:13-21. doi: 10.1016/j.yjmcc.2015.02.019. Epub 2015 Feb 28.


Circulating miR-323-3p and miR-652: candidate markers for the presence and progression of acute coronary syndromes.

Pilbrow AP, Cordeddu L, Cameron VA, Frampton CM, Troughton RW, Doughty RN, Whalley GA, Ellis CJ, Yandle TG, Richards AM, Foo RS.

Int J Cardiol. 2014 Sep 20;176(2):375-85. doi: 10.1016/j.ijcard.2014.07.068. Epub 2014 Jul 22.


Erbin is a negative modulator of cardiac hypertrophy.

Rachmin I, Tshori S, Smith Y, Oppenheim A, Marchetto S, Kay G, Foo RS, Dagan N, Golomb E, Gilon D, Borg JP, Razin E.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5902-7. doi: 10.1073/pnas.1320350111. Epub 2014 Apr 7.


The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis.

Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamaño JH, Figg N, Foo RS, Mann J, Mann DA, Oakley F.

Am J Pathol. 2012 Mar;180(3):929-39. doi: 10.1016/j.ajpath.2011.11.007. Epub 2011 Dec 30.


Distinct epigenomic features in end-stage failing human hearts.

Movassagh M, Choy MK, Knowles DA, Cordeddu L, Haider S, Down T, Siggens L, Vujic A, Simeoni I, Penkett C, Goddard M, Lio P, Bennett MR, Foo RS.

Circulation. 2011 Nov 29;124(22):2411-22. doi: 10.1161/CIRCULATIONAHA.111.040071. Epub 2011 Oct 24.


Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated.

Choy MK, Movassagh M, Goh HG, Bennett MR, Down TA, Foo RS.

BMC Genomics. 2010 Sep 27;11:519. doi: 10.1186/1471-2164-11-519.


Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure.

Movassagh M, Choy MK, Goddard M, Bennett MR, Down TA, Foo RS.

PLoS One. 2010 Jan 13;5(1):e8564. doi: 10.1371/journal.pone.0008564.


PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.

Choy MK, Movassagh M, Bennett MR, Foo RS.

J Cell Physiol. 2010 Mar;222(3):635-9. doi: 10.1002/jcp.21980.


Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes.

Harzheim D, Talasila A, Movassagh M, Foo RS, Figg N, Bootman MD, Roderick HL.

Channels (Austin). 2010 Jan-Feb;4(1):67-71. Epub 2010 Jan 17.


Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.

Harzheim D, Movassagh M, Foo RS, Ritter O, Tashfeen A, Conway SJ, Bootman MD, Roderick HL.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11406-11. doi: 10.1073/pnas.0905485106. Epub 2009 Jun 23.


Regulation of p53 tetramerization and nuclear export by ARC.

Foo RS, Nam YJ, Ostreicher MJ, Metzl MD, Whelan RS, Peng CF, Ashton AW, Fu W, Mani K, Chin SF, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20826-31. Epub 2007 Dec 17.


Simplified apoptotic cascades.

Movassagh M, Foo RS.

Heart Fail Rev. 2008 Jun;13(2):111-9. Review.


Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2.

Foo RS, Chan LK, Kitsis RN, Bennett MR.

J Biol Chem. 2007 Feb 23;282(8):5529-35. Epub 2006 Dec 2.


The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant.

Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS, Krishnamurthy B, Miao W, Ashton AW, Lefer DJ, Kitsis RN.

J Biol Chem. 2007 Feb 23;282(8):5522-8. Epub 2006 Dec 1.


Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy.

Foo RS, Siow RC, Brown MJ, Bennett MR.

J Cell Physiol. 2006 Oct;209(1):1-7.


Death begets failure in the heart.

Foo RS, Mani K, Kitsis RN.

J Clin Invest. 2005 Mar;115(3):565-71. Review.


Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension.

Deary AJ, Schumann AL, Murfet H, Haydock S, Foo RS, Brown MJ.

Clin Sci (Lond). 2002 Nov;103(5):493-9.


Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs.

Deary AJ, Schumann AL, Murfet H, Haydock SF, Foo RS, Brown MJ.

J Hypertens. 2002 Apr;20(4):771-7.


Concepts in acute coronary syndromes.

Foo RS, De Bono DP.

Singapore Med J. 2000 Dec;41(12):606-10. Review.


Inhibition of platelet thrombosis using an activated protein C-loaded stent: in vitro and in vivo results.

Foo RS, Gershlick AH, Hogrefe K, Baron JH, Johnston TW, Hussey AJ, Garner I, de Bono DP.

Thromb Haemost. 2000 Mar;83(3):496-502.


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