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Items: 19


Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate.

Sauvage E, Zervosen A, Dive G, Herman R, Amoroso A, Joris B, Fonzé E, Pratt RF, Luxen A, Charlier P, Kerff F.

J Am Chem Soc. 2009 Oct 28;131(42):15262-9. doi: 10.1021/ja9051526.


Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.

Sauvage E, Fonzé E, Quinting B, Galleni M, Frère JM, Charlier P.

Antimicrob Agents Chemother. 2006 Jul;50(7):2516-21.


Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis.

Kerff F, Charlier P, Colombo ML, Sauvage E, Brans A, Frère JM, Joris B, Fonzé E.

Biochemistry. 2003 Nov 11;42(44):12835-43.


Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.

Rhazi N, Charlier P, Dehareng D, Engher D, Vermeire M, Frère JM, Nguyen-Distèche M, Fonzé E.

Biochemistry. 2003 Mar 18;42(10):2895-906.


The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.

Sauvage E, Kerff F, Fonzé E, Herman R, Schoot B, Marquette JP, Taburet Y, Prevost D, Dumas J, Leonard G, Stefanic P, Coyette J, Charlier P.

Cell Mol Life Sci. 2002 Jul;59(7):1223-32.


Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin.

Fonzé E, Vanhove M, Dive G, Sauvage E, Frère JM, Charlier P.

Biochemistry. 2002 Feb 12;41(6):1877-85.


Expression, purification, crystallization and preliminary X-ray analysis of the native class C beta-lactamase from Enterobacter cloacae 908R and two mutants.

Wouters J, Charlier P, Monnaie D, Frère JM, Fonzé E.

Acta Crystallogr D Biol Crystallogr. 2001 Jan;57(Pt 1):162-4.


The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15.

Fonzé E, Vermeire M, Nguyen-Distèche M, Brasseur R, Charlier P.

J Biol Chem. 1999 Jul 30;274(31):21853-60.


X-ray studies of enzymes that interact with penicillins.

Kelly JA, Kuzin AP, Charlier P, Fonzé E.

Cell Mol Life Sci. 1998 Apr;54(4):353-8. Review.


Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters.

Ledent P, Duez C, Vanhove M, Lejeune A, Fonzé E, Charlier P, Rhazi-Filali F, Thamm I, Guillaume G, Samyn B, Devreese B, Van Beeumen J, Lamotte-Brasseur J, Frère JM.

FEBS Lett. 1997 Aug 18;413(2):194-6.


Penicillin and beyond: evolution, protein fold, multimodular polypeptides, and multiprotein complexes.

Ghuysen JM, Charlier P, Coyette J, Duez C, Fonzé E, Fraipont C, Goffin C, Joris B, Nguyen-Distèche M.

Microb Drug Resist. 1996 Summer;2(2):163-75. Review.


The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.

Damblon C, Raquet X, Lian LY, Lamotte-Brasseur J, Fonze E, Charlier P, Roberts GC, Frère JM.

Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1747-52.


TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant.

Fonzé E, Charlier P, To'th Y, Vermeire M, Raquet X, Dubus A, Frère JM.

Acta Crystallogr D Biol Crystallogr. 1995 Sep 1;51(Pt 5):682-94.


DD-peptidases and beta-lactamases: catalytic mechanisms and specificities.

Galleni M, Raquet X, Lamotte-Brasseur J, Fonzé E, Amicosante G, Frère JM.

J Chemother. 1995 Feb;7(1):3-7. Review.


TEM beta-lactamase mutants hydrolysing third-generation cephalosporins. A kinetic and molecular modelling analysis.

Raquet X, Lamotte-Brasseur J, Fonzé E, Goussard S, Courvalin P, Frère JM.

J Mol Biol. 1994 Dec 16;244(5):625-39.


Crystallization and X-ray diffraction study of the Streptomyces K15 penicillin-binding DD-transpeptidase.

Englebert S, Charlier P, Fonzé E, To'th Y, Vermeire M, Van Beeumen J, Grandchamps J, Hoffmann K, Leyh-Bouille M, Nguyen-Distèche M, et al.

J Mol Biol. 1994 Aug 12;241(2):295-7.


The structures and catalytic mechanisms of active-site serine beta-lactamases.

Lamotte-Brasseur J, Knox J, Kelly JA, Charlier P, Fonzé E, Dideberg O, Frére JM.

Biotechnol Genet Eng Rev. 1994;12:189-230. Review. No abstract available.


Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins.

Joris B, Ledent P, Dideberg O, Fonzé E, Lamotte-Brasseur J, Kelly JA, Ghuysen JM, Frère JM.

Antimicrob Agents Chemother. 1991 Nov;35(11):2294-301.

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