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Items: 48


DEAD-box ATPases are global regulators of phase-separated organelles.

Hondele M, Sachdev R, Heinrich S, Wang J, Vallotton P, Fontoura BMA, Weis K.

Nature. 2019 Sep;573(7772):144-148. doi: 10.1038/s41586-019-1502-y. Epub 2019 Aug 21.


Structural basis for influenza virus NS1 protein block of mRNA nuclear export.

Zhang K, Xie Y, Muñoz-Moreno R, Wang J, Zhang L, Esparza M, García-Sastre A, Fontoura BMA, Ren Y.

Nat Microbiol. 2019 Oct;4(10):1671-1679. doi: 10.1038/s41564-019-0482-x. Epub 2019 Jul 1.


Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination.

Liu Z, Yan M, Liang Y, Liu M, Zhang K, Shao D, Jiang R, Li L, Wang C, Nussenzveig DR, Zhang K, Chen S, Zhong C, Mo W, Fontoura BMA, Zhang L.

Neuron. 2019 May 8;102(3):587-601.e7. doi: 10.1016/j.neuron.2019.02.018. Epub 2019 Mar 12.


Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12218-E12227. doi: 10.1073/pnas.1818012115. Epub 2018 Dec 11.


Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.

Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, Shao D, Anantharaman A, García-Sastre A, Conrad NK, Fontoura BMA.

J Virol. 2018 Nov 27;92(24). pii: e01634-18. doi: 10.1128/JVI.01634-18. Print 2018 Dec 15.


Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.

Thompson MG, Muñoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara MR, Mallory MJ, Zhang K, García-Sastre A, Fontoura BMA, Lynch KW.

Nat Commun. 2018 Jun 19;9(1):2407. doi: 10.1038/s41467-018-04779-4.


Editorial overview: The cell nucleus: Dynamic interplay of shape and function.

Dasso M, Fontoura BMA.

Curr Opin Cell Biol. 2018 Jun;52:iv-vi. doi: 10.1016/ No abstract available.


Günter Blobel 1936-2018.

Chook YM, Fontoura BMA, Rout MP.

Nat Struct Mol Biol. 2018 Apr;25(4):297-298. doi: 10.1038/s41594-018-0053-5. No abstract available.


Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.

Kuss-Duerkop SK, Wang J, Mena I, White K, Metreveli G, Sakthivel R, Mata MA, Muñoz-Moreno R, Chen X, Krammer F, Diamond MS, Chen ZJ, García-Sastre A, Fontoura BMA.

PLoS Pathog. 2017 Sep 27;13(9):e1006635. doi: 10.1371/journal.ppat.1006635. eCollection 2017 Sep.


Corrigendum: Influenza virus mRNA trafficking through host nuclear speckles.

Mor A, White A, Zhang K, Thompson M, Esparza M, Muñoz-Moreno R, Koide K, Lynch KW, García-Sastre A, Fontoura BM.

Nat Microbiol. 2017 Jan 9;2:17002. doi: 10.1038/nmicrobiol.2017.2. No abstract available.


Gating Immunity and Death at the Nuclear Pore Complex.

Dasso M, Fontoura BMA.

Cell. 2016 Sep 8;166(6):1364-1366. doi: 10.1016/j.cell.2016.08.026.


Influenza virus mRNA trafficking through host nuclear speckles.

Mor A, White A, Zhang K, Thompson M, Esparza M, Muñoz-Moreno R, Koide K, Lynch KW, García-Sastre A, Fontoura BM.

Nat Microbiol. 2016 May 27;1(7):16069. doi: 10.1038/nmicrobiol.2016.69. Erratum in: Nat Microbiol. 2017 Jan 09;2:17002.


UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages.

Zhang M, Mishra S, Sakthivel R, Fontoura BM, Nussenzweig V.

PLoS Pathog. 2016 Jan 6;12(1):e1005370. doi: 10.1371/journal.ppat.1005370. eCollection 2016 Jan.


Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo.

Moreira TG, Zhang L, Shaulov L, Harel A, Kuss SK, Williams J, Shelton J, Somatilaka B, Seemann J, Yang J, Sakthivel R, Nussenzveig DR, Faria AM, Fontoura BM.

Sci Rep. 2015 Dec 3;5:17655. doi: 10.1038/srep17655.


Primate-specific miR-576-3p sets host defense signalling threshold.

Yarbrough ML, Zhang K, Sakthivel R, Forst CV, Posner BA, Barber GN, White MA, Fontoura BM.

Nat Commun. 2014 Sep 18;5:4963. doi: 10.1038/ncomms5963.


Nuclear trafficking in health and disease.

Mor A, White MA, Fontoura BM.

Curr Opin Cell Biol. 2014 Jun;28:28-35. doi: 10.1016/ Epub 2014 Feb 11. Review.


Viral subversion of nucleocytoplasmic trafficking.

Yarbrough ML, Mata MA, Sakthivel R, Fontoura BM.

Traffic. 2014 Feb;15(2):127-40. doi: 10.1111/tra.12137. Epub 2013 Dec 2. Review.


SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.

Das P, Deng X, Zhang L, Roth MG, Fontoura BM, Phillips MA, De Brabander JK.

ACS Med Chem Lett. 2013 Jun 13;4(6):517-521.


Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.

Kuss SK, Mata MA, Zhang L, Fontoura BM.

Viruses. 2013 Jul 18;5(7):1824-49. doi: 10.3390/v5071824. Review.


Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

Tsai PL, Chiou NT, Kuss S, García-Sastre A, Lynch KW, Fontoura BM.

PLoS Pathog. 2013;9(6):e1003460. doi: 10.1371/journal.ppat.1003460. Epub 2013 Jun 27.


Shaping the p53 response with nucleoporins.

Yarbrough ML, White MA, Fontoura BM.

Mol Cell. 2012 Dec 14;48(5):665-6. doi: 10.1016/j.molcel.2012.11.027.


Host modulators of H1N1 cytopathogenicity.

Ward SE, Kim HS, Komurov K, Mendiratta S, Tsai PL, Schmolke M, Satterly N, Manicassamy B, Forst CV, Roth MG, García-Sastre A, Blazewska KM, McKenna CE, Fontoura BM, White MA.

PLoS One. 2012;7(8):e39284. doi: 10.1371/journal.pone.0039284. Epub 2012 Aug 2.


PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.

Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ Jr, Fontoura BM, Ménard R, Dever TE, Nussenzweig V.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3956-61. doi: 10.1073/pnas.1121567109. Epub 2012 Feb 21.


Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.

Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM.

J Cell Biol. 2012 Feb 6;196(3):315-26. doi: 10.1083/jcb.201107058.


Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.

Zhang ZC, Satterly N, Fontoura BM, Chook YM.

Mol Biol Cell. 2011 Dec;22(23):4657-68. doi: 10.1091/mbc.E11-03-0222. Epub 2011 Sep 30.


Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.

Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM.

Nat Chem Biol. 2011 Sep 11;7(10):712-9. doi: 10.1038/nchembio.645.


The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands.

Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ Jr, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V.

J Exp Med. 2010 Jul 5;207(7):1465-74. doi: 10.1084/jem.20091975. Epub 2010 Jun 28.


The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores.

Mishra RK, Chakraborty P, Arnaoutov A, Fontoura BM, Dasso M.

Nat Cell Biol. 2010 Feb;12(2):164-9. doi: 10.1038/ncb2016. Epub 2010 Jan 17.


Vesicular stomatitis virus inhibits mitotic progression and triggers cell death.

Chakraborty P, Seemann J, Mishra RK, Wei JH, Weil L, Nussenzveig DR, Heiber J, Barber GN, Dasso M, Fontoura BM.

EMBO Rep. 2009 Oct;10(10):1154-60. doi: 10.1038/embor.2009.179. Epub 2009 Sep 11.


Nucleoporin levels regulate cell cycle progression and phase-specific gene expression.

Chakraborty P, Wang Y, Wei JH, van Deursen J, Yu H, Malureanu L, Dasso M, Forbes DJ, Levy DE, Seemann J, Fontoura BM.

Dev Cell. 2008 Nov;15(5):657-67. doi: 10.1016/j.devcel.2008.08.020.


NFAR-1 and -2 modulate translation and are required for efficient host defense.

Pfeifer I, Elsby R, Fernandez M, Faria PA, Nussenzveig DR, Lossos IS, Fontoura BM, Martin WD, Barber GN.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4173-8. doi: 10.1073/pnas.0711222105. Epub 2008 Mar 12.


Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.

Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V.

Cell. 2007 Nov 2;131(3):492-504. Erratum in: Cell. 2008 Apr 18;133(2):375.


Structure-based design of a pathway-specific nuclear import inhibitor.

Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM.

Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15.


Influenza virus targets the mRNA export machinery and the nuclear pore complex.

Satterly N, Tsai PL, van Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BM.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1853-8. Epub 2007 Jan 31.


Nuclear export assays for poly(A) RNAs.

Chakraborty P, Satterly N, Fontoura BM.

Methods. 2006 Aug;39(4):363-9.


The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.

Faria AM, Levay A, Wang Y, Kamphorst AO, Rosa ML, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BM.

Immunity. 2006 Mar;24(3):295-304.


Viral interactions with the nuclear transport machinery: discovering and disrupting pathways.

Fontoura BM, Faria PA, Nussenzveig DR.

IUBMB Life. 2005 Feb;57(2):65-72. Review.


VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway.

Faria PA, Chakraborty P, Levay A, Barber GN, Ezelle HJ, Enninga J, Arana C, van Deursen J, Fontoura BM.

Mol Cell. 2005 Jan 7;17(1):93-102.


Cytoplasmic complex of p53 and eEF2.

Yin X, Fontoura BM, Morimoto T, Carroll RB.

J Cell Physiol. 2003 Sep;196(3):474-82.


Role of nucleoporin induction in releasing an mRNA nuclear export block.

Enninga J, Levy DE, Blobel G, Fontoura BM.

Science. 2002 Feb 22;295(5559):1523-5. Epub 2002 Jan 24.


The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR.

Fontoura BM, Dales S, Blobel G, Zhong H.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3208-13.


Cytoplasmic p53 polypeptide is associated with ribosomes.

Fontoura BM, Atienza CA, Sorokina EA, Morimoto T, Carroll RB.

Mol Cell Biol. 1997 Jun;17(6):3146-54.


p53 is covalently linked to 5.8S rRNA.

Fontoura BM, Sorokina EA, David E, Carroll RB.

Mol Cell Biol. 1992 Nov;12(11):5145-51.


DuP 753 is a potent nonpeptide antagonist of angiotensin II receptors in isolated perfused rat kidney and cultured renal cells.

Fontoura BM, Nussenzveig DR, Timmermans PB, Maack T.

Am J Hypertens. 1991 Apr;4(4 Pt 2):303S-308S.


Atrial natriuretic factor receptors in cultured renomedullary interstitial cells.

Fontoura BM, Nussenzveig DR, Pelton KM, Maack T.

Am J Physiol. 1990 Apr;258(4 Pt 1):C692-9.


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