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Acute liver failure in a military recruit treated with valproic acid and harboring a previously unrecognized POLG-1 mutation.

Bassett JT, Rodriguez B, Mulligan L, Fontana RJ.

Epilepsy Behav Rep. 2019 Oct 25;12:100342. doi: 10.1016/j.ebr.2019.100342. eCollection 2019.


Phase Transition Is Infrequent Among North American Adults With e-Antigen-Negative Chronic Hepatitis B and Low-Level Viremia.

Zhou K, Wahed AS, Cooper S, Di Bisceglie AM, Fontana RJ, Ghany MG, Khalili M, Lok AS, Perrillo R, Lee WM, Lau DTY, Sterling R, Janssen HLA, Terrault NA.

Am J Gastroenterol. 2019 Nov;114(11):1753-1763. doi: 10.14309/ajg.0000000000000400.


Efficacy and Safety of 8 Weeks of Glecaprevir/Pibrentasvir in Treatment-Naïve, HCV-Infected Patients with APRI ≤ 1 in a Single-Arm, Open-Label, Multicenter Study.

Fontana RJ, Lens S, McPherson S, Elkhashab M, Ankoma-Sey V, Bondin M, Dos Santos AGP, Xue Z, Trinh R, Porcalla A, Zeuzem S.

Adv Ther. 2019 Dec;36(12):3458-3470. doi: 10.1007/s12325-019-01123-0. Epub 2019 Oct 23.


A Decline in Status 1 Listings: The Impact of Etiology and Medical Management of Acute Liver Failure.

Fontana RJ, Durkalski V.

Liver Transpl. 2019 Nov;25(11):1605-1608. doi: 10.1002/lt.25638. No abstract available.


Severe Acute Hepatitis Attributed to the Herbal and Dietary Supplement OxyELITE Pro.

Fontana RJ.

Clin Liver Dis (Hoboken). 2019 Sep 2;14(2):45-48. doi: 10.1002/cld.809. eCollection 2019 Aug. Review. No abstract available.


Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis.

Kamal N, Koh C, Samala N, Fontana RJ, Stolz A, Durazo F, Hayashi PH, Phillips E, Wang T, Hoofnagle JH; Drug-Induced Liver Injury Network.

Hepatol Int. 2019 Sep;13(5):641-648. doi: 10.1007/s12072-019-09971-2. Epub 2019 Aug 7.


Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury.

Bonkovsky HL, Severson T, Nicoletti P, Barnhart H, Serrano J, Chalasani N, Fontana RJ, Watkins PB, Navarro V, Stolz A, Daly AK, Aithal GP, Odin J; US DILIN Investigators.

Hepatol Commun. 2019 Jun 6;3(8):1032-1035. doi: 10.1002/hep4.1382. eCollection 2019 Aug.


Vanishing bile duct syndrome arising in a patient with HIV infection sequentially treated with trimethoprim/sulfamethoxazole and dapsone.

Kathi PR, Tama M, Ehrinpreis M, Mutchnick M, Westerhoff M, Mowers J, Fontana RJ.

Clin J Gastroenterol. 2019 Jul 17. doi: 10.1007/s12328-019-01022-5. [Epub ahead of print]


Liver injury is most commonly due to hepatic metastases rather than drug hepatotoxicity during pembrolizumab immunotherapy.

Tsung I, Dolan R, Lao CD, Fecher L, Riggenbach K, Yeboah-Korang A, Fontana RJ.

Aliment Pharmacol Ther. 2019 Oct;50(7):800-808. doi: 10.1111/apt.15413. Epub 2019 Jul 15.


Gender Disparities in Patients with Alcoholic Liver Disease Evaluated for Liver Transplantation.

McElroy LM, Likhitsup A, Winder GS, Saeed N, Hassan A, Sonnenday CJ, Fontana RJ, Mellinger J.

Transplantation. 2019 Jun 24. doi: 10.1097/TP.0000000000002843. [Epub ahead of print]


Antimicrobials and Antiepileptics Are the Leading Causes of Idiosyncratic Drug-induced Liver Injury in American Children.

DiPaola F, Molleston JP, Gu J, Cirulli ET, Chalasani N, Barnhart H, Kleiner DE, Hoofnagle JH, Fontana RJ; US Drug Induced Liver Injury Network.

J Pediatr Gastroenterol Nutr. 2019 Aug;69(2):152-159. doi: 10.1097/MPG.0000000000002383.


Prevalence and Impact of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living in the US and Canada.

McGivern DR, Lin HS, Wang J, Benzine T, Janssen HLA, Khalili M, Lisker-Melman M, Fontana RJ, Belle SH, Fried MW.

Open Forum Infect Dis. 2019 Apr 9;6(5):ofz175. doi: 10.1093/ofid/ofz175. eCollection 2019 May.


Impact of a Prohibitive Versus Restrictive Tobacco Policy on Liver Transplant Candidate Outcomes.

Likhitsup A, Hassan A, Mellinger J, Askari F, Winder GS, Saeed N, Sonnenday CJ, Sharma P, Fontana RJ.

Liver Transpl. 2019 Aug;25(8):1165-1176. doi: 10.1002/lt.25497. Epub 2019 Jul 4.


Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury.

Park MJ, D'Alecy LG, Anderson MA, Basrur V, Feng Y, Brady GF, Kim DI, Wu J, Nesvizhskii AI, Lahann J, Lukacs NW, Fontana RJ, Omary MB.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9125-9134. doi: 10.1073/pnas.1822173116. Epub 2019 Apr 12.


Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors.

Stolz A, Navarro V, Hayashi PH, Fontana RJ, Barnhart HX, Gu J, Chalasani NP, Vega MM, Bonkovsky HL, Seeff LB, Serrano J, Avula B, Khan IA, Cirulli ET, Kleiner DE, Hoofnagle JH; DILIN Investigators.

Aliment Pharmacol Ther. 2019 May;49(9):1195-1204. doi: 10.1111/apt.15211. Epub 2019 Apr 1.


Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury.

Ahmad J, Reddy KR, Tillmann HL, Hayashi PH, Chalasani N, Fontana RJ, Navarro VJ, Stolz A, Barnhart H, Cloherty GA, Hoofnagle JH.

Dig Dis Sci. 2019 Sep;64(9):2645-2652. doi: 10.1007/s10620-019-05591-w. Epub 2019 Mar 29.


Outcomes in Living Liver Donor "Heroes" After the Spotlight Fades.

Winder GS, Fontana RJ.

Liver Transpl. 2019 May;25(5):685-687. doi: 10.1002/lt.25459. No abstract available.


Author's Response to Letter to the Editor: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.

Rajajee V, Williamson CA, Fontana RJ, Courey AJ, Patil PG.

Neurocrit Care. 2019 Apr;30(2):497. doi: 10.1007/s12028-019-00681-z. No abstract available.


Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Bonkovsky HL, Barnhart HX, Foureau DM, Steuerwald N, Lee WM, Gu J, Fontana RJ, Hayashi PH, Chalasani N, Navarro VM, Odin J, Stolz A, Watkins PB, Serrano J; US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group.

PLoS One. 2019 Feb 11;14(2):e0212394. doi: 10.1371/journal.pone.0212394. eCollection 2019.


Gender Disparities in Alcohol Use Disorder Treatment Among Privately Insured Patients with Alcohol-Associated Cirrhosis.

Mellinger JL, Fernandez A, Shedden K, Winder GS, Fontana RJ, Volk ML, Blow FC, Lok ASF.

Alcohol Clin Exp Res. 2019 Feb;43(2):334-341. doi: 10.1111/acer.13944. Epub 2019 Jan 22.


A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, Fontana RJ, Hallberg P, Li YJ, Lucena MI, Long N, Molokhia M, Nelson MR, Odin JA, Pirmohamed M, Rafnar T, Serrano J, Stefánsson K, Stolz A, Daly AK, Aithal GP, Watkins PB; Drug-Induced Liver Injury Network (DILIN) investigators; International DILI consortium (iDILIC).

Gastroenterology. 2019 May;156(6):1707-1716.e2. doi: 10.1053/j.gastro.2019.01.034. Epub 2019 Jan 18.


Low Serum Hepcidin Is Associated With Reduced Short-Term Survival in Adults With Acute Liver Failure.

Spivak I, Arora J, Meinzer C, Durkalski-Mauldin V, Lee WM, Trautwein C, Fontana RJ, Strnad P; Acute Liver Failure Study Group (ALFSG).

Hepatology. 2019 May;69(5):2136-2149. doi: 10.1002/hep.30486. Epub 2019 Mar 15.


Correction to: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.

Rajajee V, Williamson CA, Fontana RJ, Courey AJ, Patil PG.

Neurocrit Care. 2018 Dec;29(3):530. doi: 10.1007/s12028-018-0634-5.


Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Bonkovsky HL, Barnhart HX, Foureau DM, Steuerwald N, Lee WM, Gu J, Fontana RJ, Hayashi PJ, Chalasani N, Navarro VM, Odin J, Stolz A, Watkins PB, Serrano J; US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group.

PLoS One. 2018 Oct 25;13(10):e0206389. doi: 10.1371/journal.pone.0206389. eCollection 2018. Erratum in: PLoS One. 2019 Feb 11;14(2):e0212394.


Liver Injury Associated with Sporting Activities.

Hassan A, Fontana RJ.

Semin Liver Dis. 2018 Nov;38(4):357-365. doi: 10.1055/s-0038-1670656. Epub 2018 Oct 24.


The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.

Fontana RJ, Cirulli ET, Gu J, Kleiner D, Ostrov D, Phillips E, Schutte R, Barnhart H, Chalasani N, Watkins PB, Hoofnagle JH.

J Hepatol. 2018 Dec;69(6):1317-1325. doi: 10.1016/j.jhep.2018.08.004. Epub 2018 Aug 21.


The diagnosis and management of idiosyncratic drug-induced liver injury.

Hassan A, Fontana RJ.

Liver Int. 2019 Jan;39(1):31-41. doi: 10.1111/liv.13931. Epub 2018 Aug 19.


Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury.

Ahmad J, Rossi S, Rodgers SK, Ghabril M, Fontana RJ, Stolz A, Hayashi PH, Barnhart H, Kleiner DE, Bjornsson ES.

Clin Gastroenterol Hepatol. 2019 Mar;17(4):789-790. doi: 10.1016/j.cgh.2018.06.035. Epub 2018 Jun 30.


Noninvasive Intracranial Pressure Assessment in Acute Liver Failure.

Rajajee V, Williamson CA, Fontana RJ, Courey AJ, Patil PG.

Neurocrit Care. 2018 Oct;29(2):280-290. doi: 10.1007/s12028-018-0540-x. Erratum in: Neurocrit Care. 2018 Dec;29(3):530.


Misconceptions, preferences and barriers to alcohol use disorder treatment in alcohol-related cirrhosis.

Mellinger JL, Scott Winder G, DeJonckheere M, Fontana RJ, Volk ML, Lok ASF, Blow FC.

J Subst Abuse Treat. 2018 Aug;91:20-27. doi: 10.1016/j.jsat.2018.05.003. Epub 2018 May 18.


The high burden of alcoholic cirrhosis in privately insured persons in the United States.

Mellinger JL, Shedden K, Winder GS, Tapper E, Adams M, Fontana RJ, Volk ML, Blow FC, Lok ASF.

Hepatology. 2018 Sep;68(3):872-882. doi: 10.1002/hep.29887. Epub 2018 May 20.


Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.

Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P, Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM, Andrade RJ, van Bömmel F, Poynard T, Watkins PB.

Hepatology. 2019 Feb;69(2):760-773. doi: 10.1002/hep.29802. Epub 2018 Jun 27.


Bleeding complications in acute liver failure.

Stravitz RT, Ellerbe C, Durkalski V, Schilsky M, Fontana RJ, Peterseim C, Lee WM; Acute Liver Failure Study Group.

Hepatology. 2018 May;67(5):1931-1942. doi: 10.1002/hep.29694. Epub 2018 Mar 26.


Comment on: MARS System Effectively Replaces Hepatic Function in Severe Acute Liver Failure.

Karvellas CJ, Stravitz RT, Fontana RJ, Ganger D, Lee WM; US Acute Liver Failure Study Group.

Ann Surg. 2018 Dec;268(6):e63-e64. doi: 10.1097/SLA.0000000000002609. No abstract available.


Identification and Characterization of Fenofibrate-Induced Liver Injury.

Ahmad J, Odin JA, Hayashi PH, Chalasani N, Fontana RJ, Barnhart H, Cirulli ET, Kleiner DE, Hoofnagle JH.

Dig Dis Sci. 2017 Dec;62(12):3596-3604. doi: 10.1007/s10620-017-4812-7. Epub 2017 Nov 8.


Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia.

Stravitz RT, Gottfried M, Durkalski V, Fontana RJ, Hanje AJ, Koch D, Hameed B, Ganger D, Subramanian RM, Bukofzer S, Ravis WR, Clasen K, Sherker A, Little L, Lee WM; Acute Liver Failure Study Group.

Hepatology. 2018 Mar;67(3):1003-1013. doi: 10.1002/hep.29621. Epub 2018 Jan 30.


The higher prevalence of truncal obesity and diabetes in American than Chinese patients with chronic hepatitis C might contribute to more rapid progression to advanced liver disease.

Rao H, Wu E, Fu S, Yang M, Feng B, Lin A, Fei R, Fontana RJ, Lok AS, Wei L.

Aliment Pharmacol Ther. 2017 Oct;46(8):731-740. doi: 10.1111/apt.14273. Epub 2017 Aug 22.


Rapidly progressive atherosclerosis after domino liver transplantation from a teenage donor with homozygous familial hypercholesterolemia.

Golbus JR, Farhat L, Fontana RJ, Rubenfire M.

J Clin Lipidol. 2017 Sep - Oct;11(5):1284-1288. doi: 10.1016/j.jacl.2017.07.006. Epub 2017 Jul 22.


Celecoxib-induced Liver Injury: Analysis of Published Case Reports and Cases Reported to the Food and Drug Administration.

Mukthinuthalapati PK, Fontana RJ, Vuppalanchi R, Chalasani N, Ghabril M.

J Clin Gastroenterol. 2018 Feb;52(2):114-122. doi: 10.1097/MCG.0000000000000888. Review.


Idiosyncratic Drug Induced Liver Injury in African-Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians.

Chalasani N, Reddy KRK, Fontana RJ, Barnhart H, Gu J, Hayashi PH, Ahmad J, Stolz A, Navarro V, Hoofnagle JH.

Am J Gastroenterol. 2017 Sep;112(9):1382-1388. doi: 10.1038/ajg.2017.215. Epub 2017 Aug 1.


Protocol based invasive intracranial pressure monitoring in acute liver failure: feasibility, safety and impact on management.

Rajajee V, Fontana RJ, Courey AJ, Patil PG.

Crit Care. 2017 Jul 11;21(1):178. doi: 10.1186/s13054-017-1762-6.


Temporal Changes in the Modes of Hepatitis C Virus Transmission in the USA and Northern China.

Wu E, Yang M, Rao H, Fu S, Feng B, Fei R, Lin A, Fontana RJ, Wei L, Lok AS.

Dig Dis Sci. 2017 Aug;62(8):2141-2149. doi: 10.1007/s10620-017-4619-6. Epub 2017 Jun 1.


Death and liver transplantation within 2 years of onset of drug-induced liver injury.

Hayashi PH, Rockey DC, Fontana RJ, Tillmann HL, Kaplowitz N, Barnhart HX, Gu J, Chalasani NP, Reddy KR, Sherker AH, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN) Investigators.

Hepatology. 2017 Oct;66(4):1275-1285. doi: 10.1002/hep.29283. Epub 2017 Aug 26.


Good for the lung but bad for the liver? Garlic-induced hepatotoxicity following liver transplantation.

Shaikh SA, Tischer S, Choi EK, Fontana RJ.

J Clin Pharm Ther. 2017 Oct;42(5):646-648. doi: 10.1111/jcpt.12558. Epub 2017 May 25.


The Natural History of Severe Acute Liver Injury.

Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky ML, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A.

Am J Gastroenterol. 2017 Sep;112(9):1389-1396. doi: 10.1038/ajg.2017.98. Epub 2017 Apr 25.


Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗35:02 as a risk factor.

Urban TJ, Nicoletti P, Chalasani N, Serrano J, Stolz A, Daly AK, Aithal GP, Dillon J, Navarro V, Odin J, Barnhart H, Ostrov D, Long N, Cirulli ET, Watkins PB, Fontana RJ; Drug-Induced Liver Injury Network (DILIN); Pharmacogenetics of Drug-Induced Liver Injury group (DILIGEN); International Serious Adverse Events Consortium (iSAEC).

J Hepatol. 2017 Jul;67(1):137-144. doi: 10.1016/j.jhep.2017.03.010. Epub 2017 Mar 18.


Vedolizumab is safe and effective in moderate-to-severe inflammatory bowel disease following liver transplantation.

Wright AP, Fontana RJ, Stidham RW.

Liver Transpl. 2017 Jul;23(7):968-971. doi: 10.1002/lt.24757. No abstract available.


Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury.

Suzuki A, Barnhart H, Gu J, Bonkovsky HL, Tillmann HL, Fontana RJ, Kleiner DE; Drug-induced Liver Injury Network (DILIN).

Liver Int. 2017 Nov;37(11):1723-1730. doi: 10.1111/liv.13380. Epub 2017 Mar 2.


Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group.

Davis BC, Tillman H, Chung RT, Stravitz RT, Reddy R, Fontana RJ, McGuire B, Davern T, Lee WM; Acute Liver Failure Study Group.

Liver Int. 2017 Apr;37(4):509-513. doi: 10.1111/liv.13373. Epub 2017 Feb 17.


Introducing the AASLD president: Anna S.F. Lok.

Su GL, Fontana RJ.

Hepatology. 2017 Apr;65(4):1084-1087. doi: 10.1002/hep.29073. Epub 2017 Mar 3. No abstract available.

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