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Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon.

Perin L, Fonseca KDS, de Carvalho TV, Carvalho LM, Madeira JV, Medeiros LDF, Molina I, Correa-Oliveira R, Carneiro CM, Vieira PMA.

Exp Parasitol. 2020 Jan 21;210:107834. doi: 10.1016/j.exppara.2020.107834. [Epub ahead of print]


D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects.

Young D, Popiolek M, Trapa P, Fonseca KR, Brevard J, Gray DL, Kozak R.

ACS Chem Neurosci. 2020 Feb 6. doi: 10.1021/acschemneuro.9b00589. [Epub ahead of print]


Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats.

Nascimento LDES, Nicolau RA, Maia Filho ALM, Santos JZLV, Fonseca KM, Ferreira DCL, Sousa RC, Viana VGF, Carvalho LFM, Figueredo-Silva J.

Acta Cir Bras. 2020 Jan 13;34(11):e201901101. doi: 10.1590/s0102-865020190110000001. eCollection 2020.


Defining the TLT-1 interactome from resting and activated human platelets.

Schmoker AM, Perez Pearson LM, Cruz C, Colon Flores LG, Branfeild S, Pagán Torres FD, Fonseca K, Cantres YM, Salgado Ramirez CA, Melendez LM, Ballif BA, Washington AV.

J Proteomics. 2020 Jan 8;215:103638. doi: 10.1016/j.jprot.2020.103638. [Epub ahead of print]


Benznidazole, itraconazole and their combination in the treatment of acute experimental Chagas disease in dogs.

Cunha ELA, Torchelsen FKVDS, Cunha LM, Oliveira MT, Reis LES, Fonseca KDS, Vieira PMA, Carneiro CM, Lana M.

MethodsX. 2019 Oct 21;6:2544-2552. doi: 10.1016/j.mex.2019.10.007. eCollection 2019.


Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum.

Cá B, Fonseca KL, Sousa J, Maceiras AR, Machado D, Sanca L, Rabna P, Rodrigues PNS, Viveiros M, Saraiva M.

Front Microbiol. 2019 Sep 10;10:2102. doi: 10.3389/fmicb.2019.02102. eCollection 2019.


Association of preharvest management with oxidative protection and enzymatic browning in minimally processed cassava.

Coelho DG, Fonseca KS, de Mélo Neto DF, de Andrade MT, Coelho Junior LF, Ferreira-Silva SL, Simões ADN.

J Food Biochem. 2019 May;43(5):e12840. doi: 10.1111/jfbc.12840. Epub 2019 Mar 18.


Benznidazole, itraconazole and their combination in the treatment of acute experimental chagas disease in dogs.

Cunha ELA, Torchelsen FKVDS, Cunha LM, de Oliveira MT, Fonseca KDS, Vieira PMA, Carneiro CM, de Lana M.

Exp Parasitol. 2019 Sep;204:107711. doi: 10.1016/j.exppara.2019.05.005. Epub 2019 Jun 27.


[Post-traumatic growth impairment following pediatric distal radius fractures resulting in an ulnar variance : A case report].

Wolf M, Da Fonseca K.

Orthopade. 2019 Jun;48(6):531-535. doi: 10.1007/s00132-019-03741-6. Review. German.


Case Report: Bartonella quintana Endocarditis Outside of the Europe-African Gradient: Comprehensive Review of Cases within North America.

Lam JC, Fonseca K, Pabbaraju K, Meatherall BL.

Am J Trop Med Hyg. 2019 May;100(5):1125-1129. doi: 10.4269/ajtmh.18-0929. Review.


Simultaneous Detection and Differentiation between Wild-Type and Vaccine Measles Viruses by a Multiplex Real-Time Reverse Transcription-PCR Assay.

Pabbaraju K, Gill K, Wong AA, Tipples GA, Hiebert J, Severini A, Fonseca K, Tellier R.

J Clin Microbiol. 2019 Mar 28;57(4). pii: e01828-18. doi: 10.1128/JCM.01828-18. Print 2019 Apr.


Dysregulation of insulin levels in Chagas heart disease is associated with altered adipocytokine levels.

Dabarian AL, Mady C, Barbosa-Ferreira JM, Ianni BM, Hotta VT, Ramires FJA, Lopes HF, Buck PC, Pessoa FG, Fonseca KCB, Nogueira AR, Fernandes F.

Can J Physiol Pharmacol. 2019 Feb;97(2):140-145. doi: 10.1139/cjpp-2018-0349. Epub 2018 Dec 17.


Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

deBruyn JCC, Soon IS, Fonseca K, Feng S, Purtzki M, Goedhart C, Kuhn S, Vanderkooi OG, Wrobel I.

Inflamm Bowel Dis. 2019 Jun 18;25(7):1218-1226. doi: 10.1093/ibd/izy366.


Design, synthesis, molecular modelling, and in vitro evaluation of tricyclic coumarins against Trypanosoma cruzi.

Coelho GS, Andrade JS, Xavier VF, Sales Junior PA, Rodrigues de Araujo BC, Fonseca KDS, Caetano MS, Murta SMF, Vieira PM, Carneiro CM, Taylor JG.

Chem Biol Drug Des. 2019 Mar;93(3):337-350. doi: 10.1111/cbdd.13420. Epub 2018 Nov 27.


Vaccine Effectiveness Against Lineage-matched and -mismatched Influenza B Viruses Across 8 Seasons in Canada, 2010-2011 to 2017-2018.

Skowronski DM, Chambers C, De Serres G, Sabaiduc S, Winter AL, Dickinson JA, Gubbay JB, Drews SJ, Fonseca K, Charest H, Martineau C, Hickman R, Chan T, Jassem A, Petric M, Rose C, Bastien N, Li Y, Krajden M.

Clin Infect Dis. 2019 May 2;68(10):1754-1757. doi: 10.1093/cid/ciy876.


Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada.

Pabbaraju K, Fonseca K, Wong S, Koch MW, Joseph JT, Tipples GA, Tellier R.

J Neurovirol. 2018 Dec;24(6):720-729. doi: 10.1007/s13365-018-0668-7. Epub 2018 Oct 5.


Should Sex Be Considered an Effect Modifier in the Evaluation of Influenza Vaccine Effectiveness?

Chambers C, Skowronski DM, Rose C, Serres G, Winter AL, Dickinson JA, Jassem A, Gubbay JB, Fonseca K, Drews SJ, Charest H, Martineau C, Petric M, Krajden M.

Open Forum Infect Dis. 2018 Sep 4;5(9):ofy211. doi: 10.1093/ofid/ofy211. eCollection 2018 Sep.


Vaccine-associated measles in a healthy 40-year-old woman.

Churchill L, Rizzuti FA, Fonseca K, Kim J.

CMAJ. 2018 Sep 4;190(35):E1046-E1048. doi: 10.1503/cmaj.180527. No abstract available.


Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition.

Chang C, Fonseca KR, Li C, Horner W, Zawadzke LE, Salafia MA, Welch KA, Strick CA, Campbell BM, Gernhardt SS, Rong H, Sawant-Basak A, Liras J, Dounay A, Tuttle JB, Verhoest P, Maurer TS.

Mol Pharmacol. 2018 Aug;94(2):823-833. doi: 10.1124/mol.118.111625. Epub 2018 May 31.


Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

McAllister LA, Butler CR, Mente S, O'Neil SV, Fonseca KR, Piro JR, Cianfrogna JA, Foley TL, Gilbert AM, Harris AR, Helal CJ, Johnson DS, Montgomery JI, Nason DM, Noell S, Pandit J, Rogers BN, Samad TA, Shaffer CL, da Silva RG, Uccello DP, Webb D, Brodney MA.

J Med Chem. 2018 Apr 12;61(7):3008-3026. doi: 10.1021/acs.jmedchem.8b00070. Epub 2018 Mar 15.


The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia.

Deressa T, Damtie D, Fonseca K, Gao S, Abate E, Alemu S, Aleka Y, Swain MG, van Marle G, Coffin CS.

PLoS One. 2017 Dec 27;12(12):e0190149. doi: 10.1371/journal.pone.0190149. eCollection 2017.


Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.

Butler CR, Beck EM, Harris A, Huang Z, McAllister LA, Am Ende CW, Fennell K, Foley TL, Fonseca K, Hawrylik SJ, Johnson DS, Knafels JD, Mente S, Noell GS, Pandit J, Phillips TB, Piro JR, Rogers BN, Samad TA, Wang J, Wan S, Brodney MA.

J Med Chem. 2017 Dec 14;60(23):9860-9873. doi: 10.1021/acs.jmedchem.7b01531. Epub 2017 Dec 5.


Erythropoietin reduces collagen deposition after myocardial infarction but does not improve cardiac function.

Pessoa FG, Mady C, Fonseca KCB, de Oliveira-Fonoff AM, Salemi VMC, Jordão MR, Fernandes F, Ramires FJA.

Can J Physiol Pharmacol. 2018 Jun;96(6):541-549. doi: 10.1139/cjpp-2017-0169. Epub 2017 Nov 9.


Age-Related Differences in Influenza B Infection by Lineage in a Community-Based Sentinel System, 2010-2011 to 2015-2016, Canada.

Skowronski DM, Chambers C, De Serres G, Sabaiduc S, Winter AL, Dickinson JA, Gubbay JB, Fonseca K, Drews SJ, Charest H, Martineau C, Krajden M, Petric M, Bastien N, Li Y.

J Infect Dis. 2017 Sep 15;216(6):697-702. doi: 10.1093/infdis/jix393.


Image-Guided Injection of Bone Allograft and Autologous Bone Marrow for the Treatment of Aneurysmal Bone Cyst of the Jaw.

Costa de Freitas RM, Fonseca KC, Procópio RJ, Cardoso Lehman LF.

J Vasc Interv Radiol. 2017 Sep;28(9):1299-1302.e2. doi: 10.1016/j.jvir.2017.03.030. No abstract available.


Experimental study of tuberculosis: From animal models to complex cell systems and organoids.

Fonseca KL, Rodrigues PNS, Olsson IAS, Saraiva M.

PLoS Pathog. 2017 Aug 17;13(8):e1006421. doi: 10.1371/journal.ppat.1006421. eCollection 2017 Aug. Review.


The role of air pollution in myocardial remodeling.

de Oliveira-Fonoff AM, Mady C, Pessoa FG, Fonseca KCB, Salemi VMC, Fernandes F, Saldiva PHN, Ramires FJA.

PLoS One. 2017 Apr 20;12(4):e0176084. doi: 10.1371/journal.pone.0176084. eCollection 2017.


Transmission of hepatitis D virus between spouses: A longitudinal study of the first reported Canadian case.

Osiowy C, Andonov A, Fonseca K, Swidinsky K, Giles E, Mason A, Coffin CS.

IDCases. 2017 Mar 6;8:37-41. doi: 10.1016/j.idcr.2017.03.001. eCollection 2017.


Control of browning of minimally processed mangoes subjected to ultraviolet radiation pulses.

de Sousa AED, Fonseca KS, da Silva Gomes WK, Monteiro da Silva AP, de Oliveira Silva E, Puschmann R.

J Food Sci Technol. 2017 Jan;54(1):253-259. doi: 10.1007/s13197-016-2457-8. Epub 2016 Dec 23.


Predictors of influenza a molecular viral shedding in Hutterite communities.

Wang B, Russell ML, Fonseca K, Earn DJD, Horsman G, Van Caeseele P, Chokani K, Vooght M, Babiuk L, Walter SD, Loeb M.

Influenza Other Respir Viruses. 2017 May;11(3):254-262. doi: 10.1111/irv.12448. Epub 2017 Mar 16.


Serial Vaccination and the Antigenic Distance Hypothesis: Effects on Influenza Vaccine Effectiveness During A(H3N2) Epidemics in Canada, 2010-2011 to 2014-2015.

Skowronski DM, Chambers C, De Serres G, Sabaiduc S, Winter AL, Dickinson JA, Gubbay JB, Fonseca K, Drews SJ, Charest H, Martineau C, Krajden M, Petric M, Bastien N, Li Y, Smith DJ.

J Infect Dis. 2017 Apr 1;215(7):1059-1099. doi: 10.1093/infdis/jix074.


Pharmacokinetics and Tissue Distribution of Benznidazole after Oral Administration in Mice.

Perin L, Moreira da Silva R, Fonseca KD, Cardoso JM, Mathias FA, Reis LE, Molina I, Correa-Oliveira R, Vieira PM, Carneiro CM.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02410-16. doi: 10.1128/AAC.02410-16. Print 2017 Apr.


Fatal Infection with Murray Valley Encephalitis Virus Imported from Australia to Canada, 2011.

Niven DJ, Afra K, Iftinca M, Tellier R, Fonseca K, Kramer A, Safronetz D, Holloway K, Drebot M, Johnson AS.

Emerg Infect Dis. 2017 Feb;23(2):280-283. doi: 10.3201/eid2302.161161.


Effect of Influenza Vaccination of Children on Infection Rate in Hutterite Communities: Follow-Up Study of a Randomized Trial.

Wang B, Russell ML, Moss L, Fonseca K, Earn DJ, Aoki F, Horsman G, Caeseele PV, Chokani K, Vooght M, Babiuk L, Webby R, Walter SD, Loeb M.

PLoS One. 2016 Dec 15;11(12):e0167281. doi: 10.1371/journal.pone.0167281. eCollection 2016.


Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial.

Loeb M, Russell ML, Manning V, Fonseca K, Earn DJ, Horsman G, Chokani K, Vooght M, Babiuk L, Schwartz L, Neupane B, Singh P, Walter SD, Pullenayegum E.

Ann Intern Med. 2016 Nov 1;165(9):617-624. doi: 10.7326/M16-0513. Epub 2016 Aug 16.


Simultaneous detection of Zika, Chikungunya and Dengue viruses by a multiplex real-time RT-PCR assay.

Pabbaraju K, Wong S, Gill K, Fonseca K, Tipples GA, Tellier R.

J Clin Virol. 2016 Oct;83:66-71. doi: 10.1016/j.jcv.2016.09.001. Epub 2016 Sep 1.


Interaction between TNF and BmooMP-Alpha-I, a Zinc Metalloprotease Derived from Bothrops moojeni Snake Venom, Promotes Direct Proteolysis of This Cytokine: Molecular Modeling and Docking at a Glance.

Silva MC, Lopes Silva T, Silva MV, Mota CM, Santiago FM, Fonseca KC, Oliveira F, Mineo TW, Mineo JR.

Toxins (Basel). 2016 Jul 20;8(7). pii: E223. doi: 10.3390/toxins8070223.


Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network.

Sciabola S, Goetz GH, Bai G, Rogers BN, Gray DL, Duplantier A, Fonseca KR, Vanase-Frawley MA, Kablaoui NM.

Bioorg Med Chem. 2016 Aug 15;24(16):3513-20. doi: 10.1016/j.bmc.2016.05.062. Epub 2016 May 31.


Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing.

Modi ME, Majchrzak MJ, Fonseca KR, Doran A, Osgood S, Vanase-Frawley M, Feyfant E, McInnes H, Darvari R, Buhl DL, Kablaoui NM.

J Pharmacol Exp Ther. 2016 Aug;358(2):164-72. doi: 10.1124/jpet.116.232702. Epub 2016 May 23.


Subacute sclerosing panencephalitis in pregnancy.

Chiu MH, Meatherall B, Nikolic A, Cannon K, Fonseca K, Joseph JT, MacDonald J, Pabbaraju K, Tellier R, Wong S, Koch MW.

Lancet Infect Dis. 2016 Mar;16(3):366-75. doi: 10.1016/S1473-3099(15)00524-1. Epub 2016 Jan 20. Review.


Systematic community- and hospital-based surveillance for enterovirus-D68 in three Canadian provinces, August to December 2014.

Skowronski DM, Chambers C, Sabaiduc S, Murti M, Gustafson R, Pollock S, Hoyano D, Rempel S, Allison S, De Serres G, Dickinson JA, Tellier R, Fonseca K, Drews SJ, Martineau C, Reyes-Domingo F, Wong T, Tang P, Krajden M.

Euro Surveill. 2015;20(43). doi: 10.2807/1560-7917.ES.2015.20.43.30047.


Immunogenicity of Influenza Vaccine for Patients with Inflammatory Bowel Disease on Maintenance Infliximab Therapy: A Randomized Trial.

deBruyn J, Fonseca K, Ghosh S, Panaccione R, Gasia MF, Ueno A, Kaplan GG, Seow CH, Wrobel I.

Inflamm Bowel Dis. 2016 Mar;22(3):638-47. doi: 10.1097/MIB.0000000000000615.


Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.

Silva AP, Macêdo AA, Costa LF, Rocha CE, Garcia LN, Farias JR, Gomes PP, Teixeira GC, Fonseca KW, Maia AR, Neves GG, Romão EL, Silva TM, Mol JP, Oliveira RM, Araújo MS, Nascimento EF, Martins-Filho OA, Brandão HM, Paixão TA, Santos RL.

PLoS One. 2015 Aug 28;10(8):e0136865. doi: 10.1371/journal.pone.0136865. eCollection 2015.


Acceptability and yield of birth-cohort screening for hepatitis C virus in a Canadian population being screened for colorectal cancer: a cross-sectional study.

Myers RP, Crotty P, Town S, English J, Fonseca K, Tellier R, Swain MG, McGregor SE, Heitman SJ, Hilsden RJ.

CMAJ Open. 2015 Jan 13;3(1):E62-7. doi: 10.9778/cmajo.20140024. eCollection 2015 Jan-Mar.


Canadian Public Health Laboratory Network laboratory guidelines for the use of serological tests (excluding point-of-care tests) for the diagnosis of syphilis in Canada.

Levett PN, Fonseca K, Tsang RS, Kadkhoda K, Serhir B, Radons SM, Morshed M.

Can J Infect Dis Med Microbiol. 2015 Jan-Feb;26 Suppl A:6A-12A.


Canadian Public Health Laboratory Network national syphilis laboratory testing recommendations: INTRODUCTION.

Members of the Canadian Public Health Laboratory Network Syphilis Laboratory Task Group during authorship (co-chairs and membership in alphabetical order), Tsang RS, Morshed M, Allen V, Chernesky MA, Fonseca K, Garceau R, Jayaraman GC, Kadkhoda K, Lee BE, Levett PN, Radons SM, Serhir B, Singh AE, Wong T.

Can J Infect Dis Med Microbiol. 2015 Jan-Feb;26 Suppl A:4A-5A. No abstract available.


Canadian Public Health Laboratory Network laboratory guidelines for congenital syphilis and syphilis screening in pregnant women in Canada.

Singh AE, Levett PN, Fonseca K, Jayaraman GC, Lee BE.

Can J Infect Dis Med Microbiol. 2015 Jan-Feb;26 Suppl A:23A-8A.


Canadian Public Health Laboratory Network laboratory guidelines for the diagnosis of neurosyphilis in Canada.

Wong T, Fonseca K, Chernesky MA, Garceau R, Levett PN, Serhir B.

Can J Infect Dis Med Microbiol. 2015 Jan-Feb;26 Suppl A:18A-22A.


Integrated Sentinel Surveillance Linking Genetic, Antigenic, and Epidemiologic Monitoring of Influenza Vaccine-Virus Relatedness and Effectiveness During the 2013-2014 Influenza Season.

Skowronski DM, Chambers C, Sabaiduc S, De Serres G, Winter AL, Dickinson JA, Gubbay J, Fonseca K, Charest H, Krajden M, Petric M, Mahmud SM, Van Caeseele P, Bastien N, Eshaghi A, Li Y.

J Infect Dis. 2015 Sep 1;212(5):726-39. doi: 10.1093/infdis/jiv177. Epub 2015 Mar 17.


Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada's Sentinel Physician Surveillance Network, January 2015.

Skowronski DM, Chambers C, Sabaiduc S, De Serres G, Dickinson JA, Winter AL, Drews SJ, Fonseca K, Charest H, Gubbay JB, Petric M, Krajden M, Kwindt TL, Martineau C, Eshaghi A, Bastien N, Li Y.

Euro Surveill. 2015 Jan 29;20(4). pii: 21022. No abstract available.

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