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Items: 8


Switchable Cas9.

Richter F, Fonfara I, Gelfert R, Nack J, Charpentier E, Möglich A.

Curr Opin Biotechnol. 2017 Dec;48:119-126. doi: 10.1016/j.copbio.2017.03.025. Epub 2017 Apr 26. Review.


Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase.

Eggenschwiler R, Moslem M, Fráguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wähner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T.

Sci Rep. 2016 Dec 2;6:38198. doi: 10.1038/srep38198.


Engineering of temperature- and light-switchable Cas9 variants.

Richter F, Fonfara I, Bouazza B, Schumacher CH, Bratovič M, Charpentier E, Möglich A.

Nucleic Acids Res. 2016 Nov 16;44(20):10003-10014. Epub 2016 Oct 15.


The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.

Fonfara I, Richter H, Bratovič M, Le Rhun A, Charpentier E.

Nature. 2016 Apr 28;532(7600):517-21. doi: 10.1038/nature17945. Epub 2016 Apr 20.


Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems.

Fonfara I, Le Rhun A, Chylinski K, Makarova KS, Lécrivain AL, Bzdrenga J, Koonin EV, Charpentier E.

Nucleic Acids Res. 2014 Feb;42(4):2577-90. doi: 10.1093/nar/gkt1074. Epub 2013 Nov 22.


A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E.

Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28.


Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases.

Fonfara I, Curth U, Pingoud A, Wende W.

Nucleic Acids Res. 2012 Jan;40(2):847-60. doi: 10.1093/nar/gkr788. Epub 2011 Sep 29.


Identification of conserved features of LAGLIDADG homing endonucleases.

Grishin A, Fonfara I, Alexeevski A, Spirin S, Zanegina O, Karyagina A, Alexeyevsky D, Wende W.

J Bioinform Comput Biol. 2010 Jun;8(3):453-69.


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