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Items: 32


Immunomimetic Designer Cells Protect Mice from MRSA Infection.

Liu Y, Bai P, Woischnig AK, Charpin-El Hamri G, Ye H, Folcher M, Xie M, Khanna N, Fussenegger M.

Cell. 2018 Jul 12;174(2):259-270.e11. doi: 10.1016/j.cell.2018.05.039. Epub 2018 Jun 21.


Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer.

Tastanova A, Folcher M, Müller M, Camenisch G, Ponti A, Horn T, Tikhomirova MS, Fussenegger M.

Sci Transl Med. 2018 Apr 18;10(437). pii: eaap8562. doi: 10.1126/scitranslmed.aap8562.


Correction to: Synthetic Biology and the Translational Imperative.

Heidari Feidt R, Ienca M, Elger BS, Folcher M.

Sci Eng Ethics. 2018 Jan 24. doi: 10.1007/s11948-018-0019-3. [Epub ahead of print]


Synthetic Biology and the Translational Imperative.

Heidari Feidt R, Ienca M, Elger BS, Folcher M.

Sci Eng Ethics. 2017 Dec 18. doi: 10.1007/s11948-017-0011-3. [Epub ahead of print] Review. Erratum in: Sci Eng Ethics. 2018 Jan 24;:.


Designed cell consortia as fragrance-programmable analog-to-digital converters.

Müller M, Ausländer S, Spinnler A, Ausländer D, Sikorski J, Folcher M, Fussenegger M.

Nat Chem Biol. 2017 Mar;13(3):309-316. doi: 10.1038/nchembio.2281. Epub 2017 Jan 16.


A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells.

Saxena P, Heng BC, Bai P, Folcher M, Zulewski H, Fussenegger M.

Nat Commun. 2016 Apr 11;7:11247. doi: 10.1038/ncomms11247.


Synthetic gene network restoring endogenous pituitary-thyroid feedback control in experimental Graves' disease.

Saxena P, Charpin-El Hamri G, Folcher M, Zulewski H, Fussenegger M.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1244-9. doi: 10.1073/pnas.1514383113. Epub 2016 Jan 19.


Overexpression of YY1 increases the protein production in mammalian cells.

Tastanova A, Schulz A, Folcher M, Tolstrup A, Puklowski A, Kaufmann H, Fussenegger M.

J Biotechnol. 2016 Feb 10;219:72-85. doi: 10.1016/j.jbiotec.2015.12.005. Epub 2015 Dec 10.


A synthetic cGMP-sensitive gene switch providing Viagra(®)-controlled gene expression in mammalian cells and mice.

Kim T, Folcher M, Charpin-El Hamri G, Fussenegger M.

Metab Eng. 2015 May;29:169-179. doi: 10.1016/j.ymben.2015.03.016. Epub 2015 Apr 2.


A synthetic erectile optogenetic stimulator enabling blue-light-inducible penile erection.

Kim T, Folcher M, Doaud-El Baba M, Fussenegger M.

Angew Chem Int Ed Engl. 2015 May 11;54(20):5933-8. doi: 10.1002/anie.201412204. Epub 2015 Mar 18.


Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant.

Folcher M, Oesterle S, Zwicky K, Thekkottil T, Heymoz J, Hohmann M, Christen M, Daoud El-Baba M, Buchmann P, Fussenegger M.

Nat Commun. 2014 Nov 11;5:5392. doi: 10.1038/ncomms6392.


WhiB7, an Fe-S-dependent transcription factor that activates species-specific repertoires of drug resistance determinants in actinobacteria.

Ramón-García S, Ng C, Jensen PR, Dosanjh M, Burian J, Morris RP, Folcher M, Eltis LD, Grzesiek S, Nguyen L, Thompson CJ.

J Biol Chem. 2013 Nov 29;288(48):34514-28. doi: 10.1074/jbc.M113.516385. Epub 2013 Oct 14.


Synthetic mammalian trigger-controlled bipartite transcription factors.

Folcher M, Xie M, Spinnler A, Fussenegger M.

Nucleic Acids Res. 2013 Jul;41(13):e134. doi: 10.1093/nar/gkt405. Epub 2013 May 17.


Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome.

Ye H, Charpin-El Hamri G, Zwicky K, Christen M, Folcher M, Fussenegger M.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):141-6. doi: 10.1073/pnas.1216801110. Epub 2012 Dec 17.


Synthetic biology advancing clinical applications.

Folcher M, Fussenegger M.

Curr Opin Chem Biol. 2012 Aug;16(3-4):345-54. doi: 10.1016/j.cbpa.2012.06.008. Epub 2012 Jul 21. Review.


Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila.

Levi A, Folcher M, Jenal U, Shuman HA.

MBio. 2011 Jan 11;2(1):e00316-10. doi: 10.1128/mBio.00316-10.


Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression.

Duerig A, Abel S, Folcher M, Nicollier M, Schwede T, Amiot N, Giese B, Jenal U.

Genes Dev. 2009 Jan 1;23(1):93-104. doi: 10.1101/gad.502409.


Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.

Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U.

Cell. 2008 May 2;133(3):452-61. doi: 10.1016/j.cell.2008.02.045. Erratum in: Cell. 2008 May 30;133(5):928.


DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus.

Christen M, Christen B, Allan MG, Folcher M, Jenö P, Grzesiek S, Jenal U.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4112-7. Epub 2007 Feb 27. Erratum in: Proc Natl Acad Sci U S A. 2007 May 1;104(18):7729.


Allosteric control of cyclic di-GMP signaling.

Christen B, Christen M, Paul R, Schmid F, Folcher M, Jenoe P, Meuwly M, Jenal U.

J Biol Chem. 2006 Oct 20;281(42):32015-24. Epub 2006 Aug 21.


Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP.

Christen M, Christen B, Folcher M, Schauerte A, Jenal U.

J Biol Chem. 2005 Sep 2;280(35):30829-37. Epub 2005 Jul 1.


Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice.

Weber W, Schoenmakers R, Spielmann M, El-Baba MD, Folcher M, Keller B, Weber CC, Link N, van de Wetering P, Heinzen C, Jolivet B, Séquin U, Aubel D, Thompson CJ, Fussenegger M.

Nucleic Acids Res. 2003 Jul 15;31(14):e71.


Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase.

Folcher M, Gaillard H, Nguyen LT, Nguyen KT, Lacroix P, Bamas-Jacques N, Rinkel M, Thompson CJ.

J Biol Chem. 2001 Nov 23;276(47):44297-306. Epub 2001 Sep 13.


Roles of aconitase in growth, metabolism, and morphological differentiation of Streptomyces coelicolor.

Viollier PH, Nguyen KT, Minas W, Folcher M, Dale GE, Thompson CJ.

J Bacteriol. 2001 May;183(10):3193-203.


Role of acid metabolism in Streptomyces coelicolor morphological differentiation and antibiotic biosynthesis.

Viollier PH, Minas W, Dale GE, Folcher M, Thompson CJ.

J Bacteriol. 2001 May;183(10):3184-92.


Design of a novel mammalian screening system for the detection of bioavailable, non-cytotoxic streptogramin antibiotics.

Aubel D, Morris R, Lennon B, Rimann M, Kaufmann H, Folcher M, Bailey JE, Thompson CJ, Fussenegger M.

J Antibiot (Tokyo). 2001 Jan;54(1):44-55.


A transcriptional regulator of a pristinamycin resistance gene in Streptomyces coelicolor.

Folcher M, Morris RP, Dale G, Salah-Bey-Hocini K, Viollier PH, Thompson CJ.

J Biol Chem. 2001 Jan 12;276(2):1479-85.


Developmental control of stress stimulons in Streptomyces coelicolor revealed by statistical analyses of global gene expression patterns.

Vohradsky J, Li XM, Dale G, Folcher M, Nguyen L, Viollier PH, Thompson CJ.

J Bacteriol. 2000 Sep;182(17):4979-86.


Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression.

Chiu ML, Folcher M, Katoh T, Puglia AM, Vohradsky J, Yun BS, Seto H, Thompson CJ.

J Biol Chem. 1999 Jul 16;274(29):20578-86.


Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividans.

Chiu ML, Folcher M, Griffin P, Holt T, Klatt T, Thompson CJ.

Biochemistry. 1996 Feb 20;35(7):2332-41.


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