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Editorial for the SEB florence special issue: functional organisation of the nuclear periphery.

Evans DE, Graumann K, Foisner R.

Nucleus. 2019 Dec;10(1):167-168. doi: 10.1080/19491034.2019.1643140. No abstract available.


The structural and gene expression hypotheses in laminopathic diseases-not so different after all.

Osmanagic-Myers S, Foisner R.

Mol Biol Cell. 2019 Jul 15;30(15):1786-1790. doi: 10.1091/mbc.E18-10-0672. Review.


Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse.

Osmanagic-Myers S, Kiss A, Manakanatas C, Hamza O, Sedlmayer F, Szabo PL, Fischer I, Fichtinger P, Podesser BK, Eriksson M, Foisner R.

J Clin Invest. 2019 Feb 1;129(2):531-545. doi: 10.1172/JCI121297. Epub 2018 Dec 18.


Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells.

Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R.

J Cell Sci. 2018 Feb 8;131(3). pii: jcs208462. doi: 10.1242/jcs.208462.


Editorial overview: The cell nucleus: New discoveries on nuclear structure, dynamics and function.

Foisner R, Straight AF.

Curr Opin Cell Biol. 2017 Jun;46:iv-vi. doi: 10.1016/ No abstract available.


Lamins in the nuclear interior - life outside the lamina.

Naetar N, Ferraioli S, Foisner R.

J Cell Sci. 2017 Jul 1;130(13):2087-2096. doi: 10.1242/jcs.203430. Review.


Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.

Thanisch K, Song C, Engelkamp D, Koch J, Wang A, Hallberg E, Foisner R, Leonhardt H, Stewart CL, Joffe B, Solovei I.

Differentiation. 2017 Mar - Apr;94:58-70. doi: 10.1016/j.diff.2016.12.002. Epub 2017 Jan 2.


Cdc48 and Ubx1 participate in a pathway associated with the inner nuclear membrane that governs Asi1 degradation.

Pantazopoulou M, Boban M, Foisner R, Ljungdahl PO.

J Cell Sci. 2016 Oct 15;129(20):3770-3780. Epub 2016 Aug 26.


The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.

Braun J, Meixner A, Brachner A, Foisner R.

PLoS One. 2016 Mar 24;11(3):e0152278. doi: 10.1371/journal.pone.0152278. eCollection 2016.


Molecular insights into the premature aging disease progeria.

Vidak S, Foisner R.

Histochem Cell Biol. 2016 Apr;145(4):401-17. doi: 10.1007/s00418-016-1411-1. Epub 2016 Feb 4. Review.


A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.

Gesson K, Rescheneder P, Skoruppa MP, von Haeseler A, Dechat T, Foisner R.

Genome Res. 2016 Apr;26(4):462-73. doi: 10.1101/gr.196220.115. Epub 2016 Jan 21.


Degradation-mediated protein quality control at the inner nuclear membrane.

Boban M, Foisner R.

Nucleus. 2016;7(1):41-9. doi: 10.1080/19491034.2016.1139273. Review.


Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes.

Loi M, Cenni V, Duchi S, Squarzoni S, Lopez-Otin C, Foisner R, Lattanzi G, Capanni C.

Oncotarget. 2016 Mar 29;7(13):15662-77. doi: 10.18632/oncotarget.6697.


Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins.

Vidak S, Kubben N, Dechat T, Foisner R.

Genes Dev. 2015 Oct 1;29(19):2022-36. doi: 10.1101/gad.263939.115.


Loss of lamin A function increases chromatin dynamics in the nuclear interior.

Bronshtein I, Kepten E, Kanter I, Berezin S, Lindner M, Redwood AB, Mai S, Gonzalo S, Foisner R, Shav-Tal Y, Garini Y.

Nat Commun. 2015 Aug 24;6:8044. doi: 10.1038/ncomms9044.


Editor's Corner.

Foisner R, Weiss A.

Nucleus. 2015;6(3):165. doi: 10.1080/19491034.2015.1060792. No abstract available.


Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.

Gruenbaum Y, Foisner R.

Annu Rev Biochem. 2015;84:131-64. doi: 10.1146/annurev-biochem-060614-034115. Epub 2015 Feb 26. Review.


Editor's corner.

Foisner R, Weiss A.

Nucleus. 2015;6(1):1. doi: 10.1080/19491034.2015.1007817. No abstract available.


Lamins at the crossroads of mechanosignaling.

Osmanagic-Myers S, Dechat T, Foisner R.

Genes Dev. 2015 Feb 1;29(3):225-37. doi: 10.1101/gad.255968.114. Review.


Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.

Boban M, Ljungdahl PO, Foisner R.

J Biol Chem. 2015 Jan 23;290(4):2489-95. doi: 10.1074/jbc.M114.600593. Epub 2014 Dec 9.


A nuclear ubiquitin-proteasome pathway targets the inner nuclear membrane protein Asi2 for degradation.

Boban M, Pantazopoulou M, Schick A, Ljungdahl PO, Foisner R.

J Cell Sci. 2014 Aug 15;127(Pt 16):3603-13. doi: 10.1242/jcs.153163. Epub 2014 Jun 13.


Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology.

Brachner A, Foisner R.

Adv Exp Med Biol. 2014;773:143-63. doi: 10.1007/978-1-4899-8032-8_7. Review.


Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease.

Gesson K, Vidak S, Foisner R.

Semin Cell Dev Biol. 2014 May;29:116-24. doi: 10.1016/j.semcdb.2013.12.009. Epub 2013 Dec 25. Review.


High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2α (LAP2α) interact and reciprocally affect their genome-wide chromatin organization.

Zhang S, Schones DE, Malicet C, Rochman M, Zhou M, Foisner R, Bustin M.

J Biol Chem. 2013 Jun 21;288(25):18104-9. doi: 10.1074/jbc.C113.469544. Epub 2013 May 14.


Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α.

Cohen TV, Gnocchi VF, Cohen JE, Phadke A, Liu H, Ellis JA, Foisner R, Stewart CL, Zammit PS, Partridge TA.

Hum Mol Genet. 2013 Jul 15;22(14):2852-69. doi: 10.1093/hmg/ddt135. Epub 2013 Mar 27.


The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice.

Pilat U, Dechat T, Bertrand AT, Woisetschläger N, Gotic I, Spilka R, Biadasiewicz K, Bonne G, Foisner R.

J Cell Sci. 2013 Apr 15;126(Pt 8):1753-62. doi: 10.1242/jcs.115246. Epub 2013 Feb 26.


LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.

Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H, Joffe B.

Cell. 2013 Jan 31;152(3):584-98. doi: 10.1016/j.cell.2013.01.009.


The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo.

Brachner A, Braun J, Ghodgaonkar M, Castor D, Zlopasa L, Ehrlich V, Jiricny J, Gotzmann J, Knasmüller S, Foisner R.

J Cell Sci. 2012 Feb 15;125(Pt 4):1048-57. doi: 10.1242/jcs.098392. Epub 2012 Mar 7.


Evolvement of LEM proteins as chromatin tethers at the nuclear periphery.

Brachner A, Foisner R.

Biochem Soc Trans. 2011 Dec;39(6):1735-41. doi: 10.1042/BST20110724. Review.


Lamins reach out to novel functions in DNA damage repair.

Brachner A, Foisner R.

Cell Cycle. 2011 Oct 15;10(20):3426. doi: 10.4161/cc.10.20.17526. Epub 2011 Oct 15. No abstract available.


Multiple novel functions of lamina associated polypeptide 2α in striated muscle.

Gotic I, Foisner R.

Nucleus. 2010 Sep-Oct;1(5):397-401. doi: 10.4161/nucl.1.5.12394.


Lamina-independent lamins in the nuclear interior serve important functions.

Dechat T, Gesson K, Foisner R.

Cold Spring Harb Symp Quant Biol. 2010;75:533-43. doi: 10.1101/sqb.2010.75.018. Epub 2011 Jan 5. Review.


Monoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482W.

Roblek M, Schüchner S, Huber V, Ollram K, Vlcek-Vesely S, Foisner R, Wehnert M, Ogris E.

PLoS One. 2010 May 13;5(5):e10604. doi: 10.1371/journal.pone.0010604.


Lamin-binding Proteins.

Wilson KL, Foisner R.

Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a000554. doi: 10.1101/cshperspect.a000554. Epub 2010 Feb 17. Review.


Lamins: 'structure goes cycling'.

Boban M, Braun J, Foisner R.

Biochem Soc Trans. 2010 Feb;38(Pt 1):301-6. doi: 10.1042/BST0380301.


The nuclear envelope from basic biology to therapy.

Worman HJ, Foisner R.

Biochem Soc Trans. 2010 Feb;38(Pt 1):253-6. doi: 10.1042/BST0380253.


Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination.

Gotic I, Schmidt WM, Biadasiewicz K, Leschnik M, Spilka R, Braun J, Stewart CL, Foisner R.

Stem Cells. 2010 Mar 31;28(3):480-8. doi: 10.1002/stem.292.


Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.

Gotic I, Leschnik M, Kolm U, Markovic M, Haubner BJ, Biadasiewicz K, Metzler B, Stewart CL, Foisner R.

Circ Res. 2010 Feb 5;106(2):346-53. doi: 10.1161/CIRCRESAHA.109.205724. Epub 2009 Nov 19.


Lamin complexes in the nuclear interior control progenitor cell proliferation and tissue homeostasis.

Naetar N, Foisner R.

Cell Cycle. 2009 May 15;8(10):1488-93. Epub 2009 May 20.


Prelamin A is involved in early steps of muscle differentiation.

Capanni C, Del Coco R, Squarzoni S, Columbaro M, Mattioli E, Camozzi D, Rocchi A, Scotlandi K, Maraldi N, Foisner R, Lattanzi G.

Exp Cell Res. 2008 Dec 10;314(20):3628-37. doi: 10.1016/j.yexcr.2008.09.026. Epub 2008 Oct 11.


Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.

Naetar N, Korbei B, Kozlov S, Kerenyi MA, Dorner D, Kral R, Gotic I, Fuchs P, Cohen TV, Bittner R, Stewart CL, Foisner R.

Nat Cell Biol. 2008 Nov;10(11):1341-8. doi: 10.1038/ncb1793. Epub 2008 Oct 12.


Sun1 forms immobile macromolecular assemblies at the nuclear envelope.

Lu W, Gotzmann J, Sironi L, Jaeger VM, Schneider M, Lüke Y, Uhlén M, Szigyarto CA, Brachner A, Ellenberg J, Foisner R, Noegel AA, Karakesisoglou I.

Biochim Biophys Acta. 2008 Dec;1783(12):2415-26. doi: 10.1016/j.bbamcr.2008.09.001. Epub 2008 Sep 19.


Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis.

Rauner M, Sipos W, Goettsch C, Wutzl A, Foisner R, Pietschmann P, Hofbauer LC.

J Bone Miner Res. 2009 Jan;24(1):78-86. doi: 10.1359/jbmr.080902.


The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections.

Mulky A, Cohen TV, Kozlov SV, Korbei B, Foisner R, Stewart CL, KewalRamani VN.

J Virol. 2008 Jun;82(12):5860-8. doi: 10.1128/JVI.00076-08. Epub 2008 Apr 9.


Drugs affecting prelamin A processing: effects on heterochromatin organization.

Mattioli E, Columbaro M, Capanni C, Santi S, Maraldi NM, D'Apice MR, Novelli G, Riccio M, Squarzoni S, Foisner R, Lattanzi G.

Exp Cell Res. 2008 Feb 1;314(3):453-62. Epub 2007 Nov 24.


Pre-Lamin A processing is linked to heterochromatin organization.

Lattanzi G, Columbaro M, Mattioli E, Cenni V, Camozzi D, Wehnert M, Santi S, Riccio M, Del Coco R, Maraldi NM, Squarzoni S, Foisner R, Capanni C.

J Cell Biochem. 2007 Dec 1;102(5):1149-59.


The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.

Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist P, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A.

Oncogene. 2007 Oct 25;26(49):6979-88. Epub 2007 May 7.

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