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PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation.

Chelban V, Wilson MP, Warman Chardon J, Vandrovcova J, Zanetti MN, Zamba-Papanicolaou E, Efthymiou S, Pope S, Conte MR, Abis G, Liu YT, Tribollet E, Haridy NA, Botía JA, Ryten M, Nicolaou P, Minaidou A, Christodoulou K, Kernohan KD, Eaton A, Osmond M, Ito Y, Bourque P, Jepson JEC, Bello O, Bremner F, Cordivari C, Reilly MM, Foiani M, Heslegrave A, Zetterberg H, Heales SJR, Wood NW, Rothman JE, Boycott KM, Mills PB, Clayton PT, Houlden H; Care4Rare Canada Consortium and the SYNaPS Study Group.

Ann Neurol. 2019 Aug;86(2):225-240. doi: 10.1002/ana.25524. Epub 2019 Jul 1.


Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S.

Cancer Cell. 2019 May 13;35(5):798-815.e5. doi: 10.1016/j.ccell.2019.03.007. Epub 2019 Apr 25.


Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest.

Foiani MS, Cicognola C, Ermann N, Woollacott IOC, Heller C, Heslegrave AJ, Keshavan A, Paterson RW, Ye K, Kornhuber J, Fox NC, Schott JM, Warren JD, Lewczuk P, Zetterberg H, Blennow K, Höglund K, Rohrer JD.

J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):740-746. doi: 10.1136/jnnp-2018-319266. Epub 2019 Apr 13.


An Error-Prone Polymerase in the Fight against Cancer.

Achar YJ, Foiani M.

Cell. 2019 Mar 7;176(6):1241-1243. doi: 10.1016/j.cell.2019.02.011.


Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy.

Lombardi V, Querin G, Ziff OJ, Zampedri L, Martinelli I, Heller C, Foiani M, Bertolin C, Lu CH, Malik B, Allen K, Rinaldi C, Zetterberg H, Heslegrave A, Greensmith L, Hanna M, Soraru G, Malaspina A, Fratta P.

Neurology. 2019 Mar 12;92(11):e1205-e1211. doi: 10.1212/WNL.0000000000007097. Epub 2019 Feb 20.


Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).

Vernieri C, Pusceddu S, Fucà G, Indelicato P, Centonze G, Castagnoli L, Ferrari E, Ajazi A, Pupa S, Casola S, Foiani M, Mazzaferro V, Pruneri G, Milione M, de Braud F.

Int J Cancer. 2019 Apr 1;144(7):1704-1712. doi: 10.1002/ijc.32042. Epub 2019 Jan 7.


Dna2 processes behind the fork long ssDNA flaps generated by Pif1 and replication-dependent strand displacement.

Rossi SE, Foiani M, Giannattasio M.

Nat Commun. 2018 Nov 16;9(1):4830. doi: 10.1038/s41467-018-07378-5.


Plasma Markers of Neurodegeneration Are Raised in Friedreich's Ataxia.

Zeitlberger AM, Thomas-Black G, Garcia-Moreno H, Foiani M, Heslegrave AJ, Zetterberg H, Giunti P.

Front Cell Neurosci. 2018 Oct 30;12:366. doi: 10.3389/fncel.2018.00366. eCollection 2018.


Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer's disease.

Sánchez-Valle R, Heslegrave A, Foiani MS, Bosch B, Antonell A, Balasa M, Lladó A, Zetterberg H, Fox NC.

Alzheimers Res Ther. 2018 Nov 3;10(1):113. doi: 10.1186/s13195-018-0439-y.


Interlaboratory validation of cerebrospinal fluid α-synuclein quantification in the diagnosis of sporadic Creutzfeldt-Jakob disease.

Kruse N, Heslegrave A, Gupta V, Foiani M, Villar-Piqué A, Schmitz M, Lehmann S, Teunissen C, Blennow K, Zetterberg H, Mollenhauer B, Zerr I, Llorens F.

Alzheimers Dement (Amst). 2018 Jul 7;10:461-470. doi: 10.1016/j.dadm.2018.06.005. eCollection 2018.


Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup.

Woollacott IOC, Nicholas JM, Heslegrave A, Heller C, Foiani MS, Dick KM, Russell LL, Paterson RW, Keshavan A, Fox NC, Warren JD, Schott JM, Zetterberg H, Rohrer JD.

Alzheimers Res Ther. 2018 Aug 16;10(1):79. doi: 10.1186/s13195-018-0405-8.


Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.

Toombs J, Foiani MS, Wellington H, Paterson RW, Arber C, Heslegrave A, Lunn MP, Schott JM, Wray S, Zetterberg H.

Alzheimers Dement (Amst). 2018 Mar 22;10:311-321. doi: 10.1016/j.dadm.2018.02.005. eCollection 2018.


A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.

Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, Biffo S, Foiani M.

Mol Cell. 2018 May 17;70(4):628-638.e5. doi: 10.1016/j.molcel.2018.04.020.


Molecular biomarkers of Alzheimer's disease: progress and prospects.

Lashley T, Schott JM, Weston P, Murray CE, Wellington H, Keshavan A, Foti SC, Foiani M, Toombs J, Rohrer JD, Heslegrave A, Zetterberg H.

Dis Model Mech. 2018 May 8;11(5). pii: dmm031781. doi: 10.1242/dmm.031781. Review.


Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic.

Paterson RW, Slattery CF, Poole T, Nicholas JM, Magdalinou NK, Toombs J, Chapman MD, Lunn MP, Heslegrave AJ, Foiani MS, Weston PSJ, Keshavan A, Rohrer JD, Rossor MN, Warren JD, Mummery CJ, Blennow K, Fox NC, Zetterberg H, Schott JM.

Alzheimers Res Ther. 2018 Mar 20;10(1):32. doi: 10.1186/s13195-018-0361-3.


Plasma tau is increased in frontotemporal dementia.

Foiani MS, Woollacott IO, Heller C, Bocchetta M, Heslegrave A, Dick KM, Russell LL, Marshall CR, Mead S, Schott JM, Fox NC, Warren JD, Zetterberg H, Rohrer JD.

J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):804-807. doi: 10.1136/jnnp-2017-317260. Epub 2018 Feb 13.


Coordinating Replication with Transcription.

Achar YJ, Foiani M.

Adv Exp Med Biol. 2017;1042:455-487. doi: 10.1007/978-981-10-6955-0_20. Review.


DNA damage causes rapid accumulation of phosphoinositides for ATR signaling.

Wang YH, Hariharan A, Bastianello G, Toyama Y, Shivashankar GV, Foiani M, Sheetz MP.

Nat Commun. 2017 Dec 14;8(1):2118. doi: 10.1038/s41467-017-01805-9.


Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.

Brambati A, Zardoni L, Achar YJ, Piccini D, Galanti L, Colosio A, Foiani M, Liberi G.

Nucleic Acids Res. 2018 Feb 16;46(3):1227-1239. doi: 10.1093/nar/gkx945.


PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.

Ferrari E, Bruhn C, Peretti M, Cassani C, Carotenuto WV, Elgendy M, Shubassi G, Lucca C, Bermejo R, Varasi M, Minucci S, Longhese MP, Foiani M.

Mol Cell. 2017 Jul 20;67(2):266-281.e4. doi: 10.1016/j.molcel.2017.05.027. Epub 2017 Jun 22.


Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation.

Muñoz MJ, Nieto Moreno N, Giono LE, Cambindo Botto AE, Dujardin G, Bastianello G, Lavore S, Torres-Méndez A, Menck CFM, Blencowe BJ, Irimia M, Foiani M, Kornblihtt AR.

Cell Rep. 2017 Mar 21;18(12):2868-2879. doi: 10.1016/j.celrep.2017.02.066.


Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration.

Toombs J, Foiani MS, Paterson RW, Heslegrave A, Wray S, Schott JM, Fox NC, Lunn MP, Blennow K, Zetterberg H.

J Alzheimers Dis. 2017;56(3):885-891. doi: 10.3233/JAD-161126.


Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.

Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V.

Cancer Discov. 2016 Dec;6(12):1315-1333. Epub 2016 Nov 21. Review.


ATR-mediated regulation of nuclear and cellular plasticity.

Kidiyoor GR, Kumar A, Foiani M.

DNA Repair (Amst). 2016 Aug;44:143-150. doi: 10.1016/j.dnarep.2016.05.020. Epub 2016 May 16. Review.


ATM and ATR signaling at a glance.

Awasthi P, Foiani M, Kumar A.

J Cell Sci. 2016 Mar 15;129(6):1285. doi: 10.1242/jcs.188631. No abstract available.


ATM and ATR signaling at a glance.

Awasthi P, Foiani M, Kumar A.

J Cell Sci. 2015 Dec 1;128(23):4255-62. doi: 10.1242/jcs.169730. Epub 2015 Nov 13. Review. Erratum in: J Cell Sci. 2016 Mar 15;129(6):1285.


Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.

Rossi SE, Ajazi A, Carotenuto W, Foiani M, Giannattasio M.

Cell Rep. 2015 Oct 6;13(1):80-92. doi: 10.1016/j.celrep.2015.08.073. Epub 2015 Sep 24.


Nuclear envelope and chromatin, lock and key of genome integrity.

Gay S, Foiani M.

Int Rev Cell Mol Biol. 2015;317:267-330. doi: 10.1016/bs.ircmb.2015.03.001. Epub 2015 Mar 30. Review.


Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.

Elgendy M, Ciro M, Abdel-Aziz AK, Belmonte G, Dal Zuffo R, Mercurio C, Miracco C, Lanfrancone L, Foiani M, Minucci S.

Nat Commun. 2014 Dec 4;5:5637. doi: 10.1038/ncomms6637.


Visualization of recombination-mediated damage bypass by template switching.

Giannattasio M, Zwicky K, Follonier C, Foiani M, Lopes M, Branzei D.

Nat Struct Mol Biol. 2014 Oct;21(10):884-92. doi: 10.1038/nsmb.2888. Epub 2014 Sep 7.


ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

Kumar A, Mazzanti M, Mistrik M, Kosar M, Beznoussenko GV, Mironov AA, Garrè M, Parazzoli D, Shivashankar GV, Scita G, Bartek J, Foiani M.

Cell. 2014 Jul 31;158(3):633-46. doi: 10.1016/j.cell.2014.05.046.


Dangerous liaisons: MYCN meets condensins.

Achar YJ, Foiani M.

Cell Cycle. 2014;13(8):1225-6. doi: 10.4161/cc.28569. Epub 2014 Mar 18. No abstract available.


Golgi feels DNA's pain.

Foiani M, Bartek J.

Cell. 2014 Jan 30;156(3):392-3. doi: 10.1016/j.cell.2014.01.030.


Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.

Alzu A, Bermejo R, Begnis M, Lucca C, Piccini D, Carotenuto W, Saponaro M, Brambati A, Cocito A, Foiani M, Liberi G.

Cell. 2012 Nov 9;151(4):835-846. doi: 10.1016/j.cell.2012.09.041.


Preserving the genome by regulating chromatin association with the nuclear envelope.

Bermejo R, Kumar A, Foiani M.

Trends Cell Biol. 2012 Sep;22(9):465-73. doi: 10.1016/j.tcb.2012.05.007. Epub 2012 Jul 5. Review.


Dna2 offers support for stalled forks.

Lai MS, Foiani M.

Cell. 2012 Jun 8;149(6):1181-3. doi: 10.1016/j.cell.2012.05.021.


Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy.

Botrugno OA, Robert T, Vanoli F, Foiani M, Minucci S.

Clin Cancer Res. 2012 May 1;18(9):2436-42. doi: 10.1158/1078-0432.CCR-11-0767. Epub 2012 Apr 18.


Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription.

Bermejo R, Lai MS, Foiani M.

Mol Cell. 2012 Mar 30;45(6):710-8. doi: 10.1016/j.molcel.2012.03.001. Review.


Acetylation: a novel link between double-strand break repair and autophagy.

Shubassi G, Robert T, Vanoli F, Minucci S, Foiani M.

Cancer Res. 2012 Mar 15;72(6):1332-5. doi: 10.1158/0008-5472.CAN-11-3172. Review.


G-quadruplex-induced instability during leading-strand replication.

Lopes J, Piazza A, Bermejo R, Kriegsman B, Colosio A, Teulade-Fichou MP, Foiani M, Nicolas A.

EMBO J. 2011 Aug 26;30(19):4033-46. doi: 10.1038/emboj.2011.316.


The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W, Cocito A, Doksani Y, Klein H, Gómez-González B, Aguilera A, Katou Y, Shirahige K, Foiani M.

Cell. 2011 Jul 22;146(2):233-46. doi: 10.1016/j.cell.2011.06.033.


Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.

Gómez-González B, García-Rubio M, Bermejo R, Gaillard H, Shirahige K, Marín A, Foiani M, Aguilera A.

EMBO J. 2011 Jun 24;30(15):3106-19. doi: 10.1038/emboj.2011.206.


HDACs link the DNA damage response, processing of double-strand breaks and autophagy.

Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA, Rothstein R, Botrugno OA, Parazzoli D, Oldani A, Minucci S, Foiani M.

Nature. 2011 Mar 3;471(7336):74-79. doi: 10.1038/nature09803.


Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.

Fachinetti D, Bermejo R, Cocito A, Minardi S, Katou Y, Kanoh Y, Shirahige K, Azvolinsky A, Zakian VA, Foiani M.

Mol Cell. 2010 Aug 27;39(4):595-605. doi: 10.1016/j.molcel.2010.07.024.


A lethal combination for cancer cells: synthetic lethality screenings for drug discovery.

Ferrari E, Lucca C, Foiani M.

Eur J Cancer. 2010 Nov;46(16):2889-95. doi: 10.1016/j.ejca.2010.07.031. Epub 2010 Aug 17. Review.


The double life of Holliday junctions.

Liberi G, Foiani M.

Cell Res. 2010 Jun;20(6):611-3. doi: 10.1038/cr.2010.73. Epub 2010 May 25. No abstract available.


Maintaining genome stability at the replication fork.

Branzei D, Foiani M.

Nat Rev Mol Cell Biol. 2010 Mar;11(3):208-19. doi: 10.1038/nrm2852. Review.


Leaping forks at inverted repeats.

Branzei D, Foiani M.

Genes Dev. 2010 Jan 1;24(1):5-9. doi: 10.1101/gad.1884810.


ChIP-on-chip analysis of DNA topoisomerases.

Bermejo R, Katou YM, Shirahige K, Foiani M.

Methods Mol Biol. 2009;582:103-18. doi: 10.1007/978-1-60761-340-4_9.


Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

Bermejo R, Capra T, Gonzalez-Huici V, Fachinetti D, Cocito A, Natoli G, Katou Y, Mori H, Kurokawa K, Shirahige K, Foiani M.

Cell. 2009 Sep 4;138(5):870-84. doi: 10.1016/j.cell.2009.06.022.

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