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Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00374-18. doi: 10.1128/AAC.00374-18. Print 2018 Nov.

Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.

Author information

1
Unité Parasitologie et entomologie, Département des maladies infectieuses, Institut de Recherche Biomédicale des Armées, Institut hospitalo-universitaire (IHU) Méditerranée Infection, Marseille, France.
2
Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection.
3
Centre National de Référence du Paludisme, Institut hospitalo-universitaire (IHU) Méditerranée Infection, Marseille, France.
4
Unité Parasitologie et entomologie, Département des maladies infectieuses, Institut de Recherche Biomédicale des Armées, Institut hospitalo-universitaire (IHU) Méditerranée Infection, Marseille, France bruno.pradines@gmail.com.

Abstract

Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine reduced susceptibility in Africa. Additionally, the few isolates with reduced susceptibility to piperaquine did not harbor amplification of the plasmepsin II gene.

KEYWORDS:

Plasmodium falciparum; antimalarial drug; in vitro; malaria; molecular marker; piperaquine; plasmepsin II gene; resistance

PMID:
30181370
PMCID:
PMC6201094
[Available on 2019-04-24]
DOI:
10.1128/AAC.00374-18

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